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The map label for this gene is map2 [H]

Identifier: 34497789

GI number: 34497789

Start: 2523917

End: 2524708

Strand: Direct

Name: map2 [H]

Synonym: CV_2334

Alternate gene names: 34497789

Gene position: 2523917-2524708 (Clockwise)

Preceding gene: 34497788

Following gene: 34497790

Centisome position: 53.12

GC content: 64.27

Gene sequence:

>792_bases
ATGAGCCGGGTGGTGATCAAGTCTCCGGCCGAGGTGGCCAAGGCGCGCGAGGCGGGCAAGCTGGTGGCGGAACTGCTGGC
GATGATAGGCGAGCACGTGAAGCCCGGCGTCAGCACCGAAGAACTGGATGCGCGCTGCAATGAATACATCGTCAAGGTGC
AGAAGGCCAAGCCGGCCAATGTCGGCTATTACGGCTATCCCAAGACCATCTGCTCCTCGGTCAACCAAGTGGTGTGCCAC
GGCATTCCATCGGCAAAGCAGATCCTGCGCGACGGCGACATCGTCAACATAGACGTGGCGGTGATCAAGAACGGCTGGCA
TGGCGACAGCAGCCGGATGTTCTATGTGGGCAGGCCAAGCGCGGAGGCGAAGCGGCTGGTGGAAACCTGCTACGACGCCA
CTTGCGCCGGCATCCGCGCGGTGCGCCCTGGCGCCACGCTGGGCGACATCGGCCACGCGATCCAGGCCATCACCGAATCC
GCGGGCTTCAGCGTGGTGCGCGAGTACTGCGGCCACGGCATCGGCAAGGTCTATCACGAGGAGCCCGAGGTCTTGCATTA
CGGCCGTCCCGGCATAGGCATGAAGCTGAAACGCGGCATGGTGTTCACCATCGAGCCGATGATCAATGCCGGCAAGGCCG
GCACCCGCCAGCTGGGCGATGGCTGGACGGTGGTGACGCAAGACGGGTCGTGGTCGGCGCAGTGGGAGCATATGGTGGCG
GTGACCGATCATGGCTTCGAAGTGCTGACGCCGTGGCCGGACGGCCTGGGCGATTATCCGGCGATCGCTTGA

Upstream 100 bases:

>100_bases
ATCCGGATTTGCGCTACAGCGAGATTTGCCAGCTGCTGCTGAAAGCGGGCCAGGATGGCGGCGGCCTGGATTTGCGACGC
CAGGCGATGGAGAGCGCGCG

Downstream 100 bases:

>100_bases
GCGATGGCGCGTTCCGAACGCTTGCTGGCGCTGCTGCAGCTGCTGCGCCGCTATCGCCGTCCGGTGACGGCGCAGACGCT
GGCCGACGAGCTGGATGTCA

Product: methionyl aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSRVVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAKPANVGYYGYPKTICSSVNQVVCH
GIPSAKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITES
AGFSVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVA
VTDHGFEVLTPWPDGLGDYPAIA

Sequences:

>Translated_263_residues
MSRVVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAKPANVGYYGYPKTICSSVNQVVCH
GIPSAKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITES
AGFSVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVA
VTDHGFEVLTPWPDGLGDYPAIA
>Mature_262_residues
SRVVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAKPANVGYYGYPKTICSSVNQVVCHG
IPSAKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESA
GFSVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAV
TDHGFEVLTPWPDGLGDYPAIA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=42.570281124498, Blast_Score=211, Evalue=4e-55,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=40.4, Blast_Score=196, Evalue=2e-50,
Organism=Escherichia coli, GI1786364, Length=251, Percent_Identity=56.1752988047809, Blast_Score=298, Evalue=2e-82,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=27.843137254902, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=242, Percent_Identity=42.1487603305785, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=41.0358565737052, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21355531, Length=249, Percent_Identity=41.3654618473896, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=40.4858299595142, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28390; Mature: 28259

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAKPAN
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEHCCCCCCC
VGYYGYPKTICSSVNQVVCHGIPSAKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPS
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEEEEECCCCCCCCCEEEEECCC
AEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSVVREYCGHGIGKVYHE
HHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHCC
EPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVA
CCCEEECCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEE
VTDHGFEVLTPWPDGLGDYPAIA
EECCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SRVVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAKPAN
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEHCCCCCCC
VGYYGYPKTICSSVNQVVCHGIPSAKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPS
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEEEEECCCCCCCCCEEEEECCC
AEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSVVREYCGHGIGKVYHE
HHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHCC
EPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVA
CCCEEECCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEE
VTDHGFEVLTPWPDGLGDYPAIA
EECCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]