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The map label for this gene is lcrF [H]

Identifier: 34498039

GI number: 34498039

Start: 2786503

End: 2787291

Strand: Direct

Name: lcrF [H]

Synonym: CV_2584

Alternate gene names: 34498039

Gene position: 2786503-2787291 (Clockwise)

Preceding gene: 34498028

Following gene: 34498040

Centisome position: 58.65

GC content: 46.51

Gene sequence:

>789_bases
ATGCCGCTTGACACAGCAAAGATAGATCATGCATCACGTTACAACAGCGCGCATAGGATTGAGATGCCAGCGATTCGACT
CATAATCAGCAGGAGTAAAGGTGAAATAACCATCCAAGAGGATACTTACGCCTTTCCAGAACACTGCCTGATTGTCACAA
ATAATAAAGCTCGAATTTCTACGGATAGCCATCCGAATGCCATGCTGTCTCTGGATTTTCTCGCCTCGGATTTGCAGCGG
CTTCTCCCGGAAGTCGTCGAATTACTGGAAGCAGACAATCAGAAAACCTTCAAAAAGGAAGCGGTGAAAATAGTAAAAAC
AGACTGCAATGCAACTGAGGTATTGGCCTCGCTTTCCCAGTTGGCGCCCTCCTCCTTCCTGTATTTTGCTTATCTTTACT
GCTTGAATCTGGATAGAGCTTACTTCTCGGCATTGCTGCGCAGCTGCATAGCTGGAAATAAGGATTTTTACGAATTCATT
GAGAAAAATGCTTTGCAACAATGGTCCATTTCCACATTGGCTGATCGATTTGGCATGCCACTGCGGAAATTCAACCAATT
GTTTCAGGAGGCGTATGGCAAGCCCGCCAAGCGCTGGATATTGGAGCATCGTTTGACGCATGCCAAAAAGCTATTGCTCA
CCACCTCGATGAGGGTGCTGGATGTGGCGCTGGAATGCGGTTTTTCAAACCATGCGCATTTCACGGATAGCTTTCGGCGC
CATTTTCAATGCAACCCCAAGCAATTTAGACAGCAAGCACTGGGCAAGCTGCGTGATAAAGAAACATAA

Upstream 100 bases:

>100_bases
CTAGAACTGCGACAAATATTCTGTTTTTTTGCACATGACTTATCCTGCCATCTCGAACACCCCGGAGCAGGAGGTCATCC
AGATATCAGGTGATCACCGG

Downstream 100 bases:

>100_bases
GGACAGTTCATGGATATCGAAGCCATCACCAGTCAATTATCACAACTGGTTGAACAAGCCGGCAATGAGGTGCAATCGAA
AGTCACCGCCGCCGATTTGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MPLDTAKIDHASRYNSAHRIEMPAIRLIISRSKGEITIQEDTYAFPEHCLIVTNNKARISTDSHPNAMLSLDFLASDLQR
LLPEVVELLEADNQKTFKKEAVKIVKTDCNATEVLASLSQLAPSSFLYFAYLYCLNLDRAYFSALLRSCIAGNKDFYEFI
EKNALQQWSISTLADRFGMPLRKFNQLFQEAYGKPAKRWILEHRLTHAKKLLLTTSMRVLDVALECGFSNHAHFTDSFRR
HFQCNPKQFRQQALGKLRDKET

Sequences:

>Translated_262_residues
MPLDTAKIDHASRYNSAHRIEMPAIRLIISRSKGEITIQEDTYAFPEHCLIVTNNKARISTDSHPNAMLSLDFLASDLQR
LLPEVVELLEADNQKTFKKEAVKIVKTDCNATEVLASLSQLAPSSFLYFAYLYCLNLDRAYFSALLRSCIAGNKDFYEFI
EKNALQQWSISTLADRFGMPLRKFNQLFQEAYGKPAKRWILEHRLTHAKKLLLTTSMRVLDVALECGFSNHAHFTDSFRR
HFQCNPKQFRQQALGKLRDKET
>Mature_261_residues
PLDTAKIDHASRYNSAHRIEMPAIRLIISRSKGEITIQEDTYAFPEHCLIVTNNKARISTDSHPNAMLSLDFLASDLQRL
LPEVVELLEADNQKTFKKEAVKIVKTDCNATEVLASLSQLAPSSFLYFAYLYCLNLDRAYFSALLRSCIAGNKDFYEFIE
KNALQQWSISTLADRFGMPLRKFNQLFQEAYGKPAKRWILEHRLTHAKKLLLTTSMRVLDVALECGFSNHAHFTDSFRRH
FQCNPKQFRQQALGKLRDKET

Specific function: Transcriptional activator of the thermally regulated virulent yopE gene. LcrF activity could be modulated by the interaction with an inducer molecule serving as a temperature messenger. The availability of the messenger would in turn be controlled by a te

COG id: COG2207

COG function: function code K; AraC-type DNA-binding domain-containing proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003313
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF02311 AraC_binding; PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 30152; Mature: 30021

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDTAKIDHASRYNSAHRIEMPAIRLIISRSKGEITIQEDTYAFPEHCLIVTNNKARIS
CCCCCCCCCHHHHCCCCCEECHHHHHHHEECCCCCEEECCCCCCCCCCEEEEECCCEEEC
TDSHPNAMLSLDFLASDLQRLLPEVVELLEADNQKTFKKEAVKIVKTDCNATEVLASLSQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LAPSSFLYFAYLYCLNLDRAYFSALLRSCIAGNKDFYEFIEKNALQQWSISTLADRFGMP
HCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LRKFNQLFQEAYGKPAKRWILEHRLTHAKKLLLTTSMRVLDVALECGFSNHAHFTDSFRR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
HFQCNPKQFRQQALGKLRDKET
HCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLDTAKIDHASRYNSAHRIEMPAIRLIISRSKGEITIQEDTYAFPEHCLIVTNNKARIS
CCCCCCCCHHHHCCCCCEECHHHHHHHEECCCCCEEECCCCCCCCCCEEEEECCCEEEC
TDSHPNAMLSLDFLASDLQRLLPEVVELLEADNQKTFKKEAVKIVKTDCNATEVLASLSQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LAPSSFLYFAYLYCLNLDRAYFSALLRSCIAGNKDFYEFIEKNALQQWSISTLADRFGMP
HCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LRKFNQLFQEAYGKPAKRWILEHRLTHAKKLLLTTSMRVLDVALECGFSNHAHFTDSFRR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
HFQCNPKQFRQQALGKLRDKET
HCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1624422; 9746557; 9748454; 11586360 [H]