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The map label for this gene is crtF [H]

Identifier: 34497716

GI number: 34497716

Start: 2450052

End: 2451077

Strand: Direct

Name: crtF [H]

Synonym: CV_2261

Alternate gene names: 34497716

Gene position: 2450052-2451077 (Clockwise)

Preceding gene: 34497715

Following gene: 34497717

Centisome position: 51.57

GC content: 57.5

Gene sequence:

>1026_bases
ATGGGATACGCGGCGCCGCAAGCGCGCCAAAGCGATAAGAAAATCTTCGACATATATTTCGGTTTTCTCCATAGCTATGC
CTTGCTGTTTGCCGATGAGGTCGGGCTGTTCGATCTGCTGCGCTGCGAGGCATTGACTCTGGATCAAGTTTCGATGGCGA
CGTCGCTGCCGTTCCGCTCAAGCCAGGCGCTGCTTTCGCTGTGCGCGAGCCTGGGTTTGTTGGAAAAGAGAGGGGAGCGA
TTTGCGCTTTCCGCCTTGGCGGAAGGCTTTCTTGTCCGCGAGGCGGAGACTTCCTTTTGCGGGGTGCTGGCATCGGCAAG
AGGGCAGGCGGCGGCGTTCTCGTATGATTTTTTCAAGGCCTCGCTACTCAAGGGCGAGTCGCAGCTGTTCGGAGGAAGGG
ATCTCTTCGACAACAATGCCCAGGATTCCGAGCATTGCGAGATATTCACGCGGGCGATGCATAGCAAGAGCAAGGGGCCG
GCCCAAGCCTGGGTCGAGAAAATCGACTTGTCCGCGCATGCCTGCCTGCTGGATGTCGGCGGCGGTTCCGGTGTGCATGC
GATCAGTGCCCTGGCTCGCTGGCCTAATCTGAACGCCGTTGTTTTCGATCTCCCTCCGGTTTGTGCGATCGCCGACACTT
TCATCGAGCGATATCAGATGATGGCGCGGGCTCAAACGCATGGCGGAGATATTTGGTATACGGATTACCCGTTTGCCGAT
GCGCATTTCTATAGCGACATCTTTCATGACTGGCCGCTTGAAAGGTGCCGGTTTCTGGCGCGCAAGAGCTTTGATGCATT
GCCAAGCGGCGGCCGCATCATCCTGCATGAGATGTTATTCAATACGCAGAAGACGGGGCCGCGCAATGTGGCGGCATACA
ACGCCAATATGCTGCTTTGGACCCAAGGCCAGCAACTGTCTGAGCCGGAGGCTGCGGACTTGTTGCAGGCCGCAGGCTTC
GTCGAGATCTTGGCCTTCCCCACAGGGTATGGAGACTGGAGCTTGGTGACGGGGGTTAAGCCTTAG

Upstream 100 bases:

>100_bases
GAAGCCAGAAGGGTGTTCGACAGGGTGGTGGATGGGATTTACTGCCATGGCATCATCGATGGATTGCAAAGACATATCTG
AATAAGGGCGGTTCATGAAC

Downstream 100 bases:

>100_bases
AGGGGCTAACAAAACCCCTGATGCTGCGTGGCGCCGACTTGCCGTACGGCTTGTGCTGTCTTCGTCGGCGCGCCTTGCCT
TAGCCGTAAAACTGAGTTTT

Product: acetylserotonin O-methyltransferase

Products: S-adenosyl-L-homocysteine; melatonin

Alternate protein names: O-methylase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MGYAAPQARQSDKKIFDIYFGFLHSYALLFADEVGLFDLLRCEALTLDQVSMATSLPFRSSQALLSLCASLGLLEKRGER
FALSALAEGFLVREAETSFCGVLASARGQAAAFSYDFFKASLLKGESQLFGGRDLFDNNAQDSEHCEIFTRAMHSKSKGP
AQAWVEKIDLSAHACLLDVGGGSGVHAISALARWPNLNAVVFDLPPVCAIADTFIERYQMMARAQTHGGDIWYTDYPFAD
AHFYSDIFHDWPLERCRFLARKSFDALPSGGRIILHEMLFNTQKTGPRNVAAYNANMLLWTQGQQLSEPEAADLLQAAGF
VEILAFPTGYGDWSLVTGVKP

Sequences:

>Translated_341_residues
MGYAAPQARQSDKKIFDIYFGFLHSYALLFADEVGLFDLLRCEALTLDQVSMATSLPFRSSQALLSLCASLGLLEKRGER
FALSALAEGFLVREAETSFCGVLASARGQAAAFSYDFFKASLLKGESQLFGGRDLFDNNAQDSEHCEIFTRAMHSKSKGP
AQAWVEKIDLSAHACLLDVGGGSGVHAISALARWPNLNAVVFDLPPVCAIADTFIERYQMMARAQTHGGDIWYTDYPFAD
AHFYSDIFHDWPLERCRFLARKSFDALPSGGRIILHEMLFNTQKTGPRNVAAYNANMLLWTQGQQLSEPEAADLLQAAGF
VEILAFPTGYGDWSLVTGVKP
>Mature_340_residues
GYAAPQARQSDKKIFDIYFGFLHSYALLFADEVGLFDLLRCEALTLDQVSMATSLPFRSSQALLSLCASLGLLEKRGERF
ALSALAEGFLVREAETSFCGVLASARGQAAAFSYDFFKASLLKGESQLFGGRDLFDNNAQDSEHCEIFTRAMHSKSKGPA
QAWVEKIDLSAHACLLDVGGGSGVHAISALARWPNLNAVVFDLPPVCAIADTFIERYQMMARAQTHGGDIWYTDYPFADA
HFYSDIFHDWPLERCRFLARKSFDALPSGGRIILHEMLFNTQKTGPRNVAAYNANMLLWTQGQQLSEPEAADLLQAAGFV
EILAFPTGYGDWSLVTGVKP

Specific function: Converts hydroxyneurosporene to methoxyneurosporene or demethylspheroidene to spheroidene [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI291045183, Length=337, Percent_Identity=26.1127596439169, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI291045181, Length=337, Percent_Identity=26.1127596439169, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI117553627, Length=337, Percent_Identity=26.1127596439169, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI283549144, Length=359, Percent_Identity=24.7910863509749, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI157168360, Length=359, Percent_Identity=24.7910863509749, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016461
- InterPro:   IPR001077
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00891 Methyltransf_2 [H]

EC number: 2.1.1.4

Molecular weight: Translated: 37553; Mature: 37422

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYAAPQARQSDKKIFDIYFGFLHSYALLFADEVGLFDLLRCEALTLDQVSMATSLPFRS
CCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCC
SQALLSLCASLGLLEKRGERFALSALAEGFLVREAETSFCGVLASARGQAAAFSYDFFKA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCHHHHHHHHHCCCCCEEEEHHHHHH
SLLKGESQLFGGRDLFDNNAQDSEHCEIFTRAMHSKSKGPAQAWVEKIDLSAHACLLDVG
HHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECC
GGSGVHAISALARWPNLNAVVFDLPPVCAIADTFIERYQMMARAQTHGGDIWYTDYPFAD
CCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCH
AHFYSDIFHDWPLERCRFLARKSFDALPSGGRIILHEMLFNTQKTGPRNVAAYNANMLLW
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCEEEE
TQGQQLSEPEAADLLQAAGFVEILAFPTGYGDWSLVTGVKP
ECCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCEEECCCCC
>Mature Secondary Structure 
GYAAPQARQSDKKIFDIYFGFLHSYALLFADEVGLFDLLRCEALTLDQVSMATSLPFRS
CCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCC
SQALLSLCASLGLLEKRGERFALSALAEGFLVREAETSFCGVLASARGQAAAFSYDFFKA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCHHHHHHHHHCCCCCEEEEHHHHHH
SLLKGESQLFGGRDLFDNNAQDSEHCEIFTRAMHSKSKGPAQAWVEKIDLSAHACLLDVG
HHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECC
GGSGVHAISALARWPNLNAVVFDLPPVCAIADTFIERYQMMARAQTHGGDIWYTDYPFAD
CCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCH
AHFYSDIFHDWPLERCRFLARKSFDALPSGGRIILHEMLFNTQKTGPRNVAAYNANMLLW
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCEEEE
TQGQQLSEPEAADLLQAAGFVEILAFPTGYGDWSLVTGVKP
ECCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; N-acetylserotonin

Specific reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721699; 10648776 [H]