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The map label for this gene is adk

Identifier: 34498798

GI number: 34498798

Start: 3641481

End: 3642137

Strand: Reverse

Name: adk

Synonym: CV_3343

Alternate gene names: 34498798

Gene position: 3642137-3641481 (Counterclockwise)

Preceding gene: 34498799

Following gene: 34498797

Centisome position: 76.66

GC content: 67.88

Gene sequence:

>657_bases
ATGCGATTGATCCTGTTGGGCGCGCCCGGCGCCGGCAAAGGCACCCAGGCCAACTACATCCGCGAGAAGTTCGGCATCCC
GCAGATCTCCACCGGCGACATGCTGCGCGCCGCGGTCAAGGCCGGCACCCCGCTGGGCCTGGAAGCCAAGGCCATCATGG
ATGCCGGCGGCCTGGTCCGCGACGACATCATCATCGGCCTGGTCAAGGAGCGAATCGCCCAGGACGACTGCGCCAACGGC
TTCCTGTTCGACGGCTTCCCGCGCACCATTCCGCAGGCGGAAGCGATGATCGCCGCCGGCGTCGACATCGACTACGTGGT
GGAGATCGACGTGCCGGACGCCGCCATCGTCGAGCGCATGGCCGGCCGCCGCGTGCACCTGGCTTCGGGCCGCACCTACC
ATGTCACCTTCAACCCGCCCAAAGCGGCCGGCAAGGACGACGTGACCGGCGAGGACCTGGTCCAGCGCGACGACGACAAG
GAAGAAACCGTGAAGAAGCGCCTGGCTGTCTACCACGAGCAGACCGCCGTGCTGGTGGGCTTCTACGGCAAGCTGGCCGA
GAGCGGCAGCGCCAAGGCGCCGAAGTACGTGAAGATCGACGGCACCCGCGCGGTGGAAACCGTGCGCGACGACGTGCTGA
AGGCGCTGGGCGCCTGA

Upstream 100 bases:

>100_bases
CGGAAGACCTGGAACGGGTGCGCCGGCTGTTCGCCTGAGGGGCAGGGAGCGGCCGCTCCGTCAAAGAATTCATAAATCAA
ACAGAACTGGAGTCACACAA

Downstream 100 bases:

>100_bases
GTCTCCGCGGCAATCGGCAAGCAAGCGGGCTTCGGCCCGCTTTTTGTTTGCGCAAACCGCTAGTCTTGGGCCGCCGGACG
GGGGACAATGGAACCCAGAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRLILLGAPGAGKGTQANYIREKFGIPQISTGDMLRAAVKAGTPLGLEAKAIMDAGGLVRDDIIIGLVKERIAQDDCANG
FLFDGFPRTIPQAEAMIAAGVDIDYVVEIDVPDAAIVERMAGRRVHLASGRTYHVTFNPPKAAGKDDVTGEDLVQRDDDK
EETVKKRLAVYHEQTAVLVGFYGKLAESGSAKAPKYVKIDGTRAVETVRDDVLKALGA

Sequences:

>Translated_218_residues
MRLILLGAPGAGKGTQANYIREKFGIPQISTGDMLRAAVKAGTPLGLEAKAIMDAGGLVRDDIIIGLVKERIAQDDCANG
FLFDGFPRTIPQAEAMIAAGVDIDYVVEIDVPDAAIVERMAGRRVHLASGRTYHVTFNPPKAAGKDDVTGEDLVQRDDDK
EETVKKRLAVYHEQTAVLVGFYGKLAESGSAKAPKYVKIDGTRAVETVRDDVLKALGA
>Mature_218_residues
MRLILLGAPGAGKGTQANYIREKFGIPQISTGDMLRAAVKAGTPLGLEAKAIMDAGGLVRDDIIIGLVKERIAQDDCANG
FLFDGFPRTIPQAEAMIAAGVDIDYVVEIDVPDAAIVERMAGRRVHLASGRTYHVTFNPPKAAGKDDVTGEDLVQRDDDK
EETVKKRLAVYHEQTAVLVGFYGKLAESGSAKAPKYVKIDGTRAVETVRDDVLKALGA

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=48.4042553191489, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=48.4042553191489, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI19923437, Length=184, Percent_Identity=45.1086956521739, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=39.010989010989, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=39.010989010989, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=39.010989010989, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=39.010989010989, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI22749187, Length=183, Percent_Identity=28.9617486338798, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=30.0546448087432, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI7706497, Length=220, Percent_Identity=28.6363636363636, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI28144897, Length=181, Percent_Identity=27.6243093922652, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI28144899, Length=181, Percent_Identity=27.6243093922652, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=67.741935483871, Blast_Score=303, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=46.2765957446808, Blast_Score=183, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=33.8709677419355, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=188, Percent_Identity=33.5106382978723, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=220, Percent_Identity=26.8181818181818, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533833, Length=220, Percent_Identity=26.8181818181818, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=222, Percent_Identity=48.1981981981982, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=42.0212765957447, Blast_Score=142, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=217, Percent_Identity=29.4930875576037, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=50, Blast_Score=196, Evalue=7e-51,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=44.0217391304348, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=44.0217391304348, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17647141, Length=218, Percent_Identity=29.8165137614679, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24663208, Length=218, Percent_Identity=29.8165137614679, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CHRVO (Q7NSS7)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903013.1
- ProteinModelPortal:   Q7NSS7
- SMR:   Q7NSS7
- GeneID:   2547821
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3343
- NMPDR:   fig|243365.1.peg.3343
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   Q7NSS7
- ProtClustDB:   PRK00279
- BioCyc:   CVIO243365:CV_3343-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23321; Mature: 23321

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQANYIREKFGIPQISTGDMLRAAVKAGTPLGLEAKAIMDAGGLVR
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
DDIIIGLVKERIAQDDCANGFLFDGFPRTIPQAEAMIAAGVDIDYVVEIDVPDAAIVERM
HHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHEEECCCEEEEEEECCCCHHHHHHH
AGRRVHLASGRTYHVTFNPPKAAGKDDVTGEDLVQRDDDKEETVKKRLAVYHEQTAVLVG
CCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEE
FYGKLAESGSAKAPKYVKIDGTRAVETVRDDVLKALGA
HHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQANYIREKFGIPQISTGDMLRAAVKAGTPLGLEAKAIMDAGGLVR
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
DDIIIGLVKERIAQDDCANGFLFDGFPRTIPQAEAMIAAGVDIDYVVEIDVPDAAIVERM
HHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHEEECCCEEEEEEECCCCHHHHHHH
AGRRVHLASGRTYHVTFNPPKAAGKDDVTGEDLVQRDDDKEETVKKRLAVYHEQTAVLVG
CCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEE
FYGKLAESGSAKAPKYVKIDGTRAVETVRDDVLKALGA
HHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782