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The map label for this gene is mmgC [H]

Identifier: 34497221

GI number: 34497221

Start: 1921362

End: 1922531

Strand: Reverse

Name: mmgC [H]

Synonym: CV_1766

Alternate gene names: 34497221

Gene position: 1922531-1921362 (Counterclockwise)

Preceding gene: 34497222

Following gene: 34497220

Centisome position: 40.47

GC content: 65.81

Gene sequence:

>1170_bases
ATGTACAGCAGCCTGCGCTTCGCCTTCGGCGAGACTTACGACCTCCTGCGCGAATCGGTGCGCGACTTCGCCGAGCGCGA
GATCGCCCCGCGCGCCGCCGCCATCGACCAGGACAATCTGTTCCCGGCCGATCTGTGGCGCAAGTTCGGCGAGCTGGGCT
TGCTCGGCATCACCGTCAGCGAGCAGTACGGCGGTGTGGACATGGGCTACCTCGCCCACATGATCGCGATGGAAGAAATC
AGCCGCGCCAGCGCCTCGGTGGGCCTGTCCTACGGCGCGCACTCCAATCTCTGCGTCAACCAGATCTACAAGAACGGCAA
CGACGCCCAGCGCAGCCGTTACCTGCCCAAGCTGATCACCGGCGAACACGTCGGGGCGCTGGCGATGTCCGAGCCCAACG
CCGGCTCCGACGTGGTCAGCATGAAGCTCAGGGCCGACAAGACCGACGGCGGCTACCTGCTCAACGGCAGCAAGATGTGG
ATCACCAACGGCGGCGATGCCGACACGCTGGTGGTTTACGCCAAGACCGACGTCAACGCCGGCCCCAAGGGCATCACCGC
CTTCATCATTGAAAAAAGCTTCGCCGGCTTCAGCCACGGCAGCAAGCTGGACAAGCTGGGCATGCGCGGCTCCAACACCT
ACCCCATCTTCTTCGACAACTGTTTCGTGCCGGACGAAAACGTGCTGGGCGGCGAAGGCAACGGCGTGAAAGTGCTGATG
AGCGGCCTGGACTACGAGCGCTCGGTGCTGGCGGCCGGCCCCCTGGGCATCATGCAGGCCAGCCTGGACATCGTCGTGCC
CTACCTGAACGAGCGCAGCCAGTTCGGCCAGCCGATAGGCGACTTCCAGCTGATGCAGGGCAAGCTGGCCGACATGTACG
TCAAGCTGTCCGCCAGCCGCGCCTACGTCTACGCCGTCGGCCAGGCGCTGGACCGAGGCGAGACCGGCCGCCAGACCCGC
AAGGACGCCGCCGGCGCCATCCTGTACGCGGCAGAGAACGCCACCCAGCTGGCGCTGGACGCCATCCAGTGCCTGGGCGG
CAACGGCTACATCAACGAATACGCCACCGGCCGCCTGTTGCGCGACGCCAAGCTGTATGAGATCGGCGCCGGCACCAGCG
AGATCCGCCGCTGGCTCATCGGCCGCGAACTGATGGCCGAAACCAGGTAG

Upstream 100 bases:

>100_bases
TGGCCTGATCATCCCGCCATATTGACGCTTACGTAAACGTAAGCGATGATGTGCTCATCAGGCGCCGCCAGCCGCGCCGC
ACGCCAACGAGGAGAATTCC

Downstream 100 bases:

>100_bases
TCGCGGCGGATAAAGGGGCCGATGCCGCGTTGCGCCGCCTGGCCGTACGATTTGTACTGTCTGCGGCGGCGCGCCTTGCC
TCGGTCCCTTTCTCCACCAC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MYSSLRFAFGETYDLLRESVRDFAEREIAPRAAAIDQDNLFPADLWRKFGELGLLGITVSEQYGGVDMGYLAHMIAMEEI
SRASASVGLSYGAHSNLCVNQIYKNGNDAQRSRYLPKLITGEHVGALAMSEPNAGSDVVSMKLRADKTDGGYLLNGSKMW
ITNGGDADTLVVYAKTDVNAGPKGITAFIIEKSFAGFSHGSKLDKLGMRGSNTYPIFFDNCFVPDENVLGGEGNGVKVLM
SGLDYERSVLAAGPLGIMQASLDIVVPYLNERSQFGQPIGDFQLMQGKLADMYVKLSASRAYVYAVGQALDRGETGRQTR
KDAAGAILYAAENATQLALDAIQCLGGNGYINEYATGRLLRDAKLYEIGAGTSEIRRWLIGRELMAETR

Sequences:

>Translated_389_residues
MYSSLRFAFGETYDLLRESVRDFAEREIAPRAAAIDQDNLFPADLWRKFGELGLLGITVSEQYGGVDMGYLAHMIAMEEI
SRASASVGLSYGAHSNLCVNQIYKNGNDAQRSRYLPKLITGEHVGALAMSEPNAGSDVVSMKLRADKTDGGYLLNGSKMW
ITNGGDADTLVVYAKTDVNAGPKGITAFIIEKSFAGFSHGSKLDKLGMRGSNTYPIFFDNCFVPDENVLGGEGNGVKVLM
SGLDYERSVLAAGPLGIMQASLDIVVPYLNERSQFGQPIGDFQLMQGKLADMYVKLSASRAYVYAVGQALDRGETGRQTR
KDAAGAILYAAENATQLALDAIQCLGGNGYINEYATGRLLRDAKLYEIGAGTSEIRRWLIGRELMAETR
>Mature_389_residues
MYSSLRFAFGETYDLLRESVRDFAEREIAPRAAAIDQDNLFPADLWRKFGELGLLGITVSEQYGGVDMGYLAHMIAMEEI
SRASASVGLSYGAHSNLCVNQIYKNGNDAQRSRYLPKLITGEHVGALAMSEPNAGSDVVSMKLRADKTDGGYLLNGSKMW
ITNGGDADTLVVYAKTDVNAGPKGITAFIIEKSFAGFSHGSKLDKLGMRGSNTYPIFFDNCFVPDENVLGGEGNGVKVLM
SGLDYERSVLAAGPLGIMQASLDIVVPYLNERSQFGQPIGDFQLMQGKLADMYVKLSASRAYVYAVGQALDRGETGRQTR
KDAAGAILYAAENATQLALDAIQCLGGNGYINEYATGRLLRDAKLYEIGAGTSEIRRWLIGRELMAETR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=62.7659574468085, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=65.3179190751445, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI4557233, Length=389, Percent_Identity=40.1028277634961, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI4501859, Length=387, Percent_Identity=35.9173126614987, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=37.1052631578947, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=37.1052631578947, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI7656849, Length=370, Percent_Identity=35.6756756756757, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4557235, Length=372, Percent_Identity=36.5591397849462, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI76496475, Length=372, Percent_Identity=36.5591397849462, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI21361497, Length=369, Percent_Identity=36.3143631436314, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=31.5926892950392, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI7669494, Length=373, Percent_Identity=31.3672922252011, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=30.5851063829787, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=22.9965156794425, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=22.9965156794425, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081958, Length=386, Percent_Identity=30.0518134715026, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1786223, Length=357, Percent_Identity=28.5714285714286, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=26.7441860465116, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081702, Length=332, Percent_Identity=23.7951807228916, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=61.038961038961, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17569725, Length=384, Percent_Identity=35.9375, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=389, Percent_Identity=33.9331619537275, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17506239, Length=368, Percent_Identity=34.2391304347826, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17508101, Length=364, Percent_Identity=34.6153846153846, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=33.8541666666667, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=36.0795454545455, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=33.4231805929919, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71990804, Length=281, Percent_Identity=40.5693950177936, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=32.8912466843501, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=36.8421052631579, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=378, Percent_Identity=30.4232804232804, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17534353, Length=372, Percent_Identity=28.2258064516129, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=32.4817518248175, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17531909, Length=236, Percent_Identity=28.3898305084746, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=268, Percent_Identity=27.2388059701493, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=268, Percent_Identity=27.2388059701493, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21355753, Length=387, Percent_Identity=59.1731266149871, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=41.4698162729659, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24646207, Length=380, Percent_Identity=37.8947368421053, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=37.7952755905512, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24666513, Length=368, Percent_Identity=33.9673913043478, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI281363737, Length=382, Percent_Identity=34.5549738219895, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=29.1777188328912, Blast_Score=154, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42207; Mature: 42207

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSSLRFAFGETYDLLRESVRDFAEREIAPRAAAIDQDNLFPADLWRKFGELGLLGITVS
CCCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCEEEEEEEE
EQYGGVDMGYLAHMIAMEEISRASASVGLSYGAHSNLCVNQIYKNGNDAQRSRYLPKLIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHHHHCCCHHHHHHCCCHHHC
GEHVGALAMSEPNAGSDVVSMKLRADKTDGGYLLNGSKMWITNGGDADTLVVYAKTDVNA
CCCCCEEEECCCCCCCCEEEEEEEECCCCCCEEEECCEEEEECCCCCCEEEEEEECCCCC
GPKGITAFIIEKSFAGFSHGSKLDKLGMRGSNTYPIFFDNCFVPDENVLGGEGNGVKVLM
CCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCEEEECCEECCCCCCCCCCCCCCEEEE
SGLDYERSVLAAGPLGIMQASLDIVVPYLNERSQFGQPIGDFQLMQGKLADMYVKLSASR
ECCCCCCCEEECCCHHHHHHHHEEEEECCCCHHHHCCCCCCHHHHHCHHEEEEEEEECCC
AYVYAVGQALDRGETGRQTRKDAAGAILYAAENATQLALDAIQCLGGNGYINEYATGRLL
EEEEEEHHHHCCCCCCCHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHCCCEE
RDAKLYEIGAGTSEIRRWLIGRELMAETR
CCCEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYSSLRFAFGETYDLLRESVRDFAEREIAPRAAAIDQDNLFPADLWRKFGELGLLGITVS
CCCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCEEEEEEEE
EQYGGVDMGYLAHMIAMEEISRASASVGLSYGAHSNLCVNQIYKNGNDAQRSRYLPKLIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHHHHCCCHHHHHHCCCHHHC
GEHVGALAMSEPNAGSDVVSMKLRADKTDGGYLLNGSKMWITNGGDADTLVVYAKTDVNA
CCCCCEEEECCCCCCCCEEEEEEEECCCCCCEEEECCEEEEECCCCCCEEEEEEECCCCC
GPKGITAFIIEKSFAGFSHGSKLDKLGMRGSNTYPIFFDNCFVPDENVLGGEGNGVKVLM
CCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCEEEECCEECCCCCCCCCCCCCCEEEE
SGLDYERSVLAAGPLGIMQASLDIVVPYLNERSQFGQPIGDFQLMQGKLADMYVKLSASR
ECCCCCCCEEECCCHHHHHHHHEEEEECCCCHHHHCCCCCCHHHHHCHHEEEEEEEECCC
AYVYAVGQALDRGETGRQTRKDAAGAILYAAENATQLALDAIQCLGGNGYINEYATGRLL
EEEEEEHHHHCCCCCCCHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHCCCEE
RDAKLYEIGAGTSEIRRWLIGRELMAETR
CCCEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]