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The map label for this gene is envZ [H]

Identifier: 34498561

GI number: 34498561

Start: 3393523

End: 3394980

Strand: Reverse

Name: envZ [H]

Synonym: CV_3106

Alternate gene names: 34498561

Gene position: 3394980-3393523 (Counterclockwise)

Preceding gene: 34498562

Following gene: 34498559

Centisome position: 71.46

GC content: 68.52

Gene sequence:

>1458_bases
ATGAGGCGTCTGCCTCGCACCCTGTACGGCCAGTTGTTGTTGACGCTGCTGACCAGCGTGCTGTTGGCCAACGTGATCGG
CATCGCGCTGGTGCTGACCGACCGCGAGCGGCTCAGCCGCACCTTGCGCGCCGAGTATGTGGCGCAGCACCTGGCGGACA
TGATCAATCTGCTGGATGAGACCGCCGCCGCCAGCCGGCCCAAGCTGGCCGGCGCGCTGACCTCGCCCAACGCCCAGGTG
CTGCTCGACCACCCCTGGCTGGCGGGAGGCAAGACCAGCCTGCCGGAGGCGGGGAAGCTGCGCGAGTTGATCCTGGCCGA
TCTCGGCTCCCCGTTCCGATTGCAGGTGCTGTCGTTCCGCGACGATTCCCCCGATGCGGCGGAGGACTTGCTTAGGCCCT
TCGTCGAGCCGGGCCGGCATGTGTTCACGCCGGGCAAGCAGTTCTGGGTTCAGGCTTTCCCCAACAAGCTGGGCGAGGGC
GGGCCGGAGTTCAAGATCCAGATGGCGACGGTGCAGGCGCAGCTGCGCGACGGCACCGTGGTGACCTTTCGCATCGGCCA
GATATCCAGCGCGGCGGAAACGCCGTGGCGGGTGACCGCCTGGCTGCTGCTGGTGGCCCTGGTGGTGGCGGCGGCGTCCG
CTTGGGCGGTGCGTCGGCTGACGCGTCCCTTGTCGCTGTTCTCCAAGGCGGCGAGCGGGCTGGCGTCCGATCTGAACCAA
CCCCCGTTGCCGGAGACCGGCACCCAGGAAGTGGTCAACGCCACCCGGGCCTTCAACCGCATGCAGCAGGAGCTGCAGCG
CTACCTGCAGACCCGCAGCCAGATGCTGGCGGGCGTTTCGCACGACCTCCGGCTGCCCATCACCCGGGTCAGGCTGCGGC
TGGAGCAGCTGGAGGAGGGCAGCGCCCGCCAAGCGATAGAGCGGGACCTGTCCGAGATGGACCAATTGATAGGCGACACA
TTGGCTTATTTGCGCATGGGGCAGGGCAACGAGAATGCCGTGCTGCTCAATGTGGGCGCGCTGCTCGAGGGCGTGATCGA
AGACATCGAGGCGCTGGGCGCGGAGGTGGCGTACCAGGCGGAGCCGGTCAGGCCGTTGTACGCGCGGCCGCAGGCCTTGC
GGCGGGCCATCGCCAATCTGCTGGAGAATGCCCGGCGCTACGGCGGGGATGGCGTGGTGGAAGTGGCGCTGCGCGAGCGC
GCCGGCCGGATCGAGATCACGGTGCGCGACCATGGTCCCGGCATCGCCGAGGCCGACCTGGAGCGCGTGTTCGAGCCCTA
TGTCCGGCTGGAGCATTCCCGGGCCAGGCACACCGGCGGCAGCGGACTGGGGCTGGCGATCTCCCGCGCCATCGCGCGGG
AACACCATGGCGACATCCTCTTGTTCAATCACCCGATGGGGGGATTGTGCGCGGAGCTGCATTTCCCTGCGCTGCGGGAT
GCGGCTTCGGAGCGTTGA

Upstream 100 bases:

>100_bases
GCCTGCGCCGCCGCCTGGGAGACGACGCGCGCGAGCCGCTGCTGATCAAGACCATACGCAGCGGCGGCTACATGCTGGCT
TGCGAGGTGGTGCCGGTGCG

Downstream 100 bases:

>100_bases
GCGGCGAGCCCGGCGCAGCGCGGCGATGACGGGCGGGCGCGCGCGCTTAACAATGTTTGACAAACAGGGTGTCGGGGGAA
ATTGATTCGAAAAACGAAAG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MRRLPRTLYGQLLLTLLTSVLLANVIGIALVLTDRERLSRTLRAEYVAQHLADMINLLDETAAASRPKLAGALTSPNAQV
LLDHPWLAGGKTSLPEAGKLRELILADLGSPFRLQVLSFRDDSPDAAEDLLRPFVEPGRHVFTPGKQFWVQAFPNKLGEG
GPEFKIQMATVQAQLRDGTVVTFRIGQISSAAETPWRVTAWLLLVALVVAAASAWAVRRLTRPLSLFSKAASGLASDLNQ
PPLPETGTQEVVNATRAFNRMQQELQRYLQTRSQMLAGVSHDLRLPITRVRLRLEQLEEGSARQAIERDLSEMDQLIGDT
LAYLRMGQGNENAVLLNVGALLEGVIEDIEALGAEVAYQAEPVRPLYARPQALRRAIANLLENARRYGGDGVVEVALRER
AGRIEITVRDHGPGIAEADLERVFEPYVRLEHSRARHTGGSGLGLAISRAIAREHHGDILLFNHPMGGLCAELHFPALRD
AASER

Sequences:

