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The map label for this gene is pgi1

Identifier: 34497824

GI number: 34497824

Start: 2553898

End: 2555550

Strand: Direct

Name: pgi1

Synonym: CV_2369

Alternate gene names: 34497824

Gene position: 2553898-2555550 (Clockwise)

Preceding gene: 34497823

Following gene: 34497825

Centisome position: 53.75

GC content: 63.94

Gene sequence:

>1653_bases
ATGGCCGCACAACGCCACATCGACATCAATTCCACCCAGGTCTGGGCCAAGCTGCACCAGCACCAGCGCGCGACGCGCCA
TATGCACATGCGCGAGTTGTTCGAGCTGGATCCGCAGCGTTTCCAGCGTTTTTCGCTGGAGCTGGATGGCCTTCTGCTCG
ACTATTCGAAAAACCGGGTGACCGAGCGCACGCTGGAGCTGTTGTTCGATCTGGCGCGCAAGGCCGACTTGAGAGGCTGG
ATGGACAGGATGCGCAGCGGCGAGCGCATCAACGTCAGCGAGAACCGCTCGGTGCTGCATACCGCTTTGCGGCTGCCGGC
GGGGGCGCGGCTCGACCTGGAAGGCCATAACGTGGCGGCCGACGTGCATCAGGTGCTGGCGCGGCTCAAGGATTTCAGCG
AGCAGGTCCGGGAAGGCCGCTGGCTGGGGTTCGCCGGGCAGCCGATCCGCGACGTGGTCAATCTCGGCATCGGCGGCTCC
GATCTCGGGCCGCTGGTGGCGGCGGACGCGCTGGCCGCGTATGCCCATCCCGATCTCAAGGTCCACTTCGTATCCAATGT
CGACGGCCAACACTTGGCGCGCACGCTGGAGCGGCTGAATCCAGCCACCACCTTGTTCATCGTCGCCTCAAAATCCTTCA
CCACGCCGGAAACCCTGCTGAACGCCCAGGCGGCGCGCGCCTGGTTTCTGCAGGCGGCCGGCGAGGCTCAGATCGCCAAG
CATTTCGTCGCAGTCTCCACCAACGAACCGGCGGTGCGGGCTTTCGGCATTGATCCGCAGCATATGTTCGGCTTCTGGGA
CTGGGTGGGGGGGCGATACTCGGTGTGGTCGGCGATAGGCCTGCCGGTCATGCTGTCCATCGGCTACGACAACTTCCGCG
CCTTCCTCGACGGCGGCCATGCGATGGACCGGCATTTCTTCGAGTCGCCGTTCGATGCCAATATGCCGGTGCTGCTTGCG
CTGATCGGCATCTGGTACAACACTTTCTACCGGGCGCACACCCATGCCATCATGCCCTATGATCATGGTCTGCGCCGCTT
GCCGGCCCACATCCAGCAGCTGGACATGGAGTCCAACGGCAAGCGGGTCGGCAGGCTGGGCGAGGCGCTCGATTTCGATA
CCGGCCCGGTGATCTGGGGCGAGGAGGGCGCTAACAGCCAGCATGCCTTCTTCCAGTTGCTGCACCAGGGCACCCGGCTG
GTGCCGTGCGACTTCATCCTGCCGCTGAACAGCCACTATCCGCTCGGCAACCAGCACGATGTGCTGGTCGCCAACTGCCT
GGCGCAAACCGAGGCGCTGATGCGCGGCAAGAACGAGGCGGAGGTGATGCGGGAGTTGAGCCATCTGTCCGGAGAGCAGC
TGGACATGCTGCTGCCGCAGAAACTGTTTCCGGGCAACCAGCCGTCGAACACGCTGGCGCTGGACAGGGTGACGCCGTAC
AGCATGGGCATGCTGATGGCGCTGTATGAGCACAAGGTGTTCGTGCAAGGGGTGATCTGGGGCATCAATTCCTTCGATCA
GTGGGGCGTGGAGTATGGCAAGCAGCTGGCGCGGCGCATCCTGCCGGAGCTGTCCGGCGACACCGGGGCGCTGGGGCACG
ACAGCTCCACCAATGGTCTGATCCGACATTACAGGGAACGCCATGGCAAATAG

Upstream 100 bases:

>100_bases
CTACCGCGAGCACTTCCTCAAGGTATAAGCTACGCCGTGTCGAGCCGGCTCGAGCGGGCCGGCTTTTTCACATTCACCTT
GTATTCCATTGGCAGAAAAC

Downstream 100 bases:

