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The map label for this gene is mraY

Identifier: 34499801

GI number: 34499801

Start: 4686281

End: 4687366

Strand: Reverse

Name: mraY

Synonym: CV_4346

Alternate gene names: 34499801

Gene position: 4687366-4686281 (Counterclockwise)

Preceding gene: 34499802

Following gene: 34499800

Centisome position: 98.66

GC content: 65.38

Gene sequence:

>1086_bases
GTGCTGCTTTGGCTGGCTGATCTGTTGGGTTCGCATATCCGGGCCTTCAATGTCTTCAATTACACCACGCTGCGCGCGGT
GATGGCCGCGTTGACCGCGCTGACCATCTCGCTGTTGCTGGGCCCGTGGGTGATCCGCAAGCTGACCGAGCTCAAAGTCG
GCCAGGCGGTGCGCAACGACGGTCCGCAGACCCACCTGGTCAAGGCGGGCACGCCGACCATGGGCGGCTCGCTGATCCTG
CTGGCCATCACCCTCACCACGCTGCTGTGGGCGGACCTGTCCAACAAATACGTGTGGCTGCTGCTGGCGGTGATGCTGGG
CACCGGCGCGCTGGGCTTTTACGACGACTGGCGCAAGGTGGTGTACAAGGACCCGAAGGGCGTGTCCGCCAAGTTCAAGA
TGGCGTGGCAGTCGGCCATCGCCATCGGCGCCGGCGTGTTTCTGATCGCCACCGCCAAGCTGCCGGCGTCCACCGAGCTG
ATCGTGCCCTTCTTCAAGACCGTCGCCTATCCGCTGGGCGCCGTCGGCTTCTGCGTGCTGACCTATTTCGTCATCGTCGG
CACCTCCAACGCGGTCAACCTGACCGACGGCCTGGATGGCCTGGCGGCGTTGCCGACGGTGCTGGTGTCGGCTGGCCTGG
CGATTTTCGCGTATGTCGCCGGCCACGCGGTGTTCTCCAAGTACCTGGGCCTGCCCTTCATCCCCGGGGCGCACGAGGTG
GTGGTGTTCTGCGCGGCGATGTGCGGCGCCTGCCTGGGCTTCCTGTGGTTCAACGCCTACCCGGCCCAGGTGTTCATGGG
CGACGTCGGCGCGCTGGCGCTGGGCGCCGCGCTCGGCACGGTGGCGGTGATCGTGCGCCAGGAGATCGTGCTGTTCCTGA
TGGGCGGCCTGTTCGTGATGGAGGCGCTGTCGGTGATGATCCAGGTGACCTCGTTCAAGCTGACCGGCAAGCGCGTGTTC
CGCATGGCGCCGCTGCATCACCATTTCGAATTGAAGGGCTGGAAGGAAACCCAGGTGGTGGTCCGCTTCTGGATCGTCAC
CATGATGCTGGTGCTGATCGGCCTGTCGACGCTGAAGCTGCGCTGA

Upstream 100 bases:

>100_bases
CTGGCTTCGGGTACCGCCGTTCTGGTCAAGGGGTCGCGCTTTATGCGCATGGAACGGGTGGTGGAACACCTGATGCAAGC
AAAGAAAGAGGGAGTTTAAG

Downstream 100 bases:

>100_bases
GGACGGAAAAATGGATTACGCCAATCGACATGTGACGGTGGTGGGATTGGGGGGCTCGGGCCTGGCGGCCGCGCGCTACC
TGGCCGCCCACGGCGCGCGC

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MLLWLADLLGSHIRAFNVFNYTTLRAVMAALTALTISLLLGPWVIRKLTELKVGQAVRNDGPQTHLVKAGTPTMGGSLIL
LAITLTTLLWADLSNKYVWLLLAVMLGTGALGFYDDWRKVVYKDPKGVSAKFKMAWQSAIAIGAGVFLIATAKLPASTEL
IVPFFKTVAYPLGAVGFCVLTYFVIVGTSNAVNLTDGLDGLAALPTVLVSAGLAIFAYVAGHAVFSKYLGLPFIPGAHEV
VVFCAAMCGACLGFLWFNAYPAQVFMGDVGALALGAALGTVAVIVRQEIVLFLMGGLFVMEALSVMIQVTSFKLTGKRVF
RMAPLHHHFELKGWKETQVVVRFWIVTMMLVLIGLSTLKLR

Sequences:

