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The map label for this gene is paaH [H]

Identifier: 34497541

GI number: 34497541

Start: 2272510

End: 2273358

Strand: Reverse

Name: paaH [H]

Synonym: CV_2086

Alternate gene names: 34497541

Gene position: 2273358-2272510 (Counterclockwise)

Preceding gene: 34497545

Following gene: 34497540

Centisome position: 47.85

GC content: 64.31

Gene sequence:

>849_bases
ATGAGCCAGAAAATCGGCGTGGTGGGCGCGGGCACGATGGGCAACGGCATCGCCCAGGTCTTCGCGATGAAGGGTTTCGA
CGTGGTATTGGCCGACGTCAGCGACGCGGCCCTGGTCAAGGGCACAGCCAACATCAACATCAGCCTGCAGCGGATGGCGA
AGAAGGAGCTGATCGCCGAAGCCAACATCCCCGGCATCCTCGCCCACATCCGCGCCACCACCAAACTGGCCGAGCTGGCC
GGCTGCGACGTGGTGGTGGAAGCCGCCACCGAAAACGCCGAGATCAAGGAAAAAATCTTCCGCGAACTGGACGCCGCCGT
CGGCGAGAAATGCGTGCTGGCGTCCAATACCTCGTCCATCTCCCTCACCCGCATCGCCAGCTGGGTCAGCCACCCGGAAC
GGGTGGTGGGCATGCACTTCATGAATCCGGTGCCGCTGATGCAGCTGGTGGAGATCATCCGCGCGCTGCAAACCGGCGAC
GAGGCCTACCACACCGTGTTCCACCTGACGCAGGCGCTGGGCAAGACCCCGGTGACGGTGAAGGACGGCGCCGGCTTCGT
CTCCAACCGCGTGCTGATGCCGATGATCAACGAGGCCGCCTTCGCGCTGTACGAGAACCTGGCCACCGCCGAGGACATCG
ACACCGTGATGAAGCTGGGCATGAATCACCCTATCGGTCCGCTGGCCCTGGCCGACCTGATCGGCCTGGACACCTGCCTG
TCCATCATGGACATCCTGCACCGCGAGTTCCGCGACAGCAAATACCGCGCCTGCCCGCTGCTCGCGCAGCTGGTGCAGGC
CGGCCATCTGGGCCGCAAGAGCGGCAAAGGCTTCTACAGCTACAACTGA

Upstream 100 bases:

>100_bases
GCGCCACAGTCGGGTGCTTTTGCATTCATTGTCTGTTGACGTTGACGTAAACGTCAAGTTATCGTGATCGAAAGTAGAGC
AAACAGTCCAGGAGAAGCAG

Downstream 100 bases:

>100_bases
GCAGCGCCATCAGCCCGAACAATTAGAGGAGGCAGTGCCATGAGCCAGTCGGTACCCAACATCAAGCTGTTGATAGGCGG
CGAATTCGTCGAGTCCCAAA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSQKIGVVGAGTMGNGIAQVFAMKGFDVVLADVSDAALVKGTANINISLQRMAKKELIAEANIPGILAHIRATTKLAELA
GCDVVVEAATENAEIKEKIFRELDAAVGEKCVLASNTSSISLTRIASWVSHPERVVGMHFMNPVPLMQLVEIIRALQTGD
EAYHTVFHLTQALGKTPVTVKDGAGFVSNRVLMPMINEAAFALYENLATAEDIDTVMKLGMNHPIGPLALADLIGLDTCL
SIMDILHREFRDSKYRACPLLAQLVQAGHLGRKSGKGFYSYN

Sequences:

