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The map label for this gene is mdtA [H]

Identifier: 34499378

GI number: 34499378

Start: 4235601

End: 4236668

Strand: Direct

Name: mdtA [H]

Synonym: CV_3923

Alternate gene names: 34499378

Gene position: 4235601-4236668 (Clockwise)

Preceding gene: 34499377

Following gene: 34499379

Centisome position: 89.15

GC content: 71.63

Gene sequence:

>1068_bases
ATGAAACATCCGCTTCCCCTCAGCCTCGCGCTCATCGCCGCGCTGGGCCTTTCCGCCTGTCAGGACAAGACCGCCGCGCC
GGAAGACATCCGCCCGGTACGCTACGTAGTGGCCGGCGGCAACGCCGAAATCGGCGGCGACAGCTACGCCGGCGAGATCC
GCGCCCGGCACGAAACCCAGCTCGCCTTCCGCGTCGCCGGCAAGGTGGTGGCCAAGCTGGTCAACAGCGGCGAGCGCGTG
AAAAAGGGCCAGGCCCTGGCGCGGCTGGACCCCAGCGACTACCAGCTGGACCTGGCCGCCAAGCAGGCGCAGCTGGCCGC
GGCCGAGTCCGACCTCGCCCAGCAGCAGCTCAACCTGAAGCGCTACCGCGAGCTGCTGGCCAAACAGTTCATCAGCCAGG
CCCAGGTAGACGCGCAGCAGAACGGCGTCAACGCCGCCCAGGCCAAGGTCAACCAGGCGCGCGCCGCGCTGTCCGCCAGC
CGCAACCAGACCGGCTACGCGACGCTGACGGCCGACGCCGACGGCGTGGTCAGCCAGATGCAGGCCGAGCCCGGCCTGGT
GGTGGCCGCCGGCCAGCCGGTGGCGCGGCTGTCGCAGGACGGCGCGCGCGAGATCGCCATCCAGGTGCCGGAAAACGCGC
TGGAGGCGGTGCGCAAGGCGGGCGCCTTCAGCGTGACGCTGTGGAAGGGCGGCGCGCCGCTGGAGGGCAGGCTGCGCGAG
CTGGCCGCCGACGCCGATCCGGCCACCCGCACCTATCCGGCGCGCATCGCGCTGGCCGGCGACAGCCATGCGCTGCAGTT
GGGCATGACCGCCACCGCCACCCTGCCCGCCCGCGCCAGCGGCGAGCTCAAGCTGCCGCTGACCGCGCTGCTGGACCTGC
AGGGCAAGCAATACGTGTGGACGATAGACGGCCAGACCCTGCGCGTCAGCCGCAAGCCGGTGCATGTGGCGTCGATAGAC
AGCAACGGCGCCGTCATCGCCGCGGGCGTCCGGCCGGGCGACAAGATCGTCACCGCCGGCGTGCACCTGCTGCGCGAAGG
CCAGCGCGTCAAGTTGCTGAATCAGTGA

Upstream 100 bases:

>100_bases
GTTGCGACACCCTCAAGGACAACCCGCTCGAATTCCTCAAGACCTCTCTGCGGCTGACGCTGCAAGGCATGCAACAGCCC
GCGCCCCAGGACGCCCGCAC

Downstream 100 bases:

>100_bases
GGACGCGCCGATGAAGAAACTGAATCTGTCCGAGTGGGCGCTGGGCCATCAGGCGCTGGTGCGCTACCTGATGATCATGC
TGATGCTGGCCGGCGCCTGG

Product: transport/efflux transmembrane protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKHPLPLSLALIAALGLSACQDKTAAPEDIRPVRYVVAGGNAEIGGDSYAGEIRARHETQLAFRVAGKVVAKLVNSGERV
KKGQALARLDPSDYQLDLAAKQAQLAAAESDLAQQQLNLKRYRELLAKQFISQAQVDAQQNGVNAAQAKVNQARAALSAS
RNQTGYATLTADADGVVSQMQAEPGLVVAAGQPVARLSQDGAREIAIQVPENALEAVRKAGAFSVTLWKGGAPLEGRLRE
LAADADPATRTYPARIALAGDSHALQLGMTATATLPARASGELKLPLTALLDLQGKQYVWTIDGQTLRVSRKPVHVASID
SNGAVIAAGVRPGDKIVTAGVHLLREGQRVKLLNQ

Sequences:

>Translated_355_residues
MKHPLPLSLALIAALGLSACQDKTAAPEDIRPVRYVVAGGNAEIGGDSYAGEIRARHETQLAFRVAGKVVAKLVNSGERV
KKGQALARLDPSDYQLDLAAKQAQLAAAESDLAQQQLNLKRYRELLAKQFISQAQVDAQQNGVNAAQAKVNQARAALSAS
RNQTGYATLTADADGVVSQMQAEPGLVVAAGQPVARLSQDGAREIAIQVPENALEAVRKAGAFSVTLWKGGAPLEGRLRE
LAADADPATRTYPARIALAGDSHALQLGMTATATLPARASGELKLPLTALLDLQGKQYVWTIDGQTLRVSRKPVHVASID
SNGAVIAAGVRPGDKIVTAGVHLLREGQRVKLLNQ
>Mature_355_residues
MKHPLPLSLALIAALGLSACQDKTAAPEDIRPVRYVVAGGNAEIGGDSYAGEIRARHETQLAFRVAGKVVAKLVNSGERV
KKGQALARLDPSDYQLDLAAKQAQLAAAESDLAQQQLNLKRYRELLAKQFISQAQVDAQQNGVNAAQAKVNQARAALSAS
RNQTGYATLTADADGVVSQMQAEPGLVVAAGQPVARLSQDGAREIAIQVPENALEAVRKAGAFSVTLWKGGAPLEGRLRE
LAADADPATRTYPARIALAGDSHALQLGMTATATLPARASGELKLPLTALLDLQGKQYVWTIDGQTLRVSRKPVHVASID
SNGAVIAAGVRPGDKIVTAGVHLLREGQRVKLLNQ

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=320, Percent_Identity=27.1875, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789665, Length=371, Percent_Identity=24.5283018867925, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081951, Length=191, Percent_Identity=27.2251308900524, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786668, Length=371, Percent_Identity=23.1805929919137, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37365; Mature: 37365

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHPLPLSLALIAALGLSACQDKTAAPEDIRPVRYVVAGGNAEIGGDSYAGEIRARHETQ
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
LAFRVAGKVVAKLVNSGERVKKGQALARLDPSDYQLDLAAKQAQLAAAESDLAQQQLNLK
HHHHHHHHHHHHHHCCCHHHHCCCHHEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
RYRELLAKQFISQAQVDAQQNGVNAAQAKVNQARAALSASRNQTGYATLTADADGVVSQM
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
QAEPGLVVAAGQPVARLSQDGAREIAIQVPENALEAVRKAGAFSVTLWKGGAPLEGRLRE
CCCCCEEEECCCCHHHHCCCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
LAADADPATRTYPARIALAGDSHALQLGMTATATLPARASGELKLPLTALLDLQGKQYVW
HHCCCCCCCCCCCEEEEEECCCCEEEECCEEEEECCCCCCCCEECCHHHEEECCCCEEEE
TIDGQTLRVSRKPVHVASIDSNGAVIAAGVRPGDKIVTAGVHLLREGQRVKLLNQ
EECCCEEEEECCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEECCC
>Mature Secondary Structure
MKHPLPLSLALIAALGLSACQDKTAAPEDIRPVRYVVAGGNAEIGGDSYAGEIRARHETQ
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
LAFRVAGKVVAKLVNSGERVKKGQALARLDPSDYQLDLAAKQAQLAAAESDLAQQQLNLK
HHHHHHHHHHHHHHCCCHHHHCCCHHEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
RYRELLAKQFISQAQVDAQQNGVNAAQAKVNQARAALSASRNQTGYATLTADADGVVSQM
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
QAEPGLVVAAGQPVARLSQDGAREIAIQVPENALEAVRKAGAFSVTLWKGGAPLEGRLRE
CCCCCEEEECCCCHHHHCCCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
LAADADPATRTYPARIALAGDSHALQLGMTATATLPARASGELKLPLTALLDLQGKQYVW
HHCCCCCCCCCCCEEEEEECCCCEEEECCEEEEECCCCCCCCEECCHHHEEECCCCEEEE
TIDGQTLRVSRKPVHVASIDSNGAVIAAGVRPGDKIVTAGVHLLREGQRVKLLNQ
EECCCEEEEECCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA