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The map label for this gene is merA [H]

Identifier: 37520133

GI number: 37520133

Start: 599518

End: 601041

Strand: Reverse

Name: merA [H]

Synonym: gll0564

Alternate gene names: 37520133

Gene position: 601041-599518 (Counterclockwise)

Preceding gene: 37520134

Following gene: 37520130

Centisome position: 12.9

GC content: 66.01

Gene sequence:

>1524_bases
ATGAGCGAACAGCCAATCGGCATCGCCCCCATGGATGTCCACAACACGCGGCTTGTGGCCCACACCCATCCGCTGGACTG
GGTCAACCCGAAGCCCGCCGGGCGCTACAACCTGGTGGTGATCGGAGGCGGCACGGCGGGGTTGGTGAGCGCGGGGGGTG
CAGCGCTGTTGGGAGGCAAAGTCGCGTTGGTGGAGCGTCACCTGCTGGGGGGTGATTGTCTGGTGGCCGGATGCGTGCCC
TCCAAGGCGCTTATCCGCTCCGCCCGGGCGATGGCCGATGTCAAGGACGCCCACCGCTACGGCATCCGGGTGCACGGTAA
TGTCGAAGCTGACTTCGGCGCGGTGATGGAGCGCCTCCGGCGGGTGCGCGCCGACATCAGTCCCCACGACGCAGCGGAGC
GCTTCAAAAATTGGGGTGTTGACGTGTTTTTGGGGGCGGCGCGCTTCACCGGTCCGGACACGGTCCGGGTGGGCGAGGTG
GAGTTGCGTTTCAAGCGCGCCATCGTCGCCACCGGCGGCCGGGCGGCCAGACCCGAGATTGCGGGCCTGGCGGAAGCGGG
CTTCCTCACCAACGAGACGGTATTCTCCCTCACCGAGCGGCCGGAACGGCTGGTGGTGATCGGCGGCGGTCCAATCGGCT
GCGAACTTGCCCAGAGCTTTGCCCGTCTCGGGTCGCAGGTGACGCTGCTGCACAAAAACGAGCGCGTGCTCGACCGCGAA
GACCCCGAGACCTCTCGGATCGTAGGCTGTGCCCTGGAGCGCGACGGGGTGCGGGTGCTCACCAAGGCCCGCATCGAGAA
GGTGAGCCGCGCGGGCAGCATCAAAACCGTACATCTAGCGGGGGGCGAGCAGGTCGCCTGCGAGGCGATTTTGCTCGCGG
CCGGGCGCGTTCCCAACGTCGAGGGCCTCGGCCTCGAAGCGGCCGGGGTGCGCTATGGCAAAGGCGGCGTCGAGGTGGAC
GACCGGCTATGCACCAGCAATCCCCGCATTTACGCCTGCGGCGATATTTGCCTGCCCTGGAAATTCACCCACGCCGCCGA
GGCTTCCGCCCGCATCGCCCTCGAAAACGCCCTGTTTGGGGGAACCCTCGTTCTGGGTCAAAAAAAAACGAGTGCCCTCA
CCATGCCCTGGTGCACCTACACCGACCCCGAGATAGCCCATGTCGGTCTAGGCGAGGACGAGGCGCGCAAGCGGGGCATC
GCCTTCGACACTATCCGCCTGCCGCTTGCCGAGTCGGACCGTGCCCTGACCGACGGCGAAGAGGATGGCTTTATCGCGGT
GCTGCTCAAGCAGGGCAGCGACAAGATCCTGGGGGCGACGCTGGTGGCCCGCCACGCGGGGGAGATGATTTCCGAAATCA
CCCTGGCGATGGTAGCGGGCAAGGGCCTCGCCACGCTTTCTCAAGTCATTCATCCCTACCCGACCCAGGCGGAAATCATC
CGCAAAGTAGCCGACGCTTATGAGTCCCGCTCGCTTGAACGGCTCAGACCCTTTACCGAGAAGTGGCTCGCCTGGTTGCG
TTAG

Upstream 100 bases:

>100_bases
TGGTGCTCATCGGGGCGGTGGTGGGGCTGGTGACGACGGTCGTGCGGGGCTTGTAAGCAAACCTATTTCATAGAATGAAG
TCAATCTTTCGGGTCAATCG

Downstream 100 bases:

>100_bases
CGCCCCTCGCGCTGGAGCACGGGTATGGAGTCGTGGTTGCGCAGGTTTTCGACTTGCCTGGAGGCGTTGAGGATCTCGAC
GCCGACCACCCGGCCGCTAC

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSEQPIGIAPMDVHNTRLVAHTHPLDWVNPKPAGRYNLVVIGGGTAGLVSAGGAALLGGKVALVERHLLGGDCLVAGCVP
SKALIRSARAMADVKDAHRYGIRVHGNVEADFGAVMERLRRVRADISPHDAAERFKNWGVDVFLGAARFTGPDTVRVGEV
ELRFKRAIVATGGRAARPEIAGLAEAGFLTNETVFSLTERPERLVVIGGGPIGCELAQSFARLGSQVTLLHKNERVLDRE
DPETSRIVGCALERDGVRVLTKARIEKVSRAGSIKTVHLAGGEQVACEAILLAAGRVPNVEGLGLEAAGVRYGKGGVEVD
DRLCTSNPRIYACGDICLPWKFTHAAEASARIALENALFGGTLVLGQKKTSALTMPWCTYTDPEIAHVGLGEDEARKRGI
AFDTIRLPLAESDRALTDGEEDGFIAVLLKQGSDKILGATLVARHAGEMISEITLAMVAGKGLATLSQVIHPYPTQAEII
RKVADAYESRSLERLRPFTEKWLAWLR

Sequences:

>Translated_507_residues
MSEQPIGIAPMDVHNTRLVAHTHPLDWVNPKPAGRYNLVVIGGGTAGLVSAGGAALLGGKVALVERHLLGGDCLVAGCVP
SKALIRSARAMADVKDAHRYGIRVHGNVEADFGAVMERLRRVRADISPHDAAERFKNWGVDVFLGAARFTGPDTVRVGEV
ELRFKRAIVATGGRAARPEIAGLAEAGFLTNETVFSLTERPERLVVIGGGPIGCELAQSFARLGSQVTLLHKNERVLDRE
DPETSRIVGCALERDGVRVLTKARIEKVSRAGSIKTVHLAGGEQVACEAILLAAGRVPNVEGLGLEAAGVRYGKGGVEVD
DRLCTSNPRIYACGDICLPWKFTHAAEASARIALENALFGGTLVLGQKKTSALTMPWCTYTDPEIAHVGLGEDEARKRGI
AFDTIRLPLAESDRALTDGEEDGFIAVLLKQGSDKILGATLVARHAGEMISEITLAMVAGKGLATLSQVIHPYPTQAEII
RKVADAYESRSLERLRPFTEKWLAWLR
>Mature_506_residues
SEQPIGIAPMDVHNTRLVAHTHPLDWVNPKPAGRYNLVVIGGGTAGLVSAGGAALLGGKVALVERHLLGGDCLVAGCVPS
KALIRSARAMADVKDAHRYGIRVHGNVEADFGAVMERLRRVRADISPHDAAERFKNWGVDVFLGAARFTGPDTVRVGEVE
LRFKRAIVATGGRAARPEIAGLAEAGFLTNETVFSLTERPERLVVIGGGPIGCELAQSFARLGSQVTLLHKNERVLDRED
PETSRIVGCALERDGVRVLTKARIEKVSRAGSIKTVHLAGGEQVACEAILLAAGRVPNVEGLGLEAAGVRYGKGGVEVDD
RLCTSNPRIYACGDICLPWKFTHAAEASARIALENALFGGTLVLGQKKTSALTMPWCTYTDPEIAHVGLGEDEARKRGIA
FDTIRLPLAESDRALTDGEEDGFIAVLLKQGSDKILGATLVARHAGEMISEITLAMVAGKGLATLSQVIHPYPTQAEIIR
KVADAYESRSLERLRPFTEKWLAWLR

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=29.6774193548387, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=29.4623655913978, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI22035672, Length=469, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI291045266, Length=470, Percent_Identity=24.8936170212766, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI33519430, Length=471, Percent_Identity=23.3545647558386, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI33519428, Length=471, Percent_Identity=23.3545647558386, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI33519426, Length=471, Percent_Identity=23.3545647558386, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI148277071, Length=471, Percent_Identity=23.3545647558386, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI148277065, Length=447, Percent_Identity=23.2662192393736, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI291045268, Length=346, Percent_Identity=25.7225433526012, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786307, Length=484, Percent_Identity=30.9917355371901, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=28.476821192053, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=26.338329764454, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789915, Length=441, Percent_Identity=28.1179138321995, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789065, Length=219, Percent_Identity=28.7671232876712, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=31.8279569892473, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=27.5574112734864, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=433, Percent_Identity=27.0207852193995, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=433, Percent_Identity=27.0207852193995, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=492, Percent_Identity=25.8130081300813, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=29.4117647058824, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=26.4069264069264, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=26.5822784810127, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21358499, Length=494, Percent_Identity=32.5910931174089, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24640551, Length=506, Percent_Identity=27.2727272727273, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=27.7432712215321, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=27.7432712215321, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17737741, Length=481, Percent_Identity=28.0665280665281, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 54305; Mature: 54174

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQPIGIAPMDVHNTRLVAHTHPLDWVNPKPAGRYNLVVIGGGTAGLVSAGGAALLGGK
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEECCE
VALVERHLLGGDCLVAGCVPSKALIRSARAMADVKDAHRYGIRVHGNVEADFGAVMERLR
EEEEHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHH
RVRADISPHDAAERFKNWGVDVFLGAARFTGPDTVRVGEVELRFKRAIVATGGRAARPEI
HHHCCCCCCHHHHHHHHCCCEEEEECEECCCCCCEEECCEEEEEEEEEEECCCCCCCCHH
AGLAEAGFLTNETVFSLTERPERLVVIGGGPIGCELAQSFARLGSQVTLLHKNERVLDRE
HHHHHCCCCCCCHHEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCC
DPETSRIVGCALERDGVRVLTKARIEKVSRAGSIKTVHLAGGEQVACEAILLAAGRVPNV
CCCCHHEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCC
EGLGLEAAGVRYGKGGVEVDDRLCTSNPRIYACGDICLPWKFTHAAEASARIALENALFG
CCCCCCCCCEEECCCCCCCCCHHCCCCCCEEEECCEEECEEECCCCCCCCEEEEECCCCC
GTLVLGQKKTSALTMPWCTYTDPEIAHVGLGEDEARKRGIAFDTIRLPLAESDRALTDGE
CEEEEECCCCCEEEECEECCCCCCEEEECCCCHHHHHCCCEEEEEEECCCCCCCCCCCCC
EDGFIAVLLKQGSDKILGATLVARHAGEMISEITLAMVAGKGLATLSQVIHPYPTQAEII
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHH
RKVADAYESRSLERLRPFTEKWLAWLR
HHHHHHHHHCCHHHHCHHHHHHHHHCC
>Mature Secondary Structure 
SEQPIGIAPMDVHNTRLVAHTHPLDWVNPKPAGRYNLVVIGGGTAGLVSAGGAALLGGK
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEECCE
VALVERHLLGGDCLVAGCVPSKALIRSARAMADVKDAHRYGIRVHGNVEADFGAVMERLR
EEEEHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHH
RVRADISPHDAAERFKNWGVDVFLGAARFTGPDTVRVGEVELRFKRAIVATGGRAARPEI
HHHCCCCCCHHHHHHHHCCCEEEEECEECCCCCCEEECCEEEEEEEEEEECCCCCCCCHH
AGLAEAGFLTNETVFSLTERPERLVVIGGGPIGCELAQSFARLGSQVTLLHKNERVLDRE
HHHHHCCCCCCCHHEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCC
DPETSRIVGCALERDGVRVLTKARIEKVSRAGSIKTVHLAGGEQVACEAILLAAGRVPNV
CCCCHHEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCC
EGLGLEAAGVRYGKGGVEVDDRLCTSNPRIYACGDICLPWKFTHAAEASARIALENALFG
CCCCCCCCCEEECCCCCCCCCHHCCCCCCEEEECCEEECEEECCCCCCCCEEEEECCCCC
GTLVLGQKKTSALTMPWCTYTDPEIAHVGLGEDEARKRGIAFDTIRLPLAESDRALTDGE
CEEEEECCCCCEEEECEECCCCCCEEEECCCCHHHHHCCCEEEEEEECCCCCCCCCCCCC
EDGFIAVLLKQGSDKILGATLVARHAGEMISEITLAMVAGKGLATLSQVIHPYPTQAEII
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHH
RKVADAYESRSLERLRPFTEKWLAWLR
HHHHHHHHHCCHHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]