Click here to switch to the map view.

The map label for this gene is fadE25 [H]

Identifier: 34499271

GI number: 34499271

Start: 4114798

End: 4116579

Strand: Reverse

Name: fadE25 [H]

Synonym: CV_3816

Alternate gene names: 34499271

Gene position: 4116579-4114798 (Counterclockwise)

Preceding gene: 34499272

Following gene: 34499270

Centisome position: 86.65

GC content: 67.9

Gene sequence:

>1782_bases
ATGATCTATCACGCCCCAATCAAGGACATCCGATTTGCATTGAACGAGCTGGCCGACCTGGCGGCGATCTGCGGACTGCC
GGGCTACGGCGAATGCTCGGTGGAACTGACCGACGCCGTGCTGGAGGAGGGCGCCAAGTTCGCCGAGGGCGTGCTGGCGC
CCATCAACAAGCAGGGCGACCAGGGCGCCAAGTGGAAGGACGGCGAAGTGAGCGCCGCGCCGGGCTTCAAGGACGCCTGG
CAACAGTATGTCGAGTCCGGCTGGGTGGGCCTGCGCGCGCCGGAGGAATATGGCGGCCAGGGCATGCCGGCGCTGGTGGC
GGCGGCGGTGGAGGAAATGTGGTGTTCGTCCAACCTGGCCTTCTCGCTGGCGCCGCTGCTGACGCTGGGCGCGGTGGAGG
CCATCCACCATCACGCCTCGGATGAGCTGAAGAACATCTATCTGCCGATGATGGCCAGCGGCCAGTGGACCGGCACCATG
AACCTGACCGAGCCGCAGGCCGGCTCCGACCTGGCCCAGGTGCGAACCAAGGCCGCGCCGGCCGCCGACGGCAGCTACCG
CGTCAGCGGCCAGAAGATCTTCATCACCTGGGGCGAGCACGACATGGCCGAGAACATCGTCCACCTGGTGCTGGCCCGTC
TGCCGGACGCGCCAGCCGGGGTGAAGGGCATCTCGCTGTTCATTGTGCCTAAGTTCCTGGTGAACGCCGACGGCTCGCTC
GGCGCGCGCAACGACGTGCGCTGCGTGTCGCTGGAGCACAAGCTGGGCATACACGGCAGCCCGACCGCGGTGATGAGCTT
CGGCGACAACGACGGCGCGGTCGGCTACCTGGTCGGCGAGCCGAACAAGGGCCTGAACTACATGTTCACCATGATGAACC
ACGCCCGCCTGGGCGTGGGCATCGAAGGCGTGGCGGTGTCGGAGCGCGCCTATCAAAAAGCGGTGGAGTACGCCCGCGAT
CGGGTGCAGAGCCGCGCCATCGGCTCGCCGGACCCGGCCGGCGTGGCCATCATCCGGCACCCTGACGTGCGCCGCATGCT
GATGACGATGCGCGCCCAGATCGAAGCGCAGCGCGCGCTGACTTTCTACGCCGCGGCCGCGCTGGACCGCGCCGCCCGCC
ATCCGGTGGCGGCCGAGGCCGCGCGCAACCAGGCGCTGCTGAATTTCCTGATTCCCATCGTCAAGGGCTGGAACACCGAG
CAGGCCAACGAGATCACCAGCCTCGCCGTCCAGGTGCATGGCGGCATGGGCTACATCGAGGAGACCGGCGTCGCCCAGTA
TTACCGCGACGCCCGCATCACCGCCATCTATGAAGGCACCACCGGCATCCAGGCGCTGGACCTGATCGGCCGCAAGACGG
CGATGGATCACGGCGTCGTGGCCCGCGCGCTGCTGGCCGAGGCGCAGTCGACGGCGGGCAAGCTGCAGGCCGCCGGCTTC
GACTCCATCGCCGGCAACCTGTCGTCGGCGATCGCCGATGCCGAGCGCTGCGTCGCCTTCATCCTGGAGACCTTCGGCGC
CCAGCCCCAGCTGGCCGCCGCGGGATCGGTGCCGTTCCTGAAGCTGATGGGCATCGTGCTGGGCGGCTGGCAGATGGGCC
GCGCCGCGCTGATCGCCAAGGACAAGCTGCAGGATGCGGACGCGGACAGCGATTTCCTGAACGCCAAGATCGTTACCGCG
CGCTTCTTCGCCGAGCATCTGCTGCCGCAGGTTTCCGGTCTGGCCGCGGCCATTTTGAAAGGTGCGGACAGCGCGCTGGC
GCTTGGCGACGATCAATTTTGA

Upstream 100 bases:

>100_bases
GCCGGAATCAACAACAGCAGCCGGCGCCCAGAGTTGAGCGCCGGTTTTTTCATGGCCCGCGGCACGCGGGCCGACGCGAG
AGAAGCAGAGGAGAAGCGCG

Downstream 100 bases:

