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The map label for this gene is dxs

Identifier: 34498147

GI number: 34498147

Start: 2914162

End: 2916012

Strand: Direct

Name: dxs

Synonym: CV_2692

Alternate gene names: 34498147

Gene position: 2914162-2916012 (Clockwise)

Preceding gene: 34498146

Following gene: 34498154

Centisome position: 61.34

GC content: 67.48

Gene sequence:

>1851_bases
ATGTATCCGCTGCTTGAAAACATAAACAGCCCCGCCGACCTGCGGCTGCTGCCCCGCACCCAGCTGCCGCAGCTGGCGGG
CGAACTGCGCGAATTCCTGGTGGAGTCGGTCAGCAAGACCGGCGGCCACTTCGCGTCCAATCTGGGCAGCATCGAGCTGA
CCATCGCCCTGCACTACGTGTTCGACACTCCGCACGACCGCCTGGTGTGGGACGTAGGCCACCAGACCTACCCGCACAAG
ATCCTGACCGGCCGCCGCGAGCGCATGCACACCATGCGCCAGCACAACGGCCTGGCCGGCTTCCCCAAGCGCGAGGAATC
CGAATACGACACCTTCGGCGTCGGCCATTCGTCCACCTCCATCGGCGCGGCCCTGGGCATGGCGGTGGCGGCCAAGACGC
TGGGCGTGGACCGCAAGAGCGTGGCCATCATCGGCGACGGCGCGATGACCGCCGGCCAGGCCTTCGAGGCGCTGAACAAC
GCCGGCGCGATGGACACCGACCTCTTGGTGATCCTCAACGACAACGACATGTCGATCTCGCCCAATGTCGGCGCGTTGAA
CAACTACCTGGCCAAGCTGATGTCCGGCCGCTTCTACGCGGCGATGCGCGAGGGCTCCAGCAAGGTGCTGGGCATCGCCC
CGCCGCTGAAGGAGATCGCCAGCAAGGTGGAAGAGCACGTCAAGGGCTTCTTCACCCCGGGCACGCTGTTCGAGGAGTTC
GGCTTCAACTACATCGGTCCGATCGACGGCCACGATGTGGACGTGCTGGTGGATACGCTGAAGAACATCCGCAGCCTGAA
AGGCCCGCAGTTCCTGCACATCGTCACCAAGAAGGGCCAGGGCTACAAGCTGGCCGAGAACGATCCGGTCAAATACCACG
GCGTCACCAAGTTCGACCCCGCCAACGGCCTCGCCAGCGGCAAGGGCGGCGCCGGCAAGCCGCAATACACCCAGGTGTTC
GGCGACTGGCTGTGCGACATGGCCAAGCTGGACAAGCGCCTGGTGGGCATCACCCCGGCGATGCGCGAAGGCTCGGGCAT
GGTACGCTTCGAGAAGGAGCACCCGGACCGCTACTACGACGTGGCCATCGCCGAGCAGCACGCGGTGACCTTCGCCGGCG
GCATGGCCTGCGACGGCCTGAAGCCGGTGGTGGCGATCTACTCCACCTTCCTGCAACGCGGCTACGACCAACTGATCCAC
GACGTGGCGCTGCAGAACCTGCCGGTGATGTTCGCGCTGGACCGCGCCGGCCTGGTCGGCGCCGACGGCCCCACCCACGC
CGGCGCCTTCGACCTCAGCTACCTGCGCTGCATCCCCAATATGACGGTGATGGCGCCGTCGGACGAAAACGAGTGCCGCC
AGTTGCTGTACACCGCCTTCCAGCTCGATACCCCGACCGCCGTCCGCTACCCGCGCGGCACCGGCCCGGGCGCGGAAATC
CAGCAGCAGATGGCGGCGCTGCCCATCGGCAAGGGCGTGGTCCGCCGCCGGGGCAAGCAGGTCGCCATCCTGGCTTTCGG
CAGCATGGTGCATCCCGCCCTGGCCGCCGCCGAAGCGCTGGACGCCACCGTCGCCGACATGCGCTTCGTCAAGCCGCTGG
ACGCCGAGCTGATCCGCAAGCTGGCGCAGACCCACGAGCTGATCGTCACCGTGGAGGAAAACGTGGTGATGGGCGGCGCG
GGCTCCGGCTGCGGCGAAGCGCTGCAGGCGATGGGACTGGCGGTGCCGACGCTGCACCTGGGCCTGCCGGACGACTACGT
CGAGCACGGCGATCCGGCGCTGCTGCTGTCGCTGTGCGGCCTGGACGCCGCCGGCATCGAGAAAAGCATACGCGAGCGCC
TGGCCGGCTGA

Upstream 100 bases:

>100_bases
TGGCCGACTACATCGTCGCCCGCTCGTTTTGAACCGCTCGTGGAGAAACCATCAGGACGGACCACCGCCCGGCGAGCCCT
CTCACTGCAGAACCACAACA

Downstream 100 bases:

>100_bases
TGGCCTCGCTGCCGCTCCCCAGTCTGGAAACCCGGCTGCAGCTGCACGCGGAGACCGCGCTGTCGCTGGTTTGCGCCGCG
CTGTTCACCTGGCTGTGGCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MYPLLENINSPADLRLLPRTQLPQLAGELREFLVESVSKTGGHFASNLGSIELTIALHYVFDTPHDRLVWDVGHQTYPHK
ILTGRRERMHTMRQHNGLAGFPKREESEYDTFGVGHSSTSIGAALGMAVAAKTLGVDRKSVAIIGDGAMTAGQAFEALNN
AGAMDTDLLVILNDNDMSISPNVGALNNYLAKLMSGRFYAAMREGSSKVLGIAPPLKEIASKVEEHVKGFFTPGTLFEEF
GFNYIGPIDGHDVDVLVDTLKNIRSLKGPQFLHIVTKKGQGYKLAENDPVKYHGVTKFDPANGLASGKGGAGKPQYTQVF
GDWLCDMAKLDKRLVGITPAMREGSGMVRFEKEHPDRYYDVAIAEQHAVTFAGGMACDGLKPVVAIYSTFLQRGYDQLIH
DVALQNLPVMFALDRAGLVGADGPTHAGAFDLSYLRCIPNMTVMAPSDENECRQLLYTAFQLDTPTAVRYPRGTGPGAEI
QQQMAALPIGKGVVRRRGKQVAILAFGSMVHPALAAAEALDATVADMRFVKPLDAELIRKLAQTHELIVTVEENVVMGGA
GSGCGEALQAMGLAVPTLHLGLPDDYVEHGDPALLLSLCGLDAAGIEKSIRERLAG

Sequences:

>Translated_616_residues
MYPLLENINSPADLRLLPRTQLPQLAGELREFLVESVSKTGGHFASNLGSIELTIALHYVFDTPHDRLVWDVGHQTYPHK
ILTGRRERMHTMRQHNGLAGFPKREESEYDTFGVGHSSTSIGAALGMAVAAKTLGVDRKSVAIIGDGAMTAGQAFEALNN
AGAMDTDLLVILNDNDMSISPNVGALNNYLAKLMSGRFYAAMREGSSKVLGIAPPLKEIASKVEEHVKGFFTPGTLFEEF
GFNYIGPIDGHDVDVLVDTLKNIRSLKGPQFLHIVTKKGQGYKLAENDPVKYHGVTKFDPANGLASGKGGAGKPQYTQVF
GDWLCDMAKLDKRLVGITPAMREGSGMVRFEKEHPDRYYDVAIAEQHAVTFAGGMACDGLKPVVAIYSTFLQRGYDQLIH
DVALQNLPVMFALDRAGLVGADGPTHAGAFDLSYLRCIPNMTVMAPSDENECRQLLYTAFQLDTPTAVRYPRGTGPGAEI
QQQMAALPIGKGVVRRRGKQVAILAFGSMVHPALAAAEALDATVADMRFVKPLDAELIRKLAQTHELIVTVEENVVMGGA
GSGCGEALQAMGLAVPTLHLGLPDDYVEHGDPALLLSLCGLDAAGIEKSIRERLAG
>Mature_616_residues
MYPLLENINSPADLRLLPRTQLPQLAGELREFLVESVSKTGGHFASNLGSIELTIALHYVFDTPHDRLVWDVGHQTYPHK
ILTGRRERMHTMRQHNGLAGFPKREESEYDTFGVGHSSTSIGAALGMAVAAKTLGVDRKSVAIIGDGAMTAGQAFEALNN
AGAMDTDLLVILNDNDMSISPNVGALNNYLAKLMSGRFYAAMREGSSKVLGIAPPLKEIASKVEEHVKGFFTPGTLFEEF
GFNYIGPIDGHDVDVLVDTLKNIRSLKGPQFLHIVTKKGQGYKLAENDPVKYHGVTKFDPANGLASGKGGAGKPQYTQVF
GDWLCDMAKLDKRLVGITPAMREGSGMVRFEKEHPDRYYDVAIAEQHAVTFAGGMACDGLKPVVAIYSTFLQRGYDQLIH
DVALQNLPVMFALDRAGLVGADGPTHAGAFDLSYLRCIPNMTVMAPSDENECRQLLYTAFQLDTPTAVRYPRGTGPGAEI
QQQMAALPIGKGVVRRRGKQVAILAFGSMVHPALAAAEALDATVADMRFVKPLDAELIRKLAQTHELIVTVEENVVMGGA
GSGCGEALQAMGLAVPTLHLGLPDDYVEHGDPALLLSLCGLDAAGIEKSIRERLAG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=648, Percent_Identity=25, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4507521, Length=648, Percent_Identity=25, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=24.3460764587525, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI225637463, Length=305, Percent_Identity=27.8688524590164, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI225637461, Length=305, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI225637459, Length=305, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI156564403, Length=224, Percent_Identity=25.8928571428571, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1786622, Length=615, Percent_Identity=61.3008130081301, Blast_Score=800, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=660, Percent_Identity=24.0909090909091, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17538422, Length=231, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666278, Length=619, Percent_Identity=25.3634894991922, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551847, Length=664, Percent_Identity=23.7951807228916, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550715, Length=664, Percent_Identity=23.7951807228916, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645119, Length=624, Percent_Identity=24.1987179487179, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_CHRVO (Q7NUK5)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902362.1
- ProteinModelPortal:   Q7NUK5
- SMR:   Q7NUK5
- GeneID:   2548770
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2692
- NMPDR:   fig|243365.1.peg.2692
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- PhylomeDB:   Q7NUK5
- ProtClustDB:   PRK05444
- BioCyc:   CVIO243365:CV_2692-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 66387; Mature: 66387

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLLENINSPADLRLLPRTQLPQLAGELREFLVESVSKTGGHFASNLGSIELTIALHYV
CCCCHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEEEEE
FDTPHDRLVWDVGHQTYPHKILTGRRERMHTMRQHNGLAGFPKREESEYDTFGVGHSSTS
ECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
IGAALGMAVAAKTLGVDRKSVAIIGDGAMTAGQAFEALNNAGAMDTDLLVILNDNDMSIS
HHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEC
PNVGALNNYLAKLMSGRFYAAMREGSSKVLGIAPPLKEIASKVEEHVKGFFTPGTLFEEF
CCCCHHHHHHHHHHCCHHEEHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHC
GFNYIGPIDGHDVDVLVDTLKNIRSLKGPQFLHIVTKKGQGYKLAENDPVKYHGVTKFDP
CCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEECCCCCCEEECCCCEECC
ANGLASGKGGAGKPQYTQVFGDWLCDMAKLDKRLVGITPAMREGSGMVRFEKEHPDRYYD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCCEEE
VAIAEQHAVTFAGGMACDGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVMFALDRAGLVG
EEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
ADGPTHAGAFDLSYLRCIPNMTVMAPSDENECRQLLYTAFQLDTPTAVRYPRGTGPGAEI
CCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHH
QQQMAALPIGKGVVRRRGKQVAILAFGSMVHPALAAAEALDATVADMRFVKPLDAELIRK
HHHHHHCCCCHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LAQTHELIVTVEENVVMGGAGSGCGEALQAMGLAVPTLHLGLPDDYVEHGDPALLLSLCG
HHCCCEEEEEEECCEEECCCCCCHHHHHHHHCCCCCEEECCCCHHHHHCCCHHHHHHHHC
LDAAGIEKSIRERLAG
CCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYPLLENINSPADLRLLPRTQLPQLAGELREFLVESVSKTGGHFASNLGSIELTIALHYV
CCCCHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEEEEE
FDTPHDRLVWDVGHQTYPHKILTGRRERMHTMRQHNGLAGFPKREESEYDTFGVGHSSTS
ECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
IGAALGMAVAAKTLGVDRKSVAIIGDGAMTAGQAFEALNNAGAMDTDLLVILNDNDMSIS
HHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEC
PNVGALNNYLAKLMSGRFYAAMREGSSKVLGIAPPLKEIASKVEEHVKGFFTPGTLFEEF
CCCCHHHHHHHHHHCCHHEEHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHC
GFNYIGPIDGHDVDVLVDTLKNIRSLKGPQFLHIVTKKGQGYKLAENDPVKYHGVTKFDP
CCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEECCCCCCEEECCCCEECC
ANGLASGKGGAGKPQYTQVFGDWLCDMAKLDKRLVGITPAMREGSGMVRFEKEHPDRYYD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCCEEE
VAIAEQHAVTFAGGMACDGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVMFALDRAGLVG
EEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
ADGPTHAGAFDLSYLRCIPNMTVMAPSDENECRQLLYTAFQLDTPTAVRYPRGTGPGAEI
CCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHH
QQQMAALPIGKGVVRRRGKQVAILAFGSMVHPALAAAEALDATVADMRFVKPLDAELIRK
HHHHHHCCCCHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LAQTHELIVTVEENVVMGGAGSGCGEALQAMGLAVPTLHLGLPDDYVEHGDPALLLSLCG
HHCCCEEEEEEECCEEECCCCCCHHHHHHHHCCCCCEEECCCCHHHHHCCCHHHHHHHHC
LDAAGIEKSIRERLAG
CCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782