Click here to switch to the map view.

The map label for this gene is neuC [H]

Identifier: 34499488

GI number: 34499488

Start: 4359845

End: 4361005

Strand: Reverse

Name: neuC [H]

Synonym: CV_4033

Alternate gene names: 34499488

Gene position: 4361005-4359845 (Counterclockwise)

Preceding gene: 34499489

Following gene: 34499487

Centisome position: 91.79

GC content: 60.29

Gene sequence:

>1161_bases
TTGAGCCTGCGCAAGATTTGCATTGTAACGGGCAGCCGCGCGGAATATGGTTTGCAGCGCTGGTTGGCGAAAGCCGTTCA
GGCCGATGAGAACCTTGAGCTGCAAATTCTGGCGACAGGCATGCACTTGGCGTTTGAATACGGCAGAACGATCAATGAGA
TTTACGCCGATGGCTTCGCGGTGGATGCGATCGTGGAAAGCCAGTTGGCGAGCGACTCGGCCGTCGGCATGGCGAAGTCC
ATGGGACTGGGCATGATCGGATGTGCAGACGCATTTCAGCGACTGCGGCCAGATATCGTCGTCTTGCTCGGCGATCGCTA
TGAAATTCTGGCTGCAGCTCAGGCCGCGGCGCTGATGGGCATTCCCGTCGCGCATATTTCTGGCGGTGAGGTGACCGAGG
GCGCGGTGGACGACTGGATTCGCCATGCGATCAGCAAGGCGTCCTGGTGGCATTTCGTGGCGACGGAAGAGTATCGCCAG
CGAGTGATCCAGTTGGGTGAGTCGCCGGAGCGCGTTTTCAATACGGGCGATCCCGGGCTGGACTCCATCAGCAACTTGCC
CCTGATGAGCCGCGAGCAGCTTGAGGCGGAAATGGGCATGCCATTGCGCCAGCCGCTGTTCATGGTGACTTATCATCCGG
CGACGCTGGGCGACGAGTCGCCGGAAGTGTCTTTCCGCAAGGTGCTGGCCTCGCTGGATCGTTTTCCGCAGGCGACGGTC
ATCATGACCAAGCCTAACGCGGATGCGGGCGGACGCGAATTGGCGGCGATGGCGGAAGAGTGGTGCCGCAGCAATGCGGA
GCGCGCGCGTTGTTTCGTCTCCATGGGGCAGTTGCGCTATTTGAGCGCCATGCGGCTTGCCAATGTGGTGATCGGCAATT
CCTCGAGCGGAATCGTCGAGGCACCGGCAGCCAAGGTGGCTACCGTGAACATCGGGCCGCGCCAGGATGGCAGATTGAAG
GCAGCCTCGATCATCGATTGCCCGGACGACGAGCAGCAGATTTACGCCGCTATCCAGCGCGCTCTGTCCGAGGACTTCGC
CGGCGCGTTGCCGCAAACGGTTTCCTTGTATGGCGAATGCGGCGCGTCCGCGCGCATGAAGCAGATTTTGTCGAGCGTTC
CATTGCCGGCAAACTTGAAAAAGAGCTTCCATGACTTGTGA

Upstream 100 bases:

>100_bases
TCCCGCTGTACCAGCATTGCCTGCATGGCGAATTGCTCAATGCAGAATGGCTAGCGGACCGCGTGGTCAATCTGCCCAGT
AGCGTGACGGGGAGCGTCCA

Downstream 100 bases:

>100_bases
GCGCAGCATAGGTGGCGAGATGGAAATTCGTCCCGAAATGTTTGGCCAGGCGCGCGCAGGCGCGGCATGGCCGGATTTCG
GGAAGCCGCATGTCTTGCGC

Product: N-acetylglucosamine-6-phosphate 2-epimerase/N-acetylglucosamine-6-phosphatase

Products: UDP-N-acetyl-D-mannosamine

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSLRKICIVTGSRAEYGLQRWLAKAVQADENLELQILATGMHLAFEYGRTINEIYADGFAVDAIVESQLASDSAVGMAKS
MGLGMIGCADAFQRLRPDIVVLLGDRYEILAAAQAAALMGIPVAHISGGEVTEGAVDDWIRHAISKASWWHFVATEEYRQ
RVIQLGESPERVFNTGDPGLDSISNLPLMSREQLEAEMGMPLRQPLFMVTYHPATLGDESPEVSFRKVLASLDRFPQATV
IMTKPNADAGGRELAAMAEEWCRSNAERARCFVSMGQLRYLSAMRLANVVIGNSSSGIVEAPAAKVATVNIGPRQDGRLK
AASIIDCPDDEQQIYAAIQRALSEDFAGALPQTVSLYGECGASARMKQILSSVPLPANLKKSFHDL

