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The map label for this gene is lpxC

Identifier: 34499792

GI number: 34499792

Start: 4675981

End: 4676895

Strand: Reverse

Name: lpxC

Synonym: CV_4337

Alternate gene names: 34499792

Gene position: 4676895-4675981 (Counterclockwise)

Preceding gene: 34499793

Following gene: 34499791

Centisome position: 98.44

GC content: 64.7

Gene sequence:

>915_bases
ATGATCTTGCAGCGCACGCTGAAGCAAGCGATCAGCGCCACGGGCGTCGGTCTGCATTCCGGCGAGCGGGTGAAGCTCAC
CCTGCTGCCGGCGCCGCCCGATACCGGCATCGTCTTCCGTCGCACCGACTTGCCCGAGCCGGTCGACGTGAAGGTGGAAC
CTTCGCTCGTCAACGACACGCGCCTCTCCTCCACGCTGGTGACGGATACCGGCGTGCGTGTCGGCACGATCGAACATCTG
ATGTCGGCGTTCGCCGGCTTCGGCATCGACAACCTGGTCGTCGAGGTGACGGCGGCGGAAATCCCCATCATGGATGGGTC
CGCCGCGCCGTTCCTCTACCTGTTGCAGACGGCCGGCGTGGTCGATCAGCCCAAGAAGAAGCGTTTCATCCGCGTCAAGC
AGAGCGTGATGGTGGAAGACCGCGGCGTATGGGTCCGGCTGGACCCGCACGACGGCTTCAAGATCACGCTGTCCATCGAG
TTCAACCATCCGGCGTTCAACCGCGCGCCGCAGACGGTGGAAGTGGATTTCGCCCGCCACTCCTACATGGACGAGATCAG
CCGCGCCCGCACCTTCGGCTTCATGCACGAGGTGGAGTACATGCGCAACCACGGCCTCGGCCGCGGCGGCAGCCTGGACA
ACGCCATCGTCATCGACGACGAATACGTGTTGAATCCGGAAGGCCTGCGTTTTCCGGACGAGTTCGTCCGCCACAAGATC
CTGGACGCGATCGGCGACCTCTACATCGTCGGCCATCCGCTGATCGCGGCGTTCTCCGGCCATAAATCCGGCCACGCGAT
GAACAACCGGCTGCTGCGCAAGCTGCTGGAAACGCCGGAGGCCTGGGAGTTCGCCAGCTTCGACGATCCGCTGGACGCGC
CGTCCAGCTTCCACCAGCTGCCGCCGCAGGAGTAG

Upstream 100 bases:

>100_bases
GCGGATAGATAAACGCTATTCATGCCAGCGAATCAATCAATAAAGCATAGCCAGTCGCTATGCTAGAATCGGGTTTTCCC
GTTTGGTTGAGTAGCCTGAA

Downstream 100 bases:

>100_bases
GGCCGTGTTCGGCTTCTGGCGGCTGTGGCTGCTGGCGACGATACTGGCGATAGGCTGGGCGCTGCTGTGCTACGCCTTCA
CCCATGATCGCCGCTACCTG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MILQRTLKQAISATGVGLHSGERVKLTLLPAPPDTGIVFRRTDLPEPVDVKVEPSLVNDTRLSSTLVTDTGVRVGTIEHL
MSAFAGFGIDNLVVEVTAAEIPIMDGSAAPFLYLLQTAGVVDQPKKKRFIRVKQSVMVEDRGVWVRLDPHDGFKITLSIE
FNHPAFNRAPQTVEVDFARHSYMDEISRARTFGFMHEVEYMRNHGLGRGGSLDNAIVIDDEYVLNPEGLRFPDEFVRHKI
LDAIGDLYIVGHPLIAAFSGHKSGHAMNNRLLRKLLETPEAWEFASFDDPLDAPSSFHQLPPQE

Sequences:

>Translated_304_residues
MILQRTLKQAISATGVGLHSGERVKLTLLPAPPDTGIVFRRTDLPEPVDVKVEPSLVNDTRLSSTLVTDTGVRVGTIEHL
MSAFAGFGIDNLVVEVTAAEIPIMDGSAAPFLYLLQTAGVVDQPKKKRFIRVKQSVMVEDRGVWVRLDPHDGFKITLSIE
FNHPAFNRAPQTVEVDFARHSYMDEISRARTFGFMHEVEYMRNHGLGRGGSLDNAIVIDDEYVLNPEGLRFPDEFVRHKI
LDAIGDLYIVGHPLIAAFSGHKSGHAMNNRLLRKLLETPEAWEFASFDDPLDAPSSFHQLPPQE
>Mature_304_residues
MILQRTLKQAISATGVGLHSGERVKLTLLPAPPDTGIVFRRTDLPEPVDVKVEPSLVNDTRLSSTLVTDTGVRVGTIEHL
MSAFAGFGIDNLVVEVTAAEIPIMDGSAAPFLYLLQTAGVVDQPKKKRFIRVKQSVMVEDRGVWVRLDPHDGFKITLSIE
FNHPAFNRAPQTVEVDFARHSYMDEISRARTFGFMHEVEYMRNHGLGRGGSLDNAIVIDDEYVLNPEGLRFPDEFVRHKI
LDAIGDLYIVGHPLIAAFSGHKSGHAMNNRLLRKLLETPEAWEFASFDDPLDAPSSFHQLPPQE

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=297, Percent_Identity=53.8720538720539, Blast_Score=349, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_CHRVO (Q7NQ05)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_904007.1
- HSSP:   O67648
- ProteinModelPortal:   Q7NQ05
- SMR:   Q7NQ05
- GeneID:   2549680
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4337
- NMPDR:   fig|243365.1.peg.4337
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   Q7NQ05
- ProtClustDB:   PRK13186
- BioCyc:   CVIO243365:CV_4337-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33829; Mature: 33829

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILQRTLKQAISATGVGLHSGERVKLTLLPAPPDTGIVFRRTDLPEPVDVKVEPSLVNDT
CCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCEEECCCCCCCC
RLSSTLVTDTGVRVGTIEHLMSAFAGFGIDNLVVEVTAAEIPIMDGSAAPFLYLLQTAGV
CCCCEEEECCCCEEHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHCCC
VDQPKKKRFIRVKQSVMVEDRGVWVRLDPHDGFKITLSIEFNHPAFNRAPQTVEVDFARH
CCCHHHHHHHHHHHHHEEECCCEEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHH
SYMDEISRARTFGFMHEVEYMRNHGLGRGGSLDNAIVIDDEYVLNPEGLRFPDEFVRHKI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEECCCCCCCCHHHHHHHH
LDAIGDLYIVGHPLIAAFSGHKSGHAMNNRLLRKLLETPEAWEFASFDDPLDAPSSFHQL
HHHHCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
PPQE
CCCC
>Mature Secondary Structure
MILQRTLKQAISATGVGLHSGERVKLTLLPAPPDTGIVFRRTDLPEPVDVKVEPSLVNDT
CCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCEEECCCCCCCC
RLSSTLVTDTGVRVGTIEHLMSAFAGFGIDNLVVEVTAAEIPIMDGSAAPFLYLLQTAGV
CCCCEEEECCCCEEHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHCCC
VDQPKKKRFIRVKQSVMVEDRGVWVRLDPHDGFKITLSIEFNHPAFNRAPQTVEVDFARH
CCCHHHHHHHHHHHHHEEECCCEEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHH
SYMDEISRARTFGFMHEVEYMRNHGLGRGGSLDNAIVIDDEYVLNPEGLRFPDEFVRHKI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEECCCCCCCCHHHHHHHH
LDAIGDLYIVGHPLIAAFSGHKSGHAMNNRLLRKLLETPEAWEFASFDDPLDAPSSFHQL
HHHHCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
PPQE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782