>Translated_282_residues
MSQKIGVVGAGTMGNGIAQVFAMKGFDVVLADVSDAALVKGTANINISLQRMAKKELIAEANIPGILAHIRATTKLAELA
GCDVVVEAATENAEIKEKIFRELDAAVGEKCVLASNTSSISLTRIASWVSHPERVVGMHFMNPVPLMQLVEIIRALQTGD
EAYHTVFHLTQALGKTPVTVKDGAGFVSNRVLMPMINEAAFALYENLATAEDIDTVMKLGMNHPIGPLALADLIGLDTCL
SIMDILHREFRDSKYRACPLLAQLVQAGHLGRKSGKGFYSYN
>Mature_281_residues
SQKIGVVGAGTMGNGIAQVFAMKGFDVVLADVSDAALVKGTANINISLQRMAKKELIAEANIPGILAHIRATTKLAELAG
CDVVVEAATENAEIKEKIFRELDAAVGEKCVLASNTSSISLTRIASWVSHPERVVGMHFMNPVPLMQLVEIIRALQTGDE
AYHTVFHLTQALGKTPVTVKDGAGFVSNRVLMPMINEAAFALYENLATAEDIDTVMKLGMNHPIGPLALADLIGLDTCLS
IMDILHREFRDSKYRACPLLAQLVQAGHLGRKSGKGFYSYN

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=39.9305555555556, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=37.7049180327869, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI20127408, Length=279, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=32.7586206896552, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI68989263, Length=289, Percent_Identity=32.5259515570934, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=29.6610169491525, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=39.9293286219081, Blast_Score=193, Evalue=9e-51,
Organism=Escherichia coli, GI1790281, Length=270, Percent_Identity=34.0740740740741, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1788682, Length=216, Percent_Identity=37.037037037037, Blast_Score=140, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17553560, Length=285, Percent_Identity=40, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17549919, Length=285, Percent_Identity=40, Blast_Score=210, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=34.1379310344828, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25144276, Length=279, Percent_Identity=36.9175627240143, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17508953, Length=279, Percent_Identity=36.9175627240143, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17508951, Length=279, Percent_Identity=36.9175627240143, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=30.7142857142857, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17558304, Length=279, Percent_Identity=36.2007168458781, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=278, Percent_Identity=28.7769784172662, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=37.2340425531915, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=37.2340425531915, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=37.2340425531915, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=29.9107142857143, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45549573, Length=238, Percent_Identity=29.4117647058824, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30303; Mature: 30172

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKIGVVGAGTMGNGIAQVFAMKGFDVVLADVSDAALVKGTANINISLQRMAKKELIAE
CCCCCCEEECCCCCHHHHHHHHHCCCEEEEECCCCCCEEECCCCEEEHHHHHHHHHHHHH
ANIPGILAHIRATTKLAELAGCDVVVEAATENAEIKEKIFRELDAAVGEKCVLASNTSSI
CCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCC
SLTRIASWVSHPERVVGMHFMNPVPLMQLVEIIRALQTGDEAYHTVFHLTQALGKTPVTV
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEE
KDGAGFVSNRVLMPMINEAAFALYENLATAEDIDTVMKLGMNHPIGPLALADLIGLDTCL
ECCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SIMDILHREFRDSKYRACPLLAQLVQAGHLGRKSGKGFYSYN
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQKIGVVGAGTMGNGIAQVFAMKGFDVVLADVSDAALVKGTANINISLQRMAKKELIAE
CCCCCEEECCCCCHHHHHHHHHCCCEEEEECCCCCCEEECCCCEEEHHHHHHHHHHHHH
ANIPGILAHIRATTKLAELAGCDVVVEAATENAEIKEKIFRELDAAVGEKCVLASNTSSI
CCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCC
SLTRIASWVSHPERVVGMHFMNPVPLMQLVEIIRALQTGDEAYHTVFHLTQALGKTPVTV
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEE
KDGAGFVSNRVLMPMINEAAFALYENLATAEDIDTVMKLGMNHPIGPLALADLIGLDTCL
ECCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SIMDILHREFRDSKYRACPLLAQLVQAGHLGRKSGKGFYSYN
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA