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The map label for this gene is tadA [H]

Identifier: 34498926

GI number: 34498926

Start: 3765060

End: 3765794

Strand: Direct

Name: tadA [H]

Synonym: CV_3471

Alternate gene names: 34498926

Gene position: 3765060-3765794 (Clockwise)

Preceding gene: 34498924

Following gene: 34498927

Centisome position: 79.25

GC content: 73.06

Gene sequence:

>735_bases
GTGACGCTCACCTCCCCTCCGCTGCCTCCCGCCGCCATCGCCTGGCTGGCCGAGCTGGACATCCATACCCGCCAGCAGCT
GCACGCCCGCGGCGTAGTCACCGCCTTTTTGCAATTGAAAGCGGCCGGACACACCGCAACCCGCCGGCTGCTGTTCGCGC
TGGAGGCCGCCGCCCGCGGCATACACTGGCGGCAGCTGGAGGAGGAGGACAAGGCGCTGCTGCTGCGCCGGCTGTCCGAC
CACCCCCCGGTGGCGCTGCCGCCGGACGCGGATGACCGCCTGCGCTACATGCGGCAGGCCCGGGATCTGGCCCAGCAGGC
CGCCGCCGAAGGCGAAGTGCCGGTGGGCGCGCTGGTGGTGAAAGACGGCGAGATCATAGGCCGCGGCTACAACCAGCCCA
TCGGCCGCCACGACCCGTCCGCCCACGCCGAGATGCAGGCGCTGCGCGACGCCGCCGCGCGGCTGCGCAACTATCGGCTG
GACGGCTGCGACCTGTACGTGACGCTTGAGCCCTGCCCGATGTGCAGCGGCGCCATCCTGCACGCGCGCGTCGCCCGCGT
GATCTACGGCGCCGCCGACGCCAAGACCGGCGCGGCCGGCAGCACGGTCGACCTGTTCGCCGACCCGCGGCTCAACCACC
ACGCGGCGGTATTCGGCGGCGTGGAAGCCGAGGCGTGCGCGGCGCAGCTGTCCGCCTTTTTCCGCCAGCGGCGCCAGTCC
GCGGGGGAGGACTGA

Upstream 100 bases:

>100_bases
CCGCGCGCGCCGCGCGCCTCGCATCCCGCCAGGGTTTGGTTCGCGGGGGGAAACACGCGATAATGACGGTATTGCCGCAA
CCCTCGTTCCGCCCGACGCC

Downstream 100 bases:

>100_bases
GATGCGCGCGAAATTCGCCGTCCTGCTGGCCTGCCTGGTCCAACCCTGCCTGGCTGCGGTCGACGACGCGGCGTTGGTCC
TGCAAGCGCAGACCGACGGC

Product: cytidine deaminase

Products: uridine; NH3

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTLTSPPLPPAAIAWLAELDIHTRQQLHARGVVTAFLQLKAAGHTATRRLLFALEAAARGIHWRQLEEEDKALLLRRLSD
HPPVALPPDADDRLRYMRQARDLAQQAAAEGEVPVGALVVKDGEIIGRGYNQPIGRHDPSAHAEMQALRDAAARLRNYRL
DGCDLYVTLEPCPMCSGAILHARVARVIYGAADAKTGAAGSTVDLFADPRLNHHAAVFGGVEAEACAAQLSAFFRQRRQS
AGED

Sequences:

>Translated_244_residues
MTLTSPPLPPAAIAWLAELDIHTRQQLHARGVVTAFLQLKAAGHTATRRLLFALEAAARGIHWRQLEEEDKALLLRRLSD
HPPVALPPDADDRLRYMRQARDLAQQAAAEGEVPVGALVVKDGEIIGRGYNQPIGRHDPSAHAEMQALRDAAARLRNYRL
DGCDLYVTLEPCPMCSGAILHARVARVIYGAADAKTGAAGSTVDLFADPRLNHHAAVFGGVEAEACAAQLSAFFRQRRQS
AGED
>Mature_243_residues
TLTSPPLPPAAIAWLAELDIHTRQQLHARGVVTAFLQLKAAGHTATRRLLFALEAAARGIHWRQLEEEDKALLLRRLSDH
PPVALPPDADDRLRYMRQARDLAQQAAAEGEVPVGALVVKDGEIIGRGYNQPIGRHDPSAHAEMQALRDAAARLRNYRLD
GCDLYVTLEPCPMCSGAILHARVARVIYGAADAKTGAAGSTVDLFADPRLNHHAAVFGGVEAEACAAQLSAFFRQRRQSA
GED

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=161, Percent_Identity=29.8136645962733, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI19923945, Length=69, Percent_Identity=50.7246376811594, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI145693172, Length=144, Percent_Identity=55.5555555555556, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1786616, Length=113, Percent_Identity=39.8230088495575, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554608, Length=100, Percent_Identity=42, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17541138, Length=148, Percent_Identity=33.7837837837838, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17555996, Length=102, Percent_Identity=36.2745098039216, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325319, Length=156, Percent_Identity=29.4871794871795, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355527, Length=146, Percent_Identity=32.1917808219178, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.5

Molecular weight: Translated: 26469; Mature: 26338

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTSPPLPPAAIAWLAELDIHTRQQLHARGVVTAFLQLKAAGHTATRRLLFALEAAARG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
IHWRQLEEEDKALLLRRLSDHPPVALPPDADDRLRYMRQARDLAQQAAAEGEVPVGALVV
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
KDGEIIGRGYNQPIGRHDPSAHAEMQALRDAAARLRNYRLDGCDLYVTLEPCPMCSGAIL
ECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHH
HARVARVIYGAADAKTGAAGSTVDLFADPRLNHHAAVFGGVEAEACAAQLSAFFRQRRQS
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHH
AGED
CCCC
>Mature Secondary Structure 
TLTSPPLPPAAIAWLAELDIHTRQQLHARGVVTAFLQLKAAGHTATRRLLFALEAAARG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
IHWRQLEEEDKALLLRRLSDHPPVALPPDADDRLRYMRQARDLAQQAAAEGEVPVGALVV
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
KDGEIIGRGYNQPIGRHDPSAHAEMQALRDAAARLRNYRLDGCDLYVTLEPCPMCSGAIL
ECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHH
HARVARVIYGAADAKTGAAGSTVDLFADPRLNHHAAVFGGVEAEACAAQLSAFFRQRRQS
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHH
AGED
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cytidine; H2O

Specific reaction: cytidine + H2O = uridine + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]