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The map label for this gene is umuD [H]

Identifier: 34497787

GI number: 34497787

Start: 2522811

End: 2523407

Strand: Reverse

Name: umuD [H]

Synonym: CV_2332

Alternate gene names: 34497787

Gene position: 2523407-2522811 (Counterclockwise)

Preceding gene: 34497791

Following gene: 34497786

Centisome position: 53.11

GC content: 64.99

Gene sequence:

>597_bases
ATGGATACCGACAAGCCCAAACAGCATGGCGGCAAACGCTCAGGTGCCGGCCGCAAATCCGTCTTCGGAGGCGACAAGAC
CGTCGCCGTACGCGTTCCGGAGCCGCTCAAACCCATCCTGCAGCAATGGTTGGACGACTACCGCAGCTGGCGCACCGCCA
ACAGCGCGCAGGCCTTCGACTTCCGCACATTGGGCGCCCAACTGAGCGAACTGTCGCTGCCGCTGTTCGCCGGCAGCGTG
CCGGCCGGCTCTCCTGTGCCGGCTGACGACCTGAAAGAAACCGATATCGACCTCAACACCCATCTGGTCAGCCGCCCCGG
CGACACCTTCATGGTCAAGGTCAAGGGCGATTCCATGCAGGGCGCCGGCATACACGACGGCGATCTGCTGCTGGTGGAGC
GCAGCCGGGAGCCGCGCAGCGGCAAGGTGGTGGTGGCGGCGCTGAATGGCGAGCTGACCGTGAAGCGCCTGGAACGCGGC
CCCGCCGGCGTGCGGCTGCTGCCGGAAAACCCGGCCTACCAGCCGATAGACGTGCCGGAAGACTCGTCGTTTCACATTTG
GGGCGTGGTGACCAGTGTCATCCACAAAGTGGATTAG

Upstream 100 bases:

>100_bases
GACAGCTCCAAACCTTGTCAGGCCTTGATCCTCCCCCGCGAGTCCCTCACCTGGACGGCAAATCCTTGCATTCGCATTTG
AAATTGTACAGAATCAAAAC

Downstream 100 bases:

>100_bases
CGTGAAGGAGAACGCAATGGGAAAGCTCAACGACAGCATCAAGATGAAATTCAACGACTGGAAGCGCCTGCCCCGCCCTT
ACCGCGCGATGATAGAAGGC

Product: SOS mutagenesis

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MDTDKPKQHGGKRSGAGRKSVFGGDKTVAVRVPEPLKPILQQWLDDYRSWRTANSAQAFDFRTLGAQLSELSLPLFAGSV
PAGSPVPADDLKETDIDLNTHLVSRPGDTFMVKVKGDSMQGAGIHDGDLLLVERSREPRSGKVVVAALNGELTVKRLERG
PAGVRLLPENPAYQPIDVPEDSSFHIWGVVTSVIHKVD

Sequences:

>Translated_198_residues
MDTDKPKQHGGKRSGAGRKSVFGGDKTVAVRVPEPLKPILQQWLDDYRSWRTANSAQAFDFRTLGAQLSELSLPLFAGSV
PAGSPVPADDLKETDIDLNTHLVSRPGDTFMVKVKGDSMQGAGIHDGDLLLVERSREPRSGKVVVAALNGELTVKRLERG
PAGVRLLPENPAYQPIDVPEDSSFHIWGVVTSVIHKVD
>Mature_198_residues
MDTDKPKQHGGKRSGAGRKSVFGGDKTVAVRVPEPLKPILQQWLDDYRSWRTANSAQAFDFRTLGAQLSELSLPLFAGSV
PAGSPVPADDLKETDIDLNTHLVSRPGDTFMVKVKGDSMQGAGIHDGDLLLVERSREPRSGKVVVAALNGELTVKRLERG
PAGVRLLPENPAYQPIDVPEDSSFHIWGVVTSVIHKVD

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=130, Percent_Identity=43.8461538461538, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790476, Length=133, Percent_Identity=41.3533834586466, Blast_Score=84, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 21470; Mature: 21470

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTDKPKQHGGKRSGAGRKSVFGGDKTVAVRVPEPLKPILQQWLDDYRSWRTANSAQAFD
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHH
FRTLGAQLSELSLPLFAGSVPAGSPVPADDLKETDIDLNTHLVSRPGDTFMVKVKGDSMQ
HHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCC
GAGIHDGDLLLVERSREPRSGKVVVAALNGELTVKRLERGPAGVRLLPENPAYQPIDVPE
CCCCCCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCEEECCCCCCCCCCCCCC
DSSFHIWGVVTSVIHKVD
CCCEEHHHHHHHHHHHCC
>Mature Secondary Structure
MDTDKPKQHGGKRSGAGRKSVFGGDKTVAVRVPEPLKPILQQWLDDYRSWRTANSAQAFD
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHH
FRTLGAQLSELSLPLFAGSVPAGSPVPADDLKETDIDLNTHLVSRPGDTFMVKVKGDSMQ
HHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCC
GAGIHDGDLLLVERSREPRSGKVVVAALNGELTVKRLERGPAGVRLLPENPAYQPIDVPE
CCCCCCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCEEECCCCCCCCCCCCCC
DSSFHIWGVVTSVIHKVD
CCCEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609; 1910151 [H]