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The map label for this gene is aaeB [H]

Identifier: 34498300

GI number: 34498300

Start: 3100232

End: 3102232

Strand: Direct

Name: aaeB [H]

Synonym: CV_2845

Alternate gene names: 34498300

Gene position: 3100232-3102232 (Clockwise)

Preceding gene: 34498299

Following gene: 34498301

Centisome position: 65.25

GC content: 72.01

Gene sequence:

>2001_bases
CTGTTCTCGGCTCGCACCTTCGCCGCCGCGATGCTGGCGCTGTACATCGCGCTGGCGCTGGGCCTGCCTCGCCCGAGCTG
GGCGATGGGCACGGTCTACATCGTGTCACATCCGCTGATCGGCGCCACCCGCTCCAAGGCGGTGTACCGCGTGTTCGGCA
CCCTGCTGGGCGCGGCGGCGGCGGTGTTCGTGGTGCCGCCGCTGGCCAACGAGCCGGTGCTGCTGAGCCTGGTGGTGGCG
CTGTGGTCCGGCTCCCTGCTCTACCTGTCGATGCTGGACCACACGCCGCGTCATTACCTGCTGCGGCTGCCGGCCTACAC
CATGCCGCTGATCGCGCTGTCGGCGGTGTACGCGCCGGAAAACGTGTTCGACATCGCCGTCGCGCGCAGCGAGGAAATCG
CCCTCGGCATCGTCTGCGCCAGCGTGGTCGCCGCGCTGGTGCTGCCCACCCGCGTGTCCGCCGCGCTCAGCCCGCGCGTG
GACGGCTGGCTCAGGGACGCCGCGGCCTGGGCGACCGACACCCTGGGCAACGCTCCCCAGCCCCCGTCCGCGGGCCGCAA
CCGGCTGGCGGCCGACCTGCTGGCCTTCGACCAATTGCTCACCCACCTCTCCTACGACGCCACCAGCCGCAACGCCGAGC
GCACCGCAGGCGAGCTGCGCGCGCGGATGAGCATGCTGCCGCCGCTGCTCTCGTCGCTGTCCGAGCTGCTGGCGGCGCTG
CGCAAGACGTCCGGCGGCGCGTCCGCGGATTTGCTCCAGCTGATGGCAGACGTGTCCGACTGGCTGGGCTATCCGGCCGA
CAATCCATGGTTCTTGAGCCAGGCGCGCGCGCTGCGCCGCCGGCTGGACCAGCCGCCGCCGGACAGCGGCTGGCCGTCGC
TGCTGGAGGGCACCGCGCGGATGCGGCTGAAATCGCTGGTCAACCTGTGGCAAGACTGCCTGACGCTGCGCGCGCTGATC
TCGCGCGGGTTGCCGCTGTGGGACTGGAAGCCCGCCTACCGCCGCTGGGAAGTGGGCGTGGAGGCCCGCCACTACGACTA
CGGCCTGCTGGCCTTCGCCGCCGGCACCGCCGCGCTGGGCATCTTCCTGGGCTGCCTCGTCTGGATCGCGCTGGGCTGGC
AGGACGGCGCCAACGCGGTGATCCTGGGCACGATAGCCTGCTGCCTGTTCGGCTCGATGGACGAGCCGGCGCCGATGCTG
CGCACCATGTTCGTCGTCAATACCGTATGCACCATGCTGGCCGGCCTGCTGCTGTTCGCCGTGCTGCCGGCGGTGCACGA
GTTCGAAATGCTGGCGCTGTGCCTGGCGCCGCCCTTCCTGTTGGGCGGCGCGCTGCTGACCCAGCCGCGCTTCGGCCCGG
TGGCGATGCTGCTGGTGGTGTTCACCGCCAACCTGATCGGCCTGCAGCAAAGCTACAACGCCGATTTCCAATCCTTTCTG
AACAGCAATCTGGCCGGCGCGGCCGGCATACTGTTCGCGCTGGTGTGGACGCTGACCACGCGCCCCTTCGGCGCGGAGCT
GACGCTGCGCCGCCTGATCCGCTCCAACTGGCGCGATCTGGCGCATAACGCCGCCGGCCGCCACGGCGGCGACTACGCGC
GGCTGACGGCGCTGATGCTGGACCGCCTGTCGCTGCTGGCGCCGCGCCTGGCCGCAGACGGCGCCGATCCGTCGGCCGGC
TTCCGCGAGCTGCGGGTGGGCTTCAGCGCGCTGGACCTGCAGCGCGACGAGCACCGCCTGGCCGGCGCCGCCCACCAGGC
GGTGGACGCGGCGCTGCAAGGCGTCAGCGAGCACTTCCGCGCCTGCGCCCAAGCCGACCGCTACCTGGACGCGCCGGATG
CGCTGCTGGGCCGGCTGGACGCGGCCATCGCCCTCACGCTGGCCGATCCCGCCCCGGCCGCGCGCGAGGCGCGAGGCGCG
CTGGTGGAGATGCGCGTGTCGCTGTTCCCCGACGCTGAAGGCTGCCAGCCGGCGTCGCCTGTTCCAGGAGTCCGGCCATG
A

Upstream 100 bases:

>100_bases
CGGGTATTCCACGTGCTGGAGCAGGCCGCGCAAACCCGGCCGCCCAACGACCCCATGCTGGACAAACGCCATGATCGCGC
TGCCCGCTAGACGCGACTGG

Downstream 100 bases:

>100_bases
TAGGCGAAGTCAATTTCTACGGGGTCTACTTCCCCAGCCTGCTGGTGATGATGGTCATCGCCTTCGCCGCCAGCAGCCTG
CTGCGCCGCGCGCTGGCCCG

Product: efflux transporter

Products: NA

Alternate protein names: pHBA efflux pump protein B [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MFSARTFAAAMLALYIALALGLPRPSWAMGTVYIVSHPLIGATRSKAVYRVFGTLLGAAAAVFVVPPLANEPVLLSLVVA
LWSGSLLYLSMLDHTPRHYLLRLPAYTMPLIALSAVYAPENVFDIAVARSEEIALGIVCASVVAALVLPTRVSAALSPRV
DGWLRDAAAWATDTLGNAPQPPSAGRNRLAADLLAFDQLLTHLSYDATSRNAERTAGELRARMSMLPPLLSSLSELLAAL
RKTSGGASADLLQLMADVSDWLGYPADNPWFLSQARALRRRLDQPPPDSGWPSLLEGTARMRLKSLVNLWQDCLTLRALI
SRGLPLWDWKPAYRRWEVGVEARHYDYGLLAFAAGTAALGIFLGCLVWIALGWQDGANAVILGTIACCLFGSMDEPAPML
RTMFVVNTVCTMLAGLLLFAVLPAVHEFEMLALCLAPPFLLGGALLTQPRFGPVAMLLVVFTANLIGLQQSYNADFQSFL
NSNLAGAAGILFALVWTLTTRPFGAELTLRRLIRSNWRDLAHNAAGRHGGDYARLTALMLDRLSLLAPRLAADGADPSAG
FRELRVGFSALDLQRDEHRLAGAAHQAVDAALQGVSEHFRACAQADRYLDAPDALLGRLDAAIALTLADPAPAAREARGA
LVEMRVSLFPDAEGCQPASPVPGVRP

Sequences:

>Translated_666_residues
MFSARTFAAAMLALYIALALGLPRPSWAMGTVYIVSHPLIGATRSKAVYRVFGTLLGAAAAVFVVPPLANEPVLLSLVVA
LWSGSLLYLSMLDHTPRHYLLRLPAYTMPLIALSAVYAPENVFDIAVARSEEIALGIVCASVVAALVLPTRVSAALSPRV
DGWLRDAAAWATDTLGNAPQPPSAGRNRLAADLLAFDQLLTHLSYDATSRNAERTAGELRARMSMLPPLLSSLSELLAAL
RKTSGGASADLLQLMADVSDWLGYPADNPWFLSQARALRRRLDQPPPDSGWPSLLEGTARMRLKSLVNLWQDCLTLRALI
SRGLPLWDWKPAYRRWEVGVEARHYDYGLLAFAAGTAALGIFLGCLVWIALGWQDGANAVILGTIACCLFGSMDEPAPML
RTMFVVNTVCTMLAGLLLFAVLPAVHEFEMLALCLAPPFLLGGALLTQPRFGPVAMLLVVFTANLIGLQQSYNADFQSFL
NSNLAGAAGILFALVWTLTTRPFGAELTLRRLIRSNWRDLAHNAAGRHGGDYARLTALMLDRLSLLAPRLAADGADPSAG
FRELRVGFSALDLQRDEHRLAGAAHQAVDAALQGVSEHFRACAQADRYLDAPDALLGRLDAAIALTLADPAPAAREARGA
LVEMRVSLFPDAEGCQPASPVPGVRP
>Mature_666_residues
MFSARTFAAAMLALYIALALGLPRPSWAMGTVYIVSHPLIGATRSKAVYRVFGTLLGAAAAVFVVPPLANEPVLLSLVVA
LWSGSLLYLSMLDHTPRHYLLRLPAYTMPLIALSAVYAPENVFDIAVARSEEIALGIVCASVVAALVLPTRVSAALSPRV
DGWLRDAAAWATDTLGNAPQPPSAGRNRLAADLLAFDQLLTHLSYDATSRNAERTAGELRARMSMLPPLLSSLSELLAAL
RKTSGGASADLLQLMADVSDWLGYPADNPWFLSQARALRRRLDQPPPDSGWPSLLEGTARMRLKSLVNLWQDCLTLRALI
SRGLPLWDWKPAYRRWEVGVEARHYDYGLLAFAAGTAALGIFLGCLVWIALGWQDGANAVILGTIACCLFGSMDEPAPML
RTMFVVNTVCTMLAGLLLFAVLPAVHEFEMLALCLAPPFLLGGALLTQPRFGPVAMLLVVFTANLIGLQQSYNADFQSFL
NSNLAGAAGILFALVWTLTTRPFGAELTLRRLIRSNWRDLAHNAAGRHGGDYARLTALMLDRLSLLAPRLAADGADPSAG
FRELRVGFSALDLQRDEHRLAGAAHQAVDAALQGVSEHFRACAQADRYLDAPDALLGRLDAAIALTLADPAPAAREARGA
LVEMRVSLFPDAEGCQPASPVPGVRP

Specific function: Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family [H]

Homologues:

Organism=Escherichia coli, GI1789636, Length=172, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787933, Length=151, Percent_Identity=33.7748344370861, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 71546; Mature: 71546

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSARTFAAAMLALYIALALGLPRPSWAMGTVYIVSHPLIGATRSKAVYRVFGTLLGAAA
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
AVFVVPPLANEPVLLSLVVALWSGSLLYLSMLDHTPRHYLLRLPAYTMPLIALSAVYAPE
HHHEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHEECCHHHHHHHHHHHHHCCC
NVFDIAVARSEEIALGIVCASVVAALVLPTRVSAALSPRVDGWLRDAAAWATDTLGNAPQ
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
PPSAGRNRLAADLLAFDQLLTHLSYDATSRNAERTAGELRARMSMLPPLLSSLSELLAAL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKTSGGASADLLQLMADVSDWLGYPADNPWFLSQARALRRRLDQPPPDSGWPSLLEGTAR
HHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
MRLKSLVNLWQDCLTLRALISRGLPLWDWKPAYRRWEVGVEARHYDYGLLAFAAGTAALG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEECCCCHHHHHHHHHHHHH
IFLGCLVWIALGWQDGANAVILGTIACCLFGSMDEPAPMLRTMFVVNTVCTMLAGLLLFA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLPAVHEFEMLALCLAPPFLLGGALLTQPRFGPVAMLLVVFTANLIGLQQSYNADFQSFL
HHHHHHHHHHHHHHHCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
NSNLAGAAGILFALVWTLTTRPFGAELTLRRLIRSNWRDLAHNAAGRHGGDYARLTALML
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DRLSLLAPRLAADGADPSAGFRELRVGFSALDLQRDEHRLAGAAHQAVDAALQGVSEHFR
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ACAQADRYLDAPDALLGRLDAAIALTLADPAPAAREARGALVEMRVSLFPDAEGCQPASP
HHHHHHHCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VPGVRP
CCCCCC
>Mature Secondary Structure
MFSARTFAAAMLALYIALALGLPRPSWAMGTVYIVSHPLIGATRSKAVYRVFGTLLGAAA
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
AVFVVPPLANEPVLLSLVVALWSGSLLYLSMLDHTPRHYLLRLPAYTMPLIALSAVYAPE
HHHEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHEECCHHHHHHHHHHHHHCCC
NVFDIAVARSEEIALGIVCASVVAALVLPTRVSAALSPRVDGWLRDAAAWATDTLGNAPQ
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
PPSAGRNRLAADLLAFDQLLTHLSYDATSRNAERTAGELRARMSMLPPLLSSLSELLAAL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKTSGGASADLLQLMADVSDWLGYPADNPWFLSQARALRRRLDQPPPDSGWPSLLEGTAR
HHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
MRLKSLVNLWQDCLTLRALISRGLPLWDWKPAYRRWEVGVEARHYDYGLLAFAAGTAALG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEECCCCHHHHHHHHHHHHH
IFLGCLVWIALGWQDGANAVILGTIACCLFGSMDEPAPMLRTMFVVNTVCTMLAGLLLFA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLPAVHEFEMLALCLAPPFLLGGALLTQPRFGPVAMLLVVFTANLIGLQQSYNADFQSFL
HHHHHHHHHHHHHHHCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
NSNLAGAAGILFALVWTLTTRPFGAELTLRRLIRSNWRDLAHNAAGRHGGDYARLTALML
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DRLSLLAPRLAADGADPSAGFRELRVGFSALDLQRDEHRLAGAAHQAVDAALQGVSEHFR
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ACAQADRYLDAPDALLGRLDAAIALTLADPAPAAREARGALVEMRVSLFPDAEGCQPASP
HHHHHHHCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VPGVRP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA