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The map label for this gene is clpB

Identifier: 34497399

GI number: 34497399

Start: 2115360

End: 2117939

Strand: Direct

Name: clpB

Synonym: CV_1944

Alternate gene names: 34497399

Gene position: 2115360-2117939 (Clockwise)

Preceding gene: 34497396

Following gene: 34497402

Centisome position: 44.52

GC content: 65.66

Gene sequence:

>2580_bases
ATGCGATTCGACAAGCTGACCACCAAGTTCCAGCAGGCGCTGGGGGATGCCCAGAGCCTCGCCGTGGCGAACGACAACCC
ATACATCGAGCCGCAGCACCTGCTGCTGGCCATGCTGGACGACGCCGAAGCCGGCGTCGGCGGCCTGCTGGCGCGCGCCG
GCGTCAACGTGCCGGCGCTGAAGGCCGGTCTCAAGCAGGCGATCGACCGCCTGCCGCGGGTGCAGGGCCATGGCGGCGAG
ATCACCGTGTCGCGCGATCTGGCCAATCTGCTCAACATCGCCGACAAGATCGCGATGAAGCTGGGCGACGAATTCATCGC
CAGCGAGCTGTATCTGTCCGCGCTGTCACAGGACAAGGGCGAGGCCGGCCGCTTGCTGAAAGAGCACGGCGGCAATCACG
CGTCCATCCAGGCGGCGATAGACGCGGTGCGCGGCGGCGAGAGCGTCAACAGCGCCGACGCCGAAGGCCAGCGCGAGGCG
CTGAAGAAATACACCATGGATCTGACCGAGCGCGCCCGCCAGGGCAAGCTGGACCCGGTGATCGGCCGCGACGACGAAAT
CCGCCGCGCGATCCAGGTATTGCAGCGCCGCACCAAGAACAACCCGGTGCTGATCGGTGAGCCGGGCGTGGGCAAGACCG
CCATCGTCGAAGGTCTGGCGCAGCGGATCGTCAACGGCGAAGTGCCGGAAAGCCTGAAGAACAAGCGCCTGCTGGTGCTG
GACCTGGCGGCGCTGATCGCCGGCGCCAAGTACCGCGGCGAGTTCGAGGAGCGGCTGAAGGCGGTGCTGAACGACCTCTC
CAAGGACGACGGCCAGACGCTGATCTTCATCGACGAAATCCACACCCTGGTGGGCGCGGGCAAGGCCGACGGCGCGATGG
ACGCCGGCAACATGCTGAAGCCGGCGCTGGCGCGCGGCGAGCTGCACTGCATCGGTGCCACCACGCTGGACGAGTACCGC
AAGTACATCGAGAAGGACGCCGCGCTGGAGCGCCGCTTCCAGAAGGTGCTGGTGGGCGAGCCGTCGGTGGAGGACACCAT
CGCCATCCTGCGCGGCCTGCAGGAAAAGTACGAAATCCACCACGGCGTGGACATCACCGACCCGGCCATCGTCGCCGCGG
CGGAACTGTCCCAGCGCTACATCACCGACCGCTTCCTGCCGGACAAGGCGATCGACCTGATCGACGAGGCCGCCAGCCGC
ATCAAGATGGAGCTGGACTCCAAGCCGGAGGCGATGGACAAGCTTGACCGCAGGCTGATCCAACTGAAGATCGAGCGCGA
AGCGGTGAACAAGGAAAGCGACGAAGCCAGCCAGAAACGGCTGAAGCTGATCGAGGACGAGATCGCCGAGCTGTCGCGCG
AATACGCCGACCTGGAAGAGATCTGGAAGGCCGAGAAGGCCGCCCAGCAGGGCTCGCAGAGCATCAAGGAGGAGATCGAC
CGCCTGAAGGTGGACATGGAGGAGCTCAAGCGCAAGGGCGACTGGCAGAAATTGGCAGAACTGCAGTACGGCAAGCTGCC
GCAGCTCGAGGCGCGGCTGAAGGAGGCCGAGTCCGCCGGCGACAAGGGCGAGGCCAAGCCCAACCGCCTGCTGCGCACCC
AGGTGGGCGCCGAGGAGATCGCCGAGGTGGTCAGCCGGGCCACCGGCATCCCGGTGTCCAAGATGTTGACCGGCGAGCGC
GAAAAGCTGCTGAAGATGGAGGATGTGCTGCACCAGCGCGTGGTCGGGCAGGACGAGGCGGTCAGCGCGGTGGCCGACGC
CATCCGCCGCTCGCGCTCCGGCCTGGCCGATCCCAACAAGCCGTACGGCTCCTTCCTGTTCCTGGGACCGACCGGCGTCG
GCAAGACCGAGCTGTGCAAGACGCTGGCCAGCTTCCTGTTCGACAGCAAAGACCACCTGATCCGCATCGACATGTCCGAG
TACATGGAGAAGCATTCGGTGGCGCGGCTGATCGGCGCGCCGCCCGGTTACGTCGGCTACGAGGAAGGCGGCTATCTCAC
CGAGCAGGTGCGCCGCAAGCCGTACAGCGTGATCCTGCTGGACGAGGTGGAAAAGGCGCATCCGGACGTGTTCAACGTGC
TGCTGCAGGTGCTGGACGACGGCCGGCTCACAGATGGCCAGGGCCGCACCGTGGACTTCAAGAACACGGTGATCGTGATG
ACGTCGAACATCGGCAGCCAGCAGATCCAGGCGATGGCCACCGACGATTACCAGGTGATCAAGCTCGCCGTGATGGCGGA
AGTGAAGACGCAGTTCCGGCCGGAATTCATCAACCGCATCGACGAGGTGGTGGTGTTCCACGGCCTGGACGAGAAACACA
TCCAGTCCATCGCCCGCATCCAGTTGAAGAGCCTGGAAAACCGCTTGGCCAAGCTGGAGCTGAGCCTGCAGATCAGCGAC
GAGGCGCTGGCGCTGTTGTCCGAAGCCGGTTTCGACCCGGTCTACGGCGCGCGGCCGCTGAAGCGGGCGATCCAGGCCGA
GCTGGAAAACCCGCTGGCCAAGGCCATCCTGGCCGGCAAGTACCCGCCGAAAGCCACGGTGATGGTGGAAGCCCGGAACG
GACAACTGGCTTTCGCCTGA

Upstream 100 bases:

>100_bases
TTGAGCGTAGTCAATCCTTGGTGTTTGGCAACTCTTGAAATGGGCATTGGCCTCCCCAAAATGGAAGTCATCGACAAGAT
TCAAACGGGGAACCGACACC

Downstream 100 bases:

>100_bases
TCCGCCTCTTGCCCGCAAAAACGGCCGCTGATGCAAGCGGCCGTTTTTCATGGGAGGGCTGCCGGCTTCAGCCGCCGGGG
TCCGGATGCAGGAAGCAGCC

Product: ATP-dependent Clp protease subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 859; Mature: 859

Protein sequence:

>859_residues
MRFDKLTTKFQQALGDAQSLAVANDNPYIEPQHLLLAMLDDAEAGVGGLLARAGVNVPALKAGLKQAIDRLPRVQGHGGE
ITVSRDLANLLNIADKIAMKLGDEFIASELYLSALSQDKGEAGRLLKEHGGNHASIQAAIDAVRGGESVNSADAEGQREA
LKKYTMDLTERARQGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPESLKNKRLLVL
DLAALIAGAKYRGEFEERLKAVLNDLSKDDGQTLIFIDEIHTLVGAGKADGAMDAGNMLKPALARGELHCIGATTLDEYR
KYIEKDAALERRFQKVLVGEPSVEDTIAILRGLQEKYEIHHGVDITDPAIVAAAELSQRYITDRFLPDKAIDLIDEAASR
IKMELDSKPEAMDKLDRRLIQLKIEREAVNKESDEASQKRLKLIEDEIAELSREYADLEEIWKAEKAAQQGSQSIKEEID
RLKVDMEELKRKGDWQKLAELQYGKLPQLEARLKEAESAGDKGEAKPNRLLRTQVGAEEIAEVVSRATGIPVSKMLTGER
EKLLKMEDVLHQRVVGQDEAVSAVADAIRRSRSGLADPNKPYGSFLFLGPTGVGKTELCKTLASFLFDSKDHLIRIDMSE
YMEKHSVARLIGAPPGYVGYEEGGYLTEQVRRKPYSVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
TSNIGSQQIQAMATDDYQVIKLAVMAEVKTQFRPEFINRIDEVVVFHGLDEKHIQSIARIQLKSLENRLAKLELSLQISD
EALALLSEAGFDPVYGARPLKRAIQAELENPLAKAILAGKYPPKATVMVEARNGQLAFA

Sequences:

>Translated_859_residues
MRFDKLTTKFQQALGDAQSLAVANDNPYIEPQHLLLAMLDDAEAGVGGLLARAGVNVPALKAGLKQAIDRLPRVQGHGGE
ITVSRDLANLLNIADKIAMKLGDEFIASELYLSALSQDKGEAGRLLKEHGGNHASIQAAIDAVRGGESVNSADAEGQREA
LKKYTMDLTERARQGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPESLKNKRLLVL
DLAALIAGAKYRGEFEERLKAVLNDLSKDDGQTLIFIDEIHTLVGAGKADGAMDAGNMLKPALARGELHCIGATTLDEYR
KYIEKDAALERRFQKVLVGEPSVEDTIAILRGLQEKYEIHHGVDITDPAIVAAAELSQRYITDRFLPDKAIDLIDEAASR
IKMELDSKPEAMDKLDRRLIQLKIEREAVNKESDEASQKRLKLIEDEIAELSREYADLEEIWKAEKAAQQGSQSIKEEID
RLKVDMEELKRKGDWQKLAELQYGKLPQLEARLKEAESAGDKGEAKPNRLLRTQVGAEEIAEVVSRATGIPVSKMLTGER
EKLLKMEDVLHQRVVGQDEAVSAVADAIRRSRSGLADPNKPYGSFLFLGPTGVGKTELCKTLASFLFDSKDHLIRIDMSE
YMEKHSVARLIGAPPGYVGYEEGGYLTEQVRRKPYSVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
TSNIGSQQIQAMATDDYQVIKLAVMAEVKTQFRPEFINRIDEVVVFHGLDEKHIQSIARIQLKSLENRLAKLELSLQISD
EALALLSEAGFDPVYGARPLKRAIQAELENPLAKAILAGKYPPKATVMVEARNGQLAFA
>Mature_859_residues
MRFDKLTTKFQQALGDAQSLAVANDNPYIEPQHLLLAMLDDAEAGVGGLLARAGVNVPALKAGLKQAIDRLPRVQGHGGE
ITVSRDLANLLNIADKIAMKLGDEFIASELYLSALSQDKGEAGRLLKEHGGNHASIQAAIDAVRGGESVNSADAEGQREA
LKKYTMDLTERARQGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPESLKNKRLLVL
DLAALIAGAKYRGEFEERLKAVLNDLSKDDGQTLIFIDEIHTLVGAGKADGAMDAGNMLKPALARGELHCIGATTLDEYR
KYIEKDAALERRFQKVLVGEPSVEDTIAILRGLQEKYEIHHGVDITDPAIVAAAELSQRYITDRFLPDKAIDLIDEAASR
IKMELDSKPEAMDKLDRRLIQLKIEREAVNKESDEASQKRLKLIEDEIAELSREYADLEEIWKAEKAAQQGSQSIKEEID
RLKVDMEELKRKGDWQKLAELQYGKLPQLEARLKEAESAGDKGEAKPNRLLRTQVGAEEIAEVVSRATGIPVSKMLTGER
EKLLKMEDVLHQRVVGQDEAVSAVADAIRRSRSGLADPNKPYGSFLFLGPTGVGKTELCKTLASFLFDSKDHLIRIDMSE
YMEKHSVARLIGAPPGYVGYEEGGYLTEQVRRKPYSVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
TSNIGSQQIQAMATDDYQVIKLAVMAEVKTQFRPEFINRIDEVVVFHGLDEKHIQSIARIQLKSLENRLAKLELSLQISD
EALALLSEAGFDPVYGARPLKRAIQAELENPLAKAILAGKYPPKATVMVEARNGQLAFA

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=325, Percent_Identity=35.6923076923077, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI1788943, Length=851, Percent_Identity=67.2150411280846, Blast_Score=1171, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=413, Percent_Identity=39.225181598063, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=711, Percent_Identity=52.1800281293952, Blast_Score=742, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=852, Percent_Identity=44.6009389671362, Blast_Score=683, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_CHRVO (Q7NWN7)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901614.1
- ProteinModelPortal:   Q7NWN7
- GeneID:   2547331
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1944
- NMPDR:   fig|243365.1.peg.1944
- HOGENOM:   HBG413133
- OMA:   KRENDEP
- PhylomeDB:   Q7NWN7
- ProtClustDB:   CLSK2485434
- BioCyc:   CVIO243365:CV_1944-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR03346

