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The map label for this gene is hilA [H]

Identifier: 34498095

GI number: 34498095

Start: 2850034

End: 2851719

Strand: Direct

Name: hilA [H]

Synonym: CV_2640

Alternate gene names: 34498095

Gene position: 2850034-2851719 (Clockwise)

Preceding gene: 34498092

Following gene: 34498096

Centisome position: 59.99

GC content: 65.72

Gene sequence:

>1686_bases
ATGGCGTTACATAACGATGGTTTCATCAATCGGCAATTCGTCTTCGGCGATTTTGTCCTGCAATTCGACGGCGTGCTCTG
TCACCAGGAACAGCAGATCAGCGTTCCGCCCAAAGAATTGGCCGTACTCACCGCCTTGCTGGAGGCAGCCGGCGAACTGG
TGAGCAAGGACGCGTTGCTGGACAAGGTCTGGCCGGACGGCGACGTCAACGAGGAATCGCTGACGCGCTGCATCTACGCA
TTGCGCCGCATCCTGCTGGAAGACAAGAGCAACCGCTACATCGATACCGTCTACGGCAAGGGATACCGCTTCAGCCGGCC
GGTGGCGGTGGTGTCCCGCCCGACGGCATCCGCGCAGAAGTGCACGATGGCCATCCTGCCCTTCCGCACCGACGGCCAGC
TGGACTCTCTGGAGCTGCATGCCGCGCTGGTCCAGTGCCTGTCGCGCTACTCGCCGTTCGGCCTGGTGGTGATGCCTGCC
ACCATCACCCGCAATTGCGGCGACATCGCCGACATCATCGCCATGATCGACCAGTTGCGGCCCGACTATTACCTGGCCGG
CCAGGTGCAGCAACAGGGGGATTCCTGGCTGCTGCGGGTGGAGCTGGTGCGCGCCGACGGCCATCAGTTGGTTCACCACG
AAAGCATAGAGATCGGCCCGGGCGAGCATATCGCCGCGCTGCAGACCCGGCTGGCGAGCCTGCTGCCGCAACGCATTCCC
GGCTTGCGCTGGCATCATGGCAACGGCAGCCAGCTGGACTCCCTGGACATGGCCATCACGTATCTGAACGGCCGCCATGA
ACTGCAGCAGCACACCCCTTCCAGCCTGAAACGCGCGCTGGCGCTGTTCCTGCAATGCACCAGCAGCCAACCCGGCAACG
CGCTGCCCTACTGCAGCCTGGCCGAATGCTATCTGGCGCTGGCCCAGCTGGGCCTGTTCGACCAGGAGCGCGCGCTGGAC
GGCGCCCAGCAGGCGGTCGACCGCGCGGTGGCGCTGGACGCGGCCAATCCGCAGGCGCTGGGCCTGCTGGCCCTGCTGAG
CAGCCTGCGCGGACAACAGACCATCGCCGAAGCCTTGTTCGAACAGGCGCGCATGCTGGCGCCCGATTCGATCGACATCC
ACTACTACCACGCCTGGCACCTGTTTCTGTCCGACCGCATTCCCCTGGCGCAACGCTCGCTCGATGCTTGCCTGGAACGC
GATCCCTCCCGCATCGCGGCCAGCATGCTGCAGCTGTGGCTGACCTATTGCGAGCACCGGCTGGACGAGGCGGTGGCGTT
GGGCAAACGCCAGCTGTGCCAGTACGGCCAGGATCATCCGGTATTGCAGAGCATGCTGGGGCTGATGCTGGCCATCCAGG
GGCAACACGCCCAGGCGGAAGAATTGGCCGCGGCGGTCAAGGCGTCGGGCGAAGAAGCCGGCCTGCTCGCCGTCAACGGC
TGCTACATCGCTCATTGCCGGATGGGAGACGCCGCGCGCCCGTTGCTGCAGGATTTTTTGTCCCGCGTCGACTGCCGCCA
GGTCCGCTCCGGCCTGCTGCCGCTGATCCTGGCGCTGCATGGCCGCGCCGGGGCGCTGCATCTGTTGGGCCAGCTGGAAT
CCGACCGCTACCTGTGGCTGCGGGCATCCCGCCAGGATCCGCGCCTGGCCGGCCTGTTCCATCCCCACTTGTCCGAAGCC
GCCTGA

Upstream 100 bases:

>100_bases
ACATGTCGCGCCGCTACGGGGAAGCGCGTGGCGCGACTGTCGACTCTATTCCTGCGGCTGGTCCGCACGGTGTTGCGCCA
CGCGCAAGAGGAACTGGAAG

Downstream 100 bases:

>100_bases
TGCGCGCCGCCTTGCTCGCCGCCCTGCTGCTGGCCTCGCCGCTGGCTCGCGCCGATTGCTGGGACTACGCCGGGACGATG
TTCAACATCTCGCCGGACCT

Product: invasion protein regulator

Products: NA

Alternate protein names: Protein iagA [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MALHNDGFINRQFVFGDFVLQFDGVLCHQEQQISVPPKELAVLTALLEAAGELVSKDALLDKVWPDGDVNEESLTRCIYA
LRRILLEDKSNRYIDTVYGKGYRFSRPVAVVSRPTASAQKCTMAILPFRTDGQLDSLELHAALVQCLSRYSPFGLVVMPA
TITRNCGDIADIIAMIDQLRPDYYLAGQVQQQGDSWLLRVELVRADGHQLVHHESIEIGPGEHIAALQTRLASLLPQRIP
GLRWHHGNGSQLDSLDMAITYLNGRHELQQHTPSSLKRALALFLQCTSSQPGNALPYCSLAECYLALAQLGLFDQERALD
GAQQAVDRAVALDAANPQALGLLALLSSLRGQQTIAEALFEQARMLAPDSIDIHYYHAWHLFLSDRIPLAQRSLDACLER
DPSRIAASMLQLWLTYCEHRLDEAVALGKRQLCQYGQDHPVLQSMLGLMLAIQGQHAQAEELAAAVKASGEEAGLLAVNG
CYIAHCRMGDAARPLLQDFLSRVDCRQVRSGLLPLILALHGRAGALHLLGQLESDRYLWLRASRQDPRLAGLFHPHLSEA
A

Sequences:

>Translated_561_residues
MALHNDGFINRQFVFGDFVLQFDGVLCHQEQQISVPPKELAVLTALLEAAGELVSKDALLDKVWPDGDVNEESLTRCIYA
LRRILLEDKSNRYIDTVYGKGYRFSRPVAVVSRPTASAQKCTMAILPFRTDGQLDSLELHAALVQCLSRYSPFGLVVMPA
TITRNCGDIADIIAMIDQLRPDYYLAGQVQQQGDSWLLRVELVRADGHQLVHHESIEIGPGEHIAALQTRLASLLPQRIP
GLRWHHGNGSQLDSLDMAITYLNGRHELQQHTPSSLKRALALFLQCTSSQPGNALPYCSLAECYLALAQLGLFDQERALD
GAQQAVDRAVALDAANPQALGLLALLSSLRGQQTIAEALFEQARMLAPDSIDIHYYHAWHLFLSDRIPLAQRSLDACLER
DPSRIAASMLQLWLTYCEHRLDEAVALGKRQLCQYGQDHPVLQSMLGLMLAIQGQHAQAEELAAAVKASGEEAGLLAVNG
CYIAHCRMGDAARPLLQDFLSRVDCRQVRSGLLPLILALHGRAGALHLLGQLESDRYLWLRASRQDPRLAGLFHPHLSEA
A
>Mature_560_residues
ALHNDGFINRQFVFGDFVLQFDGVLCHQEQQISVPPKELAVLTALLEAAGELVSKDALLDKVWPDGDVNEESLTRCIYAL
RRILLEDKSNRYIDTVYGKGYRFSRPVAVVSRPTASAQKCTMAILPFRTDGQLDSLELHAALVQCLSRYSPFGLVVMPAT
ITRNCGDIADIIAMIDQLRPDYYLAGQVQQQGDSWLLRVELVRADGHQLVHHESIEIGPGEHIAALQTRLASLLPQRIPG
LRWHHGNGSQLDSLDMAITYLNGRHELQQHTPSSLKRALALFLQCTSSQPGNALPYCSLAECYLALAQLGLFDQERALDG
AQQAVDRAVALDAANPQALGLLALLSSLRGQQTIAEALFEQARMLAPDSIDIHYYHAWHLFLSDRIPLAQRSLDACLERD
PSRIAASMLQLWLTYCEHRLDEAVALGKRQLCQYGQDHPVLQSMLGLMLAIQGQHAQAEELAAAVKASGEEAGLLAVNGC
YIAHCRMGDAARPLLQDFLSRVDCRQVRSGLLPLILALHGRAGALHLLGQLESDRYLWLRASRQDPRLAGLFHPHLSEAA

