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The map label for this gene is tlpB [H]

Identifier: 34498740

GI number: 34498740

Start: 3576949

End: 3578838

Strand: Reverse

Name: tlpB [H]

Synonym: CV_3285

Alternate gene names: 34498740

Gene position: 3578838-3576949 (Counterclockwise)

Preceding gene: 34498741

Following gene: 34498734

Centisome position: 75.33

GC content: 65.4

Gene sequence:

>1890_bases
ATGAAGATCGCGCACAAAGCCGGCCTGATTTCCGCTCTGGTGCTGGCTGTGACCTTGTCGACCCTGTCCTGGCTGCAATA
CCTGAGCGTCGCCGACAGCATACGCAGCGGCAAGGAGCAGGAGGTGGTCCAGACCAGCCAGGTGCTGGCCGAGCAGATCG
CCAACTGGCTGAACGGCAAGCTGGCGCAGATCCAGCTGATGTCGGAAACCATAGACGCCAATTTCAGCGGCGAGCGCATC
GTCGAGGTGTTTCAGCGGCCGATGCTGAAGAAGGAATTCAAGCTGGTGTTCGGCGGCCTGGATACCGACGGCAAGAAGAT
CTCCAACGATTCTTCATGGAATCCGCCGCCCGACTGGGATGCCCGCAAGCGGCCGTGGTATCCGGTGGCCAAGGCCGCGG
CCGGCGTGGGATTGACCGATCCCTACCCGGATGCCGCGTCCGGCGAGATCCTGATCTCGGTGGTGGCCAAGCTGACCGAC
AAGGGCGCGTTCAAGGGCGCGTTCGGCGGCGACCTCAGCCTGAAATCGGTGTCCGAGGCGCTGAATACCGCCACCTTCAA
CGGCGCCGGCTATGCCTTCCTGCTGTCCGCCGACGGCAAGATCATCAGCCATCCGGACGCCAAGCTGAACGGCAAGAGCG
TCGCCGAGCTGTTCGGCGGCGCCGCGCCCGCGCTGGGCGACAAGGTGCAGGAGATCGAGGCCGGCGGCCGGAAGCTGATG
GTGGCCTTCCATCCGCTGGACCGCCTGCAGCCGGCCAAGTGGCTGGTGGGCGTGGTGCTGGATGAGGACAAGGTGATGGC
CGAAGCCAGACAGATAGGCTGGCGCGGCTTCTGGGGCGCGGTGATCGGCGTGGTGCTGAGCATGGTGATCCTCAGCACGC
TGATGCAGCAGATCCTGCGCCGGCCGCTGCAGCAGCTCAAGCTGTCGCTGGCCGAACTCAACAGCGGCAACGGCGACCTG
ACGCGGCGGGTGGACGAATCGTCCAAGGACGAGTTTGGCGAAGTGGCGCGCGAATTGAACCGTTTCATCGCCTACCTGCA
GCGGCTGATCGGCGACATCCGGCAGATTTCCACCCGCGTCCATCACGGCGCCGAACAGAGCGCGGAAGAGGCTCAGCAGA
GCAGCGGCGAGGCCAGCCGGCTGCGGCAGGAGCTGGAGCAATTGGTGGCTGCCATCGGCCAGGTGGCGGAGGCGTCCGGC
GAGATGACGTCCAATGCCGGCGCGGTGGCGGAAGCCGCGCGGCTGGCGCACGAGGAGACCGGCAGCAGGATGTCGCTGGT
GACCCAGTCCAGCCAGGCGATCCGGCGCTTGGCCGACACTTTGGACCAGACCTCGAACTCGATGAATGAACTGGCCGAAT
TCAGCAAGAACATCGAATCCATCGTCAGGGTGATCACCGGCGTGGCGGAGCAGACCAATCTGCTGGCGCTGAACGCCGCC
ATCGAAGCGGCGCGCGCCGGGGAAATGGGGCGCGGCTTCGCGGTGGTGGCCGACGAGGTCCGCAAGCTGGCGTCGCAGAC
CCAGCAGGCGACGCAGGAAATCCGCAGCATGATCGAGCAGCTGCAGCGCGGCGTCGGCGAGGCGAGGGAAAAAATGGACG
AAAGCCGCGAGTGCGCCAGCAGCACGGTGAAGGACGCCGAGCAGATCAGCGAGATGCTGCTGCGCATCCAGGACGTGATT
TCCGACATCAATGCCAGGAACAGCGAAATCGCCGGCGCGGTGGGCCGCCAAAGCCAGATGACGCAGGAGATCAACGACAG
CGCCGGCAACATCCAGCATATCGGCCAGCGGGTCAGCGACGCGGCCCAGGTGCAGCTGCGGCATTGCAACGACACCGTCT
CCGACGTGGCGGAGCAGGACAAGATGATCGCGCGCTTCCGGCTGGAGTGA

