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The map label for this gene is yhcR [H]

Identifier: 34498538

GI number: 34498538

Start: 3358368

End: 3360068

Strand: Reverse

Name: yhcR [H]

Synonym: CV_3083

Alternate gene names: 34498538

Gene position: 3360068-3358368 (Counterclockwise)

Preceding gene: 34498539

Following gene: 34498534

Centisome position: 70.72

GC content: 65.61

Gene sequence:

>1701_bases
ATGAAACTGATTCCGTTGGGCATGGCCCTGGGCGCCTCGCTGGCGCTGGGCGGCTGCATGTCCGATTCCTCTTCCGTGAG
CGCGACGCGCACCCAGACCGGCGACGAAGCCGCCGCTGGCCAGGTGGCGGTCAAGATGATCGCCTTCAACGATTTTCACG
GCAATCTGGAGGCGCCGGGCACGCTGTCGATCCCCGATCCAAAAGACGCGAGCAAGACCGTCAAAGTGACGGCCGGCGGC
GTCGACTACCTGGCGGCCTGGGTCAAGCAGCTGCGCGCGCAGTCGCCGAACACCGTGGTGGTGTCGGCCGGCGACCTGAT
AGGCGCCAGCCCGCTGGTGTCCGGCCTGTTCCACGACGAGCCGACCATCGAGGCGATGAACCTGCTGGGCCTGGACATCA
ACGCGGTGGGCAACCACGAGTTCGACGACGGCCAGGACGAACTGCTGCGTATGCAGAACGGTGGCTGCAAGGCGGGCGGC
GGCAACACCACTTGCCAGAACGGCGGCAGCTTCGCCGGCGCCAAATTCAAGTTCCTGGCCGCCAACGTGCAGAAACAGGA
CGGCGGCACGCTGTTCCCCGCCTATGAGATCAAGAAATACGGCAATATTCCGGTCGCCTTCATCGGCATGACGCTGAAAG
GCACGCCTGACATCGTCTCGCCCACCGGCATCCAGGGGTTGAGCTTCAAGGACGAGGCCGACACCGTCAACGCGCTGGTG
CCCAAGCTGAAGGCGCAGGGCGTGGCCGCGGTGGTGGTGGTGGTGCACGAGGGCGGCTACCAGAGCGGCAATTACAACGA
GTGCAAGGGCATCTCCGGCCCCATCGTCGACATCGTCAAGAAGCTGGACAAGGCGGTGGGTCTGGTGGTCACCGGCCACA
CCCACCAGGCCTACAACTGCCAGATCGACGGCCGCACCGTCACCAGCGCCAAGAACTACGGACAGTTGTTCACCGAGATC
AATTTCAAGCTGAGCCACGCGACGCGGACTTTCGTGCCGGGATCCATCCAGGCGGTCAACCGCCCGGTGACCCAGGACAT
CGCGCCGCTGGCCAATATCAGCAGCCTGGTCCAGTTCTATTTGAACAAGGCCGCGCCCATCGCCAACAAGCCGGTGGGCA
CGCTGGCGGGCGGCTTGACCCGCGCAGCCAGCCCGGCGGGCGAGTCGACGCTGGGCGACGCGATCGCCGATTCGCAACTG
GAAGCCGGCAAGGCGCAGGGCGCGGTGGCCGCCTTCATGAACCCGGGCGGCATCCGCGCCGACCTGGCGCCGGCAGCGGA
TGGCAGCGTCAGCTACAAGCAGATCTATACCGTGCAGCCGTTCGGCAACACCATGATGACGATGAAGCTGACCGGCGAGC
AGATAGACCGCCTGCTGGAGCAGCAGTGGAGCAATCCGTCCCAGCCCAAGATCCTGCAGGTGTCGTCCGGCTTCCGCTAC
AGCTGGAGCCAGTCGGCGCCGGCCGGCAGCAAGGTGGACATCGGCAGCATCACGATCAACGGCGTGAAGATCGACCCCAA
GGCCAGTTACACGGTGCAGGTGAACAACTTCATCGCCGGCGGCGGAGACGGCTTCACCGTGTTGACCGAGGGCGTCAACC
GCGTCGGCGGCGGGGTGGACGTGGACGTGCTGCAAAGCTATCTGGCGGCGCATCCCGCGCTGCCGGTGCCGGCGCTTGAC
CGCATCGTCCAGTTGCCGTGA

Upstream 100 bases:

>100_bases
CAGTTCAAATGTCATTGAACTTGTGTATCTTTGCCGATCTCGATGTCATGCCGTGGCAGCGGCGGATATCGGGTGAAGAC
TATTACAAGGGAGCAAGTCA

Downstream 100 bases:

>100_bases
CCACCGGCGTTCAGAAATAGTCGACCTGGCTGGAAGCCGGCGGCGCCTCCAGCTCGCCGCCGGCTTCCAACTGTTCGTAG
CCGCGCACCTGGTTGCGGCC

Product: UDP-sugar diphosphatase

Products: UMP; alpha-D-aldose 1-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MKLIPLGMALGASLALGGCMSDSSSVSATRTQTGDEAAAGQVAVKMIAFNDFHGNLEAPGTLSIPDPKDASKTVKVTAGG
VDYLAAWVKQLRAQSPNTVVVSAGDLIGASPLVSGLFHDEPTIEAMNLLGLDINAVGNHEFDDGQDELLRMQNGGCKAGG
GNTTCQNGGSFAGAKFKFLAANVQKQDGGTLFPAYEIKKYGNIPVAFIGMTLKGTPDIVSPTGIQGLSFKDEADTVNALV
PKLKAQGVAAVVVVVHEGGYQSGNYNECKGISGPIVDIVKKLDKAVGLVVTGHTHQAYNCQIDGRTVTSAKNYGQLFTEI
NFKLSHATRTFVPGSIQAVNRPVTQDIAPLANISSLVQFYLNKAAPIANKPVGTLAGGLTRAASPAGESTLGDAIADSQL
EAGKAQGAVAAFMNPGGIRADLAPAADGSVSYKQIYTVQPFGNTMMTMKLTGEQIDRLLEQQWSNPSQPKILQVSSGFRY
SWSQSAPAGSKVDIGSITINGVKIDPKASYTVQVNNFIAGGGDGFTVLTEGVNRVGGGVDVDVLQSYLAAHPALPVPALD
RIVQLP

Sequences:

>Translated_566_residues
MKLIPLGMALGASLALGGCMSDSSSVSATRTQTGDEAAAGQVAVKMIAFNDFHGNLEAPGTLSIPDPKDASKTVKVTAGG
VDYLAAWVKQLRAQSPNTVVVSAGDLIGASPLVSGLFHDEPTIEAMNLLGLDINAVGNHEFDDGQDELLRMQNGGCKAGG
GNTTCQNGGSFAGAKFKFLAANVQKQDGGTLFPAYEIKKYGNIPVAFIGMTLKGTPDIVSPTGIQGLSFKDEADTVNALV
PKLKAQGVAAVVVVVHEGGYQSGNYNECKGISGPIVDIVKKLDKAVGLVVTGHTHQAYNCQIDGRTVTSAKNYGQLFTEI
NFKLSHATRTFVPGSIQAVNRPVTQDIAPLANISSLVQFYLNKAAPIANKPVGTLAGGLTRAASPAGESTLGDAIADSQL
EAGKAQGAVAAFMNPGGIRADLAPAADGSVSYKQIYTVQPFGNTMMTMKLTGEQIDRLLEQQWSNPSQPKILQVSSGFRY
SWSQSAPAGSKVDIGSITINGVKIDPKASYTVQVNNFIAGGGDGFTVLTEGVNRVGGGVDVDVLQSYLAAHPALPVPALD
RIVQLP
>Mature_566_residues
MKLIPLGMALGASLALGGCMSDSSSVSATRTQTGDEAAAGQVAVKMIAFNDFHGNLEAPGTLSIPDPKDASKTVKVTAGG
VDYLAAWVKQLRAQSPNTVVVSAGDLIGASPLVSGLFHDEPTIEAMNLLGLDINAVGNHEFDDGQDELLRMQNGGCKAGG
GNTTCQNGGSFAGAKFKFLAANVQKQDGGTLFPAYEIKKYGNIPVAFIGMTLKGTPDIVSPTGIQGLSFKDEADTVNALV
PKLKAQGVAAVVVVVHEGGYQSGNYNECKGISGPIVDIVKKLDKAVGLVVTGHTHQAYNCQIDGRTVTSAKNYGQLFTEI
NFKLSHATRTFVPGSIQAVNRPVTQDIAPLANISSLVQFYLNKAAPIANKPVGTLAGGLTRAASPAGESTLGDAIADSQL
EAGKAQGAVAAFMNPGGIRADLAPAADGSVSYKQIYTVQPFGNTMMTMKLTGEQIDRLLEQQWSNPSQPKILQVSSGFRY
SWSQSAPAGSKVDIGSITINGVKIDPKASYTVQVNNFIAGGGDGFTVLTEGVNRVGGGVDVDVLQSYLAAHPALPVPALD
RIVQLP

Specific function: Sugar-nonspecific endonuclease that yields nucleotide 3'-monophosphate products. No 5'-nucleotidase activity was detected, using 5'-AMP as the substrate, in the presence of diverse divalent metals and with various pH values [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TNase-like domain [H]

Homologues:

Organism=Homo sapiens, GI4505467, Length=229, Percent_Identity=28.82096069869, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1786687, Length=509, Percent_Identity=25.7367387033399, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24641187, Length=554, Percent_Identity=25.4512635379061, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573524, Length=563, Percent_Identity=23.0905861456483, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922446, Length=535, Percent_Identity=24.1121495327103, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24654424, Length=535, Percent_Identity=24.1121495327103, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161076508, Length=461, Percent_Identity=20.6073752711497, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24652512, Length=463, Percent_Identity=20.5183585313175, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921980, Length=462, Percent_Identity=20.5627705627706, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR019948
- InterPro:   IPR019931
- InterPro:   IPR004843
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR016071
- InterPro:   IPR006021 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00746 Gram_pos_anchor; PF00149 Metallophos; PF00565 SNase; PF01336 tRNA_anti [H]

EC number: 3.6.1.45; 3.1.3.5

Molecular weight: Translated: 58730; Mature: 58730

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIPLGMALGASLALGGCMSDSSSVSATRTQTGDEAAAGQVAVKMIAFNDFHGNLEAPG
CEEEECHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHCCCEEEEEEEEECCCCCCCCCE
TLSIPDPKDASKTVKVTAGGVDYLAAWVKQLRAQSPNTVVVSAGDLIGASPLVSGLFHDE
EECCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCC
PTIEAMNLLGLDINAVGNHEFDDGQDELLRMQNGGCKAGGGNTTCQNGGSFAGAKFKFLA
CCHHHHHHCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
ANVQKQDGGTLFPAYEIKKYGNIPVAFIGMTLKGTPDIVSPTGIQGLSFKDEADTVNALV
EECEECCCCEECCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
PKLKAQGVAAVVVVVHEGGYQSGNYNECKGISGPIVDIVKKLDKAVGLVVTGHTHQAYNC
HHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCEEEE
QIDGRTVTSAKNYGQLFTEINFKLSHATRTFVPGSIQAVNRPVTQDIAPLANISSLVQFY
EECCEEEECCHHHHHEEHEEEEEEECCEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHH
LNKAAPIANKPVGTLAGGLTRAASPAGESTLGDAIADSQLEAGKAQGAVAAFMNPGGIRA
HHCCCCCCCCCHHHHHCCHHHCCCCCCCCHHHHHHHCCHHHCCCCCCCEEEEECCCCCEE
DLAPAADGSVSYKQIYTVQPFGNTMMTMKLTGEQIDRLLEQQWSNPSQPKILQVSSGFRY
ECCCCCCCCCEEEEEEEECCCCCEEEEEEECHHHHHHHHHHHCCCCCCCEEEEECCCCEE
SWSQSAPAGSKVDIGSITINGVKIDPKASYTVQVNNFIAGGGDGFTVLTEGVNRVGGGVD
CCCCCCCCCCEEEECEEEEEEEEECCCCEEEEEECCEEECCCCCHHHHHHHHHHHCCCCC
VDVLQSYLAAHPALPVPALDRIVQLP
HHHHHHHHHHCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MKLIPLGMALGASLALGGCMSDSSSVSATRTQTGDEAAAGQVAVKMIAFNDFHGNLEAPG
CEEEECHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHCCCEEEEEEEEECCCCCCCCCE
TLSIPDPKDASKTVKVTAGGVDYLAAWVKQLRAQSPNTVVVSAGDLIGASPLVSGLFHDE
EECCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCC
PTIEAMNLLGLDINAVGNHEFDDGQDELLRMQNGGCKAGGGNTTCQNGGSFAGAKFKFLA
CCHHHHHHCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
ANVQKQDGGTLFPAYEIKKYGNIPVAFIGMTLKGTPDIVSPTGIQGLSFKDEADTVNALV
EECEECCCCEECCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
PKLKAQGVAAVVVVVHEGGYQSGNYNECKGISGPIVDIVKKLDKAVGLVVTGHTHQAYNC
HHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCEEEE
QIDGRTVTSAKNYGQLFTEINFKLSHATRTFVPGSIQAVNRPVTQDIAPLANISSLVQFY
EECCEEEECCHHHHHEEHEEEEEEECCEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHH
LNKAAPIANKPVGTLAGGLTRAASPAGESTLGDAIADSQLEAGKAQGAVAAFMNPGGIRA
HHCCCCCCCCCHHHHHCCHHHCCCCCCCCHHHHHHHCCHHHCCCCCCCEEEEECCCCCEE
DLAPAADGSVSYKQIYTVQPFGNTMMTMKLTGEQIDRLLEQQWSNPSQPKILQVSSGFRY
ECCCCCCCCCEEEEEEEECCCCCEEEEEEECHHHHHHHHHHHCCCCCCCEEEEECCCCEE
SWSQSAPAGSKVDIGSITINGVKIDPKASYTVQVNNFIAGGGDGFTVLTEGVNRVGGGVD
CCCCCCCCCCEEEECEEEEEEEEECCCCEEEEEECCEEECCCCCHHHHHHHHHHHCCCCC
VDVLQSYLAAHPALPVPALDRIVQLP
HHHHHHHHHHCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-sugar; H2O

Specific reaction: UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Inhibitor from Salmonella typhimurium cytoplasm [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]