Specific function: The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of invF. Also binds upstream o

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TPR repeat [H]

Homologues:

Organism=Escherichia coli, GI1789216, Length=399, Percent_Identity=32.3308270676692, Blast_Score=193, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 62003; Mature: 61872

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALHNDGFINRQFVFGDFVLQFDGVLCHQEQQISVPPKELAVLTALLEAAGELVSKDALL
CCCCCCCCCCCEEEHHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DKVWPDGDVNEESLTRCIYALRRILLEDKSNRYIDTVYGKGYRFSRPVAVVSRPTASAQK
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCEEEEECCCCCHHH
CTMAILPFRTDGQLDSLELHAALVQCLSRYSPFGLVVMPATITRNCGDIADIIAMIDQLR
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHCCCHHHHHHHHHHHHCC
PDYYLAGQVQQQGDSWLLRVELVRADGHQLVHHESIEIGPGEHIAALQTRLASLLPQRIP
CCEEEECCHHHCCCCEEEEEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCC
GLRWHHGNGSQLDSLDMAITYLNGRHELQQHTPSSLKRALALFLQCTSSQPGNALPYCSL
CCEEECCCCCCCCHHHHEEEEECCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AECYLALAQLGLFDQERALDGAQQAVDRAVALDAANPQALGLLALLSSLRGQQTIAEALF
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
EQARMLAPDSIDIHYYHAWHLFLSDRIPLAQRSLDACLERDPSRIAASMLQLWLTYCEHR
HHHHHCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LDEAVALGKRQLCQYGQDHPVLQSMLGLMLAIQGQHAQAEELAAAVKASGEEAGLLAVNG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECC
CYIAHCRMGDAARPLLQDFLSRVDCRQVRSGLLPLILALHGRAGALHLLGQLESDRYLWL
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEE
RASRQDPRLAGLFHPHLSEAA
EECCCCCCEEEECCCHHHCCC
>Mature Secondary Structure 
ALHNDGFINRQFVFGDFVLQFDGVLCHQEQQISVPPKELAVLTALLEAAGELVSKDALL
CCCCCCCCCCEEEHHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DKVWPDGDVNEESLTRCIYALRRILLEDKSNRYIDTVYGKGYRFSRPVAVVSRPTASAQK
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCEEEEECCCCCHHH
CTMAILPFRTDGQLDSLELHAALVQCLSRYSPFGLVVMPATITRNCGDIADIIAMIDQLR
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHCCCHHHHHHHHHHHHCC
PDYYLAGQVQQQGDSWLLRVELVRADGHQLVHHESIEIGPGEHIAALQTRLASLLPQRIP
CCEEEECCHHHCCCCEEEEEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCC
GLRWHHGNGSQLDSLDMAITYLNGRHELQQHTPSSLKRALALFLQCTSSQPGNALPYCSL
CCEEECCCCCCCCHHHHEEEEECCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AECYLALAQLGLFDQERALDGAQQAVDRAVALDAANPQALGLLALLSSLRGQQTIAEALF
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
EQARMLAPDSIDIHYYHAWHLFLSDRIPLAQRSLDACLERDPSRIAASMLQLWLTYCEHR
HHHHHCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LDEAVALGKRQLCQYGQDHPVLQSMLGLMLAIQGQHAQAEELAAAVKASGEEAGLLAVNG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECC
CYIAHCRMGDAARPLLQDFLSRVDCRQVRSGLLPLILALHGRAGALHLLGQLESDRYLWL
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEE
RASRQDPRLAGLFHPHLSEAA
EECCCCCCEEEECCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA