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The map label for this gene is yciK [H]

Identifier: 34498431

GI number: 34498431

Start: 3253402

End: 3254163

Strand: Reverse

Name: yciK [H]

Synonym: CV_2976

Alternate gene names: 34498431

Gene position: 3254163-3253402 (Counterclockwise)

Preceding gene: 34498432

Following gene: 34498430

Centisome position: 68.49

GC content: 67.19

Gene sequence:

>762_bases
ATGACGATGAAGACCGAATTTGCCCAAGACGCGCTGGCAGGGCGCGTGATCCTGATCACCGGCGCCTCGCAGGGCATAGG
ACGCGAAGCCGCGCTGACTTTCGCCCGCCACGGCGCCACCGTGGTGCTGCTCTCGCGCAGCGTCAAGGGGCTGGAGAAGG
TCTACGATGAAATCGTGGCGGCCGGCGGGCCGGAGCCGGCGGCGGTGCCGCTTGACCTGCTGAACGCGGGCGAGAACGAG
TTCAACCAGCTGGCGCTGACCATCCAGCGCGAGTTCGGGCGCCTGGACGGCATCGCGCACTGCGCCTCGCATTTCTATGC
ATTGTCGCCGTTGACCAACCAGACCATAGAAGAGTGGATGAACCAGTATCGGATCAACACCGTGGCGCCGTTCGCGCTGA
CCCGCGCCTGCCTGCCGCTGCTGAAGGAGGCGCCGGACGCGTCGGTGTTGTTCGTCGGCGAGCACCATGCCCTGCATCCG
GCCGCCTACTGGGGCGGTTTCGGCGCTTCCAACGCCGGCTTGCCGTACCTGACCAAGGTGGCGGCCGACGAATGGGAGAT
GTTGCCCAGTCTGCGCGTCAACCTGCTGTTGCCGGGGCCGGTCAATTCGCCGCAGCGCAACCGCACCCATCCGGGCGAGG
ACAAGAGCGAGCGCGCCGATCTGGCCGACCTGATGCCGCATTTCCTGTACTGGCTGGGCGCGGACAGCCGCGGCCGCAGC
GGGGAAGTGGTGGAGCTGGACTTGCGCAAACCGCGCGGCTGA

Upstream 100 bases:

>100_bases
GAGATTGGGCGCATCCCGATTACCCGGCGACGCTCGAAGGAGCGGCGCGCAGCGGCGTGGCCGCGGCGGCGGCCGCATTG
CAGGACTTAGGAATAGAACC

Downstream 100 bases:

>100_bases
AACGGGGAGAGGGCATGAAGAGACTGCTGCTGTTGGCCTGCGCGCTGCTGCTGGGCGGCTGCAACTACGTGAACAGCGTG
ACCGGCCTGAGCAAGGATTC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTMKTEFAQDALAGRVILITGASQGIGREAALTFARHGATVVLLSRSVKGLEKVYDEIVAAGGPEPAAVPLDLLNAGENE
FNQLALTIQREFGRLDGIAHCASHFYALSPLTNQTIEEWMNQYRINTVAPFALTRACLPLLKEAPDASVLFVGEHHALHP
AAYWGGFGASNAGLPYLTKVAADEWEMLPSLRVNLLLPGPVNSPQRNRTHPGEDKSERADLADLMPHFLYWLGADSRGRS
GEVVELDLRKPRG

Sequences:

>Translated_253_residues
MTMKTEFAQDALAGRVILITGASQGIGREAALTFARHGATVVLLSRSVKGLEKVYDEIVAAGGPEPAAVPLDLLNAGENE
FNQLALTIQREFGRLDGIAHCASHFYALSPLTNQTIEEWMNQYRINTVAPFALTRACLPLLKEAPDASVLFVGEHHALHP
AAYWGGFGASNAGLPYLTKVAADEWEMLPSLRVNLLLPGPVNSPQRNRTHPGEDKSERADLADLMPHFLYWLGADSRGRS
GEVVELDLRKPRG
>Mature_252_residues
TMKTEFAQDALAGRVILITGASQGIGREAALTFARHGATVVLLSRSVKGLEKVYDEIVAAGGPEPAAVPLDLLNAGENEF
NQLALTIQREFGRLDGIAHCASHFYALSPLTNQTIEEWMNQYRINTVAPFALTRACLPLLKEAPDASVLFVGEHHALHPA
AYWGGFGASNAGLPYLTKVAADEWEMLPSLRVNLLLPGPVNSPQRNRTHPGEDKSERADLADLMPHFLYWLGADSRGRSG
EVVELDLRKPRG

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=197, Percent_Identity=29.4416243654822, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787526, Length=239, Percent_Identity=38.0753138075314, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=28.125, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082100, Length=231, Percent_Identity=27.7056277056277, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=198, Percent_Identity=28.7878787878788, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=153, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=199, Percent_Identity=29.6482412060301, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=196, Percent_Identity=30.6122448979592, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI23397609, Length=199, Percent_Identity=32.1608040201005, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357673, Length=162, Percent_Identity=30.8641975308642, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27519; Mature: 27387

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKTEFAQDALAGRVILITGASQGIGREAALTFARHGATVVLLSRSVKGLEKVYDEIVA
CCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHH
AGGPEPAAVPLDLLNAGENEFNQLALTIQREFGRLDGIAHCASHFYALSPLTNQTIEEWM
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHH
NQYRINTVAPFALTRACLPLLKEAPDASVLFVGEHHALHPAAYWGGFGASNAGLPYLTKV
HHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCHHHHH
AADEWEMLPSLRVNLLLPGPVNSPQRNRTHPGEDKSERADLADLMPHFLYWLGADSRGRS
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
GEVVELDLRKPRG
CCEEEEECCCCCC
>Mature Secondary Structure 
TMKTEFAQDALAGRVILITGASQGIGREAALTFARHGATVVLLSRSVKGLEKVYDEIVA
CCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHH
AGGPEPAAVPLDLLNAGENEFNQLALTIQREFGRLDGIAHCASHFYALSPLTNQTIEEWM
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHH
NQYRINTVAPFALTRACLPLLKEAPDASVLFVGEHHALHPAAYWGGFGASNAGLPYLTKV
HHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCHHHHH
AADEWEMLPSLRVNLLLPGPVNSPQRNRTHPGEDKSERADLADLMPHFLYWLGADSRGRS
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
GEVVELDLRKPRG
CCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]