Sequences:

>Translated_386_residues
MSLRKICIVTGSRAEYGLQRWLAKAVQADENLELQILATGMHLAFEYGRTINEIYADGFAVDAIVESQLASDSAVGMAKS
MGLGMIGCADAFQRLRPDIVVLLGDRYEILAAAQAAALMGIPVAHISGGEVTEGAVDDWIRHAISKASWWHFVATEEYRQ
RVIQLGESPERVFNTGDPGLDSISNLPLMSREQLEAEMGMPLRQPLFMVTYHPATLGDESPEVSFRKVLASLDRFPQATV
IMTKPNADAGGRELAAMAEEWCRSNAERARCFVSMGQLRYLSAMRLANVVIGNSSSGIVEAPAAKVATVNIGPRQDGRLK
AASIIDCPDDEQQIYAAIQRALSEDFAGALPQTVSLYGECGASARMKQILSSVPLPANLKKSFHDL
>Mature_385_residues
SLRKICIVTGSRAEYGLQRWLAKAVQADENLELQILATGMHLAFEYGRTINEIYADGFAVDAIVESQLASDSAVGMAKSM
GLGMIGCADAFQRLRPDIVVLLGDRYEILAAAQAAALMGIPVAHISGGEVTEGAVDDWIRHAISKASWWHFVATEEYRQR
VIQLGESPERVFNTGDPGLDSISNLPLMSREQLEAEMGMPLRQPLFMVTYHPATLGDESPEVSFRKVLASLDRFPQATVI
MTKPNADAGGRELAAMAEEWCRSNAERARCFVSMGQLRYLSAMRLANVVIGNSSSGIVEAPAAKVATVNIGPRQDGRLKA
ASIIDCPDDEQQIYAAIQRALSEDFAGALPQTVSLYGECGASARMKQILSSVPLPANLKKSFHDL

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=384, Percent_Identity=29.9479166666667, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI190014632, Length=384, Percent_Identity=29.9479166666667, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4885285, Length=384, Percent_Identity=29.9479166666667, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI298566325, Length=352, Percent_Identity=29.5454545454545, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI298566315, Length=337, Percent_Identity=28.7833827893175, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14

Molecular weight: Translated: 41875; Mature: 41744

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRKICIVTGSRAEYGLQRWLAKAVQADENLELQILATGMHLAFEYGRTINEIYADGFA
CCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCHHHHHHHCCHH
VDAIVESQLASDSAVGMAKSMGLGMIGCADAFQRLRPDIVVLLGDRYEILAAAQAAALMG
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHC
IPVAHISGGEVTEGAVDDWIRHAISKASWWHFVATEEYRQRVIQLGESPERVFNTGDPGL
CCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCHHHHCCCCCCCC
DSISNLPLMSREQLEAEMGMPLRQPLFMVTYHPATLGDESPEVSFRKVLASLDRFPQATV
HHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEE
IMTKPNADAGGRELAAMAEEWCRSNAERARCFVSMGQLRYLSAMRLANVVIGNSSSGIVE
EEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEE
APAAKVATVNIGPRQDGRLKAASIIDCPDDEQQIYAAIQRALSEDFAGALPQTVSLYGEC
CCCCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
GASARMKQILSSVPLPANLKKSFHDL
CCHHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure 
SLRKICIVTGSRAEYGLQRWLAKAVQADENLELQILATGMHLAFEYGRTINEIYADGFA
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCHHHHHHHCCHH
VDAIVESQLASDSAVGMAKSMGLGMIGCADAFQRLRPDIVVLLGDRYEILAAAQAAALMG
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHC
IPVAHISGGEVTEGAVDDWIRHAISKASWWHFVATEEYRQRVIQLGESPERVFNTGDPGL
CCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCHHHHCCCCCCCC
DSISNLPLMSREQLEAEMGMPLRQPLFMVTYHPATLGDESPEVSFRKVLASLDRFPQATV
HHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEE
IMTKPNADAGGRELAAMAEEWCRSNAERARCFVSMGQLRYLSAMRLANVVIGNSSSGIVE
EEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEE
APAAKVATVNIGPRQDGRLKAASIIDCPDDEQQIYAAIQRALSEDFAGALPQTVSLYGEC
CCCCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
GASARMKQILSSVPLPANLKKSFHDL
CCHHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine

Specific reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]