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The map label for this gene is gcvA [H]

Identifier: 34498712

GI number: 34498712

Start: 3542681

End: 3543634

Strand: Reverse

Name: gcvA [H]

Synonym: CV_3257

Alternate gene names: 34498712

Gene position: 3543634-3542681 (Counterclockwise)

Preceding gene: 34498713

Following gene: 34498708

Centisome position: 74.59

GC content: 71.07

Gene sequence:

>954_bases
ATGTCTGAGCACCAGGCAATCGGCGAGGAATCGCCGGAGGAGCGCGCGTCAAGGCTGCCTTCGCTGAGGTTGTTGGCCGG
TTTCGAGGCCGCCGCGCGGATAGGCAGCTTCTCCCGCGCCGCCGAGTCGCTGCACCTGTCGCAATCGGCGATCAGCCACC
AGATCCAGCAACTGGAGGCATTCGTCGGCCAGCCGCTGTTCCACCGGGTGGGGCGCGGCGTGGAACTGACTTTCGCCGGC
GAAATGCTGCTGCAAAGCGTGGGGCGCGCGTTGGAAACCCTGCGTCGCGGCCTGGACCGGATCGCCGCTTACACCGATCC
CGGCCTGGTGGCGCTGGTGGGGCCGGCCTCTCTGCTGCAGGGCTGGCTGCAGCCGCGGCTGCCCGCGCTGCGCGCCGCCC
ACCCCGATATCGTCCCCTTGCTGTCCACCGACGAGGCGCCCGGCCAGGCGGACGAGGTCGACCTGGATCTGCTGATTTCG
CCGCGGCCCCTGGCCATGGCCGGCTGGGAGGATGCGCGCTGGCTGCGCGACGAGTGGCTGTTCGTCTGCGCGCCGGCGCT
GGCCGAAAGGCTGGCGGGGCTGCCGTTCGAGCGTCACCGTGACTGGGCGCGGCTGGTGTGCCTGGAGCGGGCGCGGCTGC
CGGATGGCGTCGAAGCGGAAGCGCGCCGATTGCAGCAGCGGCTCGGGGTGGCGGCCATCTACGACGATGTCCAGCTGGCG
CGCGACGCCGCGCTGCGAGGCCACGGCATCGCCTGCCTGTCCTCGTTGGCAGTGGATGAGGATCTGCGCGAAGGCCGACT
GCGGACGCTGGCCGGCTATCCGAGGCTGCCGGGCGCGCAATGGTGGCTGTCGCGGCCGGAGAACGCCTTGCGCAGCGACG
CGATGGAAAGAATGTACCAGTGGCTCAGGTCTGCTGCGCGGCCAGCGCCTGCCAGCGGAGCTGGCGCGGACTGA

Upstream 100 bases:

>100_bases
CGGAACGCGAGGTGGTGCAGCTGAACATAGACGCCATCGCGGCCGGCGGCGGCGGCATTCACTGCGCGACGCAGCAGCAG
CCCGCTTGAGGGGGACGGAC

Downstream 100 bases:

>100_bases
GTCCCAGCAACTGGCGGCATAGCCGGGTGAGGGCGCTCTGGTCGGAAAAACCGCAGCCGGCGGCGATGTCGGCCAGCGGA
CGGCGGCTGTGGCGTATCGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSEHQAIGEESPEERASRLPSLRLLAGFEAAARIGSFSRAAESLHLSQSAISHQIQQLEAFVGQPLFHRVGRGVELTFAG
EMLLQSVGRALETLRRGLDRIAAYTDPGLVALVGPASLLQGWLQPRLPALRAAHPDIVPLLSTDEAPGQADEVDLDLLIS
PRPLAMAGWEDARWLRDEWLFVCAPALAERLAGLPFERHRDWARLVCLERARLPDGVEAEARRLQQRLGVAAIYDDVQLA
RDAALRGHGIACLSSLAVDEDLREGRLRTLAGYPRLPGAQWWLSRPENALRSDAMERMYQWLRSAARPAPASGAGAD

