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The map label for this gene is neuA [H]

Identifier: 34499483

GI number: 34499483

Start: 4354922

End: 4355641

Strand: Reverse

Name: neuA [H]

Synonym: CV_4028

Alternate gene names: 34499483

Gene position: 4355641-4354922 (Counterclockwise)

Preceding gene: 34499484

Following gene: 34499482

Centisome position: 91.68

GC content: 39.31

Gene sequence:

>720_bases
GTGTCTAAAGCGAAAGTTCTTGCATTAGTACCTGCTCGTGGTGGTTCAAAGCGATTGCCAGGGAAAAATATGAAATTATT
AGGTGGTAAGCATCTGATTAATTGGACATTAGATATTGCCTTGTCGAGTGAATTATTTTGTGATGTATTGGTTTCAACAG
ATGATTCTAGTATAGCAGAGGAGGCAAAAAAAAATGGTGCCTTAGTTCCATGGTTGCGCCCAGCCTCAATGGCTACCGAT
TCGGCAACATCAGTAGATGTTGCACTGCATGCATTGAACTGGTATGAAAGTAACATTACAAATGTTGATGCCTTGATGCT
TTTGCAGCCCACATCTCCATTTAGAACTGTTGAGCTACTAAAAAATGCAATAGAAATGTTATTCTCAACGCGAGCACAAT
CAGTACTATCAGTCGTGCCAGCATTAGTTAATCCGGCATGGTGTTTTTATCAGGTTGATGGTATTTTAGATCCGTGCATG
GGAATGGATTTAATGGGAAAAGCCTCACAAGACCTACCACCCGCATACATGCTTGATGGTTCAATTTATATTATAACGCC
TGATGCTTTACGAGATAGTCGTTCATTTATTCTATCTAAATCGAGGGCGATTCTGAGCCCAGAAGAAATGTCTATAGATA
TTGACACTCAAGAAGATTGGGATTTGGCGGAAGAAAAACTTGCTCATATTTTTGGTCTGAATAATAAAAGTAGTTCGTAA

Upstream 100 bases:

>100_bases
AGGATAAATACCAGGCATTGAGAGAGAAATTTATTTCTGATCATAAGCCAACTGATCGGTTTCTTTTTTACCGTTGATTA
AAATGATTATGGGGAACAGA

Downstream 100 bases:

>100_bases
CGTTAGGGAGGCTGCTTATGGAAATTGCTTATGCGCTACTTATAATTTATTTAATAGCTCCTTATGTTGGCCTCTTCTAT
TTTGAATCGAGTGGCGAGCG

Product: N-acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSKAKVLALVPARGGSKRLPGKNMKLLGGKHLINWTLDIALSSELFCDVLVSTDDSSIAEEAKKNGALVPWLRPASMATD
SATSVDVALHALNWYESNITNVDALMLLQPTSPFRTVELLKNAIEMLFSTRAQSVLSVVPALVNPAWCFYQVDGILDPCM
GMDLMGKASQDLPPAYMLDGSIYIITPDALRDSRSFILSKSRAILSPEEMSIDIDTQEDWDLAEEKLAHIFGLNNKSSS

Sequences:

>Translated_239_residues
MSKAKVLALVPARGGSKRLPGKNMKLLGGKHLINWTLDIALSSELFCDVLVSTDDSSIAEEAKKNGALVPWLRPASMATD
SATSVDVALHALNWYESNITNVDALMLLQPTSPFRTVELLKNAIEMLFSTRAQSVLSVVPALVNPAWCFYQVDGILDPCM
GMDLMGKASQDLPPAYMLDGSIYIITPDALRDSRSFILSKSRAILSPEEMSIDIDTQEDWDLAEEKLAHIFGLNNKSSS
>Mature_238_residues
SKAKVLALVPARGGSKRLPGKNMKLLGGKHLINWTLDIALSSELFCDVLVSTDDSSIAEEAKKNGALVPWLRPASMATDS
ATSVDVALHALNWYESNITNVDALMLLQPTSPFRTVELLKNAIEMLFSTRAQSVLSVVPALVNPAWCFYQVDGILDPCMG
MDLMGKASQDLPPAYMLDGSIYIITPDALRDSRSFILSKSRAILSPEEMSIDIDTQEDWDLAEEKLAHIFGLNNKSSS

Specific function: Unknown

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=223, Percent_Identity=33.1838565022422, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26100; Mature: 25969

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAKVLALVPARGGSKRLPGKNMKLLGGKHLINWTLDIALSSELFCDVLVSTDDSSIAE
CCCCEEEEEEECCCCCCCCCCCCEEEECCCEEEEEEEEEEECCCCEEEEEEECCCHHHHH
EAKKNGALVPWLRPASMATDSATSVDVALHALNWYESNITNVDALMLLQPTSPFRTVELL
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
KNAIEMLFSTRAQSVLSVVPALVNPAWCFYQVDGILDPCMGMDLMGKASQDLPPAYMLDG
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHCHHCCCCCCCCCCCCCCCEEEECC
SIYIITPDALRDSRSFILSKSRAILSPEEMSIDIDTQEDWDLAEEKLAHIFGLNNKSSS
EEEEECCHHHHCHHHHHHHCCCCEECCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SKAKVLALVPARGGSKRLPGKNMKLLGGKHLINWTLDIALSSELFCDVLVSTDDSSIAE
CCCEEEEEEECCCCCCCCCCCCEEEECCCEEEEEEEEEEECCCCEEEEEEECCCHHHHH
EAKKNGALVPWLRPASMATDSATSVDVALHALNWYESNITNVDALMLLQPTSPFRTVELL
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
KNAIEMLFSTRAQSVLSVVPALVNPAWCFYQVDGILDPCMGMDLMGKASQDLPPAYMLDG
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHCHHCCCCCCCCCCCCCCCEEEECC
SIYIITPDALRDSRSFILSKSRAILSPEEMSIDIDTQEDWDLAEEKLAHIFGLNNKSSS
EEEEECCHHHHCHHHHHHHCCCCEECCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1398032; 7830552; 8113198; 8045888; 10710307 [H]