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The map label for this gene is trpD

Identifier: 34497628

GI number: 34497628

Start: 2346625

End: 2347653

Strand: Reverse

Name: trpD

Synonym: CV_2173

Alternate gene names: 34497628

Gene position: 2347653-2346625 (Counterclockwise)

Preceding gene: 34497629

Following gene: 34497627

Centisome position: 49.41

GC content: 65.69

Gene sequence:

>1029_bases
ATGATCACCCCGCAAGCGGCGCTGAATCGCCTGATCGACGGCAACGAGCTGTTTTATGACGAAATGCTGGCGCTGATGCG
CCAGATCATGCGCGGCGAACTGTCGCCGGCGCAGACGGCGGCCATCCTGATCGGGCTCCGGGTCAAGGTGGAGTCGGTGT
CGGAAATCGCCGCCGCCGCCACCGTGATGCGAGAGTTCGCCACCCACGTGCCGGTGTCCGACCGCCGCCACCTGGTGGAC
ACTTGCGGCACCGGCGGCGACAAATCCCACACCTTCAACATCTCCACCACCTCGGCCTTCGTCGCCGCGGCGGCCGGCGC
CCGCGTGGCCAAGCACGGCGGCCGCTCGGTATCGTCCAGCTCCGGCAGCGCCGACGTGCTGGAACTGCTGGGGGTCAATC
TGCAACTGACGCCGGAACAGGTCGGGCAATGCCTGGACGAGATCGGCCTGGGCTTCATGTTCGCGCCCAACCATCACAGC
GCGATGAAGCACGTGGCGCCGATCCGCAAGGAACTGGGCGCCCGCACCATCTTCAATATCCTGGGTCCGCTGACCAATCC
GGCGGCTGCCGACCACCAGTTGATGGGCGTGTTCCACCCCGATCTGGTAGGCATACAATCCCGCGTGCTCAAGATGCTGG
GCAGCCGGCATGTGATGATCGTCCACGGCTGCGACGGCCTGGACGAATTGACACTATCCGGCCCCAGCATGGTGGCGGAA
CTCAAGAATGGCGAGATACTGGAATACGAATTGGAGCCGGGCGAATTCGGCTTCCCGCTCTGCGAGCTGAAGGACTTGCG
CGCCGACACCGCCGCGCAGTCCCGCGACCGGCTGCTGGCGGTGCTGGATGGCCAGCCCGGCCCCGCCCGCGACATCGTGC
TGCTCAATGCCGGCGCGGCGATTTACACCGCCGATATCGCCCCAAGCCTGGCTGACGGTGTTACCATGGCGCGCGAGGCC
TTGGACAGCGGCAAGGCCAAACAGAAACTGCAGCAGCTGATCGCCTTGAGCCGAAAGCTCGGCGGCTGA

Upstream 100 bases:

>100_bases
CAGCGGCAACGGCGCCGGCCGCGCCCGCCTGGCCTGCGAAATCGACCTCGACACGCAAAGGCTGGCCGACCTGGCCGGCC
ACAGCTGATAGGAAACCCTC

Downstream 100 bases:

>100_bases
ATTCCCTGCGGGGCGGCGCACCTCCGCCCCCCAATCTCATATCGCGTCAGAACCATCATGAACAAAATATCCAAAGACAT
CTTCAAGGCGTATGACATCC

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MITPQAALNRLIDGNELFYDEMLALMRQIMRGELSPAQTAAILIGLRVKVESVSEIAAAATVMREFATHVPVSDRRHLVD
TCGTGGDKSHTFNISTTSAFVAAAAGARVAKHGGRSVSSSSGSADVLELLGVNLQLTPEQVGQCLDEIGLGFMFAPNHHS
AMKHVAPIRKELGARTIFNILGPLTNPAAADHQLMGVFHPDLVGIQSRVLKMLGSRHVMIVHGCDGLDELTLSGPSMVAE
LKNGEILEYELEPGEFGFPLCELKDLRADTAAQSRDRLLAVLDGQPGPARDIVLLNAGAAIYTADIAPSLADGVTMAREA
LDSGKAKQKLQQLIALSRKLGG

Sequences:

>Translated_342_residues
MITPQAALNRLIDGNELFYDEMLALMRQIMRGELSPAQTAAILIGLRVKVESVSEIAAAATVMREFATHVPVSDRRHLVD
TCGTGGDKSHTFNISTTSAFVAAAAGARVAKHGGRSVSSSSGSADVLELLGVNLQLTPEQVGQCLDEIGLGFMFAPNHHS
AMKHVAPIRKELGARTIFNILGPLTNPAAADHQLMGVFHPDLVGIQSRVLKMLGSRHVMIVHGCDGLDELTLSGPSMVAE
LKNGEILEYELEPGEFGFPLCELKDLRADTAAQSRDRLLAVLDGQPGPARDIVLLNAGAAIYTADIAPSLADGVTMAREA
LDSGKAKQKLQQLIALSRKLGG
>Mature_342_residues
MITPQAALNRLIDGNELFYDEMLALMRQIMRGELSPAQTAAILIGLRVKVESVSEIAAAATVMREFATHVPVSDRRHLVD
TCGTGGDKSHTFNISTTSAFVAAAAGARVAKHGGRSVSSSSGSADVLELLGVNLQLTPEQVGQCLDEIGLGFMFAPNHHS
AMKHVAPIRKELGARTIFNILGPLTNPAAADHQLMGVFHPDLVGIQSRVLKMLGSRHVMIVHGCDGLDELTLSGPSMVAE
LKNGEILEYELEPGEFGFPLCELKDLRADTAAQSRDRLLAVLDGQPGPARDIVLLNAGAAIYTADIAPSLADGVTMAREA
LDSGKAKQKLQQLIALSRKLGG

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=283, Percent_Identity=43.4628975265018, Blast_Score=214, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6320561, Length=331, Percent_Identity=30.8157099697885, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_CHRVO (Q7NW17)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901843.1
- ProteinModelPortal:   Q7NW17
- SMR:   Q7NW17
- GeneID:   2549214
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2173
- NMPDR:   fig|243365.1.peg.2173
- HOGENOM:   HBG559996
- OMA:   HGNKSAS
- PhylomeDB:   Q7NW17
- ProtClustDB:   PRK00188
- BioCyc:   CVIO243365:CV_2173-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 36297; Mature: 36297

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITPQAALNRLIDGNELFYDEMLALMRQIMRGELSPAQTAAILIGLRVKVESVSEIAAAA
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEHHHHHHHHHHH
TVMREFATHVPVSDRRHLVDTCGTGGDKSHTFNISTTSAFVAAAAGARVAKHGGRSVSSS
HHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
SGSADVLELLGVNLQLTPEQVGQCLDEIGLGFMFAPNHHSAMKHVAPIRKELGARTIFNI
CCCHHHHHHHCCCCEECHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LGPLTNPAAADHQLMGVFHPDLVGIQSRVLKMLGSRHVMIVHGCDGLDELTLSGPSMVAE
HCCCCCCCCCCCHHHEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCHHHHHH
LKNGEILEYELEPGEFGFPLCELKDLRADTAAQSRDRLLAVLDGQPGPARDIVLLNAGAA
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCE
IYTADIAPSLADGVTMAREALDSGKAKQKLQQLIALSRKLGG
EEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITPQAALNRLIDGNELFYDEMLALMRQIMRGELSPAQTAAILIGLRVKVESVSEIAAAA
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEHHHHHHHHHHH
TVMREFATHVPVSDRRHLVDTCGTGGDKSHTFNISTTSAFVAAAAGARVAKHGGRSVSSS
HHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
SGSADVLELLGVNLQLTPEQVGQCLDEIGLGFMFAPNHHSAMKHVAPIRKELGARTIFNI
CCCHHHHHHHCCCCEECHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LGPLTNPAAADHQLMGVFHPDLVGIQSRVLKMLGSRHVMIVHGCDGLDELTLSGPSMVAE
HCCCCCCCCCCCHHHEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCHHHHHH
LKNGEILEYELEPGEFGFPLCELKDLRADTAAQSRDRLLAVLDGQPGPARDIVLLNAGAA
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCE
IYTADIAPSLADGVTMAREALDSGKAKQKLQQLIALSRKLGG
EEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782