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The map label for this gene is lspA [H]

Identifier: 34499023

GI number: 34499023

Start: 3874481

End: 3874981

Strand: Reverse

Name: lspA [H]

Synonym: CV_3568

Alternate gene names: 34499023

Gene position: 3874981-3874481 (Counterclockwise)

Preceding gene: 34499024

Following gene: 34499022

Centisome position: 81.56

GC content: 61.08

Gene sequence:

>501_bases
ATGGATTCTGCAATGACTATGCCTGGCGCCCGCGGCTGGCCAAAATGGTTCGCGCTGGCGGCCCTGGTGATCGTACTGGA
CCAGATCAGCAAGCTGTATTTCAACAGCCGTTTCCAGTACGGCGAAATCCGGCCGGTGGTGGAGGGGTTCTTCAACTTCA
CCCTGGTCTACAATCCCGGCGCGGCGTTCAGCTTCCTGCACGACGCCGGCGGCTGGCAGAAGTATCTGTTCACCATCCTG
GCCTTCGCCGTGTCAGGCTGGCTGGGCTGGAACATCGTCAAGCGGCGCTTTTCCGGCCTGATGAACCTGGCCGCGGCCTT
CATCATGGGCGGCGCGCTGGGCAATGTGATCGACCGCCTGGCCTATGGCCACGTGATCGACTTCATCATGGTCCACTATT
ACAACGAGTGGTACTACCCGGCGTTCAACCTGGCCGATTCCTTCATCTGCGTCGGCGCGGCGCTGATGGTGGCGGACAGC
ATGAAGAAGCCCTCGCGCTGA

Upstream 100 bases:

>100_bases
CTGCGTCGACAATCTGGATGGCCAGGGCGAGCCGCGCCGCTACGCCTGACCATTCGCCGGGGCCGCTGCGGCGGCCCCGT
CTGCCCATGGATACCGACAG

Downstream 100 bases:

>100_bases
AAAGGGCGGGGAACAGCACCTGCGATGGCCCGCTTGGCGGGCCATTCGCGCATTCGCCGGGCAAGGCCCTGGCCTGATTG
AGGAAATACGGATGACGAAG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MDSAMTMPGARGWPKWFALAALVIVLDQISKLYFNSRFQYGEIRPVVEGFFNFTLVYNPGAAFSFLHDAGGWQKYLFTIL
AFAVSGWLGWNIVKRRFSGLMNLAAAFIMGGALGNVIDRLAYGHVIDFIMVHYYNEWYYPAFNLADSFICVGAALMVADS
MKKPSR

Sequences:

>Translated_166_residues
MDSAMTMPGARGWPKWFALAALVIVLDQISKLYFNSRFQYGEIRPVVEGFFNFTLVYNPGAAFSFLHDAGGWQKYLFTIL
AFAVSGWLGWNIVKRRFSGLMNLAAAFIMGGALGNVIDRLAYGHVIDFIMVHYYNEWYYPAFNLADSFICVGAALMVADS
MKKPSR
>Mature_166_residues
MDSAMTMPGARGWPKWFALAALVIVLDQISKLYFNSRFQYGEIRPVVEGFFNFTLVYNPGAAFSFLHDAGGWQKYLFTIL
AFAVSGWLGWNIVKRRFSGLMNLAAAFIMGGALGNVIDRLAYGHVIDFIMVHYYNEWYYPAFNLADSFICVGAALMVADS
MKKPSR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=153, Percent_Identity=41.1764705882353, Blast_Score=102, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18694; Mature: 18694

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSAMTMPGARGWPKWFALAALVIVLDQISKLYFNSRFQYGEIRPVVEGFFNFTLVYNPG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEECCC
AAFSFLHDAGGWQKYLFTILAFAVSGWLGWNIVKRRFSGLMNLAAAFIMGGALGNVIDRL
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYGHVIDFIMVHYYNEWYYPAFNLADSFICVGAALMVADSMKKPSR
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDSAMTMPGARGWPKWFALAALVIVLDQISKLYFNSRFQYGEIRPVVEGFFNFTLVYNPG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEECCC
AAFSFLHDAGGWQKYLFTILAFAVSGWLGWNIVKRRFSGLMNLAAAFIMGGALGNVIDRL
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYGHVIDFIMVHYYNEWYYPAFNLADSFICVGAALMVADSMKKPSR
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]