>100_bases
TCCTGTTTATTCGACCCTCCGACGCCGCGGTCTTGCCGCGGCGTTTTTTATGCGAGAATGCCGAAAGTTTACATTTTCCC
ATTGGAAATTCCTTGGCGAT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MIYHAPIKDIRFALNELADLAAICGLPGYGECSVELTDAVLEEGAKFAEGVLAPINKQGDQGAKWKDGEVSAAPGFKDAW
QQYVESGWVGLRAPEEYGGQGMPALVAAAVEEMWCSSNLAFSLAPLLTLGAVEAIHHHASDELKNIYLPMMASGQWTGTM
NLTEPQAGSDLAQVRTKAAPAADGSYRVSGQKIFITWGEHDMAENIVHLVLARLPDAPAGVKGISLFIVPKFLVNADGSL
GARNDVRCVSLEHKLGIHGSPTAVMSFGDNDGAVGYLVGEPNKGLNYMFTMMNHARLGVGIEGVAVSERAYQKAVEYARD
RVQSRAIGSPDPAGVAIIRHPDVRRMLMTMRAQIEAQRALTFYAAAALDRAARHPVAAEAARNQALLNFLIPIVKGWNTE
QANEITSLAVQVHGGMGYIEETGVAQYYRDARITAIYEGTTGIQALDLIGRKTAMDHGVVARALLAEAQSTAGKLQAAGF
DSIAGNLSSAIADAERCVAFILETFGAQPQLAAAGSVPFLKLMGIVLGGWQMGRAALIAKDKLQDADADSDFLNAKIVTA
RFFAEHLLPQVSGLAAAILKGADSALALGDDQF

Sequences:

>Translated_593_residues
MIYHAPIKDIRFALNELADLAAICGLPGYGECSVELTDAVLEEGAKFAEGVLAPINKQGDQGAKWKDGEVSAAPGFKDAW
QQYVESGWVGLRAPEEYGGQGMPALVAAAVEEMWCSSNLAFSLAPLLTLGAVEAIHHHASDELKNIYLPMMASGQWTGTM
NLTEPQAGSDLAQVRTKAAPAADGSYRVSGQKIFITWGEHDMAENIVHLVLARLPDAPAGVKGISLFIVPKFLVNADGSL
GARNDVRCVSLEHKLGIHGSPTAVMSFGDNDGAVGYLVGEPNKGLNYMFTMMNHARLGVGIEGVAVSERAYQKAVEYARD
RVQSRAIGSPDPAGVAIIRHPDVRRMLMTMRAQIEAQRALTFYAAAALDRAARHPVAAEAARNQALLNFLIPIVKGWNTE
QANEITSLAVQVHGGMGYIEETGVAQYYRDARITAIYEGTTGIQALDLIGRKTAMDHGVVARALLAEAQSTAGKLQAAGF
DSIAGNLSSAIADAERCVAFILETFGAQPQLAAAGSVPFLKLMGIVLGGWQMGRAALIAKDKLQDADADSDFLNAKIVTA
RFFAEHLLPQVSGLAAAILKGADSALALGDDQF
>Mature_593_residues
MIYHAPIKDIRFALNELADLAAICGLPGYGECSVELTDAVLEEGAKFAEGVLAPINKQGDQGAKWKDGEVSAAPGFKDAW
QQYVESGWVGLRAPEEYGGQGMPALVAAAVEEMWCSSNLAFSLAPLLTLGAVEAIHHHASDELKNIYLPMMASGQWTGTM
NLTEPQAGSDLAQVRTKAAPAADGSYRVSGQKIFITWGEHDMAENIVHLVLARLPDAPAGVKGISLFIVPKFLVNADGSL
GARNDVRCVSLEHKLGIHGSPTAVMSFGDNDGAVGYLVGEPNKGLNYMFTMMNHARLGVGIEGVAVSERAYQKAVEYARD
RVQSRAIGSPDPAGVAIIRHPDVRRMLMTMRAQIEAQRALTFYAAAALDRAARHPVAAEAARNQALLNFLIPIVKGWNTE
QANEITSLAVQVHGGMGYIEETGVAQYYRDARITAIYEGTTGIQALDLIGRKTAMDHGVVARALLAEAQSTAGKLQAAGF
DSIAGNLSSAIADAERCVAFILETFGAQPQLAAAGSVPFLKLMGIVLGGWQMGRAALIAKDKLQDADADSDFLNAKIVTA
RFFAEHLLPQVSGLAAAILKGADSALALGDDQF

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=431, Percent_Identity=31.0904872389791, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI4501857, Length=401, Percent_Identity=28.927680798005, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI4501859, Length=407, Percent_Identity=26.2899262899263, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI21361497, Length=360, Percent_Identity=28.3333333333333, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI4557235, Length=392, Percent_Identity=28.0612244897959, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI76496475, Length=392, Percent_Identity=28.0612244897959, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI226958412, Length=412, Percent_Identity=25.2427184466019, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI187960098, Length=433, Percent_Identity=28.6374133949192, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI4557231, Length=433, Percent_Identity=28.6374133949192, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI226958414, Length=385, Percent_Identity=25.1948051948052, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI7656849, Length=394, Percent_Identity=25.1269035532995, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI87082384, Length=339, Percent_Identity=30.0884955752212, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081958, Length=378, Percent_Identity=25.6613756613757, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786223, Length=365, Percent_Identity=23.2876712328767, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71985184, Length=431, Percent_Identity=28.7703016241299, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17508101, Length=422, Percent_Identity=26.7772511848341, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17569725, Length=422, Percent_Identity=27.9620853080569, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17534899, Length=427, Percent_Identity=28.3372365339578, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17506239, Length=407, Percent_Identity=27.2727272727273, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533517, Length=443, Percent_Identity=26.6365688487585, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17538396, Length=410, Percent_Identity=25.8536585365854, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=304, Percent_Identity=29.2763157894737, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=304, Percent_Identity=29.2763157894737, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17570075, Length=389, Percent_Identity=26.7352185089974, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985192, Length=335, Percent_Identity=27.4626865671642, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=381, Percent_Identity=27.0341207349081, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71990804, Length=301, Percent_Identity=27.2425249169435, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17551932, Length=381, Percent_Identity=25.4593175853018, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=27.9661016949153, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356377, Length=380, Percent_Identity=30.5263157894737, Blast_Score=129, Evalue=8e-30,
Organism=Drosophila melanogaster, GI281363737, Length=422, Percent_Identity=26.5402843601896, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24666513, Length=451, Percent_Identity=26.3858093126386, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646207, Length=414, Percent_Identity=25.3623188405797, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355753, Length=458, Percent_Identity=24.0174672489083, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24660351, Length=416, Percent_Identity=27.6442307692308, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 62951; Mature: 62951

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYHAPIKDIRFALNELADLAAICGLPGYGECSVELTDAVLEEGAKFAEGVLAPINKQGD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCC
QGAKWKDGEVSAAPGFKDAWQQYVESGWVGLRAPEEYGGQGMPALVAAAVEEMWCSSNLA
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCHHHCCCCCHHHHHHHHHHHHHCCCCH
FSLAPLLTLGAVEAIHHHASDELKNIYLPMMASGQWTGTMNLTEPQAGSDLAQVRTKAAP
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHCCC
AADGSYRVSGQKIFITWGEHDMAENIVHLVLARLPDAPAGVKGISLFIVPKFLVNADGSL
CCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHCCCCCC
GARNDVRCVSLEHKLGIHGSPTAVMSFGDNDGAVGYLVGEPNKGLNYMFTMMNHARLGVG
CCCCCEEEEEECCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
IEGVAVSERAYQKAVEYARDRVQSRAIGSPDPAGVAIIRHPDVRRMLMTMRAQIEAQRAL
CCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
TFYAAAALDRAARHPVAAEAARNQALLNFLIPIVKGWNTEQANEITSLAVQVHGGMGYIE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEEECCCCCHH
ETGVAQYYRDARITAIYEGTTGIQALDLIGRKTAMDHGVVARALLAEAQSTAGKLQAAGF
HCCHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
DSIAGNLSSAIADAERCVAFILETFGAQPQLAAAGSVPFLKLMGIVLGGWQMGRAALIAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCCHHHCCCCEEEH
DKLQDADADSDFLNAKIVTARFFAEHLLPQVSGLAAAILKGADSALALGDDQF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure
MIYHAPIKDIRFALNELADLAAICGLPGYGECSVELTDAVLEEGAKFAEGVLAPINKQGD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCC
QGAKWKDGEVSAAPGFKDAWQQYVESGWVGLRAPEEYGGQGMPALVAAAVEEMWCSSNLA
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCHHHCCCCCHHHHHHHHHHHHHCCCCH
FSLAPLLTLGAVEAIHHHASDELKNIYLPMMASGQWTGTMNLTEPQAGSDLAQVRTKAAP
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHCCC
AADGSYRVSGQKIFITWGEHDMAENIVHLVLARLPDAPAGVKGISLFIVPKFLVNADGSL
CCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHCCCCCC
GARNDVRCVSLEHKLGIHGSPTAVMSFGDNDGAVGYLVGEPNKGLNYMFTMMNHARLGVG
CCCCCEEEEEECCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
IEGVAVSERAYQKAVEYARDRVQSRAIGSPDPAGVAIIRHPDVRRMLMTMRAQIEAQRAL
CCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
TFYAAAALDRAARHPVAAEAARNQALLNFLIPIVKGWNTEQANEITSLAVQVHGGMGYIE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEEECCCCCHH
ETGVAQYYRDARITAIYEGTTGIQALDLIGRKTAMDHGVVARALLAEAQSTAGKLQAAGF
HCCHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
DSIAGNLSSAIADAERCVAFILETFGAQPQLAAAGSVPFLKLMGIVLGGWQMGRAALIAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCCHHHCCCCEEEH
DKLQDADADSDFLNAKIVTARFFAEHLLPQVSGLAAAILKGADSALALGDDQF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]