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The map label for this gene is ribA [H]

Identifier: 34497460

GI number: 34497460

Start: 2186305

End: 2186922

Strand: Direct

Name: ribA [H]

Synonym: CV_2005

Alternate gene names: 34497460

Gene position: 2186305-2186922 (Clockwise)

Preceding gene: 34497459

Following gene: 34497461

Centisome position: 46.02

GC content: 65.37

Gene sequence:

>618_bases
ATGTCGCCGCACCCGCAACCCGCTCCCGAACCCGTCATCCAGTATATCGCCAGCTGCAAGCTGCCCACGCCGTGGGGCGA
ATTCGTCATGCACGGCTTCGAGGAAGAGAGCGGCCAGGAGCATGTGGCGCTGACGCTGGGCGAGGTGGGCGACGGCCTGC
CGGTGCTGGCGCGGCTTCACTCGGAGTGCCTGACCGGCGACGCGCTCTTTTCTCTGCGCTGCGACTGCGGCTTCCAGCTG
GAGGCCGCGATGGAGGCGATCAGCAAAGCCGGCCGCGGCGCGCTGCTGTATTTGCGCCAGGAAGGCCGCGGCATCGGCCT
GATCAACAAGATCCGCGCCTACAAGCTGCAGGATGGCGGCGCGGATACGGTGGAAGCCAATGAAAGGCTGGGTTTCCCAG
CCGACATGCGCGATTTCCGCATTGCCCGCCACATGCTGGCGCATCTGGGCATCGGCAGCGTCAAGGTGATGACCAACAAT
CCGCGCAAGCTGGCCACGCTGGAAGCGGCCGGCATCGCGGTGGTGGAGCGTGTGCCGCTGCAAGTGGGGCGCAATCCGTA
TAATGACCGTTACCTGGACACCAAGGCCGCCAAGCTGGGCCACATGCTGCTCAAGTAA

Upstream 100 bases:

>100_bases
AGCTGCCGCCGCTTGAAAACGGGGAAACCCTCCCCAACTAAGCATCATCCAGGCCGCCGCGCGGCCTTTTCGCATTGCAC
CCCTCAGCGTTGGAGAAGTC

Downstream 100 bases:

>100_bases
GATGCGCCGGGCGCGCATGCTGGCGCTCGCCAAGCGATGATAGTTGTAATATAATGAACATTCTTATCTGGGGGCGACCT
GGTTTCGACGGGGGTTGCGA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSPHPQPAPEPVIQYIASCKLPTPWGEFVMHGFEEESGQEHVALTLGEVGDGLPVLARLHSECLTGDALFSLRCDCGFQL
EAAMEAISKAGRGALLYLRQEGRGIGLINKIRAYKLQDGGADTVEANERLGFPADMRDFRIARHMLAHLGIGSVKVMTNN
PRKLATLEAAGIAVVERVPLQVGRNPYNDRYLDTKAAKLGHMLLK

Sequences:

>Translated_205_residues
MSPHPQPAPEPVIQYIASCKLPTPWGEFVMHGFEEESGQEHVALTLGEVGDGLPVLARLHSECLTGDALFSLRCDCGFQL
EAAMEAISKAGRGALLYLRQEGRGIGLINKIRAYKLQDGGADTVEANERLGFPADMRDFRIARHMLAHLGIGSVKVMTNN
PRKLATLEAAGIAVVERVPLQVGRNPYNDRYLDTKAAKLGHMLLK
>Mature_204_residues
SPHPQPAPEPVIQYIASCKLPTPWGEFVMHGFEEESGQEHVALTLGEVGDGLPVLARLHSECLTGDALFSLRCDCGFQLE
AAMEAISKAGRGALLYLRQEGRGIGLINKIRAYKLQDGGADTVEANERLGFPADMRDFRIARHMLAHLGIGSVKVMTNNP
RKLATLEAAGIAVVERVPLQVGRNPYNDRYLDTKAAKLGHMLLK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=63.9175257731959, Blast_Score=258, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=43.3526011560694, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 22370; Mature: 22239

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPHPQPAPEPVIQYIASCKLPTPWGEFVMHGFEEESGQEHVALTLGEVGDGLPVLARLH
CCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHH
SECLTGDALFSLRCDCGFQLEAAMEAISKAGRGALLYLRQEGRGIGLINKIRAYKLQDGG
HHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHEEEECCCC
ADTVEANERLGFPADMRDFRIARHMLAHLGIGSVKVMTNNPRKLATLEAAGIAVVERVPL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHCHHHHHHHHH
QVGRNPYNDRYLDTKAAKLGHMLLK
HHCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SPHPQPAPEPVIQYIASCKLPTPWGEFVMHGFEEESGQEHVALTLGEVGDGLPVLARLH
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHH
SECLTGDALFSLRCDCGFQLEAAMEAISKAGRGALLYLRQEGRGIGLINKIRAYKLQDGG
HHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHEEEECCCC
ADTVEANERLGFPADMRDFRIARHMLAHLGIGSVKVMTNNPRKLATLEAAGIAVVERVPL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHCHHHHHHHHH
QVGRNPYNDRYLDTKAAKLGHMLLK
HHCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA