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The map label for this gene is rpfC [H]

Identifier: 37519668

GI number: 37519668

Start: 97911

End: 100268

Strand: Reverse

Name: rpfC [H]

Synonym: gll0099

Alternate gene names: 37519668

Gene position: 100268-97911 (Counterclockwise)

Preceding gene: 37519669

Following gene: 37519666

Centisome position: 2.15

GC content: 67.73

Gene sequence:

>2358_bases
GTGCAAGAAAGGCGGCGCCATGTATGTTGGATGTGCCTTGTTTGCAGTGCCGACCGTGCCCTTCCATTGGAACGACCAAT
ACACTCAACCTGGCCGACAGAGGTTTCTGCTGCCGACCCTGCCGACCCCGCGGCCTCGGAGGGGTTGGTAATGGCCTGCT
CCCCGGAAAATCTGCTCGCCGAAATTGCGGCACTACGCGAACACAATGCCCGGCTGGAGGCTTTGCTGGGCGAAGGTCGG
CTCAAAGCGCCGGCCCTGCTTGAAAGTGAGGAGCGCTACCGCTCGCTGATCACCGTCACCTCCGCCATCGTCTGGACCGC
GGGGAGCGATGGGGCGATTGTCGAGGAGGTGCCTTCCTGGGAAGAATTCACCGGCCAGTCCCCCGAGCAGTACCAGGGCT
GGGGTTGGGTCGAGATGCTCCATCCCGAAGACCGCGCTTCCACCGCCGAAATCTGGCGGCAGGCCAACGCAAACAAGCGC
CCGGTGGAAGTCGAATACCGGCTGCGGCGGCGTGACGGCGAGTATCGCCACATGGTCGCCAGGGGCGTGCCGCTGCTGAA
TGCCGGGGGCCGGTTGTGCTCGTGGGTGGGCACCGTCACCGACATTCACGATCGCAAGGTGGCCGAGCAGCAGCGCGAGT
TGCGACTTCTGCAGGCGAAGCGGCATACCACCCGCCTGCAGAAGCTGGCCGAGGCGTCGCTTGCCATCAATTCGGCTCTG
TCGATTCAGCAGGTGCTGCAGGGGATCACCGAGCAGGCCGCAGCCCTGATTGGTGCCCATATGGCCCTCACCAGCCTGAC
GCCCGAGCGCGACTGGGCGCGGGCGGTGCATACGGTGTACCTGTCGGACAAGTATCGCTACTGGCACCACGGCGAAGCGC
GCCTGGGCGGCGTCGGGATCGCCGCCGATGTGTGCCGGACCAACCGGCCTGCACGTCTGACCCAATCCCAACTGGAGGGC
CATCCGCAGGGCCGGCTGCTCGCCTTCGGGGCCACCGACCGACCGGCGCTGCGCGGCTGGCTCGCCGCCCCGCTGGTGGG
GCGCGACGGGCGCAATATCGGCCTCATTCAGCTGTCGGACAAGCACGAGGGCGATTTTAGCGAGGAGGACGAGGCCATCG
CCGTGCAACTGGCGCAACTGGCCTCGGTGGCAATCGAGAATACGCGGCTATTCGAAGCGGAGCAAGCCGCTAAGGTGGAC
GCCGAGGAGGCCAACCGCCTCAAAGACGAGTTTCTGGCCACCCTCAGCCACGAACTGCGCTCACCGCTGACGGCAATTTT
GGGATGGACCAAGCTGCTGCGCCAGGTGGATCTGGGCGCGGTGCGCGCCGCCCACGCCCTGGAGGTGATCGAGCGCAACG
CCCTCGCCCAGAACCAGCTCATCGAAGATCTGCTCGATATCTCGCGGATCGTGGCCGGCAAGCTGCGCATCGAGGCGGCC
GCGGTGGATCTGGCCGGGGTGATCGAGGCGGCCATCGGCACCGTCCGCCCGGCCGCCCAGGCAAGGGCCATCGAAGTTGA
CACCGAGATCGAACCGGGGGTGCCGCTTTTGATGGGCGATGCCACCCGTCTGCAGCAGGTGGTCTGGAACTTGCTTGCCA
ACGCGGTCAAATTCACTCCCAACGGCGGCCGGGTGCGGGTGCGGCTGTCCCGGCGCGGTACCGCCGCCGAGGTCGCCGTC
AGCGACAGCGGCCTGGGCATCGCCCCCCATCTGTTGCCCCACGTCTTCGAGCGCTTCCGCCAGGCGGACAGCTCCAGCAC
CCGCTCCCACGGCGGTCTGGGTCTGGGTCTTGCCATCGTCCGCCAACTGGTCGAACTGCACAGCGGCACCGTCTCGGCCG
CGAGCCCCGGCGAAGGGCAGGGGGCGACTTTTACGGTGCGGCTGCCCTTTGACGGAGCACGGACATTGCTCGCGGGCGAC
CACTCCCCCGGCGACTGGACGCGCGAATCTCCCACCGCCTGCTGCGGGCGGCTCGACGGCCTGCGGGTGCTGGTGGTGGA
CGACGAACCGCAGGCGCGCGAACTGGTGCGCACCACCCTGGAACTGTGCGGTGCGCAGGTGGCCACGGCGGGCTCGGCCG
CGGAAGCCCTGGCTGAGGTACGCCGATCGAAGCCGGCGGTCCTGGTCAGTGACATCGCCATGCCGGGTGAGGACGGCTAC
GCCCTGCTGCGCCAATTGCGCCTGCTCGAAGCCGAGTGCGGCGGGCGCATCCCCGCGGTGGCCCTGACCGCCTACGCCCG
CGTCGAGGACCGCCGCCGGGCGCTTTTGGCCGGTTTTCAGACCCATCTGAGCAAACCGGTCGAACCGAGCGAGTTGGTGG
CGGCGGTGGCCAATTTGAGCTGTCAGGCCGCGATCTGA

Upstream 100 bases:

>100_bases
ATCTTGATGGCGCGGCCCCTCGACAGCGATCAGGAATTGGCCTATTCGTTTGTGGTCACAATCAAGTAAGCCGGAGGTCA
GGGGGGGCTGACAGGATCTC

Downstream 100 bases:

>100_bases
AGCCCTATGGCTTAGTCGCTTTAGCCTGGGCGGCTTTCTGCTTTTGCTTTTCTTTTTCTTTGGCCCGCTTTTCTTTTTCT
TTGGCCTGCTCGCGCGCCAA

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MQERRRHVCWMCLVCSADRALPLERPIHSTWPTEVSAADPADPAASEGLVMACSPENLLAEIAALREHNARLEALLGEGR
LKAPALLESEERYRSLITVTSAIVWTAGSDGAIVEEVPSWEEFTGQSPEQYQGWGWVEMLHPEDRASTAEIWRQANANKR
PVEVEYRLRRRDGEYRHMVARGVPLLNAGGRLCSWVGTVTDIHDRKVAEQQRELRLLQAKRHTTRLQKLAEASLAINSAL
SIQQVLQGITEQAAALIGAHMALTSLTPERDWARAVHTVYLSDKYRYWHHGEARLGGVGIAADVCRTNRPARLTQSQLEG
HPQGRLLAFGATDRPALRGWLAAPLVGRDGRNIGLIQLSDKHEGDFSEEDEAIAVQLAQLASVAIENTRLFEAEQAAKVD
AEEANRLKDEFLATLSHELRSPLTAILGWTKLLRQVDLGAVRAAHALEVIERNALAQNQLIEDLLDISRIVAGKLRIEAA
AVDLAGVIEAAIGTVRPAAQARAIEVDTEIEPGVPLLMGDATRLQQVVWNLLANAVKFTPNGGRVRVRLSRRGTAAEVAV
SDSGLGIAPHLLPHVFERFRQADSSSTRSHGGLGLGLAIVRQLVELHSGTVSAASPGEGQGATFTVRLPFDGARTLLAGD
HSPGDWTRESPTACCGRLDGLRVLVVDDEPQARELVRTTLELCGAQVATAGSAAEALAEVRRSKPAVLVSDIAMPGEDGY
ALLRQLRLLEAECGGRIPAVALTAYARVEDRRRALLAGFQTHLSKPVEPSELVAAVANLSCQAAI

Sequences:

>Translated_785_residues
MQERRRHVCWMCLVCSADRALPLERPIHSTWPTEVSAADPADPAASEGLVMACSPENLLAEIAALREHNARLEALLGEGR
LKAPALLESEERYRSLITVTSAIVWTAGSDGAIVEEVPSWEEFTGQSPEQYQGWGWVEMLHPEDRASTAEIWRQANANKR
PVEVEYRLRRRDGEYRHMVARGVPLLNAGGRLCSWVGTVTDIHDRKVAEQQRELRLLQAKRHTTRLQKLAEASLAINSAL
SIQQVLQGITEQAAALIGAHMALTSLTPERDWARAVHTVYLSDKYRYWHHGEARLGGVGIAADVCRTNRPARLTQSQLEG
HPQGRLLAFGATDRPALRGWLAAPLVGRDGRNIGLIQLSDKHEGDFSEEDEAIAVQLAQLASVAIENTRLFEAEQAAKVD
AEEANRLKDEFLATLSHELRSPLTAILGWTKLLRQVDLGAVRAAHALEVIERNALAQNQLIEDLLDISRIVAGKLRIEAA
AVDLAGVIEAAIGTVRPAAQARAIEVDTEIEPGVPLLMGDATRLQQVVWNLLANAVKFTPNGGRVRVRLSRRGTAAEVAV
SDSGLGIAPHLLPHVFERFRQADSSSTRSHGGLGLGLAIVRQLVELHSGTVSAASPGEGQGATFTVRLPFDGARTLLAGD
HSPGDWTRESPTACCGRLDGLRVLVVDDEPQARELVRTTLELCGAQVATAGSAAEALAEVRRSKPAVLVSDIAMPGEDGY
ALLRQLRLLEAECGGRIPAVALTAYARVEDRRRALLAGFQTHLSKPVEPSELVAAVANLSCQAAI
>Mature_785_residues
MQERRRHVCWMCLVCSADRALPLERPIHSTWPTEVSAADPADPAASEGLVMACSPENLLAEIAALREHNARLEALLGEGR
LKAPALLESEERYRSLITVTSAIVWTAGSDGAIVEEVPSWEEFTGQSPEQYQGWGWVEMLHPEDRASTAEIWRQANANKR
PVEVEYRLRRRDGEYRHMVARGVPLLNAGGRLCSWVGTVTDIHDRKVAEQQRELRLLQAKRHTTRLQKLAEASLAINSAL
SIQQVLQGITEQAAALIGAHMALTSLTPERDWARAVHTVYLSDKYRYWHHGEARLGGVGIAADVCRTNRPARLTQSQLEG
HPQGRLLAFGATDRPALRGWLAAPLVGRDGRNIGLIQLSDKHEGDFSEEDEAIAVQLAQLASVAIENTRLFEAEQAAKVD
AEEANRLKDEFLATLSHELRSPLTAILGWTKLLRQVDLGAVRAAHALEVIERNALAQNQLIEDLLDISRIVAGKLRIEAA
AVDLAGVIEAAIGTVRPAAQARAIEVDTEIEPGVPLLMGDATRLQQVVWNLLANAVKFTPNGGRVRVRLSRRGTAAEVAV
SDSGLGIAPHLLPHVFERFRQADSSSTRSHGGLGLGLAIVRQLVELHSGTVSAASPGEGQGATFTVRLPFDGARTLLAGD
HSPGDWTRESPTACCGRLDGLRVLVVDDEPQARELVRTTLELCGAQVATAGSAAEALAEVRRSKPAVLVSDIAMPGEDGY
ALLRQLRLLEAECGGRIPAVALTAYARVEDRRRALLAGFQTHLSKPVEPSELVAAVANLSCQAAI

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=290, Percent_Identity=35.8620689655172, Blast_Score=158, Evalue=2e-39,
Organism=Escherichia coli, GI87081816, Length=401, Percent_Identity=32.4189526184539, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788713, Length=388, Percent_Identity=28.6082474226804, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI48994928, Length=387, Percent_Identity=29.9741602067183, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI145693157, Length=282, Percent_Identity=35.8156028368794, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1786600, Length=255, Percent_Identity=32.5490196078431, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=31.0344827586207, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=30.5555555555556, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=32.4324324324324, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786783, Length=232, Percent_Identity=28.8793103448276, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=31.2775330396476, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1790861, Length=247, Percent_Identity=29.5546558704453, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=28.2511210762332, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=318, Percent_Identity=25.7861635220126, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=27.2321428571429, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=28.3783783783784, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790300, Length=228, Percent_Identity=27.6315789473684, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=116, Percent_Identity=36.2068965517241, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789403, Length=209, Percent_Identity=28.7081339712919, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI1788550, Length=124, Percent_Identity=34.6774193548387, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=153, Percent_Identity=32.6797385620915, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 85184; Mature: 85184

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERRRHVCWMCLVCSADRALPLERPIHSTWPTEVSAADPADPAASEGLVMACSPENLLA
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHH
EIAALREHNARLEALLGEGRLKAPALLESEERYRSLITVTSAIVWTAGSDGAIVEEVPSW
HHHHHHHHCHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHHEEECCCCCCHHHCCCCH
EEFTGQSPEQYQGWGWVEMLHPEDRASTAEIWRQANANKRPVEVEYRLRRRDGEYRHMVA
HHHCCCCCHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEHHHHHHCCCHHHHHHH
RGVPLLNAGGRLCSWVGTVTDIHDRKVAEQQRELRLLQAKRHTTRLQKLAEASLAINSAL
HCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIQQVLQGITEQAAALIGAHMALTSLTPERDWARAVHTVYLSDKYRYWHHGEARLGGVGI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEECCEEEEECCCCCCCCCCH
AADVCRTNRPARLTQSQLEGHPQGRLLAFGATDRPALRGWLAAPLVGRDGRNIGLIQLSD
HHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEEECC
KHEGDFSEEDEAIAVQLAQLASVAIENTRLFEAEQAAKVDAEEANRLKDEFLATLSHELR
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SPLTAILGWTKLLRQVDLGAVRAAHALEVIERNALAQNQLIEDLLDISRIVAGKLRIEAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHH
AVDLAGVIEAAIGTVRPAAQARAIEVDTEIEPGVPLLMGDATRLQQVVWNLLANAVKFTP
HHHHHHHHHHHHHCCCCCHHCEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHHEEECC
NGGRVRVRLSRRGTAAEVAVSDSGLGIAPHLLPHVFERFRQADSSSTRSHGGLGLGLAIV
CCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
RQLVELHSGTVSAASPGEGQGATFTVRLPFDGARTLLAGDHSPGDWTRESPTACCGRLDG
HHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCHHHHHHCCCC
LRVLVVDDEPQARELVRTTLELCGAQVATAGSAAEALAEVRRSKPAVLVSDIAMPGEDGY
EEEEEECCCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHH
ALLRQLRLLEAECGGRIPAVALTAYARVEDRRRALLAGFQTHLSKPVEPSELVAAVANLS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
CQAAI
CCCCC
>Mature Secondary Structure
MQERRRHVCWMCLVCSADRALPLERPIHSTWPTEVSAADPADPAASEGLVMACSPENLLA
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHH
EIAALREHNARLEALLGEGRLKAPALLESEERYRSLITVTSAIVWTAGSDGAIVEEVPSW
HHHHHHHHCHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHHEEECCCCCCHHHCCCCH
EEFTGQSPEQYQGWGWVEMLHPEDRASTAEIWRQANANKRPVEVEYRLRRRDGEYRHMVA
HHHCCCCCHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEHHHHHHCCCHHHHHHH
RGVPLLNAGGRLCSWVGTVTDIHDRKVAEQQRELRLLQAKRHTTRLQKLAEASLAINSAL
HCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIQQVLQGITEQAAALIGAHMALTSLTPERDWARAVHTVYLSDKYRYWHHGEARLGGVGI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEECCEEEEECCCCCCCCCCH
AADVCRTNRPARLTQSQLEGHPQGRLLAFGATDRPALRGWLAAPLVGRDGRNIGLIQLSD
HHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEEECC
KHEGDFSEEDEAIAVQLAQLASVAIENTRLFEAEQAAKVDAEEANRLKDEFLATLSHELR
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SPLTAILGWTKLLRQVDLGAVRAAHALEVIERNALAQNQLIEDLLDISRIVAGKLRIEAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHH
AVDLAGVIEAAIGTVRPAAQARAIEVDTEIEPGVPLLMGDATRLQQVVWNLLANAVKFTP
HHHHHHHHHHHHHCCCCCHHCEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHHEEECC
NGGRVRVRLSRRGTAAEVAVSDSGLGIAPHLLPHVFERFRQADSSSTRSHGGLGLGLAIV
CCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
RQLVELHSGTVSAASPGEGQGATFTVRLPFDGARTLLAGDHSPGDWTRESPTACCGRLDG
HHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCHHHHHHCCCC
LRVLVVDDEPQARELVRTTLELCGAQVATAGSAAEALAEVRRSKPAVLVSDIAMPGEDGY
EEEEEECCCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHH
ALLRQLRLLEAECGGRIPAVALTAYARVEDRRRALLAGFQTHLSKPVEPSELVAAVANLS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
CQAAI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]