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The map label for this gene is zitB [H]

Identifier: 34499132

GI number: 34499132

Start: 3978268

End: 3979278

Strand: Reverse

Name: zitB [H]

Synonym: CV_3677

Alternate gene names: 34499132

Gene position: 3979278-3978268 (Counterclockwise)

Preceding gene: 34499138

Following gene: 34499131

Centisome position: 83.76

GC content: 70.52

Gene sequence:

>1011_bases
ATGACGCCCAGCTTCCATCTGCATGATGAGAACGGCGTGGACCACGCCCACGACGACGATCACGACGCCAACCATCCCCA
CCTTCACCGCCACGGCGGTCCGGCGGGCGGGGAGGGCCGGCGGCTGAGCAGCCGCGCGCTGGCCAAGGTGCTGGCGCTGA
CCTGCGGCTTCGCGCTGGTGGAGGCGCTGGGCGGCTGGTGGAGCGGGTCGCTGGCCTTGCTGTCCGACGCCGGCCACATG
CTGACCGATTCGCTGTCCCTGCTGCTGGCCTTGTGGGCAGCCCGCATCGGCAGGCGGCCGGCCACCGAGCGGCTGTCGTT
CGGACATGGCCGGGCCGAAGTGCTGGGCGCGCTGCTGAACAGCCTGCTGCTGTTCGGCCTGTCGGCCTTCATCGTCGCGG
AGGCGGTGGAGCGGCTGCTGCGCCCGCACGCGGTGAACGGCATGGGGGTGATGCTGATCGCCGCCATCGGACTGGCCGTC
AACGTGCTGGCGGCCCGGGTGCTCAGCCGCGGCGCGCATTCGCTGAACAGCCGGGCGGCGCTGCTGCATGTGCTGGGCGA
CCTGTTCGGCTCGGCGGCGGCCATCGCGTCCGGCGTGGTCATCTACCTGACCGGCTGGATGGCGGCGGACCCGCTGTTGT
CCATGCTGGTGGCGCTGATGCTGCTGGCAGCGGCCTGGCGCCTGATCCGCCAGGCGGTGATGGTGCTGATGGAGGGCGTG
CCGCCGCACCTGGATTACAACCGCATCGGCGAGGCGCTGTCGGCCATCGCGGGGGTCCGCTCGGTGCATGACCTGCACGT
GTGGACGATGTCGGCCGAGCGGGTGGCGCTGTCCGCCCACGTGCGCATCGCCGCGCCGCAGGACTGGCCGCGCATCCTGG
CCGCCTGCCAGCTGATGCTGTCGCGCGAATTTTGCATAGATCACGTAACCTTGCAGGCGGAATGGCCGGCGTCCGCGCCC
GCCGGCAAGCCGGTACCGATAGACATCATTTCCGAGGACAAGCTCCCATGA

Upstream 100 bases:

>100_bases
ATATTGTAAAGCCTGCGCCACTGGCTGGATATCGCCCGGCTGGAATTTAACCGAACGCCGTGGCTGAAATGCATCTGTCA
GCGGTTTGTCGGAGGTCAAA

Downstream 100 bases:

>100_bases
GGCCGCATTACCTGACCCCGCTGTTTTCCCCGCGCACCGTGGCCGTGGTCGGCGCCAGCGACCGGCCGGGCTCGATCGGC
CAGGCAGTGTTCGCCAATCT

Product: cation efflux system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTPSFHLHDENGVDHAHDDDHDANHPHLHRHGGPAGGEGRRLSSRALAKVLALTCGFALVEALGGWWSGSLALLSDAGHM
LTDSLSLLLALWAARIGRRPATERLSFGHGRAEVLGALLNSLLLFGLSAFIVAEAVERLLRPHAVNGMGVMLIAAIGLAV
NVLAARVLSRGAHSLNSRAALLHVLGDLFGSAAAIASGVVIYLTGWMAADPLLSMLVALMLLAAAWRLIRQAVMVLMEGV
PPHLDYNRIGEALSAIAGVRSVHDLHVWTMSAERVALSAHVRIAAPQDWPRILAACQLMLSREFCIDHVTLQAEWPASAP
AGKPVPIDIISEDKLP

Sequences:

>Translated_336_residues
MTPSFHLHDENGVDHAHDDDHDANHPHLHRHGGPAGGEGRRLSSRALAKVLALTCGFALVEALGGWWSGSLALLSDAGHM
LTDSLSLLLALWAARIGRRPATERLSFGHGRAEVLGALLNSLLLFGLSAFIVAEAVERLLRPHAVNGMGVMLIAAIGLAV
NVLAARVLSRGAHSLNSRAALLHVLGDLFGSAAAIASGVVIYLTGWMAADPLLSMLVALMLLAAAWRLIRQAVMVLMEGV
PPHLDYNRIGEALSAIAGVRSVHDLHVWTMSAERVALSAHVRIAAPQDWPRILAACQLMLSREFCIDHVTLQAEWPASAP
AGKPVPIDIISEDKLP
>Mature_335_residues
TPSFHLHDENGVDHAHDDDHDANHPHLHRHGGPAGGEGRRLSSRALAKVLALTCGFALVEALGGWWSGSLALLSDAGHML
TDSLSLLLALWAARIGRRPATERLSFGHGRAEVLGALLNSLLLFGLSAFIVAEAVERLLRPHAVNGMGVMLIAAIGLAVN
VLAARVLSRGAHSLNSRAALLHVLGDLFGSAAAIASGVVIYLTGWMAADPLLSMLVALMLLAAAWRLIRQAVMVLMEGVP
PHLDYNRIGEALSAIAGVRSVHDLHVWTMSAERVALSAHVRIAAPQDWPRILAACQLMLSREFCIDHVTLQAEWPASAPA
GKPVPIDIISEDKLP

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI64762489, Length=303, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI289803013, Length=303, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI289803009, Length=303, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI289803007, Length=303, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI289803003, Length=303, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI52352805, Length=309, Percent_Identity=29.7734627831715, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI21359890, Length=308, Percent_Identity=30.5194805194805, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI21361112, Length=317, Percent_Identity=31.2302839116719, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI20070323, Length=317, Percent_Identity=29.9684542586751, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=27.3148148148148, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI222080086, Length=127, Percent_Identity=38.5826771653543, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40255009, Length=127, Percent_Identity=38.5826771653543, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI52351208, Length=116, Percent_Identity=42.2413793103448, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI52352803, Length=116, Percent_Identity=46.551724137931, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1786966, Length=282, Percent_Identity=43.9716312056738, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1790349, Length=230, Percent_Identity=30, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555796, Length=338, Percent_Identity=34.0236686390533, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17555794, Length=306, Percent_Identity=33.9869281045752, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI193210990, Length=335, Percent_Identity=31.3432835820896, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32564488, Length=271, Percent_Identity=29.520295202952, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17550440, Length=153, Percent_Identity=31.3725490196078, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17550442, Length=153, Percent_Identity=31.3725490196078, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=178, Percent_Identity=34.8314606741573, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323899, Length=136, Percent_Identity=37.5, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=127, Percent_Identity=35.4330708661417, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583858, Length=315, Percent_Identity=29.2063492063492, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28574430, Length=148, Percent_Identity=33.1081081081081, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24584409, Length=148, Percent_Identity=33.1081081081081, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585900, Length=159, Percent_Identity=32.7044025157233, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24585898, Length=159, Percent_Identity=32.7044025157233, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24585896, Length=159, Percent_Identity=32.7044025157233, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19921672, Length=159, Percent_Identity=32.7044025157233, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24645863, Length=121, Percent_Identity=39.6694214876033, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656728, Length=146, Percent_Identity=32.1917808219178, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656724, Length=146, Percent_Identity=32.1917808219178, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656720, Length=146, Percent_Identity=32.1917808219178, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656715, Length=146, Percent_Identity=32.1917808219178, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357035, Length=146, Percent_Identity=32.1917808219178, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35780; Mature: 35649

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSFHLHDENGVDHAHDDDHDANHPHLHRHGGPAGGEGRRLSSRALAKVLALTCGFALV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EALGGWWSGSLALLSDAGHMLTDSLSLLLALWAARIGRRPATERLSFGHGRAEVLGALLN
HHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHH
SLLLFGLSAFIVAEAVERLLRPHAVNGMGVMLIAAIGLAVNVLAARVLSRGAHSLNSRAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLHVLGDLFGSAAAIASGVVIYLTGWMAADPLLSMLVALMLLAAAWRLIRQAVMVLMEGV
HHHHHHHHHHHHHHHHCCHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPHLDYNRIGEALSAIAGVRSVHDLHVWTMSAERVALSAHVRIAAPQDWPRILAACQLML
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEECHHHEEEEHEEEEECCCCHHHHHHHHHHHH
SREFCIDHVTLQAEWPASAPAGKPVPIDIISEDKLP
HHHHHHHHEEEEECCCCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TPSFHLHDENGVDHAHDDDHDANHPHLHRHGGPAGGEGRRLSSRALAKVLALTCGFALV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EALGGWWSGSLALLSDAGHMLTDSLSLLLALWAARIGRRPATERLSFGHGRAEVLGALLN
HHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHH
SLLLFGLSAFIVAEAVERLLRPHAVNGMGVMLIAAIGLAVNVLAARVLSRGAHSLNSRAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLHVLGDLFGSAAAIASGVVIYLTGWMAADPLLSMLVALMLLAAAWRLIRQAVMVLMEGV
HHHHHHHHHHHHHHHHCCHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPHLDYNRIGEALSAIAGVRSVHDLHVWTMSAERVALSAHVRIAAPQDWPRILAACQLML
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEECHHHEEEEHEEEEECCCCHHHHHHHHHHHH
SREFCIDHVTLQAEWPASAPAGKPVPIDIISEDKLP
HHHHHHHHEEEEECCCCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]