Upstream 100 bases:

>100_bases
CGAAACTTGGCGGTTTTTGTAAATAAATGAACAGGCCGGCTTGGCGGTGTGCACAGGTGCGCTATGGTGAAAATACTCAC
TCGACCTTGGACCCCCTGTC

Downstream 100 bases:

>100_bases
GCCGCAAGCTAGCGGGATGTCGCGGCGGAACGCCCGGCGCCGCCGGGCTTCCGCCCTATTTTTTGCGCGCCAGCATCGTC
ATCAGGAAATCCCTGCCGAA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MKIAHKAGLISALVLAVTLSTLSWLQYLSVADSIRSGKEQEVVQTSQVLAEQIANWLNGKLAQIQLMSETIDANFSGERI
VEVFQRPMLKKEFKLVFGGLDTDGKKISNDSSWNPPPDWDARKRPWYPVAKAAAGVGLTDPYPDAASGEILISVVAKLTD
KGAFKGAFGGDLSLKSVSEALNTATFNGAGYAFLLSADGKIISHPDAKLNGKSVAELFGGAAPALGDKVQEIEAGGRKLM
VAFHPLDRLQPAKWLVGVVLDEDKVMAEARQIGWRGFWGAVIGVVLSMVILSTLMQQILRRPLQQLKLSLAELNSGNGDL
TRRVDESSKDEFGEVARELNRFIAYLQRLIGDIRQISTRVHHGAEQSAEEAQQSSGEASRLRQELEQLVAAIGQVAEASG
EMTSNAGAVAEAARLAHEETGSRMSLVTQSSQAIRRLADTLDQTSNSMNELAEFSKNIESIVRVITGVAEQTNLLALNAA
IEAARAGEMGRGFAVVADEVRKLASQTQQATQEIRSMIEQLQRGVGEAREKMDESRECASSTVKDAEQISEMLLRIQDVI
SDINARNSEIAGAVGRQSQMTQEINDSAGNIQHIGQRVSDAAQVQLRHCNDTVSDVAEQDKMIARFRLE

Sequences:

>Translated_629_residues
MKIAHKAGLISALVLAVTLSTLSWLQYLSVADSIRSGKEQEVVQTSQVLAEQIANWLNGKLAQIQLMSETIDANFSGERI
VEVFQRPMLKKEFKLVFGGLDTDGKKISNDSSWNPPPDWDARKRPWYPVAKAAAGVGLTDPYPDAASGEILISVVAKLTD
KGAFKGAFGGDLSLKSVSEALNTATFNGAGYAFLLSADGKIISHPDAKLNGKSVAELFGGAAPALGDKVQEIEAGGRKLM
VAFHPLDRLQPAKWLVGVVLDEDKVMAEARQIGWRGFWGAVIGVVLSMVILSTLMQQILRRPLQQLKLSLAELNSGNGDL
TRRVDESSKDEFGEVARELNRFIAYLQRLIGDIRQISTRVHHGAEQSAEEAQQSSGEASRLRQELEQLVAAIGQVAEASG
EMTSNAGAVAEAARLAHEETGSRMSLVTQSSQAIRRLADTLDQTSNSMNELAEFSKNIESIVRVITGVAEQTNLLALNAA
IEAARAGEMGRGFAVVADEVRKLASQTQQATQEIRSMIEQLQRGVGEAREKMDESRECASSTVKDAEQISEMLLRIQDVI
SDINARNSEIAGAVGRQSQMTQEINDSAGNIQHIGQRVSDAAQVQLRHCNDTVSDVAEQDKMIARFRLE
>Mature_629_residues
MKIAHKAGLISALVLAVTLSTLSWLQYLSVADSIRSGKEQEVVQTSQVLAEQIANWLNGKLAQIQLMSETIDANFSGERI
VEVFQRPMLKKEFKLVFGGLDTDGKKISNDSSWNPPPDWDARKRPWYPVAKAAAGVGLTDPYPDAASGEILISVVAKLTD
KGAFKGAFGGDLSLKSVSEALNTATFNGAGYAFLLSADGKIISHPDAKLNGKSVAELFGGAAPALGDKVQEIEAGGRKLM
VAFHPLDRLQPAKWLVGVVLDEDKVMAEARQIGWRGFWGAVIGVVLSMVILSTLMQQILRRPLQQLKLSLAELNSGNGDL
TRRVDESSKDEFGEVARELNRFIAYLQRLIGDIRQISTRVHHGAEQSAEEAQQSSGEASRLRQELEQLVAAIGQVAEASG
EMTSNAGAVAEAARLAHEETGSRMSLVTQSSQAIRRLADTLDQTSNSMNELAEFSKNIESIVRVITGVAEQTNLLALNAA
IEAARAGEMGRGFAVVADEVRKLASQTQQATQEIRSMIEQLQRGVGEAREKMDESRECASSTVKDAEQISEMLLRIQDVI
SDINARNSEIAGAVGRQSQMTQEINDSAGNIQHIGQRVSDAAQVQLRHCNDTVSDVAEQDKMIARFRLE

