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The map label for this gene is macA [H]

Identifier: 34499853

GI number: 34499853

Start: 4741607

End: 4742821

Strand: Reverse

Name: macA [H]

Synonym: CV_4398

Alternate gene names: 34499853

Gene position: 4742821-4741607 (Counterclockwise)

Preceding gene: 34499854

Following gene: 34499852

Centisome position: 99.83

GC content: 71.77

Gene sequence:

>1215_bases
ATGAAGCGGAAGTGGTTGGGCCCCGCGCTGCTGGTCGCGGTGGCGGCGCTGCCTTTCGTGGCGCGCGCGTTCAGGCAGGA
GACGGTGTACCAGGTGACGGCCGCCGTCGCCGCGACGCGGGAAATCCGCTCGTCGGTGCTGGCTTCCTGCAGCCTGGTCT
ACCAGGATCAGGCCCAGCTGTCGTCCGAGGTGACCGGTAAGGTCAGCGCGGTGCTGGTGCGGGAGGGCGACCATGTGCGG
GCCGGCCAGCCGGTGCTGAGGCTGGACGACGAGGGCTATGCCGCCGAAGTGACGCAGCAGGCGGCCGCGGTCAGGCAGCA
GGCGCTGCAGCAGCGGCAGCAGGCGCTGACGTTGGCGAACCAGCAGTCCGCCTATCGCCGCAAGGAGGCCCTGCACCGGG
CCGGCATGGTGGCGGACGCGATGCTGGAGGACGCCCGCTACGCGGTGGACGAGGCCAGGGTAGGCCTGAAGAACGGCGGC
GAGCAGCTGCGGCAGAGCGAGGCGGTGCTGGCCCAGGCCAGGCAGCGCGCCGCCAAGACAGTGATCCGCGCGCCGATGAG
CGGCGTGGTCACCTCGATCGACATCAAGCCCGGCGAGACGGCCATCGCCAGCCAGGTGGGCATGGTCACGCCCAGCCTGA
TGACGATAGCCAATACCGGCACCATGCTGGTCGAGGCCAATATCGACGAGGCGGACATCGGCGGCGTCGGCAGCGGCCAG
CCGGCCAAGGTGCAGCTGGTGGCTTATCCGGGCGCGCCGCTGTCGGCGACGGTGCTGCAGATACCGCTGTCGCCGAAGCG
CATGGCCGGCGCGCCCGCCGGCGTGCCGGGCGGACAGGCGCGCAGCTATCCGGTGCGGCTGGCGCTGTCCGGAAGCGGCC
GCGGGTTGCTGCGGCCGGGCATGAGCTGCCGGGTGGAAATCTTCACCACGCGGGCCGGCAAGGCGCTGACGGTGCCGCTG
CAGGCGGTGTTGTCCGAGGCGGAAACCTCGGCCCGCCGCGATGCCGACGCCGGCGACGGCGAGGCGAGGGTGCTGGTGGT
GAAGGATGGCCGGCTGGAATCGCGGCGGGTCCGGACCGGCGAGTCGGACGACGCCCAGCAGCAGATACTGTCCGGATTGC
GCGCCGGCGAACGGGTGGTGACCGGGCCGGCCAAGCTCTTGTACAGCCTGAAGCCGGGCGACGCGGTCTCGGTCCAGGAC
GGGAGGCCGTCATGA

Upstream 100 bases:

>100_bases
GTGGAGCGGCGACCGCTGGCCCGTCAGCGCCGCGGTGGCCTGGGCGCCGGCCGCGCTGTTCTACGGCGTCTGGATCGCCT
TCAAGGCCTGGTGAGCGGAT

Downstream 100 bases:

>100_bases
CGCCGCTGATCGAGCTGCGCGGCATCTGCAAGCGCTACCAGCAGGATGAAGCGGCGCCGCCGGCGCTGTCGGCGCTGAAT
CTCAGCGTCAGCGCCAACGA

Product: ABC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKRKWLGPALLVAVAALPFVARAFRQETVYQVTAAVAATREIRSSVLASCSLVYQDQAQLSSEVTGKVSAVLVREGDHVR
AGQPVLRLDDEGYAAEVTQQAAAVRQQALQQRQQALTLANQQSAYRRKEALHRAGMVADAMLEDARYAVDEARVGLKNGG
EQLRQSEAVLAQARQRAAKTVIRAPMSGVVTSIDIKPGETAIASQVGMVTPSLMTIANTGTMLVEANIDEADIGGVGSGQ
PAKVQLVAYPGAPLSATVLQIPLSPKRMAGAPAGVPGGQARSYPVRLALSGSGRGLLRPGMSCRVEIFTTRAGKALTVPL
QAVLSEAETSARRDADAGDGEARVLVVKDGRLESRRVRTGESDDAQQQILSGLRAGERVVTGPAKLLYSLKPGDAVSVQD
GRPS

