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The map label for this gene is ltrA [H]

Identifier: 37519746

GI number: 37519746

Start: 168961

End: 170742

Strand: Reverse

Name: ltrA [H]

Synonym: gll0177

Alternate gene names: 37519746

Gene position: 170742-168961 (Counterclockwise)

Preceding gene: 37519749

Following gene: 37519744

Centisome position: 3.66

GC content: 49.89

Gene sequence:

>1782_bases
ATGGTGGAATGGAATTCTCTCAATTGGCGTCAAATCCAACGCAGAGTATTCAAGCTGCAAACACGCATATTCAAAGCCTC
GCAACGTGGTGATTTCAAGGCAGTCCGTAAACTCCAGAAACTACTGATACGTTCTTGGTCAGCAAGATGTCTTGCCGTAC
GAAGGGTGACTCAGGATAATCAGGGCAAGAAAACAGCTGGGGTTGATGGAGTCAAATCCCTCACCCCAAAAGCGAGACTT
GCACTCACCAAAAACCTGAGAATAAGCGAGAAGGCAAAACCAATGCGACGGGTCTGGATTGCCAAACCCGGCACTCAGGA
AAAACGCCCTCTTGGTATCCCGACGATGACAGACAGGGCGCGGCAAGCTCTGCTTACTCTCGCCCTGGAACCTGAATGGG
AAGCTCGCTTCGAGCCAAACAGCTACGGGTTCCGACCAGGACGCTCATGCCATGATGCACTCCAAGCCATCTACAACGCG
ATACGGCAACAAAGCAAATTTGTTCTTGATGCCGATATCGCGAAATGCTTCGACCGCATCGACCAGCAAGCACTGCTCAA
GAAAATGAACACATCCTCAGCTATCCGTCGGCAAATACGCGCCTGGCTGAAAGCAGGAGTGATGGAAGGTAGTGAACTAT
TCCCCACACCGACAGGCACACCCCAAGGCGGCGTGATTTCACCCCTGTTAGCGAATATCGCTTTACATGGCATGGAAGAA
CGAGTCAAACAGGTGTCCAAGATGGCACAACTGATCCGCTATGCTGACGATTTTGTGTGTATCCACACAGACCAACAGAT
AGTGCAAAGTTGCCAGACGGTCCTGGAGGAATGGCTGGCAGGCATGGGATTGGAATTGAAGCCAAGCAAAACACGGATAG
CTCACACTCTTCTTTTAGAAGAAGGGCAACCGGGTTTCGACTTTCTGGGGTTTACCGTTCGACAATTTCCCGTTGGCAAG
TACCATACAGGAACGAATAGTCGCGGCAAACCCCTGGGCTTCAAAACGATTATCAAACCAAGCAAGAAGAGCATCAAGAC
TCACACCGAAAAGCTGAGAAGAATAATCCACAAACATAAGGCACAGCCTCAATCATTCCTGATTGAGCACCTCAATCCGA
TAATTCGGGGATGGACACATTTCTTCTCTAAAGTTGTGAGCGGAGCCACGTTCAAGAAGCTGGACAGGACTCTCTACATG
CAATTGAAAGCTTGGGCAACCAGTCATCATCGCAACCAAAGTCAGAAATGGCTGGCCAGGAAATACTGGCTAACGATTGG
CACGCAAAACTGGTGCTTTGCCGTCCAAAAAGGGGAGGGAATTAAGCGCCTGGTTCAACACTCAGATAGGCCGATTACTC
GGCACGTCAAGGTGAAAGAACGCCGTAGCCCGTACGATGGCGACTGGGTGTACTGGAGTAATCGGATAGGACAGCATCCG
CAAATAAAAGCGGAAGTAGCCCGACTGCTGAAATCCCAGACAGGCAAGTGCACTCACTGCGGGTTGTATTTCATGAATGG
AGAGTTGCTGGAAGTGGATCACCGGAAGCCGAAACGATTCGGCGGAAGGAATATTTCATCAAATAAGCAGCTACTTCATC
GACATTGCCACCATCAGAAAACCGCCGCTGAGCGCATCCAACAGTTACAATCCCAATCGAGGATAACAGAAGCGGAACGT
CTTCAGCTACAAGCCAAACGGCAAGCACTGCTGGAAGATTATCAACCCTACAAATCCAAGAAAAGGTTGACGGACGCAGA
ATGGATGCAACAGTGGCACTGA

Upstream 100 bases:

>100_bases
CCCTGAGTAATGTCAGGGACATGCTGACGTAGGCACGATGACCAGGAATGAATAGGAGCCAGTAGCAGTGCACAGATCCA
AGACACGAGAGCAATCTTCG

Downstream 100 bases:

>100_bases
GATAGAGGTACTCATGACAAGAGCCTGGTCATCGAGGAGCCGGATGAGGTGAAAGTCTCATGTCCGGTTTTGAAGACCAG
CCGGGTGGGCGACTGCCCGG

Product: reverse transcriptase-like protein

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MVEWNSLNWRQIQRRVFKLQTRIFKASQRGDFKAVRKLQKLLIRSWSARCLAVRRVTQDNQGKKTAGVDGVKSLTPKARL
ALTKNLRISEKAKPMRRVWIAKPGTQEKRPLGIPTMTDRARQALLTLALEPEWEARFEPNSYGFRPGRSCHDALQAIYNA
IRQQSKFVLDADIAKCFDRIDQQALLKKMNTSSAIRRQIRAWLKAGVMEGSELFPTPTGTPQGGVISPLLANIALHGMEE
RVKQVSKMAQLIRYADDFVCIHTDQQIVQSCQTVLEEWLAGMGLELKPSKTRIAHTLLLEEGQPGFDFLGFTVRQFPVGK
YHTGTNSRGKPLGFKTIIKPSKKSIKTHTEKLRRIIHKHKAQPQSFLIEHLNPIIRGWTHFFSKVVSGATFKKLDRTLYM
QLKAWATSHHRNQSQKWLARKYWLTIGTQNWCFAVQKGEGIKRLVQHSDRPITRHVKVKERRSPYDGDWVYWSNRIGQHP
QIKAEVARLLKSQTGKCTHCGLYFMNGELLEVDHRKPKRFGGRNISSNKQLLHRHCHHQKTAAERIQQLQSQSRITEAER
LQLQAKRQALLEDYQPYKSKKRLTDAEWMQQWH

Sequences:

>Translated_593_residues
MVEWNSLNWRQIQRRVFKLQTRIFKASQRGDFKAVRKLQKLLIRSWSARCLAVRRVTQDNQGKKTAGVDGVKSLTPKARL
ALTKNLRISEKAKPMRRVWIAKPGTQEKRPLGIPTMTDRARQALLTLALEPEWEARFEPNSYGFRPGRSCHDALQAIYNA
IRQQSKFVLDADIAKCFDRIDQQALLKKMNTSSAIRRQIRAWLKAGVMEGSELFPTPTGTPQGGVISPLLANIALHGMEE
RVKQVSKMAQLIRYADDFVCIHTDQQIVQSCQTVLEEWLAGMGLELKPSKTRIAHTLLLEEGQPGFDFLGFTVRQFPVGK
YHTGTNSRGKPLGFKTIIKPSKKSIKTHTEKLRRIIHKHKAQPQSFLIEHLNPIIRGWTHFFSKVVSGATFKKLDRTLYM
QLKAWATSHHRNQSQKWLARKYWLTIGTQNWCFAVQKGEGIKRLVQHSDRPITRHVKVKERRSPYDGDWVYWSNRIGQHP
QIKAEVARLLKSQTGKCTHCGLYFMNGELLEVDHRKPKRFGGRNISSNKQLLHRHCHHQKTAAERIQQLQSQSRITEAER
LQLQAKRQALLEDYQPYKSKKRLTDAEWMQQWH
>Mature_593_residues
MVEWNSLNWRQIQRRVFKLQTRIFKASQRGDFKAVRKLQKLLIRSWSARCLAVRRVTQDNQGKKTAGVDGVKSLTPKARL
ALTKNLRISEKAKPMRRVWIAKPGTQEKRPLGIPTMTDRARQALLTLALEPEWEARFEPNSYGFRPGRSCHDALQAIYNA
IRQQSKFVLDADIAKCFDRIDQQALLKKMNTSSAIRRQIRAWLKAGVMEGSELFPTPTGTPQGGVISPLLANIALHGMEE
RVKQVSKMAQLIRYADDFVCIHTDQQIVQSCQTVLEEWLAGMGLELKPSKTRIAHTLLLEEGQPGFDFLGFTVRQFPVGK
YHTGTNSRGKPLGFKTIIKPSKKSIKTHTEKLRRIIHKHKAQPQSFLIEHLNPIIRGWTHFFSKVVSGATFKKLDRTLYM
QLKAWATSHHRNQSQKWLARKYWLTIGTQNWCFAVQKGEGIKRLVQHSDRPITRHVKVKERRSPYDGDWVYWSNRIGQHP
QIKAEVARLLKSQTGKCTHCGLYFMNGELLEVDHRKPKRFGGRNISSNKQLLHRHCHHQKTAAERIQQLQSQSRITEAER
LQLQAKRQALLEDYQPYKSKKRLTDAEWMQQWH

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226521, Length=321, Percent_Identity=24.2990654205607, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6226520, Length=149, Percent_Identity=30.2013422818792, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 68667; Mature: 68667

Theoretical pI: Translated: 11.10; Mature: 11.10

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEWNSLNWRQIQRRVFKLQTRIFKASQRGDFKAVRKLQKLLIRSWSARCLAVRRVTQDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGKKTAGVDGVKSLTPKARLALTKNLRISEKAKPMRRVWIAKPGTQEKRPLGIPTMTDRA
CCCCCCCCCCHHHCCCHHHHHHHCCCCCCHHCCHHHHEEEECCCCCCCCCCCCCCHHHHH
RQALLTLALEPEWEARFEPNSYGFRPGRSCHDALQAIYNAIRQQSKFVLDADIAKCFDRI
HHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHH
DQQALLKKMNTSSAIRRQIRAWLKAGVMEGSELFPTPTGTPQGGVISPLLANIALHGMEE
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RVKQVSKMAQLIRYADDFVCIHTDQQIVQSCQTVLEEWLAGMGLELKPSKTRIAHTLLLE
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
EGQPGFDFLGFTVRQFPVGKYHTGTNSRGKPLGFKTIIKPSKKSIKTHTEKLRRIIHKHK
CCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHC
AQPQSFLIEHLNPIIRGWTHFFSKVVSGATFKKLDRTLYMQLKAWATSHHRNQSQKWLAR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KYWLTIGTQNWCFAVQKGEGIKRLVQHSDRPITRHVKVKERRSPYDGDWVYWSNRIGQHP
HHHHEECCCCEEEEEECCCHHHHHHHCCCCCCHHHEEEHHCCCCCCCCEEEECCCCCCCC
QIKAEVARLLKSQTGKCTHCGLYFMNGELLEVDHRKPKRFGGRNISSNKQLLHRHCHHQK
CHHHHHHHHHHHCCCCCEEEEEEEECCCEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHH
TAAERIQQLQSQSRITEAERLQLQAKRQALLEDYQPYKSKKRLTDAEWMQQWH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MVEWNSLNWRQIQRRVFKLQTRIFKASQRGDFKAVRKLQKLLIRSWSARCLAVRRVTQDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGKKTAGVDGVKSLTPKARLALTKNLRISEKAKPMRRVWIAKPGTQEKRPLGIPTMTDRA
CCCCCCCCCCHHHCCCHHHHHHHCCCCCCHHCCHHHHEEEECCCCCCCCCCCCCCHHHHH
RQALLTLALEPEWEARFEPNSYGFRPGRSCHDALQAIYNAIRQQSKFVLDADIAKCFDRI
HHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHH
DQQALLKKMNTSSAIRRQIRAWLKAGVMEGSELFPTPTGTPQGGVISPLLANIALHGMEE
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RVKQVSKMAQLIRYADDFVCIHTDQQIVQSCQTVLEEWLAGMGLELKPSKTRIAHTLLLE
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
EGQPGFDFLGFTVRQFPVGKYHTGTNSRGKPLGFKTIIKPSKKSIKTHTEKLRRIIHKHK
CCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHC
AQPQSFLIEHLNPIIRGWTHFFSKVVSGATFKKLDRTLYMQLKAWATSHHRNQSQKWLAR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KYWLTIGTQNWCFAVQKGEGIKRLVQHSDRPITRHVKVKERRSPYDGDWVYWSNRIGQHP
HHHHEECCCCEEEEEECCCHHHHHHHCCCCCCHHHEEEHHCCCCCCCCEEEECCCCCCCC
QIKAEVARLLKSQTGKCTHCGLYFMNGELLEVDHRKPKRFGGRNISSNKQLLHRHCHHQK
CHHHHHHHHHHHCCCCCEEEEEEEECCCEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHH
TAAERIQQLQSQSRITEAERLQLQAKRQALLEDYQPYKSKKRLTDAEWMQQWH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]