>Translated_361_residues
MLLWLADLLGSHIRAFNVFNYTTLRAVMAALTALTISLLLGPWVIRKLTELKVGQAVRNDGPQTHLVKAGTPTMGGSLIL
LAITLTTLLWADLSNKYVWLLLAVMLGTGALGFYDDWRKVVYKDPKGVSAKFKMAWQSAIAIGAGVFLIATAKLPASTEL
IVPFFKTVAYPLGAVGFCVLTYFVIVGTSNAVNLTDGLDGLAALPTVLVSAGLAIFAYVAGHAVFSKYLGLPFIPGAHEV
VVFCAAMCGACLGFLWFNAYPAQVFMGDVGALALGAALGTVAVIVRQEIVLFLMGGLFVMEALSVMIQVTSFKLTGKRVF
RMAPLHHHFELKGWKETQVVVRFWIVTMMLVLIGLSTLKLR
>Mature_361_residues
MLLWLADLLGSHIRAFNVFNYTTLRAVMAALTALTISLLLGPWVIRKLTELKVGQAVRNDGPQTHLVKAGTPTMGGSLIL
LAITLTTLLWADLSNKYVWLLLAVMLGTGALGFYDDWRKVVYKDPKGVSAKFKMAWQSAIAIGAGVFLIATAKLPASTEL
IVPFFKTVAYPLGAVGFCVLTYFVIVGTSNAVNLTDGLDGLAALPTVLVSAGLAIFAYVAGHAVFSKYLGLPFIPGAHEV
VVFCAAMCGACLGFLWFNAYPAQVFMGDVGALALGAALGTVAVIVRQEIVLFLMGGLFVMEALSVMIQVTSFKLTGKRVF
RMAPLHHHFELKGWKETQVVVRFWIVTMMLVLIGLSTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=361, Percent_Identity=58.1717451523546, Blast_Score=411, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_CHRVO (Q7NPZ6)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_904016.1
- GeneID:   2549597
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4346
- NMPDR:   fig|243365.1.peg.4346
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   Q7NPZ6
- ProtClustDB:   PRK00108
- BioCyc:   CVIO243365:CV_4346-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 38944; Mature: 38944

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13ea8820)-; HASH(0x14552584)-; HASH(0x1150898c)-; HASH(0x13cb7c18)-; HASH(0x10b4e408)-; HASH(0x1468d498)-; HASH(0x14a8eb6c)-; HASH(0xff15f44)-; HASH(0x135aa9a4)-; HASH(0x1442512c)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLWLADLLGSHIRAFNVFNYTTLRAVMAALTALTISLLLGPWVIRKLTELKVGQAVRND
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPQTHLVKAGTPTMGGSLILLAITLTTLLWADLSNKYVWLLLAVMLGTGALGFYDDWRKV
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHH
VYKDPKGVSAKFKMAWQSAIAIGAGVFLIATAKLPASTELIVPFFKTVAYPLGAVGFCVL
HHCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TYFVIVGTSNAVNLTDGLDGLAALPTVLVSAGLAIFAYVAGHAVFSKYLGLPFIPGAHEV
HHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
VVFCAAMCGACLGFLWFNAYPAQVFMGDVGALALGAALGTVAVIVRQEIVLFLMGGLFVM
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALSVMIQVTSFKLTGKRVFRMAPLHHHFELKGWKETQVVVRFWIVTMMLVLIGLSTLKL
HHHHHHHHHHHEEECHHHHHHHCCCHHCEECCCCHHHHHHHHHHHHHHHHHHHCHHHHCC
R
H
>Mature Secondary Structure
MLLWLADLLGSHIRAFNVFNYTTLRAVMAALTALTISLLLGPWVIRKLTELKVGQAVRND
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPQTHLVKAGTPTMGGSLILLAITLTTLLWADLSNKYVWLLLAVMLGTGALGFYDDWRKV
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHH
VYKDPKGVSAKFKMAWQSAIAIGAGVFLIATAKLPASTELIVPFFKTVAYPLGAVGFCVL
HHCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TYFVIVGTSNAVNLTDGLDGLAALPTVLVSAGLAIFAYVAGHAVFSKYLGLPFIPGAHEV
HHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
VVFCAAMCGACLGFLWFNAYPAQVFMGDVGALALGAALGTVAVIVRQEIVLFLMGGLFVM
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALSVMIQVTSFKLTGKRVFRMAPLHHHFELKGWKETQVVVRFWIVTMMLVLIGLSTLKL
HHHHHHHHHHHEEECHHHHHHHCCCHHCEECCCCHHHHHHHHHHHHHHHHHHHCHHHHCC
R
H

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782