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The map label for this gene is hbpA [H]

Identifier: 34497433

GI number: 34497433

Start: 2153022

End: 2154800

Strand: Direct

Name: hbpA [H]

Synonym: CV_1978

Alternate gene names: 34497433

Gene position: 2153022-2154800 (Clockwise)

Preceding gene: 34497431

Following gene: 34497434

Centisome position: 45.32

GC content: 61.55

Gene sequence:

>1779_bases
ATGTGCCTGAGAAAGCCCCTGGTGGCGGCACTGATGGTCTGGGGGAGCGTGACGCCGCTGCATGCGGCCGCCGCGGAGAA
GGTGCTGCATGTGGCGTTCAGCGCGCCGGAGACCGGATTTGATCCGGCCAAGATATCCGACATCTATTCGTCCGCGGTGA
TCGAGCACATCTACGATCCCTTGCTGACTTTTGACTACCTGTCCCGCCCGGTGAAGGTGGTGCCCAATGTGACCACGGCG
ATGCCGACGGTCAGCGCCGACGGTCTGACTTACACTTTCCATTTGAAGAAGGGCATTTATTTCGCGCCTGACCCGGCGTT
CAAGGGCAAGAAGCGCGAACTGACCGCCGCCGATTACGTGTACTCGATCAAGCGCCTGTCCGATCCGACGGTGGCTTCGC
CGCTCAGCGATACCTTCACCGACAAGCTGGCGGGCTTGGCTGAGCTGGTGAAGAAAGCGGGCAAGGGCAAACTGGACTAC
GACACGGTGGTGGAAGGCGTGAAGACGCTGGACCGCTACACCTTGCAGCTCAAGTTCAAGCAGCCATTCCCATCCCTGCC
TTTCCTGCTGGCCGGCAGCTGGGTGGAGGGACAGGCGCGGGAAGTGGTCGATGCCTATGGCGACAATACCAATGCCCACC
CGGTCGGCACCGGGCCTTATGTTTTGAAGGACTGGAAGCCGGGCAACAGCATGACGCTGGTGCGCAATCCCAATTTCCGC
CGAGAGGTCTTCCATTATGGCGCGGCCGCCGATGCCGGCGATCAACGGATCGCCGCGCGGATGAACGGCAAGCGCTATCC
GCAGATAGACCGGATCGAGGTGTCGGTGATCCAGGAGGAACAGCCGGCCTGGCTGGCCTTCAAGAGTGGGGAGTTGGATC
TCGTAGGCATTCCTCAGCCTTTGATCCGGCAAGTCCTGCGGCTGGACCCCAAGAATCCCTGGCGCGCGGAGCTGAAGCCG
GAACTGAAAAACAAGGGCGTTCAGCTTAGCCGCGAGCTGGGCGAGGAGGTCACCTTCTACGCGTTCAATATGAAGGACCC
GGTCGTCGGCGGGTACGGCAAGGACAAGATCGCGCTGCGCCGCGCGATTTCCATGGCTTTCGACACCAACGAAACGATAC
GCGACATCCGCCGCAACCAGGCGGTGCAGGTGCAGTACATCGTGCCGCCCAACGTGGCCGGGCACAATCCCGATTTCCGC
GCCGCCTATCCTTACAACCCGCCCTTGGCCAATGCCTTGCTGGACCAGTTCGGCTACAAGATCGGCGCCGACGGCTACCG
CCATGCTCCGGACGGCAAGCCCGTCGTCGTCGATTTCCTGACCGGCCCCACCGCCATCGACAAGCAGTGGAACGAGTATT
GGCAGAAGGCCTTCGACCGCATCAAGGTGAAGGTGAATTTCCGCGTGATGCAGTGGAACGAGCAGGTGAAGGCGCAGCGC
GACTGCAAGTTCGGCATGAACGGCGGCGCCTGGAGCGCGGATTACCCCGACGGCGACAACTTCACGCAACTGCTGTACGG
CGGCAATGTCGGCAACTCCAACAACGCCTGCTACCAGTCCCCGCGCTACGACAAGCTCTACGAACAGTCGCGCCTGCTGC
CGGACGGACCGGAGCGCAACCGCCTGTACGACCAGATGAACAAGATCGTGGCCGGCGACACGCCGTGGATGTTCAGCGAC
ATTCGTTTCACCAACGCGCTGGCGCAGCCGTGGGTGAGGGGGTTCAAGCACCACCCCAACTTCAATGCCATCTGGCGTTT
CCTGGACGTAGAAAAATAA

Upstream 100 bases:

>100_bases
AGCCTGCGCGGCCGCGGACGCCAAGCGGCCGGCCGCGATAGAAAATCGACCATCCCGATGCGGACTGGTTCCGATTAGAA
AAATAGAGGAGAAAACGTCT

Downstream 100 bases:

>100_bases
GCGGGGAGCGAGGAGAATCATCATGTCCGCATTCATCATCCGCCGGCTGCTGCAAATGATCCCGACCCTGTTCGGGGTGA
TGCTGCTGGTATTCATCCTG

Product: heme-binding protein A

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MCLRKPLVAALMVWGSVTPLHAAAAEKVLHVAFSAPETGFDPAKISDIYSSAVIEHIYDPLLTFDYLSRPVKVVPNVTTA
MPTVSADGLTYTFHLKKGIYFAPDPAFKGKKRELTAADYVYSIKRLSDPTVASPLSDTFTDKLAGLAELVKKAGKGKLDY
DTVVEGVKTLDRYTLQLKFKQPFPSLPFLLAGSWVEGQAREVVDAYGDNTNAHPVGTGPYVLKDWKPGNSMTLVRNPNFR
REVFHYGAAADAGDQRIAARMNGKRYPQIDRIEVSVIQEEQPAWLAFKSGELDLVGIPQPLIRQVLRLDPKNPWRAELKP
ELKNKGVQLSRELGEEVTFYAFNMKDPVVGGYGKDKIALRRAISMAFDTNETIRDIRRNQAVQVQYIVPPNVAGHNPDFR
AAYPYNPPLANALLDQFGYKIGADGYRHAPDGKPVVVDFLTGPTAIDKQWNEYWQKAFDRIKVKVNFRVMQWNEQVKAQR
DCKFGMNGGAWSADYPDGDNFTQLLYGGNVGNSNNACYQSPRYDKLYEQSRLLPDGPERNRLYDQMNKIVAGDTPWMFSD
IRFTNALAQPWVRGFKHHPNFNAIWRFLDVEK

Sequences:

>Translated_592_residues
MCLRKPLVAALMVWGSVTPLHAAAAEKVLHVAFSAPETGFDPAKISDIYSSAVIEHIYDPLLTFDYLSRPVKVVPNVTTA
MPTVSADGLTYTFHLKKGIYFAPDPAFKGKKRELTAADYVYSIKRLSDPTVASPLSDTFTDKLAGLAELVKKAGKGKLDY
DTVVEGVKTLDRYTLQLKFKQPFPSLPFLLAGSWVEGQAREVVDAYGDNTNAHPVGTGPYVLKDWKPGNSMTLVRNPNFR
REVFHYGAAADAGDQRIAARMNGKRYPQIDRIEVSVIQEEQPAWLAFKSGELDLVGIPQPLIRQVLRLDPKNPWRAELKP
ELKNKGVQLSRELGEEVTFYAFNMKDPVVGGYGKDKIALRRAISMAFDTNETIRDIRRNQAVQVQYIVPPNVAGHNPDFR
AAYPYNPPLANALLDQFGYKIGADGYRHAPDGKPVVVDFLTGPTAIDKQWNEYWQKAFDRIKVKVNFRVMQWNEQVKAQR
DCKFGMNGGAWSADYPDGDNFTQLLYGGNVGNSNNACYQSPRYDKLYEQSRLLPDGPERNRLYDQMNKIVAGDTPWMFSD
IRFTNALAQPWVRGFKHHPNFNAIWRFLDVEK
>Mature_592_residues
MCLRKPLVAALMVWGSVTPLHAAAAEKVLHVAFSAPETGFDPAKISDIYSSAVIEHIYDPLLTFDYLSRPVKVVPNVTTA
MPTVSADGLTYTFHLKKGIYFAPDPAFKGKKRELTAADYVYSIKRLSDPTVASPLSDTFTDKLAGLAELVKKAGKGKLDY
DTVVEGVKTLDRYTLQLKFKQPFPSLPFLLAGSWVEGQAREVVDAYGDNTNAHPVGTGPYVLKDWKPGNSMTLVRNPNFR
REVFHYGAAADAGDQRIAARMNGKRYPQIDRIEVSVIQEEQPAWLAFKSGELDLVGIPQPLIRQVLRLDPKNPWRAELKP
ELKNKGVQLSRELGEEVTFYAFNMKDPVVGGYGKDKIALRRAISMAFDTNETIRDIRRNQAVQVQYIVPPNVAGHNPDFR
AAYPYNPPLANALLDQFGYKIGADGYRHAPDGKPVVVDFLTGPTAIDKQWNEYWQKAFDRIKVKVNFRVMQWNEQVKAQR
DCKFGMNGGAWSADYPDGDNFTQLLYGGNVGNSNNACYQSPRYDKLYEQSRLLPDGPERNRLYDQMNKIVAGDTPWMFSD
IRFTNALAQPWVRGFKHHPNFNAIWRFLDVEK

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=556, Percent_Identity=22.841726618705, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1789397, Length=591, Percent_Identity=22.3350253807107, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787495, Length=598, Percent_Identity=23.5785953177258, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI87081878, Length=544, Percent_Identity=23.3455882352941, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 66650; Mature: 66650

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLRKPLVAALMVWGSVTPLHAAAAEKVLHVAFSAPETGFDPAKISDIYSSAVIEHIYDP
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHH
LLTFDYLSRPVKVVPNVTTAMPTVSADGLTYTFHLKKGIYFAPDPAFKGKKRELTAADYV
HHHHHHHCCCCEECCCCHHHCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCHHHHHH
YSIKRLSDPTVASPLSDTFTDKLAGLAELVKKAGKGKLDYDTVVEGVKTLDRYTLQLKFK
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEEEEEC
QPFPSLPFLLAGSWVEGQAREVVDAYGDNTNAHPVGTGPYVLKDWKPGNSMTLVRNPNFR
CCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCHH
REVFHYGAAADAGDQRIAARMNGKRYPQIDRIEVSVIQEEQPAWLAFKSGELDLVGIPQP
HHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEECCCEEEEECCHH
LIRQVLRLDPKNPWRAELKPELKNKGVQLSRELGEEVTFYAFNMKDPVVGGYGKDKIALR
HHHHHHHCCCCCCCCCCCCCHHHCCCCHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHH
RAISMAFDTNETIRDIRRNQAVQVQYIVPPNVAGHNPDFRAAYPYNPPLANALLDQFGYK
HHHHHHCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHCCE
IGADGYRHAPDGKPVVVDFLTGPTAIDKQWNEYWQKAFDRIKVKVNFRVMQWNEQVKAQR
ECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHEEEEEEEEEEEECCHHHHHHH
DCKFGMNGGAWSADYPDGDNFTQLLYGGNVGNSNNACYQSPRYDKLYEQSRLLPDGPERN
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHH
RLYDQMNKIVAGDTPWMFSDIRFTNALAQPWVRGFKHHPNFNAIWRFLDVEK
HHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCC
>Mature Secondary Structure
MCLRKPLVAALMVWGSVTPLHAAAAEKVLHVAFSAPETGFDPAKISDIYSSAVIEHIYDP
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHH
LLTFDYLSRPVKVVPNVTTAMPTVSADGLTYTFHLKKGIYFAPDPAFKGKKRELTAADYV
HHHHHHHCCCCEECCCCHHHCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCHHHHHH
YSIKRLSDPTVASPLSDTFTDKLAGLAELVKKAGKGKLDYDTVVEGVKTLDRYTLQLKFK
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEEEEEC
QPFPSLPFLLAGSWVEGQAREVVDAYGDNTNAHPVGTGPYVLKDWKPGNSMTLVRNPNFR
CCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCHH
REVFHYGAAADAGDQRIAARMNGKRYPQIDRIEVSVIQEEQPAWLAFKSGELDLVGIPQP
HHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEECCCEEEEECCHH
LIRQVLRLDPKNPWRAELKPELKNKGVQLSRELGEEVTFYAFNMKDPVVGGYGKDKIALR
HHHHHHHCCCCCCCCCCCCCHHHCCCCHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHH
RAISMAFDTNETIRDIRRNQAVQVQYIVPPNVAGHNPDFRAAYPYNPPLANALLDQFGYK
HHHHHHCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHCCE
IGADGYRHAPDGKPVVVDFLTGPTAIDKQWNEYWQKAFDRIKVKVNFRVMQWNEQVKAQR
ECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHEEEEEEEEEEEECCHHHHHHH
DCKFGMNGGAWSADYPDGDNFTQLLYGGNVGNSNNACYQSPRYDKLYEQSRLLPDGPERN
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHH
RLYDQMNKIVAGDTPWMFSDIRFTNALAQPWVRGFKHHPNFNAIWRFLDVEK
HHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]