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The map label for this gene is fes [H]

Identifier: 34497686

GI number: 34497686

Start: 2409340

End: 2410644

Strand: Direct

Name: fes [H]

Synonym: CV_2231

Alternate gene names: 34497686

Gene position: 2409340-2410644 (Clockwise)

Preceding gene: 34497684

Following gene: 34497687

Centisome position: 50.71

GC content: 71.8

Gene sequence:

>1305_bases
TTGGCTGTAGCGAGTGCGGCCTGGCTGCAACACCCGGAGGCGGGTGAGCCGCAATGGTGGGACCGGCTGGCCGCCGCGGG
CGCGCCGCTGCGCGAGCGGCTGCCGGATGGACGCGTGCGCGTGACCTTCCTGTGGCGCGATCCGGCGGGCGGGCCCGCCG
CTTCGGCCACGGTCCGCGTGTACGCCGATGTGAACTCCGTCACCGATCATCACAGTTCGCAGCCGCAGTCGCTGTCCCGC
CTGGGCGATACCGATGTCTGGTGGTGGCAGGCCGTGCTGCCTGCCGACTGGCGCGGCAGCTACGCCTATATCCCGGTGTC
GGCCGGGCAGACGCCGCCCGCGCCGAACGCAGACGTCCGCGAGAGCCGGCTGCGCCATCGCGAGTGGTGGCTAAGCATCA
TGGGACAGGCCATCTCCGATCCGCTCAACCCCGCCGCCGGCTACCGCAGCAGCTGGGGCGCGGCGCTGTCGCCGCTGCAT
CTGCCCGACGCGCCGGACCAGTCCGCCTGGGCGGCATGGGACCAGGCCGGGCAGGGGGCGGATCCGCGCCGCTTGGCCGA
GATCTGCTGGGACAGCGCCATGCTGGGCAAGGCGCGCCGGGTCTGGATTTACCACACCGGCTCCGTGCCGGCCGGACAAT
GGGCGGAGCGGCCGCTGGCCATCCTGTTGGATGGCCAGCACTGGGCGCAGCGCCTGCCAGTGTTTTCCGCGCTGGACGAA
GACACCCGCCGCGGCCGCTTGCCGCCCGCGGTATATCTGTTGGTGGACAGCATCGACGGCCGCAACCGTGAGGAGGACCT
GCCCTGCAATGCCGATTTCTGGCTGGCATTGCAGGCGGAACTGCTGCCGCAGGCGGCCTTGATCGCCCCGTTCAGCGACC
GCGCCGACCGCACCGTGGTGGCAGGGCAGAGCTATGGCGGCCTGGCGGCGATGTTCGCCGGCTTGCAGTGGCCGGAGCGC
TTCGGCTGCGTGCTCAGCCAGTCCGGCTCGTTCTGGTGGCCGCATGTGGAGTTGCATGAAAGGGCGCGCGCGGCGAGCGC
CCGCCGCCTGCCGGGCAGCAAGGGGCGCCTGACCGAGCGGCTGGAGGCGGGCGAGATGCCGCCCGGACGGCTGCGCGTGT
ACCAGGAGGTGGGCAGCCGCGAAGAGGTGATGGTGGATGTCAACGACAGCCACCGCGCGGCGCTGGAACGCGCGGGGCAC
GACGTGCATTACCGGGTGTTCGAGGGCGGGCACGACTGGCTGTGCTGGCGCGGCGGTTTGTTGCAGGGGCTGGGCTGTCT
GTGGCGGCCTTGGGTCGCCCCCTAA

Upstream 100 bases:

>100_bases
CATTATCAATATGCAATCAAAAAGCGGAGCGCGGAGCCTAAACCTGGCCCGGACGGTTCCGCAGCCTGGATCGTTGGAGA
GAATTGTGGAATCAAATCAG

Downstream 100 bases:

>100_bases
AAACAAACCAGAATCGTCCGAAGGCGGGCCAGGCCCGCCTGCAGGCCGGCTCGCCTTGCTGGAGTGTTCGCCATGAGCGC
GGAGCAAACCAATCCTTTCG

Product: enterobactin/ferric enterobactin esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MAVASAAWLQHPEAGEPQWWDRLAAAGAPLRERLPDGRVRVTFLWRDPAGGPAASATVRVYADVNSVTDHHSSQPQSLSR
LGDTDVWWWQAVLPADWRGSYAYIPVSAGQTPPAPNADVRESRLRHREWWLSIMGQAISDPLNPAAGYRSSWGAALSPLH
LPDAPDQSAWAAWDQAGQGADPRRLAEICWDSAMLGKARRVWIYHTGSVPAGQWAERPLAILLDGQHWAQRLPVFSALDE
DTRRGRLPPAVYLLVDSIDGRNREEDLPCNADFWLALQAELLPQAALIAPFSDRADRTVVAGQSYGGLAAMFAGLQWPER
FGCVLSQSGSFWWPHVELHERARAASARRLPGSKGRLTERLEAGEMPPGRLRVYQEVGSREEVMVDVNDSHRAALERAGH
DVHYRVFEGGHDWLCWRGGLLQGLGCLWRPWVAP

Sequences:

>Translated_434_residues
MAVASAAWLQHPEAGEPQWWDRLAAAGAPLRERLPDGRVRVTFLWRDPAGGPAASATVRVYADVNSVTDHHSSQPQSLSR
LGDTDVWWWQAVLPADWRGSYAYIPVSAGQTPPAPNADVRESRLRHREWWLSIMGQAISDPLNPAAGYRSSWGAALSPLH
LPDAPDQSAWAAWDQAGQGADPRRLAEICWDSAMLGKARRVWIYHTGSVPAGQWAERPLAILLDGQHWAQRLPVFSALDE
DTRRGRLPPAVYLLVDSIDGRNREEDLPCNADFWLALQAELLPQAALIAPFSDRADRTVVAGQSYGGLAAMFAGLQWPER
FGCVLSQSGSFWWPHVELHERARAASARRLPGSKGRLTERLEAGEMPPGRLRVYQEVGSREEVMVDVNDSHRAALERAGH
DVHYRVFEGGHDWLCWRGGLLQGLGCLWRPWVAP
>Mature_433_residues
AVASAAWLQHPEAGEPQWWDRLAAAGAPLRERLPDGRVRVTFLWRDPAGGPAASATVRVYADVNSVTDHHSSQPQSLSRL
GDTDVWWWQAVLPADWRGSYAYIPVSAGQTPPAPNADVRESRLRHREWWLSIMGQAISDPLNPAAGYRSSWGAALSPLHL
PDAPDQSAWAAWDQAGQGADPRRLAEICWDSAMLGKARRVWIYHTGSVPAGQWAERPLAILLDGQHWAQRLPVFSALDED
TRRGRLPPAVYLLVDSIDGRNREEDLPCNADFWLALQAELLPQAALIAPFSDRADRTVVAGQSYGGLAAMFAGLQWPERF
GCVLSQSGSFWWPHVELHERARAASARRLPGSKGRLTERLEAGEMPPGRLRVYQEVGSREEVMVDVNDSHRAALERAGHD
VHYRVFEGGHDWLCWRGGLLQGLGCLWRPWVAP

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=393, Percent_Identity=49.3638676844784, Blast_Score=346, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 48207; Mature: 48076

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVASAAWLQHPEAGEPQWWDRLAAAGAPLRERLPDGRVRVTFLWRDPAGGPAASATVRV
CCCCCCHHHCCCCCCCCHHHHHHHHCCCCHHHHCCCCCEEEEEEEECCCCCCCCCCEEEE
YADVNSVTDHHSSQPQSLSRLGDTDVWWWQAVLPADWRGSYAYIPVSAGQTPPAPNADVR
EEECCHHHHCCCCCCHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHH
ESRLRHREWWLSIMGQAISDPLNPAAGYRSSWGAALSPLHLPDAPDQSAWAAWDQAGQGA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
DPRRLAEICWDSAMLGKARRVWIYHTGSVPAGQWAERPLAILLDGQHWAQRLPVFSALDE
CHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHCCCEEEEECCHHHHHHCCHHHHHCC
DTRRGRLPPAVYLLVDSIDGRNREEDLPCNADFWLALQAELLPQAALIAPFSDRADRTVV
HHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHCCCHHEECCCCCCCCCEEE
AGQSYGGLAAMFAGLQWPERFGCVLSQSGSFWWPHVELHERARAASARRLPGSKGRLTER
ECCCCCCHHHHHHCCCCHHHHCHHEECCCCEECCCHHHHHHHHHHHHHCCCCCCCHHHHH
LEAGEMPPGRLRVYQEVGSREEVMVDVNDSHRAALERAGHDVHYRVFEGGHDWLCWRGGL
HHCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCEEEEEEECCCCEEEECCCH
LQGLGCLWRPWVAP
HHHHHHHCCCCCCC
>Mature Secondary Structure 
AVASAAWLQHPEAGEPQWWDRLAAAGAPLRERLPDGRVRVTFLWRDPAGGPAASATVRV
CCCCCHHHCCCCCCCCHHHHHHHHCCCCHHHHCCCCCEEEEEEEECCCCCCCCCCEEEE
YADVNSVTDHHSSQPQSLSRLGDTDVWWWQAVLPADWRGSYAYIPVSAGQTPPAPNADVR
EEECCHHHHCCCCCCHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHH
ESRLRHREWWLSIMGQAISDPLNPAAGYRSSWGAALSPLHLPDAPDQSAWAAWDQAGQGA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
DPRRLAEICWDSAMLGKARRVWIYHTGSVPAGQWAERPLAILLDGQHWAQRLPVFSALDE
CHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHCCCEEEEECCHHHHHHCCHHHHHCC
DTRRGRLPPAVYLLVDSIDGRNREEDLPCNADFWLALQAELLPQAALIAPFSDRADRTVV
HHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHCCCHHEECCCCCCCCCEEE
AGQSYGGLAAMFAGLQWPERFGCVLSQSGSFWWPHVELHERARAASARRLPGSKGRLTER
ECCCCCCHHHHHHCCCCHHHHCHHEECCCCEECCCHHHHHHHHHHHHHCCCCCCCHHHHH
LEAGEMPPGRLRVYQEVGSREEVMVDVNDSHRAALERAGHDVHYRVFEGGHDWLCWRGGL
HHCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCEEEEEEECCCCEEEECCCH
LQGLGCLWRPWVAP
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA