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The map label for this gene is dcp1 [H]

Identifier: 34498835

GI number: 34498835

Start: 3673877

End: 3675901

Strand: Direct

Name: dcp1 [H]

Synonym: CV_3380

Alternate gene names: 34498835

Gene position: 3673877-3675901 (Clockwise)

Preceding gene: 34498834

Following gene: 34498836

Centisome position: 77.33

GC content: 69.38

Gene sequence:

>2025_bases
ATGAACGCCAATCCCCTGCTGCAAGACTGGACCACCCCGCACCAGTTGCCCCCGTTCGAGCAGATCCGTCCCGAGCACTT
CGAACCGGCCTTCGACGCGCTGTTCGCCGAACACCTGGCCGAGATCGACGCGCTGGCGGCGCGGGCGGAACCCGCCGACT
TCGACAACACCGCCGCCGCCTTCGATCGCTGCGGCCTGAAGCTGGAGCGCGCCCAACTGCTGCTGGACAACCTGACCGCG
TCGGAAACCTCGCCCGAGCTGCAGGAAGTGGAGCGCCGGATGGCGCCCAAGCTGGCCGGCCACCGCAGCCGCGTATACAT
GCACGAGGGTTTCTTCGCCCGGCTCGACGCCGTCCATGCCCGGCGGGACAGCCTGGGGCTGAGCGAGGAACAGGGCCGGC
TGCTGGACCTGATCCACCGCGACTTCGTCCGCGCCGGCGCCAAGCTGCAAGGCGACGACCGCCGGCGTTACGCCGACATC
GTGTCCCGGCTGGCCGAACTGACCACCGCCTTCAGCCAAAACGTGCTGGCCGACGAAAGCGAATACGCGCTGCAGCTGGG
CGAGGCCGACCTCGCCGGCCTGCCTCCCTTCCTGCTGGACGCCGCCCGCGCAGCGGCCGAAGCGCGCGGCTTGCCGGGCT
GGGCGATCACGCTGTCGCGCTCGTCCATCGTGCCCTTCCTCACCTTCTCCGCCCGCCGCGAGCTGCGCGAAACCGCTTGG
CGCGCCTGGACCGGCCGCGGCGAACACCCGGAGCGCGACAACCGTCCGCTGGCCAGGCAGATCCTGGCGCTGCGCGTCGA
GCAGGCCGGGCTGCTCGGCTACGCCAGCTTCGCCGACTATGCGATCGCCAACCGCATGGCCGGCACCCCGGCCGCGGTCC
ACGCGCTGATGGACCAGGTGTGGGAGCCGGCCAAGGCCCGCTTCGAAGCGGAAAAAGCGATGCTGCGCGAAGAGGCCGCC
AAGCTCGGCGAGCCGGCCGACATCCAGCCCTGGGACTGGTTTTACCTGGCGGAGAAAGTGCGTATCGCCCGCTACGCGCT
GGACGACGCCGAGATCAAGCCCTACTTCGGCCTGGACAATATGATCGCCGCGATGTTCGACGTCGCCGGCCGCCTGTTCG
GCCTCGAGTTCGCCGAACGGCACGACCTCAAGCTCTACCACCCCGACGTGCGCGCCTGGGACGTCAGCCGCGGCGGCAAG
GTGATCGGCCTGTTCCTAGGCGACAACTACGCCCGCCAGAACAAGCGCGGCGGCGCCTGGATGCATGTCTACCGCTGGCA
GGCCCGCAACGGCGGCGTGGCGCTGCCCATCGTCGTCAACAACAACAACTTCGCCAAGTCCGGCCGCGGCCAGACGCTGC
TGAGCTTCGACGACGTGCGCACGCTGTTCCACGAATTCGGCCACGGCCTGCACGGCCTGCTGTCCGATGTCGAATACCGG
CTGCTGGCCAGCCCCAACTGCCCATGGGACTACGTCGAGCTGCCGTCGCAGCTGATGGAGAACTGGGCGCTGGTGCCGGA
GGTGCTGGAAAAACACGCCCGCCACGCGCAAACCGGCGCGGCCATCCCGGCCGAACTGGTCGCCAAGATCAAGGCGGCGC
GCCACTTCAACCAGGGCTTCGAAACGGTGCGCTACGCCGCGTCCACGCTGATCGACCTGGCGCTGCACGAGCGCGCCGAC
GCCGAGGGCGTCGACATCGCCGCCTTCGAGGCGGCGGAGCGCGAGCGGCTGGGCATCCCGCCGGCGGCCGGCATGAATCA
CCGCCCGCCCCACTTCGGCCATATCTTCTCCGACGACGCCTACGCCGCCGGCTACTACGTCTACATGTGGGCGGAAGTGC
TGGAAGCCGAAGCGTTCGCCGCGTTCGAGGAAGCCGGCGACCCGTTTGATCCGGAACTGGCGGACAAGCTGTACCGCCAC
ATCTACAGCGCCGGCGACGCCCGCGAGCAGCGCGCCGCCTTCCGCGCCTTCCGCGGCCGCGATCCGCAAGCGGAAGCGAT
GCTGAAAAACCGCGGCCTGCTGTAA

Upstream 100 bases:

>100_bases
CGCAGAACCTATGACATTTCTTCGGCATGGATTGGTTTGTTCCGACCCGAAACAATGCTAAAGTCATGAGCTCAACGCCA
ACCCAAGCGAGAAGAGCGCC

Downstream 100 bases:

>100_bases
GGGACCGAGCCGCCGGGACCGCCCGGCGGCTGCTACATTGCCGCTCCGGCGCCAAGGAATCATCATGAACAACCCGCTGC
TGCAAGCCTGGGACACGCCA

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MNANPLLQDWTTPHQLPPFEQIRPEHFEPAFDALFAEHLAEIDALAARAEPADFDNTAAAFDRCGLKLERAQLLLDNLTA
SETSPELQEVERRMAPKLAGHRSRVYMHEGFFARLDAVHARRDSLGLSEEQGRLLDLIHRDFVRAGAKLQGDDRRRYADI
VSRLAELTTAFSQNVLADESEYALQLGEADLAGLPPFLLDAARAAAEARGLPGWAITLSRSSIVPFLTFSARRELRETAW
RAWTGRGEHPERDNRPLARQILALRVEQAGLLGYASFADYAIANRMAGTPAAVHALMDQVWEPAKARFEAEKAMLREEAA
KLGEPADIQPWDWFYLAEKVRIARYALDDAEIKPYFGLDNMIAAMFDVAGRLFGLEFAERHDLKLYHPDVRAWDVSRGGK
VIGLFLGDNYARQNKRGGAWMHVYRWQARNGGVALPIVVNNNNFAKSGRGQTLLSFDDVRTLFHEFGHGLHGLLSDVEYR
LLASPNCPWDYVELPSQLMENWALVPEVLEKHARHAQTGAAIPAELVAKIKAARHFNQGFETVRYAASTLIDLALHERAD
AEGVDIAAFEAAERERLGIPPAAGMNHRPPHFGHIFSDDAYAAGYYVYMWAEVLEAEAFAAFEEAGDPFDPELADKLYRH
IYSAGDAREQRAAFRAFRGRDPQAEAMLKNRGLL

Sequences:

>Translated_674_residues
MNANPLLQDWTTPHQLPPFEQIRPEHFEPAFDALFAEHLAEIDALAARAEPADFDNTAAAFDRCGLKLERAQLLLDNLTA
SETSPELQEVERRMAPKLAGHRSRVYMHEGFFARLDAVHARRDSLGLSEEQGRLLDLIHRDFVRAGAKLQGDDRRRYADI
VSRLAELTTAFSQNVLADESEYALQLGEADLAGLPPFLLDAARAAAEARGLPGWAITLSRSSIVPFLTFSARRELRETAW
RAWTGRGEHPERDNRPLARQILALRVEQAGLLGYASFADYAIANRMAGTPAAVHALMDQVWEPAKARFEAEKAMLREEAA
KLGEPADIQPWDWFYLAEKVRIARYALDDAEIKPYFGLDNMIAAMFDVAGRLFGLEFAERHDLKLYHPDVRAWDVSRGGK
VIGLFLGDNYARQNKRGGAWMHVYRWQARNGGVALPIVVNNNNFAKSGRGQTLLSFDDVRTLFHEFGHGLHGLLSDVEYR
LLASPNCPWDYVELPSQLMENWALVPEVLEKHARHAQTGAAIPAELVAKIKAARHFNQGFETVRYAASTLIDLALHERAD
AEGVDIAAFEAAERERLGIPPAAGMNHRPPHFGHIFSDDAYAAGYYVYMWAEVLEAEAFAAFEEAGDPFDPELADKLYRH
IYSAGDAREQRAAFRAFRGRDPQAEAMLKNRGLL
>Mature_674_residues
MNANPLLQDWTTPHQLPPFEQIRPEHFEPAFDALFAEHLAEIDALAARAEPADFDNTAAAFDRCGLKLERAQLLLDNLTA
SETSPELQEVERRMAPKLAGHRSRVYMHEGFFARLDAVHARRDSLGLSEEQGRLLDLIHRDFVRAGAKLQGDDRRRYADI
VSRLAELTTAFSQNVLADESEYALQLGEADLAGLPPFLLDAARAAAEARGLPGWAITLSRSSIVPFLTFSARRELRETAW
RAWTGRGEHPERDNRPLARQILALRVEQAGLLGYASFADYAIANRMAGTPAAVHALMDQVWEPAKARFEAEKAMLREEAA
KLGEPADIQPWDWFYLAEKVRIARYALDDAEIKPYFGLDNMIAAMFDVAGRLFGLEFAERHDLKLYHPDVRAWDVSRGGK
VIGLFLGDNYARQNKRGGAWMHVYRWQARNGGVALPIVVNNNNFAKSGRGQTLLSFDDVRTLFHEFGHGLHGLLSDVEYR
LLASPNCPWDYVELPSQLMENWALVPEVLEKHARHAQTGAAIPAELVAKIKAARHFNQGFETVRYAASTLIDLALHERAD
AEGVDIAAFEAAERERLGIPPAAGMNHRPPHFGHIFSDDAYAAGYYVYMWAEVLEAEAFAAFEEAGDPFDPELADKLYRH
IYSAGDAREQRAAFRAFRGRDPQAEAMLKNRGLL

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=589, Percent_Identity=28.6926994906621, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI14149738, Length=667, Percent_Identity=25.3373313343328, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI156105687, Length=630, Percent_Identity=22.0634920634921, Blast_Score=133, Evalue=7e-31,
Organism=Escherichia coli, GI1787819, Length=682, Percent_Identity=37.2434017595308, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1789913, Length=683, Percent_Identity=35.2855051244509, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71999758, Length=565, Percent_Identity=24.2477876106195, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=544, Percent_Identity=23.7132352941176, Blast_Score=99, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319793, Length=585, Percent_Identity=27.1794871794872, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322715, Length=577, Percent_Identity=22.7036395147314, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356111, Length=542, Percent_Identity=25.4612546125461, Blast_Score=162, Evalue=9e-40,
Organism=Drosophila melanogaster, GI20129717, Length=577, Percent_Identity=24.7833622183709, Blast_Score=124, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 75541; Mature: 75541

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANPLLQDWTTPHQLPPFEQIRPEHFEPAFDALFAEHLAEIDALAARAEPADFDNTAAA
CCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
FDRCGLKLERAQLLLDNLTASETSPELQEVERRMAPKLAGHRSRVYMHEGFFARLDAVHA
HHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
RRDSLGLSEEQGRLLDLIHRDFVRAGAKLQGDDRRRYADIVSRLAELTTAFSQNVLADES
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EYALQLGEADLAGLPPFLLDAARAAAEARGLPGWAITLSRSSIVPFLTFSARRELRETAW
HHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
RAWTGRGEHPERDNRPLARQILALRVEQAGLLGYASFADYAIANRMAGTPAAVHALMDQV
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
WEPAKARFEAEKAMLREEAAKLGEPADIQPWDWFYLAEKVRIARYALDDAEIKPYFGLDN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
MIAAMFDVAGRLFGLEFAERHDLKLYHPDVRAWDVSRGGKVIGLFLGDNYARQNKRGGAW
HHHHHHHHHHHHHCCHHHCCCCCEEECCCCCEEECCCCCCEEEEEECCCHHHHCCCCCCE
MHVYRWQARNGGVALPIVVNNNNFAKSGRGQTLLSFDDVRTLFHEFGHGLHGLLSDVEYR
EEEEEEEECCCCEEEEEEECCCCCCCCCCCCEEECHHHHHHHHHHHCCHHHHHHHHHHHH
LLASPNCPWDYVELPSQLMENWALVPEVLEKHARHAQTGAAIPAELVAKIKAARHFNQGF
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ETVRYAASTLIDLALHERADAEGVDIAAFEAAERERLGIPPAAGMNHRPPHFGHIFSDDA
HHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
YAAGYYVYMWAEVLEAEAFAAFEEAGDPFDPELADKLYRHIYSAGDAREQRAAFRAFRGR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
DPQAEAMLKNRGLL
CCHHHHHHHHCCCC
>Mature Secondary Structure
MNANPLLQDWTTPHQLPPFEQIRPEHFEPAFDALFAEHLAEIDALAARAEPADFDNTAAA
CCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
FDRCGLKLERAQLLLDNLTASETSPELQEVERRMAPKLAGHRSRVYMHEGFFARLDAVHA
HHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
RRDSLGLSEEQGRLLDLIHRDFVRAGAKLQGDDRRRYADIVSRLAELTTAFSQNVLADES
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EYALQLGEADLAGLPPFLLDAARAAAEARGLPGWAITLSRSSIVPFLTFSARRELRETAW
HHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
RAWTGRGEHPERDNRPLARQILALRVEQAGLLGYASFADYAIANRMAGTPAAVHALMDQV
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
WEPAKARFEAEKAMLREEAAKLGEPADIQPWDWFYLAEKVRIARYALDDAEIKPYFGLDN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
MIAAMFDVAGRLFGLEFAERHDLKLYHPDVRAWDVSRGGKVIGLFLGDNYARQNKRGGAW
HHHHHHHHHHHHHCCHHHCCCCCEEECCCCCEEECCCCCCEEEEEECCCHHHHCCCCCCE
MHVYRWQARNGGVALPIVVNNNNFAKSGRGQTLLSFDDVRTLFHEFGHGLHGLLSDVEYR
EEEEEEEECCCCEEEEEEECCCCCCCCCCCCEEECHHHHHHHHHHHCCHHHHHHHHHHHH
LLASPNCPWDYVELPSQLMENWALVPEVLEKHARHAQTGAAIPAELVAKIKAARHFNQGF
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ETVRYAASTLIDLALHERADAEGVDIAAFEAAERERLGIPPAAGMNHRPPHFGHIFSDDA
HHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
YAAGYYVYMWAEVLEAEAFAAFEEAGDPFDPELADKLYRHIYSAGDAREQRAAFRAFRGR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
DPQAEAMLKNRGLL
CCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]