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The map label for this gene is iorB [H]

Identifier: 34497129

GI number: 34497129

Start: 1813550

End: 1815721

Strand: Direct

Name: iorB [H]

Synonym: CV_1674

Alternate gene names: 34497129

Gene position: 1813550-1815721 (Clockwise)

Preceding gene: 34497128

Following gene: 34497130

Centisome position: 38.17

GC content: 69.84

Gene sequence:

>2172_bases
ATGACGACCACCGGAGTTTCCCGCCGCGGTTTCCTGAAGATGAGCGGCGCGGTCGGCGGGGCGCTGTGCCTGGGCTTTGT
CCTGAACGAGAGGGGGGGCAAGGCCGAGGCGGCCGAGGCCAAGAGCGCCATCCCCGCCCCCAACGCCTTCGTCCGCATCG
AGAAGGACGGCGGCGTCACCATCGTCAGCAACAAGTCGGAAATGGGGCAGGGCATCTACACCTCGCTGGCGATGCTGATC
GCCGAGGAGCTGGAGTGCGACTGGAACCGGATCAAGGTGGTGTCGGCGCCGGCGGCTCCGGTCTATGTCCATACCGCCTT
CCATATCCAGATCACCGGCGGCAGCACCAGCACGCTGTCCAGCTACGACCAGTACCGCAAGATAGGCGCCGCCGCGCGCG
ACATGCTGATCGCGGCCGCCGCGCAACGCTGGCGGGTGCCGGCCTCGCAATGCCGCGCCGAAAACAGCCGAGTGTTCAAC
AACGCCAACGGCGCCAGCCTGGGTTACGGCGAGCTGACCGAGGCCGCCGGCAAGTTGCCGGTGCCTGACACGGTGGAGCT
GAAGCCGCGCCACCGCTGGAAGCTGCTGGGCACCCGCGTGCACCGGGTGGACGGCGACGAGAAGCTGGACGGCCGCGCGC
AGTTCGCGATGGATGTCCGCTTGCCCGGCATGCTGACGGCGCTGGTCAAGCGCTGCCCCAGCTATGGCGGCAAACCCAAG
GGCTTCAACGCCGACGCGGCCAGGGCGGTGCCCGGCGTCAGGGACGTGTTCGCGATCAGCAACGGCGTCGCCGTGCTGGC
TGACGGTTTCTGGCCGGCCAAGAAGGCGCGCGATCTGTTGACCGTGGACTGGGATCATGGGCCGAATGCCGGGTTGGATT
CTGCCAAGCTGCGCGCCGACTATCGCGCGCGCGCGGCCACGCCCGGGCAAACCTATCGCAGCGAGGGCGACGCCGAGGCC
GCGCTGGCCGGCGCGGCCAAGAAGCTGGAAGCCTGGTACGAGGTGCCGTACCTGTCCCACTCGCCGATGGAGCCGCTCAA
CTGCGTGGTCTGGCTGAAGCCCGGCAGCTGCCAGATCTGGAGCGGCACCCAGTCGCAGACGCTGGACGCCGGCATGGCCG
CCGCAATGGCCGGGCTGAAGCCGGAGCAGGTCTCGCTGCACACCACCTTGCTGGGCGGCGGCTTCGGCCGGCGCGCGGTG
CCGGCGGGGGCCGACTGGCTGAAGGAGGCGATGGAAGTGGCCAAGCGTCACGGCCAGGGCGCGCCGATCCGGCTGATGTG
GACCCGCGACGACGATTTGGCCGGCGCCTACTACCGGCCGATGTGGCTGGACCGCGTGCGCGGCGGCATAGCCGCGGATG
GCAAACCGGCCGCCTGGCTGCAGACCGGCGTCGGCCAGTCCATCATCGCCGGCACGCCGTTCGCGCCGATGATGATCAAG
AACGGCATCGACGCGGTGTCGGTGGAGGGCACCGACGACATGCCCTACGCGCTGCCGGCGGTGGCGCTGGACCTGCACAC
GGCGCAGACGCCGCTGCCGGTATTGTGGTGGCGCTCGGTCGGCCATTCCCACAGCGCCTTCACCAAGGAAAGCTATATCG
ACGAATTGGCGCGGCTGGCGCGCCAGGACCCGGTCGCCTACCGGCTGGCGCTGCTGGGCAAGGCGCCGCGCGAGCAGGGC
GTGCTGCGCGAGGCGGCGCGGATGGCCGGCTGGGGCCGCAAGCTGCCCAAGGGCCACGGCCTGGGCGCGGCGGTGCACAG
CTCCTTCGGCTCCCATGTCGCCCAGGTGGTGGAGGTGTCGCTCAAGGGCAAGGAGCTGAAAGTCGAGCATGTCTGGTGCG
CGATCGATTGCGGCGTGGTGGTCAACCCCGACCAGGTGGCGGCGCAGATGGAGGGCGGCATCCTGTTCGGCCTGTCGGCG
GCGCTGTTCGGCGAGATCACCTTCAAGGACGGCGAGGTGGAGCAGAAGAATTTCGACGGCTACCCCATCGTCAGGATGTT
CCAGGCGCCCAAGGTGGACGTTTCCATCGTCGCCAGCGAAGAGGCGCCGGGCGGCACCGGCGAGCCGGCGGTGCCGGTGG
TGGCGCCGGCGCTGGCCAACGCCATCCACGCGGCTTCCGGCAAGCGGCTGCGAGAGCTGCCGCTGAGCCGGCACGGTTAC
CAGGCGGTATGA

Upstream 100 bases:

>100_bases
CATCGACCTGGCGATGAGCGGCAACCTATGCCGCTGCGGCACCTATCCCCGCATCCGCGCGGCCATCCACGCCGCCGCCA
AACTGTTGTAGGAGGCCGCG

Downstream 100 bases:

>100_bases
GGGAGGCCGACATGAACATCTCGACTGTCCTGTGCTGGGCGCTGGCCGCCTGGCTGCCGGCCGCCTGGGCGGCGGACGAT
CCGGCCGCGTCGCGGCAGGC

Product: isoquinoline 1-oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MTTTGVSRRGFLKMSGAVGGALCLGFVLNERGGKAEAAEAKSAIPAPNAFVRIEKDGGVTIVSNKSEMGQGIYTSLAMLI
AEELECDWNRIKVVSAPAAPVYVHTAFHIQITGGSTSTLSSYDQYRKIGAAARDMLIAAAAQRWRVPASQCRAENSRVFN
NANGASLGYGELTEAAGKLPVPDTVELKPRHRWKLLGTRVHRVDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPK
GFNADAARAVPGVRDVFAISNGVAVLADGFWPAKKARDLLTVDWDHGPNAGLDSAKLRADYRARAATPGQTYRSEGDAEA
ALAGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCQIWSGTQSQTLDAGMAAAMAGLKPEQVSLHTTLLGGGFGRRAV
PAGADWLKEAMEVAKRHGQGAPIRLMWTRDDDLAGAYYRPMWLDRVRGGIAADGKPAAWLQTGVGQSIIAGTPFAPMMIK
NGIDAVSVEGTDDMPYALPAVALDLHTAQTPLPVLWWRSVGHSHSAFTKESYIDELARLARQDPVAYRLALLGKAPREQG
VLREAARMAGWGRKLPKGHGLGAAVHSSFGSHVAQVVEVSLKGKELKVEHVWCAIDCGVVVNPDQVAAQMEGGILFGLSA
ALFGEITFKDGEVEQKNFDGYPIVRMFQAPKVDVSIVASEEAPGGTGEPAVPVVAPALANAIHAASGKRLRELPLSRHGY
QAV

Sequences:

>Translated_723_residues
MTTTGVSRRGFLKMSGAVGGALCLGFVLNERGGKAEAAEAKSAIPAPNAFVRIEKDGGVTIVSNKSEMGQGIYTSLAMLI
AEELECDWNRIKVVSAPAAPVYVHTAFHIQITGGSTSTLSSYDQYRKIGAAARDMLIAAAAQRWRVPASQCRAENSRVFN
NANGASLGYGELTEAAGKLPVPDTVELKPRHRWKLLGTRVHRVDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPK
GFNADAARAVPGVRDVFAISNGVAVLADGFWPAKKARDLLTVDWDHGPNAGLDSAKLRADYRARAATPGQTYRSEGDAEA
ALAGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCQIWSGTQSQTLDAGMAAAMAGLKPEQVSLHTTLLGGGFGRRAV
PAGADWLKEAMEVAKRHGQGAPIRLMWTRDDDLAGAYYRPMWLDRVRGGIAADGKPAAWLQTGVGQSIIAGTPFAPMMIK
NGIDAVSVEGTDDMPYALPAVALDLHTAQTPLPVLWWRSVGHSHSAFTKESYIDELARLARQDPVAYRLALLGKAPREQG
VLREAARMAGWGRKLPKGHGLGAAVHSSFGSHVAQVVEVSLKGKELKVEHVWCAIDCGVVVNPDQVAAQMEGGILFGLSA
ALFGEITFKDGEVEQKNFDGYPIVRMFQAPKVDVSIVASEEAPGGTGEPAVPVVAPALANAIHAASGKRLRELPLSRHGY
QAV
>Mature_722_residues
TTTGVSRRGFLKMSGAVGGALCLGFVLNERGGKAEAAEAKSAIPAPNAFVRIEKDGGVTIVSNKSEMGQGIYTSLAMLIA
EELECDWNRIKVVSAPAAPVYVHTAFHIQITGGSTSTLSSYDQYRKIGAAARDMLIAAAAQRWRVPASQCRAENSRVFNN
ANGASLGYGELTEAAGKLPVPDTVELKPRHRWKLLGTRVHRVDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPKG
FNADAARAVPGVRDVFAISNGVAVLADGFWPAKKARDLLTVDWDHGPNAGLDSAKLRADYRARAATPGQTYRSEGDAEAA
LAGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCQIWSGTQSQTLDAGMAAAMAGLKPEQVSLHTTLLGGGFGRRAVP
AGADWLKEAMEVAKRHGQGAPIRLMWTRDDDLAGAYYRPMWLDRVRGGIAADGKPAAWLQTGVGQSIIAGTPFAPMMIKN
GIDAVSVEGTDDMPYALPAVALDLHTAQTPLPVLWWRSVGHSHSAFTKESYIDELARLARQDPVAYRLALLGKAPREQGV
LREAARMAGWGRKLPKGHGLGAAVHSSFGSHVAQVVEVSLKGKELKVEHVWCAIDCGVVVNPDQVAAQMEGGILFGLSAA
LFGEITFKDGEVEQKNFDGYPIVRMFQAPKVDVSIVASEEAPGGTGEPAVPVVAPALANAIHAASGKRLRELPLSRHGYQ
AV

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 77096; Mature: 76965

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTGVSRRGFLKMSGAVGGALCLGFVLNERGGKAEAAEAKSAIPAPNAFVRIEKDGGVT
CCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCEEEEEECCCCEE
IVSNKSEMGQGIYTSLAMLIAEELECDWNRIKVVSAPAAPVYVHTAFHIQITGGSTSTLS
EEECHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCHHHH
SYDQYRKIGAAARDMLIAAAAQRWRVPASQCRAENSRVFNNANGASLGYGELTEAAGKLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEECCCCCCCCCCHHHHHCCCCC
VPDTVELKPRHRWKLLGTRVHRVDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPK
CCCCEECCCCCHHHHHCCEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCC
GFNADAARAVPGVRDVFAISNGVAVLADGFWPAKKARDLLTVDWDHGPNAGLDSAKLRAD
CCCCCHHHHCCCHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHH
YRARAATPGQTYRSEGDAEAALAGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCQIW
HHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEE
SGTQSQTLDAGMAAAMAGLKPEQVSLHTTLLGGGFGRRAVPAGADWLKEAMEVAKRHGQG
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC
APIRLMWTRDDDLAGAYYRPMWLDRVRGGIAADGKPAAWLQTGVGQSIIAGTPFAPMMIK
CCEEEEEECCCCCCCCEECHHHHHHHCCCCCCCCCCHHHHHHCCCCCEECCCCCCHHHHH
NGIDAVSVEGTDDMPYALPAVALDLHTAQTPLPVLWWRSVGHSHSAFTKESYIDELARLA
CCCCEEEECCCCCCCCHHHHHEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHH
RQDPVAYRLALLGKAPREQGVLREAARMAGWGRKLPKGHGLGAAVHSSFGSHVAQVVEVS
HCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LKGKELKVEHVWCAIDCGVVVNPDQVAAQMEGGILFGLSAALFGEITFKDGEVEQKNFDG
CCCCEEEEEEEEEEEECCEEECHHHHHHHHCCCEEEEEHHHHHEEEEECCCCCCCCCCCC
YPIVRMFQAPKVDVSIVASEEAPGGTGEPAVPVVAPALANAIHAASGKRLRELPLSRHGY
CCEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
QAV
CCC
>Mature Secondary Structure 
TTTGVSRRGFLKMSGAVGGALCLGFVLNERGGKAEAAEAKSAIPAPNAFVRIEKDGGVT
CCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCEEEEEECCCCEE
IVSNKSEMGQGIYTSLAMLIAEELECDWNRIKVVSAPAAPVYVHTAFHIQITGGSTSTLS
EEECHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCHHHH
SYDQYRKIGAAARDMLIAAAAQRWRVPASQCRAENSRVFNNANGASLGYGELTEAAGKLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEECCCCCCCCCCHHHHHCCCCC
VPDTVELKPRHRWKLLGTRVHRVDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPK
CCCCEECCCCCHHHHHCCEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCC
GFNADAARAVPGVRDVFAISNGVAVLADGFWPAKKARDLLTVDWDHGPNAGLDSAKLRAD
CCCCCHHHHCCCHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHH
YRARAATPGQTYRSEGDAEAALAGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCQIW
HHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEE
SGTQSQTLDAGMAAAMAGLKPEQVSLHTTLLGGGFGRRAVPAGADWLKEAMEVAKRHGQG
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC
APIRLMWTRDDDLAGAYYRPMWLDRVRGGIAADGKPAAWLQTGVGQSIIAGTPFAPMMIK
CCEEEEEECCCCCCCCEECHHHHHHHCCCCCCCCCCHHHHHHCCCCCEECCCCCCHHHHH
NGIDAVSVEGTDDMPYALPAVALDLHTAQTPLPVLWWRSVGHSHSAFTKESYIDELARLA
CCCCEEEECCCCCCCCHHHHHEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHH
RQDPVAYRLALLGKAPREQGVLREAARMAGWGRKLPKGHGLGAAVHSSFGSHVAQVVEVS
HCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LKGKELKVEHVWCAIDCGVVVNPDQVAAQMEGGILFGLSAALFGEITFKDGEVEQKNFDG
CCCCEEEEEEEEEEEECCEEECHHHHHHHHCCCEEEEEHHHHHEEEEECCCCCCCCCCCC
YPIVRMFQAPKVDVSIVASEEAPGGTGEPAVPVVAPALANAIHAASGKRLRELPLSRHGY
CCEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
QAV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]