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The map label for this gene is yfhK [H]

Identifier: 34499673

GI number: 34499673

Start: 4552722

End: 4554125

Strand: Direct

Name: yfhK [H]

Synonym: CV_4218

Alternate gene names: 34499673

Gene position: 4552722-4554125 (Clockwise)

Preceding gene: 34499672

Following gene: 34499674

Centisome position: 95.82

GC content: 71.51

Gene sequence:

>1404_bases
ATGCTCCGCTTCATTTCCTTCCGAGGCCTGCTGTTGACGGGCTTCCTCGGCGTCGCGCTGACTCCCGCCGCGGCGCTGAT
GCAGTTGCGCCACGAACTGGGCCTGGCCGCCGACAGCGCCCAGCACCACCAGCGGCAAGCCCAGCGCTGGCAGGACATCG
CCCGCCTGTCCCAGGAGCAGGCAGTTCAATTCGAACGCGCCAGCCGGCAGGCGGCGATCCTGCGCGACCGCAAGCTCACC
GAAACCGCCAGCCAGGCGCGCGGCGAACTGCAACGCGCGCAGCGGACGCTGCGGCTGGACGCGCCGCCCGAGGCGCTGCC
CGGCATAGACGCCGCGCTCGGCCTCGCCGCGCAGTTGCAGACGCTTCCGCCCTCCCGCCGCCAGCAGCGCGACGCCCTTT
TCCGCCAGCTGAACCGCGTGCTGGACCAACAGCAGCAAACGCTGGCCCAGGCCGGCGAAAAACGTCAGGCCAGCTGGCGC
GACGACATCGAGCGGATGCGGCTGCAGGCCAACCGGCTGGCCTGGCTGGCGCTGGCCGCCGCCGTGCTGCTGGCGCTGAT
CGTCACCCTGCTGATCCACGCCCCGCTGCGCGGCCTGCAACGCCGCATCGCCCGGCTGGCCGGCGGCGCGCGCCAGCTGA
ATTGGCGGCAGACGGGACCTGCCGACCTGCAGCGCCTGGGCCGGGAACTGGAACAACTGGATTTGCGCCTGGTGGAGCTG
GAGCAGCAAAAGACCCGCTTCTTCCGCCAGGTGTCGCACGAGCTGAAAACGCCGCTGGCGTCGATACACGAGGCCGCCGC
GCTGCTGCGGGAACAGGTGGCCGGCCCGCTCAATCCGCAGCAGCGCCACATCGTCGACATCCTGGGCAACAACGCGCAGA
CGCTGCGCCAGCGCGTGGAGGCGCTGCTGAGGCAGGACGCCGGCCCCTGGCTGTCCAGCGCGCTGAACATTTCCGCCTTC
CCCCTGCGCAGCCTGATCGAAGACCGCCTAGCGAGCTGCCAGCCGCTATGGCAGGCCAAGCGGCTGACCGTCGCGCTGGA
CGGCCCGGCCGGGCTGGTGCGCGGCGACGCGTCCAAGGTAGAGACCATCGTCGACAACCTGTTGCTCAACGCCATCCGCC
ACAGCCCCCCGGGAGGACGGCTGGCGCTGCGCTTCGCGCGCGAGCGCGGCCAGGTCTGGCTGGAAGTGGCCGATCAGGGG
GCCGGCGTGCCCGGCGAGCTGCGCGACAGGATATTCGAACCTTTCTGGAGCGGACCCGCGCCCGACGGCGAGCGTCCCGG
CAGCGGCCTCGGCCTGACCATGGCGCGCGGCTACGCGCAGCTGATGGGCGGCGAGCTGCGGCTGCTGGGCGACGGCCCAG
GCACCTGCTTCCGCCTCCATTGGCCTGAACCGGAGCCGATATGA

Upstream 100 bases:

>100_bases
CTGGCCGCGCGCTGACCGCAGGCGGCGGCGAACCAATCGGCCTCCCGCCTGTCTGCTGAACAGGGGCGCATCCGCGCCCC
TGTTCCACTTTCATGACGCC

Downstream 100 bases:

>100_bases
CCCCAATCGTTTTCCCGCGCCGCTGGCTGCCGCTGTTGTCGCTGCCGCTGCTCGCCGCCTGCGCCGGCGTCCAGCCGCCG
CCCGCGCCGATACGCTACTG

Product: two-component system sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MLRFISFRGLLLTGFLGVALTPAAALMQLRHELGLAADSAQHHQRQAQRWQDIARLSQEQAVQFERASRQAAILRDRKLT
ETASQARGELQRAQRTLRLDAPPEALPGIDAALGLAAQLQTLPPSRRQQRDALFRQLNRVLDQQQQTLAQAGEKRQASWR
DDIERMRLQANRLAWLALAAAVLLALIVTLLIHAPLRGLQRRIARLAGGARQLNWRQTGPADLQRLGRELEQLDLRLVEL
EQQKTRFFRQVSHELKTPLASIHEAAALLREQVAGPLNPQQRHIVDILGNNAQTLRQRVEALLRQDAGPWLSSALNISAF
PLRSLIEDRLASCQPLWQAKRLTVALDGPAGLVRGDASKVETIVDNLLLNAIRHSPPGGRLALRFARERGQVWLEVADQG
AGVPGELRDRIFEPFWSGPAPDGERPGSGLGLTMARGYAQLMGGELRLLGDGPGTCFRLHWPEPEPI

Sequences:

>Translated_467_residues
MLRFISFRGLLLTGFLGVALTPAAALMQLRHELGLAADSAQHHQRQAQRWQDIARLSQEQAVQFERASRQAAILRDRKLT
ETASQARGELQRAQRTLRLDAPPEALPGIDAALGLAAQLQTLPPSRRQQRDALFRQLNRVLDQQQQTLAQAGEKRQASWR
DDIERMRLQANRLAWLALAAAVLLALIVTLLIHAPLRGLQRRIARLAGGARQLNWRQTGPADLQRLGRELEQLDLRLVEL
EQQKTRFFRQVSHELKTPLASIHEAAALLREQVAGPLNPQQRHIVDILGNNAQTLRQRVEALLRQDAGPWLSSALNISAF
PLRSLIEDRLASCQPLWQAKRLTVALDGPAGLVRGDASKVETIVDNLLLNAIRHSPPGGRLALRFARERGQVWLEVADQG
AGVPGELRDRIFEPFWSGPAPDGERPGSGLGLTMARGYAQLMGGELRLLGDGPGTCFRLHWPEPEPI
>Mature_467_residues
MLRFISFRGLLLTGFLGVALTPAAALMQLRHELGLAADSAQHHQRQAQRWQDIARLSQEQAVQFERASRQAAILRDRKLT
ETASQARGELQRAQRTLRLDAPPEALPGIDAALGLAAQLQTLPPSRRQQRDALFRQLNRVLDQQQQTLAQAGEKRQASWR
DDIERMRLQANRLAWLALAAAVLLALIVTLLIHAPLRGLQRRIARLAGGARQLNWRQTGPADLQRLGRELEQLDLRLVEL
EQQKTRFFRQVSHELKTPLASIHEAAALLREQVAGPLNPQQRHIVDILGNNAQTLRQRVEALLRQDAGPWLSSALNISAF
PLRSLIEDRLASCQPLWQAKRLTVALDGPAGLVRGDASKVETIVDNLLLNAIRHSPPGGRLALRFARERGQVWLEVADQG
AGVPGELRDRIFEPFWSGPAPDGERPGSGLGLTMARGYAQLMGGELRLLGDGPGTCFRLHWPEPEPI

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=421, Percent_Identity=30.4038004750594, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1790861, Length=288, Percent_Identity=31.25, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=33.4661354581673, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=23.3766233766234, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=343, Percent_Identity=23.9067055393586, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=26.3779527559055, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI48994928, Length=230, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=29.3040293040293, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786837, Length=124, Percent_Identity=37.9032258064516, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=27.9475982532751, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=27.0742358078603, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=23.6111111111111, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=24.6511627906977, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787894, Length=251, Percent_Identity=26.6932270916335, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51941; Mature: 51941

Theoretical pI: Translated: 11.50; Mature: 11.50

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFISFRGLLLTGFLGVALTPAAALMQLRHELGLAADSAQHHQRQAQRWQDIARLSQEQ
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVQFERASRQAAILRDRKLTETASQARGELQRAQRTLRLDAPPEALPGIDAALGLAAQLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
TLPPSRRQQRDALFRQLNRVLDQQQQTLAQAGEKRQASWRDDIERMRLQANRLAWLALAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AVLLALIVTLLIHAPLRGLQRRIARLAGGARQLNWRQTGPADLQRLGRELEQLDLRLVEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EQQKTRFFRQVSHELKTPLASIHEAAALLREQVAGPLNPQQRHIVDILGNNAQTLRQRVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHH
ALLRQDAGPWLSSALNISAFPLRSLIEDRLASCQPLWQAKRLTVALDGPAGLVRGDASKV
HHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCCCCCCCHHHH
ETIVDNLLLNAIRHSPPGGRLALRFARERGQVWLEVADQGAGVPGELRDRIFEPFWSGPA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
PDGERPGSGLGLTMARGYAQLMGGELRLLGDGPGTCFRLHWPEPEPI
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCC
>Mature Secondary Structure
MLRFISFRGLLLTGFLGVALTPAAALMQLRHELGLAADSAQHHQRQAQRWQDIARLSQEQ
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVQFERASRQAAILRDRKLTETASQARGELQRAQRTLRLDAPPEALPGIDAALGLAAQLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
TLPPSRRQQRDALFRQLNRVLDQQQQTLAQAGEKRQASWRDDIERMRLQANRLAWLALAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AVLLALIVTLLIHAPLRGLQRRIARLAGGARQLNWRQTGPADLQRLGRELEQLDLRLVEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EQQKTRFFRQVSHELKTPLASIHEAAALLREQVAGPLNPQQRHIVDILGNNAQTLRQRVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHH
ALLRQDAGPWLSSALNISAFPLRSLIEDRLASCQPLWQAKRLTVALDGPAGLVRGDASKV
HHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCCCCCCCHHHH
ETIVDNLLLNAIRHSPPGGRLALRFARERGQVWLEVADQGAGVPGELRDRIFEPFWSGPA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
PDGERPGSGLGLTMARGYAQLMGGELRLLGDGPGTCFRLHWPEPEPI
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]