>Translated_485_residues
MRRLPRTLYGQLLLTLLTSVLLANVIGIALVLTDRERLSRTLRAEYVAQHLADMINLLDETAAASRPKLAGALTSPNAQV
LLDHPWLAGGKTSLPEAGKLRELILADLGSPFRLQVLSFRDDSPDAAEDLLRPFVEPGRHVFTPGKQFWVQAFPNKLGEG
GPEFKIQMATVQAQLRDGTVVTFRIGQISSAAETPWRVTAWLLLVALVVAAASAWAVRRLTRPLSLFSKAASGLASDLNQ
PPLPETGTQEVVNATRAFNRMQQELQRYLQTRSQMLAGVSHDLRLPITRVRLRLEQLEEGSARQAIERDLSEMDQLIGDT
LAYLRMGQGNENAVLLNVGALLEGVIEDIEALGAEVAYQAEPVRPLYARPQALRRAIANLLENARRYGGDGVVEVALRER
AGRIEITVRDHGPGIAEADLERVFEPYVRLEHSRARHTGGSGLGLAISRAIAREHHGDILLFNHPMGGLCAELHFPALRD
AASER
>Mature_485_residues
MRRLPRTLYGQLLLTLLTSVLLANVIGIALVLTDRERLSRTLRAEYVAQHLADMINLLDETAAASRPKLAGALTSPNAQV
LLDHPWLAGGKTSLPEAGKLRELILADLGSPFRLQVLSFRDDSPDAAEDLLRPFVEPGRHVFTPGKQFWVQAFPNKLGEG
GPEFKIQMATVQAQLRDGTVVTFRIGQISSAAETPWRVTAWLLLVALVVAAASAWAVRRLTRPLSLFSKAASGLASDLNQ
PPLPETGTQEVVNATRAFNRMQQELQRYLQTRSQMLAGVSHDLRLPITRVRLRLEQLEEGSARQAIERDLSEMDQLIGDT
LAYLRMGQGNENAVLLNVGALLEGVIEDIEALGAEVAYQAEPVRPLYARPQALRRAIANLLENARRYGGDGVVEVALRER
AGRIEITVRDHGPGIAEADLERVFEPYVRLEHSRARHTGGSGLGLAISRAIAREHHGDILLFNHPMGGLCAELHFPALRD
AASER

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=289, Percent_Identity=34.9480968858132, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=32.3308270676692, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=35.5263157894737, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788393, Length=306, Percent_Identity=27.1241830065359, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786783, Length=273, Percent_Identity=26.3736263736264, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=27.6094276094276, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790551, Length=259, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786912, Length=256, Percent_Identity=30.46875, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=27.1551724137931, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=24.21875, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=25.6410256410256, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787374, Length=289, Percent_Identity=25.9515570934256, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=333, Percent_Identity=24.9249249249249, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1786600, Length=253, Percent_Identity=28.8537549407115, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=297, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=25.5230125523013, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=25.7261410788382, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=25.6521739130435, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=25.2252252252252, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53305; Mature: 53305

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLPRTLYGQLLLTLLTSVLLANVIGIALVLTDRERLSRTLRAEYVAQHLADMINLLDE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHH
TAAASRPKLAGALTSPNAQVLLDHPWLAGGKTSLPEAGKLRELILADLGSPFRLQVLSFR
HHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEC
DDSPDAAEDLLRPFVEPGRHVFTPGKQFWVQAFPNKLGEGGPEFKIQMATVQAQLRDGTV
CCCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCE
VTFRIGQISSAAETPWRVTAWLLLVALVVAAASAWAVRRLTRPLSLFSKAASGLASDLNQ
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PPLPETGTQEVVNATRAFNRMQQELQRYLQTRSQMLAGVSHDLRLPITRVRLRLEQLEEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
SARQAIERDLSEMDQLIGDTLAYLRMGQGNENAVLLNVGALLEGVIEDIEALGAEVAYQA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCHHHHHCC
EPVRPLYARPQALRRAIANLLENARRYGGDGVVEVALRERAGRIEITVRDHGPGIAEADL
CCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCEEEEEEECCCCCCCHHHH
ERVFEPYVRLEHSRARHTGGSGLGLAISRAIAREHHGDILLFNHPMGGLCAELHFPALRD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCHHHHH
AASER
HCCCC
>Mature Secondary Structure
MRRLPRTLYGQLLLTLLTSVLLANVIGIALVLTDRERLSRTLRAEYVAQHLADMINLLDE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHH
TAAASRPKLAGALTSPNAQVLLDHPWLAGGKTSLPEAGKLRELILADLGSPFRLQVLSFR
HHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEC
DDSPDAAEDLLRPFVEPGRHVFTPGKQFWVQAFPNKLGEGGPEFKIQMATVQAQLRDGTV
CCCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCE
VTFRIGQISSAAETPWRVTAWLLLVALVVAAASAWAVRRLTRPLSLFSKAASGLASDLNQ
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PPLPETGTQEVVNATRAFNRMQQELQRYLQTRSQMLAGVSHDLRLPITRVRLRLEQLEEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
SARQAIERDLSEMDQLIGDTLAYLRMGQGNENAVLLNVGALLEGVIEDIEALGAEVAYQA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCHHHHHCC
EPVRPLYARPQALRRAIANLLENARRYGGDGVVEVALRERAGRIEITVRDHGPGIAEADL
CCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCEEEEEEECCCCCCCHHHH
ERVFEPYVRLEHSRARHTGGSGLGLAISRAIAREHHGDILLFNHPMGGLCAELHFPALRD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCHHHHH
AASER
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]