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The map label for this gene is panB1 [H]

Identifier: 34498745

GI number: 34498745

Start: 3581218

End: 3582000

Strand: Reverse

Name: panB1 [H]

Synonym: CV_3290

Alternate gene names: 34498745

Gene position: 3582000-3581218 (Counterclockwise)

Preceding gene: 34498751

Following gene: 34498743

Centisome position: 75.39

GC content: 72.16

Gene sequence:

>783_bases
ATGAGCAGCAAGGCAAGCGTTAGCCGGCGCGTGACCGTGCCGGCCATCCGGAACAGCAAGGGGCGGCGCAAGCTGATGGC
CCTGACCGCCTACAGCGGCGCCATCGCGGAGGCCGTCGACGAATGGGTGGACATCGTGCTGATAGACGACGCTGTCCCGA
TGGAGGGGGATGCCCAGCCTGGCGCGCAATCGTTCGCGCTGGAGCGCATGGTCCGTCACACGGGCGCAGTAGCGCGGGCG
ACCGAGCGCGCCTGCGTGGTGGCGGACCTGCCCATGCCCTGCTGCGGGGCGTCTTCGGAGCAGGCGCTGCGCAGCGCAGC
CCGGCTGCTGGAGGCCGGCGCCGCGGCGGTCAGGCTGGCGGGCGGCCCGGAGACGGCGGACACGATGGCGTTTCTGGTCT
CCTGCGGCGTGCCGGTGATGGGGCACATCAGAAGGGAATCGGCGCGCGCCGGCATGGCGCCGCACGAGGCGGCGGCGCGG
GAGATGGAGCGGGCCGGGGCCTTCGGCCTGTTGCTGGACGGGGTGGACGAGCCGGCCGCGCGGAGGATCGCCGACGAGGT
CTCGATTCCGGTGATATCCGGCCCGGCCTGCGATGGCCAGATGCTGGAGACCGAAGACATCCTTGGCCTGGGCGGGGATT
TCGTCCAGCGTTACGCCGAGCAGTATGCCGATGTGAGAGCGGTGGCGGAACAGGTGGCGCGCGACCATGCCGGCGCGCAA
GCTTACGCGGCCGCCTCGGGTACCCGCGGCTTCGGCGCGGCGCGCTCGCCGGCCGCGATCTGA

Upstream 100 bases:

>100_bases
CAGGATATGACAAATTCTCATTAACCTATCGGCAGGATACTCTAATAGCATGCCCGCTTCATCCCCGGCGAGCGCGCCGG
TCATCCTAGGAGCATGCATC

Downstream 100 bases:

>100_bases
GCGGCCGCGCCGTCCCGCAGGATGAGGCGCAGCTGTTCCGCCGCGACGGGCAAGGGCGTCTGCGCCCGCCATAGCGCCAG
TTCCAGCTTCTGCAGGGGCG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase 1; KPHMT 1 [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSSKASVSRRVTVPAIRNSKGRRKLMALTAYSGAIAEAVDEWVDIVLIDDAVPMEGDAQPGAQSFALERMVRHTGAVARA
TERACVVADLPMPCCGASSEQALRSAARLLEAGAAAVRLAGGPETADTMAFLVSCGVPVMGHIRRESARAGMAPHEAAAR
EMERAGAFGLLLDGVDEPAARRIADEVSIPVISGPACDGQMLETEDILGLGGDFVQRYAEQYADVRAVAEQVARDHAGAQ
AYAAASGTRGFGAARSPAAI

Sequences:

>Translated_260_residues
MSSKASVSRRVTVPAIRNSKGRRKLMALTAYSGAIAEAVDEWVDIVLIDDAVPMEGDAQPGAQSFALERMVRHTGAVARA
TERACVVADLPMPCCGASSEQALRSAARLLEAGAAAVRLAGGPETADTMAFLVSCGVPVMGHIRRESARAGMAPHEAAAR
EMERAGAFGLLLDGVDEPAARRIADEVSIPVISGPACDGQMLETEDILGLGGDFVQRYAEQYADVRAVAEQVARDHAGAQ
AYAAASGTRGFGAARSPAAI
>Mature_259_residues
SSKASVSRRVTVPAIRNSKGRRKLMALTAYSGAIAEAVDEWVDIVLIDDAVPMEGDAQPGAQSFALERMVRHTGAVARAT
ERACVVADLPMPCCGASSEQALRSAARLLEAGAAAVRLAGGPETADTMAFLVSCGVPVMGHIRRESARAGMAPHEAAARE
MERAGAFGLLLDGVDEPAARRIADEVSIPVISGPACDGQMLETEDILGLGGDFVQRYAEQYADVRAVAEQVARDHAGAQA
YAAASGTRGFGAARSPAAI

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=253, Percent_Identity=28.0632411067194, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319653, Length=278, Percent_Identity=24.4604316546763, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 26990; Mature: 26859

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKASVSRRVTVPAIRNSKGRRKLMALTAYSGAIAEAVDEWVDIVLIDDAVPMEGDAQP
CCCCCCCCCEEECCHHHCCCCHHHEEEHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC
GAQSFALERMVRHTGAVARATERACVVADLPMPCCGASSEQALRSAARLLEAGAAAVRLA
CHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEC
GGPETADTMAFLVSCGVPVMGHIRRESARAGMAPHEAAAREMERAGAFGLLLDGVDEPAA
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCHHH
RRIADEVSIPVISGPACDGQMLETEDILGLGGDFVQRYAEQYADVRAVAEQVARDHAGAQ
HHHHHHHCCCEEECCCCCCCEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AYAAASGTRGFGAARSPAAI
HHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSKASVSRRVTVPAIRNSKGRRKLMALTAYSGAIAEAVDEWVDIVLIDDAVPMEGDAQP
CCCCCCCCEEECCHHHCCCCHHHEEEHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC
GAQSFALERMVRHTGAVARATERACVVADLPMPCCGASSEQALRSAARLLEAGAAAVRLA
CHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEC
GGPETADTMAFLVSCGVPVMGHIRRESARAGMAPHEAAAREMERAGAFGLLLDGVDEPAA
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCHHH
RRIADEVSIPVISGPACDGQMLETEDILGLGGDFVQRYAEQYADVRAVAEQVARDHAGAQ
HHHHHHHCCCEEECCCCCCCEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AYAAASGTRGFGAARSPAAI
HHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA