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The map label for this gene is pth

Identifier: 37520107

GI number: 37520107

Start: 574700

End: 575296

Strand: Reverse

Name: pth

Synonym: gvip057

Alternate gene names: 37520107

Gene position: 575296-574700 (Counterclockwise)

Preceding gene: 37520110

Following gene: 37520106

Centisome position: 12.35

GC content: 63.65

Gene sequence:

>597_bases
ATGGAACTGCGCTTGTTCGTCGGGCTTGGCAATCCTGGCCTCCAGTACACCCAGACCCGCCACAACGCCGGGTTTCTTGC
TGTGGACGCCCTCGCGAAACGTTGGCAATGCAGTTGGGTCGAAAAGAGCCGCTTCAAAGGCTATCTGGCCGAGGGGGCCG
GCCCTGGGGGCCGGGCCATTCTGCTCAAGCCGACCACCTACATGAACCACTCCGGCCAATCGGTGCGCGCGGTGGCCGAT
TACTTTCGGCTGCCGCCGCAACAGCTGCTGGTGCTCTACGACGAGGTCGCCCTGCCCCTGGGCAAAATCCGCCTGCGCCC
CGAAGGGTCCGCCGCCGGTCACAACGGCATCAAATCGCTTATCGAACATCTGGGCACCAACCAGTTTGCCCGGCTGCGCA
TCGGCATCGGCCGGGAGCCGCCTCCGCCGGTGCTCACCAACTACGTGCTGGGCAAATTCGCTCCCGAGGAGCAGGAGCAG
TTGCCTGCCATCCTTGACGGCTGCGTGGAGGCAGTGGAGGCGGTGCTCGCCAAGGGGCTGGAAAAGGCGATGAGCATTTA
TAATGCGAGGAGTTTTGGATCCCCCCCAGACCCTTAG

Upstream 100 bases:

>100_bases
ATACGTTAGCCACGGGGTGACTGCTCCATTATGGGCCGATTGCTCCGCCACCCACACCCAGCCGTTGCGGCGAGCCGCTG
TGGGGCGATTGAATAAAGTC

Downstream 100 bases:

>100_bases
CGCGGGGGAGGTGATCTTTGTGGTACTGCCCGAGGCGAGCTTTTGACTCTTTGTCGGCTTCGAGCGTCGCCTGGCGCGCG
GCGGCGATGAGTTCGAGGCG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MELRLFVGLGNPGLQYTQTRHNAGFLAVDALAKRWQCSWVEKSRFKGYLAEGAGPGGRAILLKPTTYMNHSGQSVRAVAD
YFRLPPQQLLVLYDEVALPLGKIRLRPEGSAAGHNGIKSLIEHLGTNQFARLRIGIGREPPPPVLTNYVLGKFAPEEQEQ
LPAILDGCVEAVEAVLAKGLEKAMSIYNARSFGSPPDP

Sequences:

>Translated_198_residues
MELRLFVGLGNPGLQYTQTRHNAGFLAVDALAKRWQCSWVEKSRFKGYLAEGAGPGGRAILLKPTTYMNHSGQSVRAVAD
YFRLPPQQLLVLYDEVALPLGKIRLRPEGSAAGHNGIKSLIEHLGTNQFARLRIGIGREPPPPVLTNYVLGKFAPEEQEQ
LPAILDGCVEAVEAVLAKGLEKAMSIYNARSFGSPPDP
>Mature_198_residues
MELRLFVGLGNPGLQYTQTRHNAGFLAVDALAKRWQCSWVEKSRFKGYLAEGAGPGGRAILLKPTTYMNHSGQSVRAVAD
YFRLPPQQLLVLYDEVALPLGKIRLRPEGSAAGHNGIKSLIEHLGTNQFARLRIGIGREPPPPVLTNYVLGKFAPEEQEQ
LPAILDGCVEAVEAVLAKGLEKAMSIYNARSFGSPPDP

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=38.8235294117647, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=41.0526315789474, Blast_Score=125, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321983, Length=169, Percent_Identity=35.5029585798817, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_GLOVI (Q7NN75)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923484.1
- ProteinModelPortal:   Q7NN75
- SMR:   Q7NN75
- GeneID:   2599645
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.538
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   GVIO251221:GLL0538-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21589; Mature: 21589

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRLFVGLGNPGLQYTQTRHNAGFLAVDALAKRWQCSWVEKSRFKGYLAEGAGPGGRAI
CCEEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHCCHHHHHHHHCEEHHCCCCCCCCEE
LLKPTTYMNHSGQSVRAVADYFRLPPQQLLVLYDEVALPLGKIRLRPEGSAAGHNGIKSL
EECCCHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHH
IEHLGTNQFARLRIGIGREPPPPVLTNYVLGKFAPEEQEQLPAILDGCVEAVEAVLAKGL
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKAMSIYNARSFGSPPDP
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MELRLFVGLGNPGLQYTQTRHNAGFLAVDALAKRWQCSWVEKSRFKGYLAEGAGPGGRAI
CCEEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHCCHHHHHHHHCEEHHCCCCCCCCEE
LLKPTTYMNHSGQSVRAVADYFRLPPQQLLVLYDEVALPLGKIRLRPEGSAAGHNGIKSL
EECCCHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHH
IEHLGTNQFARLRIGIGREPPPPVLTNYVLGKFAPEEQEQLPAILDGCVEAVEAVLAKGL
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKAMSIYNARSFGSPPDP
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292