Click here to switch to the map view.

The map label for this gene is trxB [H]

Identifier: 37520049

GI number: 37520049

Start: 516903

End: 518570

Strand: Direct

Name: trxB [H]

Synonym: glr0480

Alternate gene names: 37520049

Gene position: 516903-518570 (Clockwise)

Preceding gene: 37520045

Following gene: 37520050

Centisome position: 11.09

GC content: 65.53

Gene sequence:

>1668_bases
ATGGCCAAACCGGCGTTACTGACGGTCGACGACGATCCCGAGGTGTTGCAGGCGGTGGGGCGCGACCTGCAAAGCAAATA
CGGCGGCCGGTTTCGGGTATTGAGGGCCGATTCGGGCGCCTCGGCTCTTGCCGCGCTCAAACAACTGCAACTGCGCAACC
AGCCGGTGGCGCTGTTCCTGGTCGACCAGCGCATGCCCCAGATGAGCGGCGTCGAATTTCTCGAACAGGCGTTGCCGTTG
TTCCCGGAGGCCAAGCGGGTGCTGCTCACCGCCTACGCCGACACAGATGCCGCCATCCGCGCCATCAACAGCGTGCGCAC
CGACTACTATCTGCTCAAACCCTGGGATCCGCCTGAAGAGAGGCTGTACCCGGTGCTCGACGATCTGCTGGATGACTGGC
TTGCCAACCACAAGCCGCCCTTTGAAGGCATCCGGGTGGTGGGCAACCGCTGGTCGCCCCAGTCCCACCGGGTCAAAGAT
TTTCTGGCCCGCCAGCAGGTGCCCTACCAGTGGCTCGATCTCGAAATCCAACCGGAGGCGCAGCATCTTTTGAATGCTGC
CGGTGACGACCAGGCGCACCTGCCGCTGGTGGTCTTTGCGGACGGCTCGCGCCTGGCACAGCCCACCAACGCCGAAATTG
CCGAGAAGCTGGGGCTGCGCACTCGGGCGGAGCGGCCTTTTTACGACCTGATAATCGTGGGAGGCGGCCCGGCGGGTCTC
GCGGCAGCGGTCTACGGCGCCTCGGAGGGACTCAGCACCGTGATGGTCGAGCGCCAGGCTCCGGGGGGCCAGGCGGGATC
CAGCTCGCGCATCGAAAATTATCTGGGCTTTCCGGTGGGCCTGAGCGGCGCGGATCTGGCCCGGCGGGCGGTGGCGCAGG
CTCGCCGCTTCGGCGTCGAGATTCTCTCCCCACAGGAAGTGACCGGCATCCGCATCGAACCGCCCTACCGGGTAGTCACT
CTGGCGGACGGCAGCGAGGTGAGCTGCCACGCGCTGCTCATCGCCACCGGCGTCTCCTACCGCAAACTGGAGGTGGCGGG
GGCGGAGGCGCTCACCGGGGCGGGAGTCTACTACGGTGCCGCCCAGTCCGAGGCGCTCGCCTGCAGCAACGAAGCAGTTT
TTATCGTGGGGGGCGCCAACTCCGCCGGCCAAGCCGCCGTCTACTTTGCGCGCTACGCGAAGCAGGTGACGATGCTGGTG
CGCGGCGAATCGCTCACGGCAAGCATGTCGCAATACCTCATCGAGCAAATCGCCCAGACTGAAAACATTGTCGTACGCAC
CCGCACCAGCGTCACAGCCGTCAAAGGCGAGAGCAACCTGGAGGCGATTACCGTCCACGACGACGCCACCGGCGAGACCC
AGACGCTCCCTGCCAATTCGCTGTTTATCTTGATCGGGGCGGCCCCCAACACCGACTGGCTCGCAGGCGTGGTCGAGCGC
GACGAGCGCGGATTTATCCTGGCCGGTCCCGACTTGATGCGCGACCGGCGCCGCCCGCGCGGTTGGACGCTCGATCGCGA
CCCATTCTTGCTTGAGACCAGCGTGCCGGGCATCTTCGTGGCGGGCGACGTGCGCTGCAAATCGGTCAAACGGGTGGCTT
CCGGGGTGGGCGAAGGCTCGATCGCCGTGCAGTTCATTCACCAGTACCTGAGCAAAGTGGGGACATAA

Upstream 100 bases:

>100_bases
GGGCACCCGCTCCCTCGACTTTGCCGGAGGTTCGGGGTCTCAGCTCTTAAAATGAGAGTCCAGATCCACTTTGACAACTT
TCGGGGGGCGCGAGGAGTTT

Downstream 100 bases:

>100_bases
GCGGGGGAACTCGGCCGGGCTTTGCCGCCCCCCTTGCGCCCTGCCTCCGGATGCGCTAGATTTTGGTTGTGCGACCAACC
AACATCGTTTCGACCGTGAA

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MAKPALLTVDDDPEVLQAVGRDLQSKYGGRFRVLRADSGASALAALKQLQLRNQPVALFLVDQRMPQMSGVEFLEQALPL
FPEAKRVLLTAYADTDAAIRAINSVRTDYYLLKPWDPPEERLYPVLDDLLDDWLANHKPPFEGIRVVGNRWSPQSHRVKD
FLARQQVPYQWLDLEIQPEAQHLLNAAGDDQAHLPLVVFADGSRLAQPTNAEIAEKLGLRTRAERPFYDLIIVGGGPAGL
AAAVYGASEGLSTVMVERQAPGGQAGSSSRIENYLGFPVGLSGADLARRAVAQARRFGVEILSPQEVTGIRIEPPYRVVT
LADGSEVSCHALLIATGVSYRKLEVAGAEALTGAGVYYGAAQSEALACSNEAVFIVGGANSAGQAAVYFARYAKQVTMLV
RGESLTASMSQYLIEQIAQTENIVVRTRTSVTAVKGESNLEAITVHDDATGETQTLPANSLFILIGAAPNTDWLAGVVER
DERGFILAGPDLMRDRRRPRGWTLDRDPFLLETSVPGIFVAGDVRCKSVKRVASGVGEGSIAVQFIHQYLSKVGT

Sequences:

>Translated_555_residues
MAKPALLTVDDDPEVLQAVGRDLQSKYGGRFRVLRADSGASALAALKQLQLRNQPVALFLVDQRMPQMSGVEFLEQALPL
FPEAKRVLLTAYADTDAAIRAINSVRTDYYLLKPWDPPEERLYPVLDDLLDDWLANHKPPFEGIRVVGNRWSPQSHRVKD
FLARQQVPYQWLDLEIQPEAQHLLNAAGDDQAHLPLVVFADGSRLAQPTNAEIAEKLGLRTRAERPFYDLIIVGGGPAGL
AAAVYGASEGLSTVMVERQAPGGQAGSSSRIENYLGFPVGLSGADLARRAVAQARRFGVEILSPQEVTGIRIEPPYRVVT
LADGSEVSCHALLIATGVSYRKLEVAGAEALTGAGVYYGAAQSEALACSNEAVFIVGGANSAGQAAVYFARYAKQVTMLV
RGESLTASMSQYLIEQIAQTENIVVRTRTSVTAVKGESNLEAITVHDDATGETQTLPANSLFILIGAAPNTDWLAGVVER
DERGFILAGPDLMRDRRRPRGWTLDRDPFLLETSVPGIFVAGDVRCKSVKRVASGVGEGSIAVQFIHQYLSKVGT
>Mature_554_residues
AKPALLTVDDDPEVLQAVGRDLQSKYGGRFRVLRADSGASALAALKQLQLRNQPVALFLVDQRMPQMSGVEFLEQALPLF
PEAKRVLLTAYADTDAAIRAINSVRTDYYLLKPWDPPEERLYPVLDDLLDDWLANHKPPFEGIRVVGNRWSPQSHRVKDF
LARQQVPYQWLDLEIQPEAQHLLNAAGDDQAHLPLVVFADGSRLAQPTNAEIAEKLGLRTRAERPFYDLIIVGGGPAGLA
AAVYGASEGLSTVMVERQAPGGQAGSSSRIENYLGFPVGLSGADLARRAVAQARRFGVEILSPQEVTGIRIEPPYRVVTL
ADGSEVSCHALLIATGVSYRKLEVAGAEALTGAGVYYGAAQSEALACSNEAVFIVGGANSAGQAAVYFARYAKQVTMLVR
GESLTASMSQYLIEQIAQTENIVVRTRTSVTAVKGESNLEAITVHDDATGETQTLPANSLFILIGAAPNTDWLAGVVERD
ERGFILAGPDLMRDRRRPRGWTLDRDPFLLETSVPGIFVAGDVRCKSVKRVASGVGEGSIAVQFIHQYLSKVGT

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=326, Percent_Identity=29.1411042944785, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI87081763, Length=372, Percent_Identity=29.0322580645161, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320560, Length=334, Percent_Identity=30.2395209580838, Blast_Score=137, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6321898, Length=334, Percent_Identity=30.2395209580838, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 60059; Mature: 59928

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPALLTVDDDPEVLQAVGRDLQSKYGGRFRVLRADSGASALAALKQLQLRNQPVALFL
CCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEE
VDQRMPQMSGVEFLEQALPLFPEAKRVLLTAYADTDAAIRAINSVRTDYYLLKPWDPPEE
ECCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCEEEECCCCCCHH
RLYPVLDDLLDDWLANHKPPFEGIRVVGNRWSPQSHRVKDFLARQQVPYQWLDLEIQPEA
HHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCH
QHLLNAAGDDQAHLPLVVFADGSRLAQPTNAEIAEKLGLRTRAERPFYDLIIVGGGPAGL
HHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCHHH
AAAVYGASEGLSTVMVERQAPGGQAGSSSRIENYLGFPVGLSGADLARRAVAQARRFGVE
HHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEE
ILSPQEVTGIRIEPPYRVVTLADGSEVSCHALLIATGVSYRKLEVAGAEALTGAGVYYGA
EECCCCCCEEEECCCEEEEEEECCCCCEEEEEEEECCCCEEEEEECCCHHHCCCCEEECC
AQSEALACSNEAVFIVGGANSAGQAAVYFARYAKQVTMLVRGESLTASMSQYLIEQIAQT
CCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCC
ENIVVRTRTSVTAVKGESNLEAITVHDDATGETQTLPANSLFILIGAAPNTDWLAGVVER
CCEEEEEECEEEEEECCCCCEEEEEECCCCCCCEECCCCCEEEEEECCCCCCHHHHHHCC
DERGFILAGPDLMRDRRRPRGWTLDRDPFLLETSVPGIFVAGDVRCKSVKRVASGVGEGS
CCCCEEEECHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHCCCCCH
IAVQFIHQYLSKVGT
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKPALLTVDDDPEVLQAVGRDLQSKYGGRFRVLRADSGASALAALKQLQLRNQPVALFL
CCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEE
VDQRMPQMSGVEFLEQALPLFPEAKRVLLTAYADTDAAIRAINSVRTDYYLLKPWDPPEE
ECCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCEEEECCCCCCHH
RLYPVLDDLLDDWLANHKPPFEGIRVVGNRWSPQSHRVKDFLARQQVPYQWLDLEIQPEA
HHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCH
QHLLNAAGDDQAHLPLVVFADGSRLAQPTNAEIAEKLGLRTRAERPFYDLIIVGGGPAGL
HHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCHHH
AAAVYGASEGLSTVMVERQAPGGQAGSSSRIENYLGFPVGLSGADLARRAVAQARRFGVE
HHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEE
ILSPQEVTGIRIEPPYRVVTLADGSEVSCHALLIATGVSYRKLEVAGAEALTGAGVYYGA
EECCCCCCEEEECCCEEEEEEECCCCCEEEEEEEECCCCEEEEEECCCHHHCCCCEEECC
AQSEALACSNEAVFIVGGANSAGQAAVYFARYAKQVTMLVRGESLTASMSQYLIEQIAQT
CCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCC
ENIVVRTRTSVTAVKGESNLEAITVHDDATGETQTLPANSLFILIGAAPNTDWLAGVVER
CCEEEEEECEEEEEECCCCCEEEEEECCCCCCCEECCCCCEEEEEECCCCCCHHHHHHCC
DERGFILAGPDLMRDRRRPRGWTLDRDPFLLETSVPGIFVAGDVRCKSVKRVASGVGEGS
CCCCEEEECHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHCCCCCH
IAVQFIHQYLSKVGT
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA