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The map label for this gene is atoC [H]

Identifier: 34498593

GI number: 34498593

Start: 3422948

End: 3424324

Strand: Reverse

Name: atoC [H]

Synonym: CV_3138

Alternate gene names: 34498593

Gene position: 3424324-3422948 (Counterclockwise)

Preceding gene: 34498594

Following gene: 34498592

Centisome position: 72.07

GC content: 63.11

Gene sequence:

>1377_bases
ATGAAGTATCTTCCGATTCTGGTGGTCGAAGACGACGCGGATCTGCGCGAGGCCATCGTCGACACGCTTTCCCTGGCGGG
CTATCCGACGCTGGAGGCCGCCGATGGCGGCTCCGCTCTGCAGAAGCTGGCCCAGGAGCCGGTGGGGCTGATCATTTCCG
ACGCCCAGATGGCGCCGATGGACGGCTATGACCTGTTCGAGGAGGCGAAGAAGCGCTATCCCGGCGTGCCCTTCATCCTG
ATGACCGCCTATGGCGTGATCGAGCGCGCGATCGAGCTCTTGCGCGCCGGGGCCGCGCATTACCTGCTCAAGCCCTTCGA
GCCGCAGAGCCTGTTGGCCGAGGTGGACAAGCATCTGCTGGCGATGCCGGGAGACGGCGGCGGCGATGTGGTGGCTGAAT
CCGCGGCGATGCGCCAGTTGTTCGCGTTGGCGGGCCGGGTGGCGCAGAGCGACGCCAGCGTGATGATTTCCGGCCCCAGC
GGCAGCGGCAAGGAAGTGCTGGCGCGTTACATCCACCGCCACTCCAAGCGCGGCAGCGGGCCGTTCGTCGCGGTCAATTG
CGCGGCTATCCCGGACAATCTGCTGGAGTCCACGCTGTTCGGCCATGAGCGCGGCGCCTTCACCGGCGCGGCGCAGGCCT
TGCCGGGCAAGTTCGAGCAGGCTCAGGGCGGCACCATCCTGCTGGACGAAGTGACCGAGATGCCGCTGCCCTTGCAGGCC
AAGCTGTTGCGGGTGCTGCAGGAGCGCGAGGTGGAGCGGATAGGCGCCACGCGCACCATCAAGCTGGACATTCGCGTGCT
GGCCACCTCCAATCGCGATCTGCAGGCGGCGGTGGAGGCTGGGAATTTCAGAGAAGACCTGTATTTCCGTCTGAATGTTT
TCCCGCTGAGAATACCGGCGCTCGCCGAGCGGCCGGAGGATATTCTACCTTTGGCACGATTCCTGCTTAAAAAACATGCG
GAGGCCGCTGGACGGGCATCTCTGGTGTTTTCCAGGGATGCGGAACGTCATTTGACGGCCTATAGTTGGGAGGGTAACAT
CCGCGAACTGGATAATGTCGTGCAGCGGGCGGTGATTCTTGCCGCCGGAGCGGAAATTCTTGCCGCCGATCTGATGCTGG
GCGATATTGCTGGCGTGGGGCAGTTTACCCGAGCGGAGTCCGAATCGGACAGTTCGGTGTCGGGTGAAACCGACATGAAA
ACCCTTGAGAAACGCCATATCCTGGAAACATTGGCGGCAGTCGGCGGCGTGAAGAAGCTGGCTGCGGAGAAACTGGGCAT
CAGCGAGCGCACTTTGCGCTACAAACTGCAGCGCTACCGTGATGAGGATGCTGCGGATGCCGGTGGAAATGTTCCGGAGG
GAAGTGGCACGGAGTAG

Upstream 100 bases:

>100_bases
CACGAGGTGCTGGGACTGCCCAGCATCGCCCAGAGGCTGGTCACGCTGGTTCACCAGCGTCAGCCGTCGGTGTAACCATA
ATTAAGAAGCATTGGACTCC

Downstream 100 bases:

>100_bases
CCATGTCAGTCAATAACATCGACCAGTTGCTTGGCGAGCTGAAAAGCGCGGCGGCGCTGGCTTCCGGCAAGCAGGCGCCG
GCGGCACAGCAGACGCCGCA

Product: two-component response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKYLPILVVEDDADLREAIVDTLSLAGYPTLEAADGGSALQKLAQEPVGLIISDAQMAPMDGYDLFEEAKKRYPGVPFIL
MTAYGVIERAIELLRAGAAHYLLKPFEPQSLLAEVDKHLLAMPGDGGGDVVAESAAMRQLFALAGRVAQSDASVMISGPS
GSGKEVLARYIHRHSKRGSGPFVAVNCAAIPDNLLESTLFGHERGAFTGAAQALPGKFEQAQGGTILLDEVTEMPLPLQA
KLLRVLQEREVERIGATRTIKLDIRVLATSNRDLQAAVEAGNFREDLYFRLNVFPLRIPALAERPEDILPLARFLLKKHA
EAAGRASLVFSRDAERHLTAYSWEGNIRELDNVVQRAVILAAGAEILAADLMLGDIAGVGQFTRAESESDSSVSGETDMK
TLEKRHILETLAAVGGVKKLAAEKLGISERTLRYKLQRYRDEDAADAGGNVPEGSGTE

Sequences:

>Translated_458_residues
MKYLPILVVEDDADLREAIVDTLSLAGYPTLEAADGGSALQKLAQEPVGLIISDAQMAPMDGYDLFEEAKKRYPGVPFIL
MTAYGVIERAIELLRAGAAHYLLKPFEPQSLLAEVDKHLLAMPGDGGGDVVAESAAMRQLFALAGRVAQSDASVMISGPS
GSGKEVLARYIHRHSKRGSGPFVAVNCAAIPDNLLESTLFGHERGAFTGAAQALPGKFEQAQGGTILLDEVTEMPLPLQA
KLLRVLQEREVERIGATRTIKLDIRVLATSNRDLQAAVEAGNFREDLYFRLNVFPLRIPALAERPEDILPLARFLLKKHA
EAAGRASLVFSRDAERHLTAYSWEGNIRELDNVVQRAVILAAGAEILAADLMLGDIAGVGQFTRAESESDSSVSGETDMK
TLEKRHILETLAAVGGVKKLAAEKLGISERTLRYKLQRYRDEDAADAGGNVPEGSGTE
>Mature_458_residues
MKYLPILVVEDDADLREAIVDTLSLAGYPTLEAADGGSALQKLAQEPVGLIISDAQMAPMDGYDLFEEAKKRYPGVPFIL
MTAYGVIERAIELLRAGAAHYLLKPFEPQSLLAEVDKHLLAMPGDGGGDVVAESAAMRQLFALAGRVAQSDASVMISGPS
GSGKEVLARYIHRHSKRGSGPFVAVNCAAIPDNLLESTLFGHERGAFTGAAQALPGKFEQAQGGTILLDEVTEMPLPLQA
KLLRVLQEREVERIGATRTIKLDIRVLATSNRDLQAAVEAGNFREDLYFRLNVFPLRIPALAERPEDILPLARFLLKKHA
EAAGRASLVFSRDAERHLTAYSWEGNIRELDNVVQRAVILAAGAEILAADLMLGDIAGVGQFTRAESESDSSVSGETDMK
TLEKRHILETLAAVGGVKKLAAEKLGISERTLRYKLQRYRDEDAADAGGNVPEGSGTE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=44.0265486725664, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1788905, Length=455, Percent_Identity=40.8791208791209, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=40.625, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=37.2844827586207, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=43.9252336448598, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI1789087, Length=314, Percent_Identity=44.9044585987261, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1789233, Length=317, Percent_Identity=41.6403785488959, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87082152, Length=247, Percent_Identity=46.1538461538462, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87081872, Length=324, Percent_Identity=36.7283950617284, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786524, Length=249, Percent_Identity=44.1767068273092, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1787583, Length=310, Percent_Identity=35.1612903225806, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789828, Length=229, Percent_Identity=38.4279475982533, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI87081858, Length=345, Percent_Identity=28.695652173913, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49422; Mature: 49422

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLPILVVEDDADLREAIVDTLSLAGYPTLEAADGGSALQKLAQEPVGLIISDAQMAPM
CCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCC
DGYDLFEEAKKRYPGVPFILMTAYGVIERAIELLRAGAAHYLLKPFEPQSLLAEVDKHLL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHE
AMPGDGGGDVVAESAAMRQLFALAGRVAQSDASVMISGPSGSGKEVLARYIHRHSKRGSG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCC
PFVAVNCAAIPDNLLESTLFGHERGAFTGAAQALPGKFEQAQGGTILLDEVTEMPLPLQA
CEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCHHCCCCEEEEEHHHCCCCCHHH
KLLRVLQEREVERIGATRTIKLDIRVLATSNRDLQAAVEAGNFREDLYFRLNVFPLRIPA
HHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHHHCCCCCCCEEEEEEEEEEECCH
LAERPEDILPLARFLLKKHAEAAGRASLVFSRDAERHLTAYSWEGNIRELDNVVQRAVIL
HHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCEEEECCCCHHHHHHHHHHHHHH
AAGAEILAADLMLGDIAGVGQFTRAESESDSSVSGETDMKTLEKRHILETLAAVGGVKKL
HHCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AAEKLGISERTLRYKLQRYRDEDAADAGGNVPEGSGTE
HHHHCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKYLPILVVEDDADLREAIVDTLSLAGYPTLEAADGGSALQKLAQEPVGLIISDAQMAPM
CCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCC
DGYDLFEEAKKRYPGVPFILMTAYGVIERAIELLRAGAAHYLLKPFEPQSLLAEVDKHLL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHE
AMPGDGGGDVVAESAAMRQLFALAGRVAQSDASVMISGPSGSGKEVLARYIHRHSKRGSG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCC
PFVAVNCAAIPDNLLESTLFGHERGAFTGAAQALPGKFEQAQGGTILLDEVTEMPLPLQA
CEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCHHCCCCEEEEEHHHCCCCCHHH
KLLRVLQEREVERIGATRTIKLDIRVLATSNRDLQAAVEAGNFREDLYFRLNVFPLRIPA
HHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHHHCCCCCCCEEEEEEEEEEECCH
LAERPEDILPLARFLLKKHAEAAGRASLVFSRDAERHLTAYSWEGNIRELDNVVQRAVIL
HHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCEEEECCCCHHHHHHHHHHHHHH
AAGAEILAADLMLGDIAGVGQFTRAESESDSSVSGETDMKTLEKRHILETLAAVGGVKKL
HHCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AAEKLGISERTLRYKLQRYRDEDAADAGGNVPEGSGTE
HHHHCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]