Sequences:

>Translated_317_residues
MSEHQAIGEESPEERASRLPSLRLLAGFEAAARIGSFSRAAESLHLSQSAISHQIQQLEAFVGQPLFHRVGRGVELTFAG
EMLLQSVGRALETLRRGLDRIAAYTDPGLVALVGPASLLQGWLQPRLPALRAAHPDIVPLLSTDEAPGQADEVDLDLLIS
PRPLAMAGWEDARWLRDEWLFVCAPALAERLAGLPFERHRDWARLVCLERARLPDGVEAEARRLQQRLGVAAIYDDVQLA
RDAALRGHGIACLSSLAVDEDLREGRLRTLAGYPRLPGAQWWLSRPENALRSDAMERMYQWLRSAARPAPASGAGAD
>Mature_316_residues
SEHQAIGEESPEERASRLPSLRLLAGFEAAARIGSFSRAAESLHLSQSAISHQIQQLEAFVGQPLFHRVGRGVELTFAGE
MLLQSVGRALETLRRGLDRIAAYTDPGLVALVGPASLLQGWLQPRLPALRAAHPDIVPLLSTDEAPGQADEVDLDLLISP
RPLAMAGWEDARWLRDEWLFVCAPALAERLAGLPFERHRDWARLVCLERARLPDGVEAEARRLQQRLGVAAIYDDVQLAR
DAALRGHGIACLSSLAVDEDLREGRLRTLAGYPRLPGAQWWLSRPENALRSDAMERMYQWLRSAARPAPASGAGAD

Specific function: Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786448, Length=173, Percent_Identity=39.3063583815029, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789173, Length=261, Percent_Identity=30.6513409961686, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788706, Length=174, Percent_Identity=35.632183908046, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI157672245, Length=119, Percent_Identity=40.3361344537815, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786401, Length=261, Percent_Identity=26.8199233716475, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787128, Length=258, Percent_Identity=28.6821705426357, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790208, Length=172, Percent_Identity=32.5581395348837, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34825; Mature: 34694

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHQAIGEESPEERASRLPSLRLLAGFEAAARIGSFSRAAESLHLSQSAISHQIQQLEA
CCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVGQPLFHRVGRGVELTFAGEMLLQSVGRALETLRRGLDRIAAYTDPGLVALVGPASLLQ
HHCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHH
GWLQPRLPALRAAHPDIVPLLSTDEAPGQADEVDLDLLISPRPLAMAGWEDARWLRDEWL
HHHHCCCHHHHCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCEECCCHHHHHHHHHHH
FVCAPALAERLAGLPFERHRDWARLVCLERARLPDGVEAEARRLQQRLGVAAIYDDVQLA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHH
RDAALRGHGIACLSSLAVDEDLREGRLRTLAGYPRLPGAQWWLSRPENALRSDAMERMYQ
HHHHHCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHH
WLRSAARPAPASGAGAD
HHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SEHQAIGEESPEERASRLPSLRLLAGFEAAARIGSFSRAAESLHLSQSAISHQIQQLEA
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVGQPLFHRVGRGVELTFAGEMLLQSVGRALETLRRGLDRIAAYTDPGLVALVGPASLLQ
HHCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHH
GWLQPRLPALRAAHPDIVPLLSTDEAPGQADEVDLDLLISPRPLAMAGWEDARWLRDEWL
HHHHCCCHHHHCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCEECCCHHHHHHHHHHH
FVCAPALAERLAGLPFERHRDWARLVCLERARLPDGVEAEARRLQQRLGVAAIYDDVQLA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHH
RDAALRGHGIACLSSLAVDEDLREGRLRTLAGYPRLPGAQWWLSRPENALRSDAMERMYQ
HHHHHCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHH
WLRSAARPAPASGAGAD
HHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]