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The map label for this gene is glmU

Identifier: 37520012

GI number: 37520012

Start: 470886

End: 472256

Strand: Direct

Name: glmU

Synonym: glr0443

Alternate gene names: 37520012

Gene position: 470886-472256 (Clockwise)

Preceding gene: 37520010

Following gene: 37520014

Centisome position: 10.11

GC content: 66.45

Gene sequence:

>1371_bases
ATGAGTGCGCGATTGGCGGCGATTGTACTGGCGGCGGGCAAAGGCACCCGCATGCGCTCCACCCTGCCCAAGGTGCTGCA
TCCCCTGGCGGGCAGCACCATCCTCGAACGGGTGCTCGCCGCGTTGGGCGAACTTGCCTTGGCCGAATGCTTTATTGTCG
TGGGTCAGGGGGCCGAGCTGGTGCGCGGGCGCATCGCCCGTCCGGGGGTCCAGTTTGTGGAGCAAACCGAACAGCGGGGC
ACCGGGCACGCCGTTCAGCAGGTGATCCCGCACCTGGAGGGCTTCGAGGGCGAAGTCCTGGTGCTCAACGGCGACGCGCC
GCTGTTGCGGCCCAGCACGGTCGCCCATCTGGTCGAAAAACACCGCAGCTTCGCGGCCGACGCCACGATTCTCGCCGCCC
GGATCGCCGATCCGGGCGGCTATGGCCGGGTGTTCCTCGACGCCGATGGCCGGGTGCGCCAGGTGATCGAAGATCGCGAT
TGTACCGAGGAGCAGCGCCGCAACGACTTGATCAACGGCGGAGTCTACTGCTTTCGGTGGCCTGCGCTGATGACGGTATT
GCCTGCATTGAGCGCCGACAACGACCAGGGCGAGCTGTACCTGCCGGACGCACTGCCGATGCTCACCCACGTGCGCGCCG
TCGCAGTGGAAGACCCCCAGGAGATCTTTGGAATCAACGACCGGCTGCAACTGTCCCAGGCGAGCCGCATCCTGAATGAG
CGCACGCTGGTGGGGTTGATGCTCTCGGGGGTGACCATCGTCGACCCGTTGCGGGTCACCATCGACGAGACCGTCGAAAT
CGAACCGGACGTGGTGATCGAGCCGGAGACCCACCTGCGCGGCGCCACCCGCATCGCCGGAGGCTGCCGCATCGGTCCCG
GGACCCTGCTGGAAGATACGGTCGTGGGGGCGGGCACCGAAATTCTGTACTCGGTCTTGCGCCGTTCGCGCGTGGGAGCG
CACTCCACCATCGGTCCGTACTCACACCTGCGGCCCGGTGCCGATGTGGGCTCCCACTGCCGGGTCGGCAACTACGTAGA
AATCAAAAACGCCACCATCGGCGATCACACCAACGCGGCGCACCTGAGCTATGTGGGCGACGCAAGTGTCGGCGAGCGGG
TCAACTTCGGCGCCGGCACGATCGTGGTTAACTACGACGGCAAACACAAGCACCGTACCGAAATCGGCGACGGGGTGCGT
ACCGGCGCCAACTCCTGCCTGGTGGCCCCGCTCAAGCTGGGCGACGGGGTGACCGTCGCCGCCGGCTCCACCGTCACCGA
AGATGTGCCCTGCGGATTGGTGATTGCCCGCAGCCGCCAGGTGGTGAAGCCCGACTGGAAAGCGCCCTACGAGCGCACCG
AGGATGGTTAG

Upstream 100 bases:

>100_bases
TGCATACGTCTGCTGCTTCGGCTGATTGTAGGGCCAATTTTAGCAATTCCACCCCCGCCGATATACTGTTTGAGCATCAG
TAAGGAGAGACGGAGAGACG

Downstream 100 bases:

>100_bases
CCGCCCGCCAGGGGATCAAAGATTTTCTCCCACTGCCGGGCGCCCAGTAATCCGATCCCCGGTTCGTAGGTGAGGTCGTA
CTTGAGCGGGGTGATCGCGA

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSARLAAIVLAAGKGTRMRSTLPKVLHPLAGSTILERVLAALGELALAECFIVVGQGAELVRGRIARPGVQFVEQTEQRG
TGHAVQQVIPHLEGFEGEVLVLNGDAPLLRPSTVAHLVEKHRSFAADATILAARIADPGGYGRVFLDADGRVRQVIEDRD
CTEEQRRNDLINGGVYCFRWPALMTVLPALSADNDQGELYLPDALPMLTHVRAVAVEDPQEIFGINDRLQLSQASRILNE
RTLVGLMLSGVTIVDPLRVTIDETVEIEPDVVIEPETHLRGATRIAGGCRIGPGTLLEDTVVGAGTEILYSVLRRSRVGA
HSTIGPYSHLRPGADVGSHCRVGNYVEIKNATIGDHTNAAHLSYVGDASVGERVNFGAGTIVVNYDGKHKHRTEIGDGVR
TGANSCLVAPLKLGDGVTVAAGSTVTEDVPCGLVIARSRQVVKPDWKAPYERTEDG

Sequences:

>Translated_456_residues
MSARLAAIVLAAGKGTRMRSTLPKVLHPLAGSTILERVLAALGELALAECFIVVGQGAELVRGRIARPGVQFVEQTEQRG
TGHAVQQVIPHLEGFEGEVLVLNGDAPLLRPSTVAHLVEKHRSFAADATILAARIADPGGYGRVFLDADGRVRQVIEDRD
CTEEQRRNDLINGGVYCFRWPALMTVLPALSADNDQGELYLPDALPMLTHVRAVAVEDPQEIFGINDRLQLSQASRILNE
RTLVGLMLSGVTIVDPLRVTIDETVEIEPDVVIEPETHLRGATRIAGGCRIGPGTLLEDTVVGAGTEILYSVLRRSRVGA
HSTIGPYSHLRPGADVGSHCRVGNYVEIKNATIGDHTNAAHLSYVGDASVGERVNFGAGTIVVNYDGKHKHRTEIGDGVR
TGANSCLVAPLKLGDGVTVAAGSTVTEDVPCGLVIARSRQVVKPDWKAPYERTEDG
>Mature_455_residues
SARLAAIVLAAGKGTRMRSTLPKVLHPLAGSTILERVLAALGELALAECFIVVGQGAELVRGRIARPGVQFVEQTEQRGT
GHAVQQVIPHLEGFEGEVLVLNGDAPLLRPSTVAHLVEKHRSFAADATILAARIADPGGYGRVFLDADGRVRQVIEDRDC
TEEQRRNDLINGGVYCFRWPALMTVLPALSADNDQGELYLPDALPMLTHVRAVAVEDPQEIFGINDRLQLSQASRILNER
TLVGLMLSGVTIVDPLRVTIDETVEIEPDVVIEPETHLRGATRIAGGCRIGPGTLLEDTVVGAGTEILYSVLRRSRVGAH
STIGPYSHLRPGADVGSHCRVGNYVEIKNATIGDHTNAAHLSYVGDASVGERVNFGAGTIVVNYDGKHKHRTEIGDGVRT
GANSCLVAPLKLGDGVTVAAGSTVTEDVPCGLVIARSRQVVKPDWKAPYERTEDG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=458, Percent_Identity=37.7729257641921, Blast_Score=301, Evalue=8e-83,
Organism=Drosophila melanogaster, GI21355443, Length=375, Percent_Identity=25.3333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644084, Length=375, Percent_Identity=25.3333333333333, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_GLOVI (Q7NNG8)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923389.1
- ProteinModelPortal:   Q7NNG8
- SMR:   Q7NNG8
- GeneID:   2599747
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr0443
- NMPDR:   fig|251221.1.peg.443
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- BioCyc:   GVIO251221:GLR0443-MONOMER
- BRENDA:   2.3.1.157
- BRENDA:   2.7.7.23
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48763; Mature: 48632

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 361-361 BINDING 75-75 BINDING 142-142 BINDING 157-157 BINDING 172-172 BINDING 385-385 BINDING 421-421 BINDING 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARLAAIVLAAGKGTRMRSTLPKVLHPLAGSTILERVLAALGELALAECFIVVGQGAEL
CCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCHHH
VRGRIARPGVQFVEQTEQRGTGHAVQQVIPHLEGFEGEVLVLNGDAPLLRPSTVAHLVEK
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHH
HRSFAADATILAARIADPGGYGRVFLDADGRVRQVIEDRDCTEEQRRNDLINGGVYCFRW
HHHHHHHHHEEEEEECCCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEEEH
PALMTVLPALSADNDQGELYLPDALPMLTHVRAVAVEDPQEIFGINDRLQLSQASRILNE
HHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHEEECCHHHHHCCCCHHHHHHHHHHHHH
RTLVGLMLSGVTIVDPLRVTIDETVEIEPDVVIEPETHLRGATRIAGGCRIGPGTLLEDT
HHHHHHHHCCCEEECCEEEEECCEEEECCCEEECCCHHHCCCHHHCCCCCCCCCCCHHHH
VVGAGTEILYSVLRRSRVGAHSTIGPYSHLRPGADVGSHCRVGNYVEIKNATIGDHTNAA
HHCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCE
HLSYVGDASVGERVNFGAGTIVVNYDGKHKHRTEIGDGVRTGANSCLVAPLKLGDGVTVA
EEEECCCCCCCCEEECCCCEEEEECCCCCCHHHHHCCCHHCCCCCEEEEEEECCCCEEEE
AGSTVTEDVPCGLVIARSRQVVKPDWKAPYERTEDG
CCCCCCCCCCCCEEEECCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SARLAAIVLAAGKGTRMRSTLPKVLHPLAGSTILERVLAALGELALAECFIVVGQGAEL
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCHHH
VRGRIARPGVQFVEQTEQRGTGHAVQQVIPHLEGFEGEVLVLNGDAPLLRPSTVAHLVEK
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHH
HRSFAADATILAARIADPGGYGRVFLDADGRVRQVIEDRDCTEEQRRNDLINGGVYCFRW
HHHHHHHHHEEEEEECCCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEEEH
PALMTVLPALSADNDQGELYLPDALPMLTHVRAVAVEDPQEIFGINDRLQLSQASRILNE
HHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHEEECCHHHHHCCCCHHHHHHHHHHHHH
RTLVGLMLSGVTIVDPLRVTIDETVEIEPDVVIEPETHLRGATRIAGGCRIGPGTLLEDT
HHHHHHHHCCCEEECCEEEEECCEEEECCCEEECCCHHHCCCHHHCCCCCCCCCCCHHHH
VVGAGTEILYSVLRRSRVGAHSTIGPYSHLRPGADVGSHCRVGNYVEIKNATIGDHTNAA
HHCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCE
HLSYVGDASVGERVNFGAGTIVVNYDGKHKHRTEIGDGVRTGANSCLVAPLKLGDGVTVA
EEEECCCCCCCCEEECCCCEEEEECCCCCCHHHHHCCCHHCCCCCEEEEEEECCCCEEEE
AGSTVTEDVPCGLVIARSRQVVKPDWKAPYERTEDG
CCCCCCCCCCCCEEEECCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292