>100_bases
CAGACAACTGGCCTCGGACCTAGGCGAGGCCTTGCAGGCCCGAGGCGAAAGCGTGGCCACCGCGGAGTCCTGCACTGGCG
GCATGATCGCGGCAGCCATC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI 2; Phosphoglucose isomerase 2; PGI 2; Phosphohexose isomerase 2; PHI 2

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MAAQRHIDINSTQVWAKLHQHQRATRHMHMRELFELDPQRFQRFSLELDGLLLDYSKNRVTERTLELLFDLARKADLRGW
MDRMRSGERINVSENRSVLHTALRLPAGARLDLEGHNVAADVHQVLARLKDFSEQVREGRWLGFAGQPIRDVVNLGIGGS
DLGPLVAADALAAYAHPDLKVHFVSNVDGQHLARTLERLNPATTLFIVASKSFTTPETLLNAQAARAWFLQAAGEAQIAK
HFVAVSTNEPAVRAFGIDPQHMFGFWDWVGGRYSVWSAIGLPVMLSIGYDNFRAFLDGGHAMDRHFFESPFDANMPVLLA
LIGIWYNTFYRAHTHAIMPYDHGLRRLPAHIQQLDMESNGKRVGRLGEALDFDTGPVIWGEEGANSQHAFFQLLHQGTRL
VPCDFILPLNSHYPLGNQHDVLVANCLAQTEALMRGKNEAEVMRELSHLSGEQLDMLLPQKLFPGNQPSNTLALDRVTPY
SMGMLMALYEHKVFVQGVIWGINSFDQWGVEYGKQLARRILPELSGDTGALGHDSSTNGLIRHYRERHGK

Sequences:

>Translated_550_residues
MAAQRHIDINSTQVWAKLHQHQRATRHMHMRELFELDPQRFQRFSLELDGLLLDYSKNRVTERTLELLFDLARKADLRGW
MDRMRSGERINVSENRSVLHTALRLPAGARLDLEGHNVAADVHQVLARLKDFSEQVREGRWLGFAGQPIRDVVNLGIGGS
DLGPLVAADALAAYAHPDLKVHFVSNVDGQHLARTLERLNPATTLFIVASKSFTTPETLLNAQAARAWFLQAAGEAQIAK
HFVAVSTNEPAVRAFGIDPQHMFGFWDWVGGRYSVWSAIGLPVMLSIGYDNFRAFLDGGHAMDRHFFESPFDANMPVLLA
LIGIWYNTFYRAHTHAIMPYDHGLRRLPAHIQQLDMESNGKRVGRLGEALDFDTGPVIWGEEGANSQHAFFQLLHQGTRL
VPCDFILPLNSHYPLGNQHDVLVANCLAQTEALMRGKNEAEVMRELSHLSGEQLDMLLPQKLFPGNQPSNTLALDRVTPY
SMGMLMALYEHKVFVQGVIWGINSFDQWGVEYGKQLARRILPELSGDTGALGHDSSTNGLIRHYRERHGK
>Mature_549_residues
AAQRHIDINSTQVWAKLHQHQRATRHMHMRELFELDPQRFQRFSLELDGLLLDYSKNRVTERTLELLFDLARKADLRGWM
DRMRSGERINVSENRSVLHTALRLPAGARLDLEGHNVAADVHQVLARLKDFSEQVREGRWLGFAGQPIRDVVNLGIGGSD
LGPLVAADALAAYAHPDLKVHFVSNVDGQHLARTLERLNPATTLFIVASKSFTTPETLLNAQAARAWFLQAAGEAQIAKH
FVAVSTNEPAVRAFGIDPQHMFGFWDWVGGRYSVWSAIGLPVMLSIGYDNFRAFLDGGHAMDRHFFESPFDANMPVLLAL
IGIWYNTFYRAHTHAIMPYDHGLRRLPAHIQQLDMESNGKRVGRLGEALDFDTGPVIWGEEGANSQHAFFQLLHQGTRLV
PCDFILPLNSHYPLGNQHDVLVANCLAQTEALMRGKNEAEVMRELSHLSGEQLDMLLPQKLFPGNQPSNTLALDRVTPYS
MGMLMALYEHKVFVQGVIWGINSFDQWGVEYGKQLARRILPELSGDTGALGHDSSTNGLIRHYRERHGK

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=541, Percent_Identity=51.7560073937153, Blast_Score=594, Evalue=1e-170,
Organism=Homo sapiens, GI296080693, Length=541, Percent_Identity=48.6136783733826, Blast_Score=541, Evalue=1e-154,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=53.9162112932605, Blast_Score=608, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI71996708, Length=550, Percent_Identity=50, Blast_Score=568, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=50.4587155963303, Blast_Score=566, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6319673, Length=542, Percent_Identity=49.0774907749078, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24651916, Length=548, Percent_Identity=52.3722627737226, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24651914, Length=548, Percent_Identity=52.3722627737226, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI17737445, Length=548, Percent_Identity=52.3722627737226, Blast_Score=588, Evalue=1e-168,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI2_CHRVO (Q7NVH4)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902039.1
- ProteinModelPortal:   Q7NVH4
- SMR:   Q7NVH4
- GeneID:   2546984
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2369
- NMPDR:   fig|243365.1.peg.2369
- HOGENOM:   HBG352954
- OMA:   AHTHAIM
- PhylomeDB:   Q7NVH4
- ProtClustDB:   CLSK2485482
- BioCyc:   CVIO243365:CV_2369-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61928; Mature: 61797

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 357-357 ACT_SITE 388-388 ACT_SITE 514-514

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQRHIDINSTQVWAKLHQHQRATRHMHMRELFELDPQRFQRFSLELDGLLLDYSKNRV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCEEEECCHHHH
TERTLELLFDLARKADLRGWMDRMRSGERINVSENRSVLHTALRLPAGARLDLEGHNVAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHCCCCCEEECCCCCHHH
DVHQVLARLKDFSEQVREGRWLGFAGQPIRDVVNLGIGGSDLGPLVAADALAAYAHPDLK
HHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEE
VHFVSNVDGQHLARTLERLNPATTLFIVASKSFTTPETLLNAQAARAWFLQAAGEAQIAK
EEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
HFVAVSTNEPAVRAFGIDPQHMFGFWDWVGGRYSVWSAIGLPVMLSIGYDNFRAFLDGGH
HEEEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHCCCH
AMDRHFFESPFDANMPVLLALIGIWYNTFYRAHTHAIMPYDHGLRRLPAHIQQLDMESNG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHCCCCCC
KRVGRLGEALDFDTGPVIWGEEGANSQHAFFQLLHQGTRLVPCDFILPLNSHYPLGNQHD
CHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCC
VLVANCLAQTEALMRGKNEAEVMRELSHLSGEQLDMLLPQKLFPGNQPSNTLALDRVTPY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCHHHCCCCCCCCCEEECCCCHH
SMGMLMALYEHKVFVQGVIWGINSFDQWGVEYGKQLARRILPELSGDTGALGHDSSTNGL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
IRHYRERHGK
HHHHHHHCCC
>Mature Secondary Structure 
AAQRHIDINSTQVWAKLHQHQRATRHMHMRELFELDPQRFQRFSLELDGLLLDYSKNRV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCEEEECCHHHH
TERTLELLFDLARKADLRGWMDRMRSGERINVSENRSVLHTALRLPAGARLDLEGHNVAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHCCCCCEEECCCCCHHH
DVHQVLARLKDFSEQVREGRWLGFAGQPIRDVVNLGIGGSDLGPLVAADALAAYAHPDLK
HHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEE
VHFVSNVDGQHLARTLERLNPATTLFIVASKSFTTPETLLNAQAARAWFLQAAGEAQIAK
EEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
HFVAVSTNEPAVRAFGIDPQHMFGFWDWVGGRYSVWSAIGLPVMLSIGYDNFRAFLDGGH
HEEEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHCCCH
AMDRHFFESPFDANMPVLLALIGIWYNTFYRAHTHAIMPYDHGLRRLPAHIQQLDMESNG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHCCCCCC
KRVGRLGEALDFDTGPVIWGEEGANSQHAFFQLLHQGTRLVPCDFILPLNSHYPLGNQHD
CHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCC
VLVANCLAQTEALMRGKNEAEVMRELSHLSGEQLDMLLPQKLFPGNQPSNTLALDRVTPY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCHHHCCCCCCCCCEEECCCCHH
SMGMLMALYEHKVFVQGVIWGINSFDQWGVEYGKQLARRILPELSGDTGALGHDSSTNGL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
IRHYRERHGK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782