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The map label for this gene is aqpZ

Identifier: 37519936

GI number: 37519936

Start: 380846

End: 381592

Strand: Reverse

Name: aqpZ

Synonym: gll0367

Alternate gene names: 37519936

Gene position: 381592-380846 (Counterclockwise)

Preceding gene: 37519937

Following gene: 37519935

Centisome position: 8.19

GC content: 61.98

Gene sequence:

>747_bases
ATGTCACTTGTCAAGCGTTCCGTAGCCGAGTTCATCGGAACTTTTTGGCTGGTCCTGGGAGGTTGCGGTGCCGCCGTGCT
CGCGGCGGCCTTTCCGAATCTGGGTATCGGGTTTGCCGGGGTGTCGCTGGCGTTTGGTCTGACGCTTTTGACGATGGCCT
TTGCCATTGGCCACATCTCGGGTTGTCACATCAATCCGGCGGTATCGATCGGACTTTGGGCGGCCAAGCGCTTCCCGGCC
ACCGAGCTGTTGCCCTACATCGCCGCCCAGGTATTGGGCGGGATTGCCGGAGCCGGGGTGCTCTATTTGATCGCCGGCGG
CAAAGCCGGGTTCAGCCTGAGCGGCGGCTTCGCCTCCAACGGCTACGGCCTCCATTCGCCGGGCGGCTACACGTTGCTTG
CCTGCCTGGTCTGCGAGGTGGTGATGACCTTCATGTTCTTGATGATCATCCTCGGTTCCACCGACCGTCGCGCCCCCAAG
GGATTTGCTCCTATCGCCATCGGTTTGAGCCTGACGCTGATTCACCTGATCAGCATCCCAGTCACCAACACCTCCGTCAA
CCCGGCCCGCAGTACCGGCCCGGCGTTGTTCGTGGGCGATTGGGCGATTGCCGAGTTGTGGCTATTTTGGCTCGCTCCGA
TTGTCGGAGCGGCCCTGGCGGGTCTTTTCTACCACGCTTTTCTCGACGAACCCGGCGAGGAAACAGAGGGCACTCCCGCC
TCTGCCCAACTGCGCACCGAAGCCTAA

Upstream 100 bases:

>100_bases
AATGTGTTTATCCTGACGTAAACATAGCTTCAACTATTCATCCGGCTTTTGACTTTTTTGATAGGATACCACTACCGATT
TTTCAAAGCGGGTTATAGAC

Downstream 100 bases:

>100_bases
TTTGTCTCCGCATCCTGGCGATCGCGCCTTGAGTGAACCGCCCGCAGGTATCCGCCCTGCGGGCGGTTCGGCATTCGGGC
TGAAATAATAGGGCAGGAGC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MSLVKRSVAEFIGTFWLVLGGCGAAVLAAAFPNLGIGFAGVSLAFGLTLLTMAFAIGHISGCHINPAVSIGLWAAKRFPA
TELLPYIAAQVLGGIAGAGVLYLIAGGKAGFSLSGGFASNGYGLHSPGGYTLLACLVCEVVMTFMFLMIILGSTDRRAPK
GFAPIAIGLSLTLIHLISIPVTNTSVNPARSTGPALFVGDWAIAELWLFWLAPIVGAALAGLFYHAFLDEPGEETEGTPA
SAQLRTEA

Sequences:

>Translated_248_residues
MSLVKRSVAEFIGTFWLVLGGCGAAVLAAAFPNLGIGFAGVSLAFGLTLLTMAFAIGHISGCHINPAVSIGLWAAKRFPA
TELLPYIAAQVLGGIAGAGVLYLIAGGKAGFSLSGGFASNGYGLHSPGGYTLLACLVCEVVMTFMFLMIILGSTDRRAPK
GFAPIAIGLSLTLIHLISIPVTNTSVNPARSTGPALFVGDWAIAELWLFWLAPIVGAALAGLFYHAFLDEPGEETEGTPA
SAQLRTEA
>Mature_247_residues
SLVKRSVAEFIGTFWLVLGGCGAAVLAAAFPNLGIGFAGVSLAFGLTLLTMAFAIGHISGCHINPAVSIGLWAAKRFPAT
ELLPYIAAQVLGGIAGAGVLYLIAGGKAGFSLSGGFASNGYGLHSPGGYTLLACLVCEVVMTFMFLMIILGSTDRRAPKG
FAPIAIGLSLTLIHLISIPVTNTSVNPARSTGPALFVGDWAIAELWLFWLAPIVGAALAGLFYHAFLDEPGEETEGTPAS
AQLRTEA

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family

Homologues:

Organism=Homo sapiens, GI4502183, Length=231, Percent_Identity=38.5281385281385, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4755125, Length=228, Percent_Identity=36.4035087719298, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4502181, Length=228, Percent_Identity=36.4035087719298, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI37694062, Length=228, Percent_Identity=38.1578947368421, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI4502179, Length=227, Percent_Identity=34.3612334801762, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI6912506, Length=222, Percent_Identity=33.7837837837838, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI157266307, Length=273, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI86792455, Length=227, Percent_Identity=29.9559471365639, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4826645, Length=260, Percent_Identity=27.6923076923077, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI45446752, Length=211, Percent_Identity=28.436018957346, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI297307120, Length=92, Percent_Identity=41.304347826087, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI297307116, Length=92, Percent_Identity=41.304347826087, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI297307118, Length=92, Percent_Identity=41.304347826087, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22538420, Length=279, Percent_Identity=26.8817204301075, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1787101, Length=229, Percent_Identity=65.938864628821, Blast_Score=284, Evalue=4e-78,
Organism=Escherichia coli, GI1790362, Length=278, Percent_Identity=26.978417266187, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=240, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17558372, Length=238, Percent_Identity=28.1512605042017, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71992966, Length=234, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=244, Percent_Identity=28.2786885245902, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17531431, Length=244, Percent_Identity=28.2786885245902, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24652747, Length=231, Percent_Identity=34.6320346320346, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI45551084, Length=231, Percent_Identity=34.6320346320346, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24652751, Length=246, Percent_Identity=31.3008130081301, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19922038, Length=246, Percent_Identity=31.3008130081301, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45550503, Length=246, Percent_Identity=30.0813008130081, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136672, Length=230, Percent_Identity=29.1304347826087, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24762342, Length=212, Percent_Identity=28.7735849056604, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24762346, Length=241, Percent_Identity=29.8755186721992, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24762348, Length=241, Percent_Identity=29.8755186721992, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20130305, Length=241, Percent_Identity=29.8755186721992, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24762344, Length=241, Percent_Identity=29.8755186721992, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AQPZ_GLOVI (Q7NNP3)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923313.1
- ProteinModelPortal:   Q7NNP3
- SMR:   Q7NNP3
- GeneID:   2599766
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll0367
- NMPDR:   fig|251221.1.peg.367
- HOGENOM:   HBG705794
- OMA:   GFGEHSP
- ProtClustDB:   PRK05420
- BioCyc:   GVIO251221:GLL0367-MONOMER
- HAMAP:   MF_01146
- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357
- PANTHER:   PTHR19139
- PRINTS:   PR00783
- TIGRFAMs:   TIGR00861

Pfam domain/function: PF00230 MIP

EC number: NA

Molecular weight: Translated: 25526; Mature: 25395

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00221 MIP; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10cddad8)-; HASH(0x11268954)-; HASH(0x1194af30)-; HASH(0x115b99b4)-; HASH(0x11960ba8)-; HASH(0x114bbae0)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVKRSVAEFIGTFWLVLGGCGAAVLAAAFPNLGIGFAGVSLAFGLTLLTMAFAIGHIS
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GCHINPAVSIGLWAAKRFPATELLPYIAAQVLGGIAGAGVLYLIAGGKAGFSLSGGFASN
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCC
GYGLHSPGGYTLLACLVCEVVMTFMFLMIILGSTDRRAPKGFAPIAIGLSLTLIHLISIP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
VTNTSVNPARSTGPALFVGDWAIAELWLFWLAPIVGAALAGLFYHAFLDEPGEETEGTPA
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SAQLRTEA
CCCCCCCH
>Mature Secondary Structure 
SLVKRSVAEFIGTFWLVLGGCGAAVLAAAFPNLGIGFAGVSLAFGLTLLTMAFAIGHIS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GCHINPAVSIGLWAAKRFPATELLPYIAAQVLGGIAGAGVLYLIAGGKAGFSLSGGFASN
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCC
GYGLHSPGGYTLLACLVCEVVMTFMFLMIILGSTDRRAPKGFAPIAIGLSLTLIHLISIP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
VTNTSVNPARSTGPALFVGDWAIAELWLFWLAPIVGAALAGLFYHAFLDEPGEETEGTPA
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SAQLRTEA
CCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292