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The map label for this gene is mutT [H]

Identifier: 34497242

GI number: 34497242

Start: 1942604

End: 1943140

Strand: Direct

Name: mutT [H]

Synonym: CV_1787

Alternate gene names: 34497242

Gene position: 1942604-1943140 (Clockwise)

Preceding gene: 34497241

Following gene: 34497243

Centisome position: 40.89

GC content: 62.76

Gene sequence:

>537_bases
TTGTCGTCGGAGCTGGTCTATCAGGGCGGTTTCATCAAGGTGCGCAAGGACAGGGTGGCCCTGCCGGACGGAAACGAATC
CGCGCGCGAATACATCCTTCATCCCGGCGCGGTGGCGGTATTGGCGCTGACGCCGGAAGGCGAGCTGGTGCTGGAGCGGC
AATACCGCTATCCGGCCGGCCGCGAGTTCATCGAGATTCCGGCCGGCAAGATCGATCCGGACGAGGCTCCGGAGCTGACA
GCCAGGCGCGAGCTGCTGGAGGAGACCGGCTATCGGGCCGGGCGCTGGACTTATCTGGGCACCGCCCATCCTTGCATCGG
CTATTCCAACGAAAAAATCAGCTATTACCTCGCGCAAGATCTTATGCTTAGCGAAAGGCAACTGGACGCGGGCGAATTCC
TGGAGGTGCTGACCCTGCCCCTGGATGCCGCGATGAACATGGCGCTGACCGGCGAGATTTGCGACAGCAAGTCCATCGTC
GGCCTGCACTGGCTGGCGGCCTACCTGGGCGGGAGGATGCGAGGTGTCGAGATTTGA

Upstream 100 bases:

>100_bases
GGCGCGGCCGGCTATCTGGCCACCCGGGTGCTGTGGCGCTGGGCGGTCGTCAGCGCGTGGAACGATAGAAAGGTGAAGTG
TGGATCTCGTTGAGAAGCAG

Downstream 100 bases:

>100_bases
CGCGTATTACGACCGGCGGCGCGGCCGCCGGGTCAGCATGGGGTGCAAGGCCCGCATCAAGTCGCTGCTGAGCGGGCAAA
CGTTTTACGGCGAGTGCGTG

Product: ADP ribose diphosphatase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSSELVYQGGFIKVRKDRVALPDGNESAREYILHPGAVAVLALTPEGELVLERQYRYPAGREFIEIPAGKIDPDEAPELT
ARRELLEETGYRAGRWTYLGTAHPCIGYSNEKISYYLAQDLMLSERQLDAGEFLEVLTLPLDAAMNMALTGEICDSKSIV
GLHWLAAYLGGRMRGVEI

Sequences:

>Translated_178_residues
MSSELVYQGGFIKVRKDRVALPDGNESAREYILHPGAVAVLALTPEGELVLERQYRYPAGREFIEIPAGKIDPDEAPELT
ARRELLEETGYRAGRWTYLGTAHPCIGYSNEKISYYLAQDLMLSERQLDAGEFLEVLTLPLDAAMNMALTGEICDSKSIV
GLHWLAAYLGGRMRGVEI
>Mature_177_residues
SSELVYQGGFIKVRKDRVALPDGNESAREYILHPGAVAVLALTPEGELVLERQYRYPAGREFIEIPAGKIDPDEAPELTA
RRELLEETGYRAGRWTYLGTAHPCIGYSNEKISYYLAQDLMLSERQLDAGEFLEVLTLPLDAAMNMALTGEICDSKSIVG
LHWLAAYLGGRMRGVEI

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788810, Length=143, Percent_Identity=35.6643356643357, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 19792; Mature: 19661

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00893 NUDIX ; PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSELVYQGGFIKVRKDRVALPDGNESAREYILHPGAVAVLALTPEGELVLERQYRYPAG
CCCCEEEECCEEEEECCEEECCCCCHHHHHEEECCCCEEEEEECCCCCEEEEECCCCCCC
REFIEIPAGKIDPDEAPELTARRELLEETGYRAGRWTYLGTAHPCIGYSNEKISYYLAQD
CEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHH
LMLSERQLDAGEFLEVLTLPLDAAMNMALTGEICDSKSIVGLHWLAAYLGGRMRGVEI
HHHHHCCCCHHHHHHHHHCCHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
SSELVYQGGFIKVRKDRVALPDGNESAREYILHPGAVAVLALTPEGELVLERQYRYPAG
CCCEEEECCEEEEECCEEECCCCCHHHHHEEECCCCEEEEEECCCCCEEEEECCCCCCC
REFIEIPAGKIDPDEAPELTARRELLEETGYRAGRWTYLGTAHPCIGYSNEKISYYLAQD
CEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHH
LMLSERQLDAGEFLEVLTLPLDAAMNMALTGEICDSKSIVGLHWLAAYLGGRMRGVEI
HHHHHCCCCHHHHHHHHHCCHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]