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The map label for this gene is msrA

Identifier: 34497780

GI number: 34497780

Start: 2517380

End: 2517910

Strand: Reverse

Name: msrA

Synonym: CV_2325

Alternate gene names: 34497780

Gene position: 2517910-2517380 (Counterclockwise)

Preceding gene: 34497781

Following gene: 34497779

Centisome position: 53.0

GC content: 61.02

Gene sequence:

>531_bases
ATGGAAAAAGCGATTCTGGGCGGCGGCTGCTTCTGGTGCCTCGAGGCAGCCTTCTCCCAGCTGAAAGGCGTGGAGCGGGT
GGTTTCCGGCTATTGCGGCGGCCACACCGACAGTCCCGACTACCGCCAGGTATGCTCGGGGGACTCCGGCCACGTGGAGG
TGGTAGAGATCAGCTACGATCCCGCCTTGATCGACTATGCCACGCTGCTGCAGGTGTTCTTCGCCGTGCACGATCCCACC
ACGCTCAACCGCCAGGGCCACGATGTCGGCACCCAGTACGCGTCGGCGATCTTCTACCTGGATGAAACCCAGCGCGAATG
CGCGCGGCGCGTCATCGCGCAACTGGACGCGGAACAGATATTCGACGCGCCCATCGTCACCCGGGTCGAATCCGCGCCTC
GCTTCCACCCGGCCGAGGATTACCATCAAAACTACTATGCGCAGAATCAGCAACAGAATTACTGCCAGCTGGTGATTTCG
CCCAAGCTGGCAAAAATCCGCCGCCGATTCTCCCATCTGCTGCAAAACTAA

Upstream 100 bases:

>100_bases
CATCCGGACCAGGTCCGCGAGTCCGAGCTGAGCGCGGCGGAAAGGCAAGGCCTGACGCTGGCCGCGCCAAACCCTCAACC
CAAGAATTACAGGAGTCATC

Downstream 100 bases:

>100_bases
CGGGCAAAACCGGGGCGCGGCCGGTATAATGGCCGGCGCCCCGCGGCACGCGTTCCAACCTTGCACCCACCAAAGTCCGA
AGCATGTCCGATGTCGAAGT

Product: protein-methionine-S-oxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MEKAILGGGCFWCLEAAFSQLKGVERVVSGYCGGHTDSPDYRQVCSGDSGHVEVVEISYDPALIDYATLLQVFFAVHDPT
TLNRQGHDVGTQYASAIFYLDETQRECARRVIAQLDAEQIFDAPIVTRVESAPRFHPAEDYHQNYYAQNQQQNYCQLVIS
PKLAKIRRRFSHLLQN

Sequences:

>Translated_176_residues
MEKAILGGGCFWCLEAAFSQLKGVERVVSGYCGGHTDSPDYRQVCSGDSGHVEVVEISYDPALIDYATLLQVFFAVHDPT
TLNRQGHDVGTQYASAIFYLDETQRECARRVIAQLDAEQIFDAPIVTRVESAPRFHPAEDYHQNYYAQNQQQNYCQLVIS
PKLAKIRRRFSHLLQN
>Mature_176_residues
MEKAILGGGCFWCLEAAFSQLKGVERVVSGYCGGHTDSPDYRQVCSGDSGHVEVVEISYDPALIDYATLLQVFFAVHDPT
TLNRQGHDVGTQYASAIFYLDETQRECARRVIAQLDAEQIFDAPIVTRVESAPRFHPAEDYHQNYYAQNQQQNYCQLVIS
PKLAKIRRRFSHLLQN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=42.6751592356688, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=42.6751592356688, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=40.7079646017699, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=48.0263157894737, Blast_Score=138, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17533973, Length=159, Percent_Identity=31.4465408805031, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=36.875, Blast_Score=95, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=40.6060606060606, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=40.625, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=39.3939393939394, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_CHRVO (Q7NVL7)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901995.1
- HSSP:   P0A744
- ProteinModelPortal:   Q7NVL7
- SMR:   Q7NVL7
- GeneID:   2549853
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2325
- NMPDR:   fig|243365.1.peg.2325
- HOGENOM:   HBG748152
- OMA:   TQRECAR
- PhylomeDB:   Q7NVL7
- BioCyc:   CVIO243365:CV_2325-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19904; Mature: 19904

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAILGGGCFWCLEAAFSQLKGVERVVSGYCGGHTDSPDYRQVCSGDSGHVEVVEISYD
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEECC
PALIDYATLLQVFFAVHDPTTLNRQGHDVGTQYASAIFYLDETQRECARRVIAQLDAEQI
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
FDAPIVTRVESAPRFHPAEDYHQNYYAQNQQQNYCQLVISPKLAKIRRRFSHLLQN
HCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKAILGGGCFWCLEAAFSQLKGVERVVSGYCGGHTDSPDYRQVCSGDSGHVEVVEISYD
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEECC
PALIDYATLLQVFFAVHDPTTLNRQGHDVGTQYASAIFYLDETQRECARRVIAQLDAEQI
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
FDAPIVTRVESAPRFHPAEDYHQNYYAQNQQQNYCQLVISPKLAKIRRRFSHLLQN
HCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782