Sequences:

>Translated_404_residues
MKRKWLGPALLVAVAALPFVARAFRQETVYQVTAAVAATREIRSSVLASCSLVYQDQAQLSSEVTGKVSAVLVREGDHVR
AGQPVLRLDDEGYAAEVTQQAAAVRQQALQQRQQALTLANQQSAYRRKEALHRAGMVADAMLEDARYAVDEARVGLKNGG
EQLRQSEAVLAQARQRAAKTVIRAPMSGVVTSIDIKPGETAIASQVGMVTPSLMTIANTGTMLVEANIDEADIGGVGSGQ
PAKVQLVAYPGAPLSATVLQIPLSPKRMAGAPAGVPGGQARSYPVRLALSGSGRGLLRPGMSCRVEIFTTRAGKALTVPL
QAVLSEAETSARRDADAGDGEARVLVVKDGRLESRRVRTGESDDAQQQILSGLRAGERVVTGPAKLLYSLKPGDAVSVQD
GRPS
>Mature_404_residues
MKRKWLGPALLVAVAALPFVARAFRQETVYQVTAAVAATREIRSSVLASCSLVYQDQAQLSSEVTGKVSAVLVREGDHVR
AGQPVLRLDDEGYAAEVTQQAAAVRQQALQQRQQALTLANQQSAYRRKEALHRAGMVADAMLEDARYAVDEARVGLKNGG
EQLRQSEAVLAQARQRAAKTVIRAPMSGVVTSIDIKPGETAIASQVGMVTPSLMTIANTGTMLVEANIDEADIGGVGSGQ
PAKVQLVAYPGAPLSATVLQIPLSPKRMAGAPAGVPGGQARSYPVRLALSGSGRGLLRPGMSCRVEIFTTRAGKALTVPL
QAVLSEAETSARRDADAGDGEARVLVVKDGRLESRRVRTGESDDAQQQILSGLRAGERVVTGPAKLLYSLKPGDAVSVQD
GRPS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=347, Percent_Identity=29.1066282420749, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789041, Length=226, Percent_Identity=27.4336283185841, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42559; Mature: 42559

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKWLGPALLVAVAALPFVARAFRQETVYQVTAAVAATREIRSSVLASCSLVYQDQAQL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSEVTGKVSAVLVREGDHVRAGQPVLRLDDEGYAAEVTQQAAAVRQQALQQRQQALTLAN
HHHHCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQSAYRRKEALHRAGMVADAMLEDARYAVDEARVGLKNGGEQLRQSEAVLAQARQRAAKT
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VIRAPMSGVVTSIDIKPGETAIASQVGMVTPSLMTIANTGTMLVEANIDEADIGGVGSGQ
HHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHEEECCCEEEEEECCCCCCCCCCCCCC
PAKVQLVAYPGAPLSATVLQIPLSPKRMAGAPAGVPGGQARSYPVRLALSGSGRGLLRPG
CCEEEEEEECCCCCEEEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
MSCRVEIFTTRAGKALTVPLQAVLSEAETSARRDADAGDGEARVLVVKDGRLESRRVRTG
CCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHCCCC
ESDDAQQQILSGLRAGERVVTGPAKLLYSLKPGDAVSVQDGRPS
CCCHHHHHHHHHHHCCCEEEECHHHHEEEECCCCEEECCCCCCC
>Mature Secondary Structure
MKRKWLGPALLVAVAALPFVARAFRQETVYQVTAAVAATREIRSSVLASCSLVYQDQAQL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSEVTGKVSAVLVREGDHVRAGQPVLRLDDEGYAAEVTQQAAAVRQQALQQRQQALTLAN
HHHHCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQSAYRRKEALHRAGMVADAMLEDARYAVDEARVGLKNGGEQLRQSEAVLAQARQRAAKT
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VIRAPMSGVVTSIDIKPGETAIASQVGMVTPSLMTIANTGTMLVEANIDEADIGGVGSGQ
HHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHEEECCCEEEEEECCCCCCCCCCCCCC
PAKVQLVAYPGAPLSATVLQIPLSPKRMAGAPAGVPGGQARSYPVRLALSGSGRGLLRPG
CCEEEEEEECCCCCEEEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
MSCRVEIFTTRAGKALTVPLQAVLSEAETSARRDADAGDGEARVLVVKDGRLESRRVRTG
CCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHCCCC
ESDDAQQQILSGLRAGERVVTGPAKLLYSLKPGDAVSVQDGRPS
CCCHHHHHHHHHHHCCCEEEECHHHHEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]