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: 3.4.21.92

Molecular weight: Translated: 94754; Mature: 94754

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDKLTTKFQQALGDAQSLAVANDNPYIEPQHLLLAMLDDAEAGVGGLLARAGVNVPAL
CCCHHHHHHHHHHHCCHHHEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCHHH
KAGLKQAIDRLPRVQGHGGEITVSRDLANLLNIADKIAMKLGDEFIASELYLSALSQDKG
HHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EAGRLLKEHGGNHASIQAAIDAVRGGESVNSADAEGQREALKKYTMDLTERARQGKLDPV
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPESLKNKRLLVL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHH
DLAALIAGAKYRGEFEERLKAVLNDLSKDDGQTLIFIDEIHTLVGAGKADGAMDAGNMLK
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVGEPSVEDTIAILRGLQEKYEIH
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HGVDITDPAIVAAAELSQRYITDRFLPDKAIDLIDEAASRIKMELDSKPEAMDKLDRRLI
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QLKIEREAVNKESDEASQKRLKLIEDEIAELSREYADLEEIWKAEKAAQQGSQSIKEEID
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKVDMEELKRKGDWQKLAELQYGKLPQLEARLKEAESAGDKGEAKPNRLLRTQVGAEEI
HHHCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHH
AEVVSRATGIPVSKMLTGEREKLLKMEDVLHQRVVGQDEAVSAVADAIRRSRSGLADPNK
HHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
PYGSFLFLGPTGVGKTELCKTLASFLFDSKDHLIRIDMSEYMEKHSVARLIGAPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
EEGGYLTEQVRRKPYSVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
CCCCCHHHHHCCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNIGSQQIQAMATDDYQVIKLAVMAEVKTQFRPEFINRIDEVVVFHGLDEKHIQSIARI
ECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
QLKSLENRLAKLELSLQISDEALALLSEAGFDPVYGARPLKRAIQAELENPLAKAILAGK
HHHHHHHHHHHEEEEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
YPPKATVMVEARNGQLAFA
CCCCEEEEEEECCCCEECC
>Mature Secondary Structure
MRFDKLTTKFQQALGDAQSLAVANDNPYIEPQHLLLAMLDDAEAGVGGLLARAGVNVPAL
CCCHHHHHHHHHHHCCHHHEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCHHH
KAGLKQAIDRLPRVQGHGGEITVSRDLANLLNIADKIAMKLGDEFIASELYLSALSQDKG
HHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EAGRLLKEHGGNHASIQAAIDAVRGGESVNSADAEGQREALKKYTMDLTERARQGKLDPV
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPESLKNKRLLVL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHH
DLAALIAGAKYRGEFEERLKAVLNDLSKDDGQTLIFIDEIHTLVGAGKADGAMDAGNMLK
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVGEPSVEDTIAILRGLQEKYEIH
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HGVDITDPAIVAAAELSQRYITDRFLPDKAIDLIDEAASRIKMELDSKPEAMDKLDRRLI
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QLKIEREAVNKESDEASQKRLKLIEDEIAELSREYADLEEIWKAEKAAQQGSQSIKEEID
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKVDMEELKRKGDWQKLAELQYGKLPQLEARLKEAESAGDKGEAKPNRLLRTQVGAEEI
HHHCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHH
AEVVSRATGIPVSKMLTGEREKLLKMEDVLHQRVVGQDEAVSAVADAIRRSRSGLADPNK
HHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
PYGSFLFLGPTGVGKTELCKTLASFLFDSKDHLIRIDMSEYMEKHSVARLIGAPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
EEGGYLTEQVRRKPYSVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
CCCCCHHHHHCCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNIGSQQIQAMATDDYQVIKLAVMAEVKTQFRPEFINRIDEVVVFHGLDEKHIQSIARI
ECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
QLKSLENRLAKLELSLQISDEALALLSEAGFDPVYGARPLKRAIQAELENPLAKAILAGK
HHHHHHHHHHHEEEEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
YPPKATVMVEARNGQLAFA
CCCCEEEEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782