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The map label for this gene is groEL1

Identifier: 34499469

GI number: 34499469

Start: 4339962

End: 4341602

Strand: Reverse

Name: groEL1

Synonym: CV_4014

Alternate gene names: 34499469

Gene position: 4341602-4339962 (Counterclockwise)

Preceding gene: 34499470

Following gene: 34499464

Centisome position: 91.38

GC content: 63.25

Gene sequence:

>1641_bases
ATGGCAGCTAAAGACGTAAAGTTCGGTGATTCCGCTCGCAGCAAGATGGTTGCCGGCGTCAACATCCTGGCCGACGCGGT
CAAGGTTACCCTGGGTCCCAAGGGCCGCAACGTTGTGCTGGACCGCTCCTTCGGCGCGCCGACCATCACCAAGGACGGCG
TGTCGGTGGCCAAGGAAATCGAACTGAAGGACAAGTTCGAGAACATGGGCGCCCAGATGGTCAAGGAAGTGGCTTCCAAG
ACCTCCGACGTGGCCGGCGACGGCACCACCACCGCCACCGTGCTGGCTCAGGCCATCGTGCAGGAAGGCATGAAGTTCGT
CGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCTGTGGTGTCACTGGTCGGCGAGATCGCCAAGA
TCGCCAAGCCCTGCGCGACCTCCAAGGAAATCGCCCAGGTAGGCTCCATCTCCGCCAACTCCGATAGCGATATCGGCGAA
ATCATCGCCAATGCGATGGAAAAAGTGGGCAAGGAAGGCGTGATCACCGTTGAAGACGGCAAGAGCCTGAACAACGAACT
GGACGTGGTGGAAGGCATGCAGTTCGACCGCGGTTACCTGTCCCCGTACTTCATCAACAACCAGGACAAGCAGATCGCCG
CCCTGGACAATCCGTTCATCCTGCTGTTCGACAAGAAGATCTCCAACATCCGCGACCTGCTGCCGGTGCTGGAGCAAGTG
GCCAAGTCCGGCCGCCCGCTGCTGATCATCGCCGAAGACGTCGAAGGCGAAGCGCTGGCCACTCTGGTGGTGAACACCAT
TCGCGGCATCCTGAAGGTCGTGGCTGTCAAGGCTCCGGGCTTCGGCGACCGCCGCAAGGCCATGCTGACCGACATCGCCG
TGCTGACCGGCGGCGAAGTCATCGCCGAAGAAGTCGGCCTGACTCTGGAAAAAGCCACGCTGGACCAACTGGGCCAGGCC
AAGCGCGTCGAAGTGGGCAAGGAAAACACCACCATCATCGACGGCGCCGGCGAAGCCGCCACCATCCAGGCTCGCGTGGG
CGAGATCCGCAAGCAGATCGAAGAAGCCACTTCCGACTACGACCGCGAGAAGCTGCAAGAGCGCGTGGCCAAGCTGGCCG
GCGGCGTTGCCGTGATCAAGGTCGGCGCCGCCACCGAAGTGGAAATGAAAGAGAAGAAGGCCCGCGTCGAAGACGCGCTG
CACGCCACCCGCGCAGCCGTTGAAGAAGGCGTGGTGCCCGGTGGCGGCGTGGCCCTGCTGCGTGCCCGCGCGACGCTGGA
AAACCTGAAGACCGACAATGCCGAACAGGAAGCTGGCGTGAAGATCGTGCTGCGCGCGATCGAAGCCCCGCTGCGCCAGA
TCGTCAAGAACGCCGGCGACGAGCCGTCGGTTGTCGTGAACAAGGTGCTGGAAGGCAAGGGCAACTTCGGTTACAACGCC
GCCAGCGGCGAATACGGCGACATGCTGGAAATGGGCGTGCTGGATCCGGCCAAGGTGACCCGCTCCGCTCTGCAGCACGC
CGCTTCCGTGGCCGGCCTGATGCTGACCACCGACTGCATGATCGCCGAGCTGCCGGAAGACAAGCCGGCCGCTGGCATGC
CGGACATGGGCGGCATGGGCGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
GCGAAGAAGTCCTCGTGATGCGCGAGGAAGATGTAATGGGCATCGTTGAGTAATCCGACCCTTACCTGAACTTCATAAAC
AGATATTGGAGATTTCGAGA

Downstream 100 bases:

>100_bases
ATCGAGCCGGTCAGGCGGGCATGTTCGCATGCCTGCCCAAACAAACAGCCCCGCGGCTTATGCCTGCGGGGCTGTTTGCA
TTTCAGAAATGGCTTCAGCG

Product: chaperonin 60kD subunit

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKDVKFGDSARSKMVAGVNILADAVKVTLGPKGRNVVLDRSFGAPTITKDGVSVAKEIELKDKFENMGAQMVKEVASK
TSDVAGDGTTTATVLAQAIVQEGMKFVAAGMNPMDLKRGIDKAVVSLVGEIAKIAKPCATSKEIAQVGSISANSDSDIGE
IIANAMEKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNQDKQIAALDNPFILLFDKKISNIRDLLPVLEQV
AKSGRPLLIIAEDVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLTDIAVLTGGEVIAEEVGLTLEKATLDQLGQA
KRVEVGKENTTIIDGAGEAATIQARVGEIRKQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALLRARATLENLKTDNAEQEAGVKIVLRAIEAPLRQIVKNAGDEPSVVVNKVLEGKGNFGYNA
ASGEYGDMLEMGVLDPAKVTRSALQHAASVAGLMLTTDCMIAELPEDKPAAGMPDMGGMGGMGGMM

Sequences:

>Translated_546_residues
MAAKDVKFGDSARSKMVAGVNILADAVKVTLGPKGRNVVLDRSFGAPTITKDGVSVAKEIELKDKFENMGAQMVKEVASK
TSDVAGDGTTTATVLAQAIVQEGMKFVAAGMNPMDLKRGIDKAVVSLVGEIAKIAKPCATSKEIAQVGSISANSDSDIGE
IIANAMEKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNQDKQIAALDNPFILLFDKKISNIRDLLPVLEQV
AKSGRPLLIIAEDVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLTDIAVLTGGEVIAEEVGLTLEKATLDQLGQA
KRVEVGKENTTIIDGAGEAATIQARVGEIRKQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALLRARATLENLKTDNAEQEAGVKIVLRAIEAPLRQIVKNAGDEPSVVVNKVLEGKGNFGYNA
ASGEYGDMLEMGVLDPAKVTRSALQHAASVAGLMLTTDCMIAELPEDKPAAGMPDMGGMGGMGGMM
>Mature_545_residues
AAKDVKFGDSARSKMVAGVNILADAVKVTLGPKGRNVVLDRSFGAPTITKDGVSVAKEIELKDKFENMGAQMVKEVASKT
SDVAGDGTTTATVLAQAIVQEGMKFVAAGMNPMDLKRGIDKAVVSLVGEIAKIAKPCATSKEIAQVGSISANSDSDIGEI
IANAMEKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNQDKQIAALDNPFILLFDKKISNIRDLLPVLEQVA
KSGRPLLIIAEDVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLTDIAVLTGGEVIAEEVGLTLEKATLDQLGQAK
RVEVGKENTTIIDGAGEAATIQARVGEIRKQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGVVPGGGVALLRARATLENLKTDNAEQEAGVKIVLRAIEAPLRQIVKNAGDEPSVVVNKVLEGKGNFGYNAA
SGEYGDMLEMGVLDPAKVTRSALQHAASVAGLMLTTDCMIAELPEDKPAAGMPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=51.2333965844402, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=51.2333965844402, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI5453607, Length=533, Percent_Identity=22.8893058161351, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI38455427, Length=553, Percent_Identity=21.6998191681736, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=76.2264150943396, Blast_Score=808, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.7958412098299, Blast_Score=547, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=50.7109004739336, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17564182, Length=566, Percent_Identity=23.4982332155477, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532603, Length=568, Percent_Identity=23.0633802816901, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.9923954372624, Blast_Score=553, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322524, Length=580, Percent_Identity=22.0689655172414, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=51.3307984790874, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=51.3307984790874, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=49.8091603053435, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=49.8091603053435, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=49.8091603053435, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI17864606, Length=540, Percent_Identity=42.962962962963, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=37.3584905660377, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=37.3584905660377, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_CHRVO (Q7NQX1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903684.1
- ProteinModelPortal:   Q7NQX1
- SMR:   Q7NQX1
- GeneID:   2550987
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4014
- NMPDR:   fig|243365.1.peg.4014
- HOGENOM:   HBG625289
- OMA:   DKPAAGM
- PhylomeDB:   Q7NQX1
- BioCyc:   CVIO243365:CV_4014-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57419; Mature: 57288

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGDSARSKMVAGVNILADAVKVTLGPKGRNVVLDRSFGAPTITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELKDKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQAIVQEGMKFVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVVSLVGEIAKIAKPCATSKEIAQVGSISANSDSDIGEIIANAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLNNELDVVEGMQFDRGYLSPYFINNQDKQIAALDNPFILLFDKKISNIRDLLPVLEQV
CCCCCCHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKSGRPLLIIAEDVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLTDIAVLTGGEV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHH
IAEEVGLTLEKATLDQLGQAKRVEVGKENTTIIDGAGEAATIQARVGEIRKQIEEATSDY
HHHHHCCCHHHHHHHHHCCCHHEECCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARATLENLKTDNAEQEAGVKIVLRAIEAPLRQIVKNAGDEPSVVVNKVLEGKGNFGYNA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ASGEYGDMLEMGVLDPAKVTRSALQHAASVAGLMLTTDCMIAELPEDKPAAGMPDMGGMG
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GMGGMM
CCCCCC
>Mature Secondary Structure 
AAKDVKFGDSARSKMVAGVNILADAVKVTLGPKGRNVVLDRSFGAPTITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELKDKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQAIVQEGMKFVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVVSLVGEIAKIAKPCATSKEIAQVGSISANSDSDIGEIIANAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLNNELDVVEGMQFDRGYLSPYFINNQDKQIAALDNPFILLFDKKISNIRDLLPVLEQV
CCCCCCHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKSGRPLLIIAEDVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLTDIAVLTGGEV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHH
IAEEVGLTLEKATLDQLGQAKRVEVGKENTTIIDGAGEAATIQARVGEIRKQIEEATSDY
HHHHHCCCHHHHHHHHHCCCHHEECCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARATLENLKTDNAEQEAGVKIVLRAIEAPLRQIVKNAGDEPSVVVNKVLEGKGNFGYNA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ASGEYGDMLEMGVLDPAKVTRSALQHAASVAGLMLTTDCMIAELPEDKPAAGMPDMGGMG
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GMGGMM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782