Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 34498688

GI number: 34498688

Start: 3514751

End: 3516367

Strand: Direct

Name: groEL

Synonym: CV_3233

Alternate gene names: 34498688

Gene position: 3514751-3516367 (Clockwise)

Preceding gene: 34498687

Following gene: 34498689

Centisome position: 73.98

GC content: 65.8

Gene sequence:

>1617_bases
ATGGCTGCGAAAGAAGTCCGCTTCCACGACAACGCCCGTGAGCGCATCGTCAACGGCGTCAATGTGCTGGCCGATGCCGT
GAAAGTCACCCTGGGCCCGAAAGGCCGCAACGTGCTGCTGGCGCGCAGCTTCGGCGCGCCGCACATCACCAAGGACGGCG
TGTCTGTCGCCAAGGAGATCGAACTGAAGGATCCGTTCGAGAACATGGGCGCGCAGATGGTGAAGGAAGTGGCGTCCAAG
ACCGCCGACGTGGCGGGCGACGGCACCACCACCGCCACCGTGCTGGCCCAGGCCATCGTGCAGGAAGGCATGAAATACGT
GGCCTCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCCGTCCATGCCGTAATCAAAGAACTGCAAACCC
TGTCCAAACCGGTGACCAACAGCAAGGAAACCGCCCAGGTGGCCGCGCTGTCCGCCAATTCCGACGAAGCCATCGGCAAG
ATCATCGCCGACGCGATGGACAAGGTGGGCAAGGAAGGCGTGATCACCGTCGAGGACGGCAAGTCGCTGGACAACGAGCT
GGCCGTGGTTGAGGGCATGCAGTTCGACCGCGGCTACCTGTCGCCGTATTTCATCACCGATCCGGAAAAGCAGACCGCCG
TGCTGGAAGACCCGCTGGTGCTGCTCTACGACAAGAAGATCAGCAATATCCGCGACCTCTTGCCGGTGCTGGAGCAAGTG
GCCAAGGCCGGCAAGCCGCTGCTGATCGTCGCCGAGGACGTGGAGGGCGAAGCGCTGGCCACCCTGGTGGTGAACAGCAT
GCGCGGCATCCTGAAGGTGGCCGCCGTCAAGGCTCCGGGCTTCGGCGACCGCCGCAAAGCCATGCTGGAAGACATCGCCA
TCCTCACCGGCGGCACCGTCATCGCCGAGGAAACCGGCCTCACGCTGGAAAAAGCCGGCCTGGCCGAGCTGGGCAGCGCC
AAGCGCGTGGAAATCGGCAAGGAAAACACCACCATCATCGACGGCGCCGGCGACAAGGCCAAGATCGACGCGCGCGTGCA
AGCCATCCGCGCCCAGATCGACGCGGCGACCAGCGACTATGACCGCGAGAAGCTGCAGGAGCGCGTGGCCAAGCTGTCCG
GCGGCGTGGCGGTGATCCGCATCGGCGCGGCCACCGAAGTGGAAATGAAAGAGAAGAAAGACCGCGTGGACGACGCGCTG
CACGCCACCCGCGCCGCGGTGGAAGAAGGCATCGTCGCCGGCGGCGGCGTGGCCCTGCTGCGCGCCCGCGCCCACATCAA
GGAGCTGAAGGGCGACAACCCCGACCAGGACGCCGGCATCCAGATCGTGCTGCGCGCGCTGGAAGCGCCGCTGCGCGCCA
TCGCCGCCAATGCCGGCGACGAGCCGTCGGTGATCGTCAACAAGGTGCTGGAGGGCAAGGGCAACCACGGCTACAACGCC
GCCAGCGGCCAGTTCGGCGACCTGGTGGAAATGGGCGTGATCGACCCGACCAAGGTGACGCGCACCGCGCTGCAAAACGC
GGCCTCCATCGCCAGCCTGATCCTGACTACCGACGCCACCGTGGCCGAAGCGGGGCAGGACAGCAAGGCCAAAGCCCCGG
CGGAGCTGGATTACTGA

Upstream 100 bases:

>100_bases
TGGTGCTGCGCGAAGAGGATGTCTTCGGAGTCGTTGAAGACGCATCCCAATCCGGCCGCAAGGCTGCCTGATTTCTCACC
ATCATCACAGGAGTTAAACC

Downstream 100 bases:

>100_bases
TCCGCCGATCTGGTCCCCTTTCCTCATTGGCCCGCGCTCAGGCGCGGGCTTTTTTTCGTGGCGGAAACCTCAGCTCCATG
GCGGCACGAGCCATTCAGAC

Product: molecular chaperone GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MAAKEVRFHDNARERIVNGVNVLADAVKVTLGPKGRNVLLARSFGAPHITKDGVSVAKEIELKDPFENMGAQMVKEVASK
TADVAGDGTTTATVLAQAIVQEGMKYVASGMNPMDLKRGIDKAVHAVIKELQTLSKPVTNSKETAQVAALSANSDEAIGK
IIADAMDKVGKEGVITVEDGKSLDNELAVVEGMQFDRGYLSPYFITDPEKQTAVLEDPLVLLYDKKISNIRDLLPVLEQV
AKAGKPLLIVAEDVEGEALATLVVNSMRGILKVAAVKAPGFGDRRKAMLEDIAILTGGTVIAEETGLTLEKAGLAELGSA
KRVEIGKENTTIIDGAGDKAKIDARVQAIRAQIDAATSDYDREKLQERVAKLSGGVAVIRIGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVAGGGVALLRARAHIKELKGDNPDQDAGIQIVLRALEAPLRAIAANAGDEPSVIVNKVLEGKGNHGYNA
ASGQFGDLVEMGVIDPTKVTRTALQNAASIASLILTTDATVAEAGQDSKAKAPAELDY

Sequences:

>Translated_538_residues
MAAKEVRFHDNARERIVNGVNVLADAVKVTLGPKGRNVLLARSFGAPHITKDGVSVAKEIELKDPFENMGAQMVKEVASK
TADVAGDGTTTATVLAQAIVQEGMKYVASGMNPMDLKRGIDKAVHAVIKELQTLSKPVTNSKETAQVAALSANSDEAIGK
IIADAMDKVGKEGVITVEDGKSLDNELAVVEGMQFDRGYLSPYFITDPEKQTAVLEDPLVLLYDKKISNIRDLLPVLEQV
AKAGKPLLIVAEDVEGEALATLVVNSMRGILKVAAVKAPGFGDRRKAMLEDIAILTGGTVIAEETGLTLEKAGLAELGSA
KRVEIGKENTTIIDGAGDKAKIDARVQAIRAQIDAATSDYDREKLQERVAKLSGGVAVIRIGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVAGGGVALLRARAHIKELKGDNPDQDAGIQIVLRALEAPLRAIAANAGDEPSVIVNKVLEGKGNHGYNA
ASGQFGDLVEMGVIDPTKVTRTALQNAASIASLILTTDATVAEAGQDSKAKAPAELDY
>Mature_537_residues
AAKEVRFHDNARERIVNGVNVLADAVKVTLGPKGRNVLLARSFGAPHITKDGVSVAKEIELKDPFENMGAQMVKEVASKT
ADVAGDGTTTATVLAQAIVQEGMKYVASGMNPMDLKRGIDKAVHAVIKELQTLSKPVTNSKETAQVAALSANSDEAIGKI
IADAMDKVGKEGVITVEDGKSLDNELAVVEGMQFDRGYLSPYFITDPEKQTAVLEDPLVLLYDKKISNIRDLLPVLEQVA
KAGKPLLIVAEDVEGEALATLVVNSMRGILKVAAVKAPGFGDRRKAMLEDIAILTGGTVIAEETGLTLEKAGLAELGSAK
RVEIGKENTTIIDGAGDKAKIDARVQAIRAQIDAATSDYDREKLQERVAKLSGGVAVIRIGAATEVEMKEKKDRVDDALH
ATRAAVEEGIVAGGGVALLRARAHIKELKGDNPDQDAGIQIVLRALEAPLRAIAANAGDEPSVIVNKVLEGKGNHGYNAA
SGQFGDLVEMGVIDPTKVTRTALQNAASIASLILTTDATVAEAGQDSKAKAPAELDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=53.4971644612476, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=53.4971644612476, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI5453607, Length=540, Percent_Identity=23.5185185185185, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI38455427, Length=562, Percent_Identity=23.8434163701068, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI58331173, Length=554, Percent_Identity=22.7436823104693, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI302058290, Length=529, Percent_Identity=23.4404536862004, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790586, Length=523, Percent_Identity=71.8929254302103, Blast_Score=757, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=524, Percent_Identity=52.4809160305344, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI193210679, Length=206, Percent_Identity=53.8834951456311, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17564182, Length=548, Percent_Identity=23.5401459854015, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32566944, Length=214, Percent_Identity=27.1028037383178, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.6259541984733, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322350, Length=549, Percent_Identity=23.4972677595628, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=559, Percent_Identity=22.3613595706619, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641193, Length=522, Percent_Identity=52.4904214559387, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24641191, Length=522, Percent_Identity=52.4904214559387, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550936, Length=522, Percent_Identity=50.7662835249042, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550132, Length=522, Percent_Identity=50.7662835249042, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550935, Length=522, Percent_Identity=50.7662835249042, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17864606, Length=529, Percent_Identity=44.234404536862, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24584129, Length=536, Percent_Identity=38.9925373134328, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI19921262, Length=536, Percent_Identity=38.9925373134328, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24645179, Length=536, Percent_Identity=22.9477611940299, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24583944, Length=577, Percent_Identity=24.4367417677643, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_CHRVO (Q7NT31)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902903.1
- ProteinModelPortal:   Q7NT31
- SMR:   Q7NT31
- GeneID:   2549005
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3233
- NMPDR:   fig|243365.1.peg.3233
- HOGENOM:   HBG625289
- OMA:   KRVTQIK
- PhylomeDB:   Q7NT31
- ProtClustDB:   PRK00013
- BioCyc:   CVIO243365:CV_3233-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56678; Mature: 56547

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVRFHDNARERIVNGVNVLADAVKVTLGPKGRNVLLARSFGAPHITKDGVSVAKEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCHHHHHHHC
ELKDPFENMGAQMVKEVASKTADVAGDGTTTATVLAQAIVQEGMKYVASGMNPMDLKRGI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVHAVIKELQTLSKPVTNSKETAQVAALSANSDEAIGKIIADAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCCHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCC
KSLDNELAVVEGMQFDRGYLSPYFITDPEKQTAVLEDPLVLLYDKKISNIRDLLPVLEQV
CCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCHHHCCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIVAEDVEGEALATLVVNSMRGILKVAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKAGLAELGSAKRVEIGKENTTIIDGAGDKAKIDARVQAIRAQIDAATSDY
EEECCCCEEHHCCHHHCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
DREKLQERVAKLSGGVAVIRIGAATEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARAHIKELKGDNPDQDAGIQIVLRALEAPLRAIAANAGDEPSVIVNKVLEGKGNHGYNA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC
ASGQFGDLVEMGVIDPTKVTRTALQNAASIASLILTTDATVAEAGQDSKAKAPAELDY
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAKEVRFHDNARERIVNGVNVLADAVKVTLGPKGRNVLLARSFGAPHITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCHHHHHHHC
ELKDPFENMGAQMVKEVASKTADVAGDGTTTATVLAQAIVQEGMKYVASGMNPMDLKRGI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVHAVIKELQTLSKPVTNSKETAQVAALSANSDEAIGKIIADAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCCHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCC
KSLDNELAVVEGMQFDRGYLSPYFITDPEKQTAVLEDPLVLLYDKKISNIRDLLPVLEQV
CCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCHHHCCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIVAEDVEGEALATLVVNSMRGILKVAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKAGLAELGSAKRVEIGKENTTIIDGAGDKAKIDARVQAIRAQIDAATSDY
EEECCCCEEHHCCHHHCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
DREKLQERVAKLSGGVAVIRIGAATEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARAHIKELKGDNPDQDAGIQIVLRALEAPLRAIAANAGDEPSVIVNKVLEGKGNHGYNA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC
ASGQFGDLVEMGVIDPTKVTRTALQNAASIASLILTTDATVAEAGQDSKAKAPAELDY
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782