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=268, Percent_Identity=32.8358208955224, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787690, Length=318, Percent_Identity=30.188679245283, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788195, Length=296, Percent_Identity=30.0675675675676, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788194, Length=325, Percent_Identity=30.1538461538462, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1789453, Length=333, Percent_Identity=26.1261261261261, Blast_Score=99, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 68200; Mature: 68200

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAHKAGLISALVLAVTLSTLSWLQYLSVADSIRSGKEQEVVQTSQVLAEQIANWLNGK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
LAQIQLMSETIDANFSGERIVEVFQRPMLKKEFKLVFGGLDTDGKKISNDSSWNPPPDWD
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
ARKRPWYPVAKAAAGVGLTDPYPDAASGEILISVVAKLTDKGAFKGAFGGDLSLKSVSEA
CCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
LNTATFNGAGYAFLLSADGKIISHPDAKLNGKSVAELFGGAAPALGDKVQEIEAGGRKLM
HHHCCCCCCCEEEEEECCCCEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
VAFHPLDRLQPAKWLVGVVLDEDKVMAEARQIGWRGFWGAVIGVVLSMVILSTLMQQILR
EEECCHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RPLQQLKLSLAELNSGNGDLTRRVDESSKDEFGEVARELNRFIAYLQRLIGDIRQISTRV
HHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HHGAEQSAEEAQQSSGEASRLRQELEQLVAAIGQVAEASGEMTSNAGAVAEAARLAHEET
HCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
GSRMSLVTQSSQAIRRLADTLDQTSNSMNELAEFSKNIESIVRVITGVAEQTNLLALNAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEAARAGEMGRGFAVVADEVRKLASQTQQATQEIRSMIEQLQRGVGEAREKMDESRECAS
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STVKDAEQISEMLLRIQDVISDINARNSEIAGAVGRQSQMTQEINDSAGNIQHIGQRVSD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHH
AAQVQLRHCNDTVSDVAEQDKMIARFRLE
HHHHHHHHHCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAHKAGLISALVLAVTLSTLSWLQYLSVADSIRSGKEQEVVQTSQVLAEQIANWLNGK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
LAQIQLMSETIDANFSGERIVEVFQRPMLKKEFKLVFGGLDTDGKKISNDSSWNPPPDWD
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
ARKRPWYPVAKAAAGVGLTDPYPDAASGEILISVVAKLTDKGAFKGAFGGDLSLKSVSEA
CCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
LNTATFNGAGYAFLLSADGKIISHPDAKLNGKSVAELFGGAAPALGDKVQEIEAGGRKLM
HHHCCCCCCCEEEEEECCCCEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
VAFHPLDRLQPAKWLVGVVLDEDKVMAEARQIGWRGFWGAVIGVVLSMVILSTLMQQILR
EEECCHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RPLQQLKLSLAELNSGNGDLTRRVDESSKDEFGEVARELNRFIAYLQRLIGDIRQISTRV
HHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HHGAEQSAEEAQQSSGEASRLRQELEQLVAAIGQVAEASGEMTSNAGAVAEAARLAHEET
HCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
GSRMSLVTQSSQAIRRLADTLDQTSNSMNELAEFSKNIESIVRVITGVAEQTNLLALNAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEAARAGEMGRGFAVVADEVRKLASQTQQATQEIRSMIEQLQRGVGEAREKMDESRECAS
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STVKDAEQISEMLLRIQDVISDINARNSEIAGAVGRQSQMTQEINDSAGNIQHIGQRVSD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHH
AAQVQLRHCNDTVSDVAEQDKMIARFRLE
HHHHHHHHHCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]