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The map label for this gene is tdh [H]

Identifier: 37519938

GI number: 37519938

Start: 383159

End: 384193

Strand: Direct

Name: tdh [H]

Synonym: glr0369

Alternate gene names: 37519938

Gene position: 383159-384193 (Clockwise)

Preceding gene: 37519933

Following gene: 37519939

Centisome position: 8.22

GC content: 65.89

Gene sequence:

>1035_bases
ATGCACTCGGCGATGCTGTACGGGGTGGAAGATGTGCGGCTGGAGGAAGTGCCTTGTCCCGAGCCGGGGCCTGGGGAGGT
GCTGGTGCGGGTGGCGGTGGCACCCACCTGCGGCACCGACCTCAAAGTCTGGCTGCGCGGCGGCCACGCGCGGATGCTGG
TCCCCCCGACGCCTTTCGGCCACGAGTTCGCAGGCGAAATTGCCGCCCTTGGCGAAGGAGTGAGCGGCTGGCGGAGTGGG
GAGCGGGTGGTGGCCAACAATTCCGCTCCCTGCTTCGATTGCTTTTATTGCCGGCGCGAGCGCTTCAGCCTCTGCGAAAA
CTTGCTCTTCAACAACGGAACGTTCGCTGAATACCTGCGCATTCCGGCTGCCATCGTCCGGCACAACTTGCTTGCTGTCC
CGCCTGGGTTGCCCCTCGAACTCGCGGCGATGAGCGAACCGCTCGCCTGTGTGCTGCACGGCGTCGAAGAAGCGGGGGTC
AGGGCGGGCGATACGGTGGTGGTGATGGGGGACGGTGCGATCGGCCTGATGCTGGTGGCCGTCTGTGCTGTGCGCGGGGC
TGCGGTGATCCTCGCAGGCGGCCAATCGGCCCGGCTTGCCGTGGCGGAACAATTGGGAGCACAGGTGACCCTCAACTACC
GCCAGGCAGGCGATCCGGTGGGGCGGTTACGAGCATTGACCGAGGGTGGCCGGGGTGCGGATATCGTTATCGAAGCCACC
GGCAAACCGGCCGCCTGGGAGGCGGCCATCGCCACGGCCCGGCCGGGGGCGACGGTGCTGCTGTTTGGGGGCTGTCCGCG
CGGAACGGCGGTGAGCGTCGATACGGAAAACCTCCATTACAACGAACTGACCCTCAAGGGGGTCTTTCACAACACCCCGC
GCCATGTGCGCGAGGCGCTGGCATTGATTGCTTGCCGGCGCATTGCTTTTGAATTGCTCGTGAGCGACAGTTTGCCCCTC
GGCAAACTGGATGAGGCCCTGGCGCGCATGCGCGATCGGACAGCCATCAAAGTGGCGATGCTGCCGGGAAGCTGA

Upstream 100 bases:

>100_bases
AAACGGGGACAAATGAGCGTTTGCAGAGAATATGCACTGCTGTCGAATGGGTTGGCCGGTGTTCCGGCGAAAATGGGAAT
GTCACTGCGGGAGAACAAAG

Downstream 100 bases:

>100_bases
ACGGTTGAGGAGCGTTCGGGGCTGTTTTGGTGATGGCATAGGCAAACCGTAAGGACTATTGACGCCGCGTGCGCTGCCGG
AGAATCTTCGCCTGGTCCCT

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MHSAMLYGVEDVRLEEVPCPEPGPGEVLVRVAVAPTCGTDLKVWLRGGHARMLVPPTPFGHEFAGEIAALGEGVSGWRSG
ERVVANNSAPCFDCFYCRRERFSLCENLLFNNGTFAEYLRIPAAIVRHNLLAVPPGLPLELAAMSEPLACVLHGVEEAGV
RAGDTVVVMGDGAIGLMLVAVCAVRGAAVILAGGQSARLAVAEQLGAQVTLNYRQAGDPVGRLRALTEGGRGADIVIEAT
GKPAAWEAAIATARPGATVLLFGGCPRGTAVSVDTENLHYNELTLKGVFHNTPRHVREALALIACRRIAFELLVSDSLPL
GKLDEALARMRDRTAIKVAMLPGS

Sequences:

>Translated_344_residues
MHSAMLYGVEDVRLEEVPCPEPGPGEVLVRVAVAPTCGTDLKVWLRGGHARMLVPPTPFGHEFAGEIAALGEGVSGWRSG
ERVVANNSAPCFDCFYCRRERFSLCENLLFNNGTFAEYLRIPAAIVRHNLLAVPPGLPLELAAMSEPLACVLHGVEEAGV
RAGDTVVVMGDGAIGLMLVAVCAVRGAAVILAGGQSARLAVAEQLGAQVTLNYRQAGDPVGRLRALTEGGRGADIVIEAT
GKPAAWEAAIATARPGATVLLFGGCPRGTAVSVDTENLHYNELTLKGVFHNTPRHVREALALIACRRIAFELLVSDSLPL
GKLDEALARMRDRTAIKVAMLPGS
>Mature_344_residues
MHSAMLYGVEDVRLEEVPCPEPGPGEVLVRVAVAPTCGTDLKVWLRGGHARMLVPPTPFGHEFAGEIAALGEGVSGWRSG
ERVVANNSAPCFDCFYCRRERFSLCENLLFNNGTFAEYLRIPAAIVRHNLLAVPPGLPLELAAMSEPLACVLHGVEEAGV
RAGDTVVVMGDGAIGLMLVAVCAVRGAAVILAGGQSARLAVAEQLGAQVTLNYRQAGDPVGRLRALTEGGRGADIVIEAT
GKPAAWEAAIATARPGATVLLFGGCPRGTAVSVDTENLHYNELTLKGVFHNTPRHVREALALIACRRIAFELLVSDSLPL
GKLDEALARMRDRTAIKVAMLPGS

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=350, Percent_Identity=28.8571428571429, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI156523966, Length=364, Percent_Identity=26.0989010989011, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501939, Length=354, Percent_Identity=26.5536723163842, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=23.7196765498652, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI71565154, Length=277, Percent_Identity=23.4657039711191, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788075, Length=348, Percent_Identity=30.1724137931034, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI226510992, Length=325, Percent_Identity=32.3076923076923, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790045, Length=338, Percent_Identity=26.6272189349112, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788407, Length=348, Percent_Identity=29.0229885057471, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1788073, Length=289, Percent_Identity=29.757785467128, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787863, Length=269, Percent_Identity=31.5985130111524, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786825, Length=276, Percent_Identity=28.6231884057971, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790718, Length=324, Percent_Identity=26.2345679012346, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082125, Length=278, Percent_Identity=28.7769784172662, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI48994910, Length=370, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=31.3218390804598, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17562878, Length=344, Percent_Identity=27.906976744186, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=319, Percent_Identity=29.153605015674, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562584, Length=332, Percent_Identity=27.1084337349398, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=332, Percent_Identity=25.6024096385542, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=282, Percent_Identity=25.177304964539, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=331, Percent_Identity=28.0966767371601, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=331, Percent_Identity=27.7945619335347, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319621, Length=315, Percent_Identity=30.1587301587302, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323099, Length=329, Percent_Identity=25.8358662613982, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323961, Length=318, Percent_Identity=27.9874213836478, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=266, Percent_Identity=27.0676691729323, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=306, Percent_Identity=27.1241830065359, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=337, Percent_Identity=25.5192878338279, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=309, Percent_Identity=25.5663430420712, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17737897, Length=352, Percent_Identity=29.8295454545455, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17137530, Length=341, Percent_Identity=28.1524926686217, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=23.5616438356164, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 36326; Mature: 36326

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSAMLYGVEDVRLEEVPCPEPGPGEVLVRVAVAPTCGTDLKVWLRGGHARMLVPPTPFG
CCCCEEECCCCCEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCEEEEECCCCCC
HEFAGEIAALGEGVSGWRSGERVVANNSAPCFDCFYCRRERFSLCENLLFNNGTFAEYLR
HHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
IPAAIVRHNLLAVPPGLPLELAAMSEPLACVLHGVEEAGVRAGDTVVVMGDGAIGLMLVA
HHHHHHHCCEEECCCCCCEEHHHCCCCHHHHHHCHHHHCCCCCCEEEEEECCHHHHHHHH
VCAVRGAAVILAGGQSARLAVAEQLGAQVTLNYRQAGDPVGRLRALTEGGRGADIVIEAT
HHHHCCCEEEEECCCCCHHHHHHHCCCEEEEEEHHCCCHHHHHHHHHCCCCCCEEEEEEC
GKPAAWEAAIATARPGATVLLFGGCPRGTAVSVDTENLHYNELTLKGVFHNTPRHVREAL
CCCCHHHHHHEECCCCCEEEEECCCCCCCEEEEECCCCEECEEEEEEEECCCHHHHHHHH
ALIACRRIAFELLVSDSLPLGKLDEALARMRDRTAIKVAMLPGS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCC
>Mature Secondary Structure
MHSAMLYGVEDVRLEEVPCPEPGPGEVLVRVAVAPTCGTDLKVWLRGGHARMLVPPTPFG
CCCCEEECCCCCEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCEEEEECCCCCC
HEFAGEIAALGEGVSGWRSGERVVANNSAPCFDCFYCRRERFSLCENLLFNNGTFAEYLR
HHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
IPAAIVRHNLLAVPPGLPLELAAMSEPLACVLHGVEEAGVRAGDTVVVMGDGAIGLMLVA
HHHHHHHCCEEECCCCCCEEHHHCCCCHHHHHHCHHHHCCCCCCEEEEEECCHHHHHHHH
VCAVRGAAVILAGGQSARLAVAEQLGAQVTLNYRQAGDPVGRLRALTEGGRGADIVIEAT
HHHHCCCEEEEECCCCCHHHHHHHCCCEEEEEEHHCCCHHHHHHHHHCCCCCCEEEEEEC
GKPAAWEAAIATARPGATVLLFGGCPRGTAVSVDTENLHYNELTLKGVFHNTPRHVREAL
CCCCHHHHHHEECCCCCEEEEECCCCCCCEEEEECCCCEECEEEEEEEECCCHHHHHHHH
ALIACRRIAFELLVSDSLPLGKLDEALARMRDRTAIKVAMLPGS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA