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The map label for this gene is murC

Identifier: 34499797

GI number: 34499797

Start: 4681235

End: 4682629

Strand: Reverse

Name: murC

Synonym: CV_4342

Alternate gene names: 34499797

Gene position: 4682629-4681235 (Counterclockwise)

Preceding gene: 34499798

Following gene: 34499796

Centisome position: 98.56

GC content: 69.68

Gene sequence:

>1395_bases
ATGAAACACAGGGTCAAACACATACATTTCGTGGGCATAGGCGGCGTCGGCATGTGCGGCATCGCCGAGGTGCTGCACGG
CCTCGGCTACACCGTGTCCGGCTCGGACATGGCCGACGGCGCGACCACCAAGCGGCTGGCCGCCGAAGGCGTGCGCGTGT
TTTTCGGCCACGACGCCACCTATGTGGAAGGCGCGGACGTGGTGGTGACTTCCACCGCGGTGAAGGCCGACAACCCGGAA
GTGCTGGCGGCGCGCGACAAGCGCATCCCGGTGATCCCGCGCGCGCTGATGCTGGCCGAGCTGATGCGCTTCAAGCAGGG
CATCGCCATCGCCGGCACCCACGGCAAGACCACCACCACCAGCCTGACCGCGTCGGTGCTGGGCGCGGCCGGGCTGGACC
CGACCTTCGTCATCGGCGGCAAGCTGACCGCGGCCGGCACCAACGCCAAGCTGGGCCTGGGCGAGTTCCTGGTGGCCGAG
GCCGACGAGTCGGACGCGTCCTTCCTGCACCTGACCCCGGTGATGGCGGTGGTGACCAATATCGACGCCGACCACATGGA
CACCTACGACCACAGTTTCGACAAGCTGAAGCAGGCCTTCGTCGATTTCCTGCAGCGGATGCCGTTCTACGGCCGCGCGG
TGCTGTGCGTCGACGACCCGAACGTGCGCGAGATCCGCGAGCGCGTCACCAAGCCGGTGACCACCTACGGCCTCGACGAT
TCGGCCGACATCTATGCCGAGAACGTGCGCGCGGCCGCCGGCCAGATGCATTTCGACGTGGTGGTGAAGAACGGCGCCAT
CACCCGCTTCCCGCTGGTGCTGAACCTGCCGGGCCGCCACAACGTGCTGAACGCGCTGTCGGCGATCGCCATCGGCCTGG
AATGCGGCGCCAGCATCGAGGCCATCCAGAAGGGCCTGTCCGAGTTCGCCGGCGTCGGCCGCCGCTTCCAGCGCTACGGC
GAAGTGAAAGCCCAGGACGGCGGCAGCTTCACGCTGATCGACGACTACGGCCACCACCCGGTGGAAATGGCCGCCACGCT
GGCCGCGGTGCGCGGGGCCTTCCCGGACCGCCGGCTGCTGCTGGCCTTCCAGCCGCACCGCTACACTCGCACCCGCGACC
TGTTCGAAGACTTCGTCAAGGTGCTGTCCGGCGTCGACGCGCTGCTGCTGTCCGAGGTGTACGCGGCCGGCGAGGCGCCC
ATCGTGGCGGCCGACGGCCGGGCGCTGGCGCGCGCGGTGCGCGTGGGCGGCAAGGTGGAGCCGCTGTTCGTCGAGGACAT
CGCCGACATGCCGCAGGCCATCCTGGACGCCGCCCGCGACGGCGACGTGGTGGTGACCATGGGCGCCGGCTCGGTGGGCG
CGGTGCCGGGCAAGGTGACGGCCCTGGCGGGCTGA

Upstream 100 bases:

>100_bases
CTGGCCCGCTCCGGCGCGGCCGGCCGGGTGGCCGACCTGTGCCAGCAGCTGGCCGGGGAATGACAGGGCGCCGAGCGAGC
GTCCAAGCAGAGACACAGAC

Downstream 100 bases:

>100_bases
TCGGAATTTCCGTCCGCGCCGTGGGCGCGGGCTTGTTGAGGGTAGATAGATGAAGCAGTACGGCAAGGTGGCGGTATTGA
TGGGCGGAAGCTCGTCGGAG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKHRVKHIHFVGIGGVGMCGIAEVLHGLGYTVSGSDMADGATTKRLAAEGVRVFFGHDATYVEGADVVVTSTAVKADNPE
VLAARDKRIPVIPRALMLAELMRFKQGIAIAGTHGKTTTTSLTASVLGAAGLDPTFVIGGKLTAAGTNAKLGLGEFLVAE
ADESDASFLHLTPVMAVVTNIDADHMDTYDHSFDKLKQAFVDFLQRMPFYGRAVLCVDDPNVREIRERVTKPVTTYGLDD
SADIYAENVRAAAGQMHFDVVVKNGAITRFPLVLNLPGRHNVLNALSAIAIGLECGASIEAIQKGLSEFAGVGRRFQRYG
EVKAQDGGSFTLIDDYGHHPVEMAATLAAVRGAFPDRRLLLAFQPHRYTRTRDLFEDFVKVLSGVDALLLSEVYAAGEAP
IVAADGRALARAVRVGGKVEPLFVEDIADMPQAILDAARDGDVVVTMGAGSVGAVPGKVTALAG

Sequences:

>Translated_464_residues
MKHRVKHIHFVGIGGVGMCGIAEVLHGLGYTVSGSDMADGATTKRLAAEGVRVFFGHDATYVEGADVVVTSTAVKADNPE
VLAARDKRIPVIPRALMLAELMRFKQGIAIAGTHGKTTTTSLTASVLGAAGLDPTFVIGGKLTAAGTNAKLGLGEFLVAE
ADESDASFLHLTPVMAVVTNIDADHMDTYDHSFDKLKQAFVDFLQRMPFYGRAVLCVDDPNVREIRERVTKPVTTYGLDD
SADIYAENVRAAAGQMHFDVVVKNGAITRFPLVLNLPGRHNVLNALSAIAIGLECGASIEAIQKGLSEFAGVGRRFQRYG
EVKAQDGGSFTLIDDYGHHPVEMAATLAAVRGAFPDRRLLLAFQPHRYTRTRDLFEDFVKVLSGVDALLLSEVYAAGEAP
IVAADGRALARAVRVGGKVEPLFVEDIADMPQAILDAARDGDVVVTMGAGSVGAVPGKVTALAG
>Mature_464_residues
MKHRVKHIHFVGIGGVGMCGIAEVLHGLGYTVSGSDMADGATTKRLAAEGVRVFFGHDATYVEGADVVVTSTAVKADNPE
VLAARDKRIPVIPRALMLAELMRFKQGIAIAGTHGKTTTTSLTASVLGAAGLDPTFVIGGKLTAAGTNAKLGLGEFLVAE
ADESDASFLHLTPVMAVVTNIDADHMDTYDHSFDKLKQAFVDFLQRMPFYGRAVLCVDDPNVREIRERVTKPVTTYGLDD
SADIYAENVRAAAGQMHFDVVVKNGAITRFPLVLNLPGRHNVLNALSAIAIGLECGASIEAIQKGLSEFAGVGRRFQRYG
EVKAQDGGSFTLIDDYGHHPVEMAATLAAVRGAFPDRRLLLAFQPHRYTRTRDLFEDFVKVLSGVDALLLSEVYAAGEAP
IVAADGRALARAVRVGGKVEPLFVEDIADMPQAILDAARDGDVVVTMGAGSVGAVPGKVTALAG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=456, Percent_Identity=52.8508771929825, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1790680, Length=469, Percent_Identity=27.9317697228145, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_CHRVO (Q7NQ00)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_904012.1
- ProteinModelPortal:   Q7NQ00
- SMR:   Q7NQ00
- GeneID:   2549666
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4342
- NMPDR:   fig|243365.1.peg.4342
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q7NQ00
- ProtClustDB:   PRK00421
- BioCyc:   CVIO243365:CV_4342-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49151; Mature: 49151

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHRVKHIHFVGIGGVGMCGIAEVLHGLGYTVSGSDMADGATTKRLAAEGVRVFFGHDAT
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCEEEEECCCCC
YVEGADVVVTSTAVKADNPEVLAARDKRIPVIPRALMLAELMRFKQGIAIAGTHGKTTTT
EECCCCEEEEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHH
SLTASVLGAAGLDPTFVIGGKLTAAGTNAKLGLGEFLVAEADESDASFLHLTPVMAVVTN
HHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
IDADHMDTYDHSFDKLKQAFVDFLQRMPFYGRAVLCVDDPNVREIRERVTKPVTTYGLDD
CCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCEECCCCC
SADIYAENVRAAAGQMHFDVVVKNGAITRFPLVLNLPGRHNVLNALSAIAIGLECGASIE
CCHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCHH
AIQKGLSEFAGVGRRFQRYGEVKAQDGGSFTLIDDYGHHPVEMAATLAAVRGAFPDRRLL
HHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEE
LAFQPHRYTRTRDLFEDFVKVLSGVDALLLSEVYAAGEAPIVAADGRALARAVRVGGKVE
EEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCC
PLFVEDIADMPQAILDAARDGDVVVTMGAGSVGAVPGKVTALAG
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECC
>Mature Secondary Structure
MKHRVKHIHFVGIGGVGMCGIAEVLHGLGYTVSGSDMADGATTKRLAAEGVRVFFGHDAT
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCEEEEECCCCC
YVEGADVVVTSTAVKADNPEVLAARDKRIPVIPRALMLAELMRFKQGIAIAGTHGKTTTT
EECCCCEEEEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHH
SLTASVLGAAGLDPTFVIGGKLTAAGTNAKLGLGEFLVAEADESDASFLHLTPVMAVVTN
HHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
IDADHMDTYDHSFDKLKQAFVDFLQRMPFYGRAVLCVDDPNVREIRERVTKPVTTYGLDD
CCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCEECCCCC
SADIYAENVRAAAGQMHFDVVVKNGAITRFPLVLNLPGRHNVLNALSAIAIGLECGASIE
CCHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCHH
AIQKGLSEFAGVGRRFQRYGEVKAQDGGSFTLIDDYGHHPVEMAATLAAVRGAFPDRRLL
HHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEE
LAFQPHRYTRTRDLFEDFVKVLSGVDALLLSEVYAAGEAPIVAADGRALARAVRVGGKVE
EEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCC
PLFVEDIADMPQAILDAARDGDVVVTMGAGSVGAVPGKVTALAG
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782