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The map label for this gene is tdh

Identifier: 34497106

GI number: 34497106

Start: 1788323

End: 1789348

Strand: Direct

Name: tdh

Synonym: CV_1651

Alternate gene names: 34497106

Gene position: 1788323-1789348 (Clockwise)

Preceding gene: 34497105

Following gene: 34497108

Centisome position: 37.64

GC content: 63.65

Gene sequence:

>1026_bases
ATGAAGGCGCTTGCCAAGCTGAAGGCCGCTCCCGGCCTGGAAATGACCGATGTTCCGCTGCCGGAAGTCGGCCACAACGA
TCTGTTGATCAAGATCGTCAAGACCGCGATCTGCGGCACCGACATCCATATCTGGAACTGGGACGAGTGGTCGCAGAAGA
CCATCCCGGTGCCGATGCACGTCGGGCACGAGTACGTCGGCGTCGTCGCCGGCATGGGTTCGGAAGTGCAGGGCTTCAAG
ATCGGCCAGCGCGTGTCCGGCGAAGGCCACATCACCTGCGGCTATTGCCGCAACTGCCGCGCCGGCCGCCGCCACCTGTG
CCGCAACACCACCGGCGTCGGCGTCAACCGCGAAGGCGCGTTCGCCGAATACCTGGTGATTCCGGCCTTCAATGCCTTCC
CGATCCCGGACGACATCTCCGACGACCTGGCCTCCATCTTCGACCCGTTCGGCAATGCCGTGCACACCGCGCTGTCGTTC
AACCTGGTGGGCGAGGACGTGCTGATCACAGGCGCCGGCCCGATCGGCATCATGGCGGTGGCCATCGCCAAGCATGTCGG
CGCGCGCCATGTCGTCATCACCGACGTCAACGACTACCGGCTGGAGCTGGCGAAGAAGATGGGCGCCACCCGTGCCGTCA
ACGTCGCCCGCGAGGACCTGAAGGCGGTGATGCAGGAGCTGCACATGAGCGAGGGCTTCGACGTGGGCCTGGAAATGTCC
GGCAATCCGCAGGCTTTCCGCCAGATGCTGGAAACGATGAACCACGGCGGCAAGGTGGCGCTGCTGGGCATTCCGCCGTC
CAATACCGCCATCGACTGGAACCAGGTGATCTTCAAGGGCCTGGAAATCAAGGGCATTTACGGCCGCGAGATGTTCGAGA
CCTGGTACAAGATGGTGGCCCTGATCCAGTCCGGCCTGGACATCAGTCCTATCATCACCCACCACTTCAAGGTGGACGAG
TTCGAGCAGGGCTTCGCCGCGATGCTGTCCGGCCAGAGCGGCAAGGTGATCCTGGACTGGCGCTGA

Upstream 100 bases:

>100_bases
GCTGTTGCCGCCTTCATCAAGGTCGGCCGCGAGCTGGGCGTAATCTGATTTGACCGCATGACAGGCCGCGCGGCGTCCGC
GCGGCTTCAAGGATAGAGAC

Downstream 100 bases:

>100_bases
GTCCCGCGTCCGTCAGCATGCGAAGCGGCCCCGTAACGGGCCGCTTTTTTCATGCCGGCGCGGCGCGTGTCCTGAAGTAA
GCGATCATCCGCCGCAGCTG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALAKLKAAPGLEMTDVPLPEVGHNDLLIKIVKTAICGTDIHIWNWDEWSQKTIPVPMHVGHEYVGVVAGMGSEVQGFK
IGQRVSGEGHITCGYCRNCRAGRRHLCRNTTGVGVNREGAFAEYLVIPAFNAFPIPDDISDDLASIFDPFGNAVHTALSF
NLVGEDVLITGAGPIGIMAVAIAKHVGARHVVITDVNDYRLELAKKMGATRAVNVAREDLKAVMQELHMSEGFDVGLEMS
GNPQAFRQMLETMNHGGKVALLGIPPSNTAIDWNQVIFKGLEIKGIYGREMFETWYKMVALIQSGLDISPIITHHFKVDE
FEQGFAAMLSGQSGKVILDWR

Sequences:

>Translated_341_residues
MKALAKLKAAPGLEMTDVPLPEVGHNDLLIKIVKTAICGTDIHIWNWDEWSQKTIPVPMHVGHEYVGVVAGMGSEVQGFK
IGQRVSGEGHITCGYCRNCRAGRRHLCRNTTGVGVNREGAFAEYLVIPAFNAFPIPDDISDDLASIFDPFGNAVHTALSF
NLVGEDVLITGAGPIGIMAVAIAKHVGARHVVITDVNDYRLELAKKMGATRAVNVAREDLKAVMQELHMSEGFDVGLEMS
GNPQAFRQMLETMNHGGKVALLGIPPSNTAIDWNQVIFKGLEIKGIYGREMFETWYKMVALIQSGLDISPIITHHFKVDE
FEQGFAAMLSGQSGKVILDWR
>Mature_341_residues
MKALAKLKAAPGLEMTDVPLPEVGHNDLLIKIVKTAICGTDIHIWNWDEWSQKTIPVPMHVGHEYVGVVAGMGSEVQGFK
IGQRVSGEGHITCGYCRNCRAGRRHLCRNTTGVGVNREGAFAEYLVIPAFNAFPIPDDISDDLASIFDPFGNAVHTALSF
NLVGEDVLITGAGPIGIMAVAIAKHVGARHVVITDVNDYRLELAKKMGATRAVNVAREDLKAVMQELHMSEGFDVGLEMS
GNPQAFRQMLETMNHGGKVALLGIPPSNTAIDWNQVIFKGLEIKGIYGREMFETWYKMVALIQSGLDISPIITHHFKVDE
FEQGFAAMLSGQSGKVILDWR

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=26.0479041916168, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=25.7452574525745, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=25.3443526170799, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=26.0387811634349, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=26.0387811634349, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI34577061, Length=361, Percent_Identity=25.7617728531856, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501939, Length=357, Percent_Identity=25.2100840336134, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=24.5283018867925, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=25.8064516129032, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=80.5882352941177, Blast_Score=579, Evalue=1e-167,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=31.3351498637602, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1788073, Length=330, Percent_Identity=28.1818181818182, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1787863, Length=306, Percent_Identity=28.7581699346405, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI226510992, Length=249, Percent_Identity=30.9236947791165, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87082125, Length=346, Percent_Identity=29.7687861271676, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1788407, Length=338, Percent_Identity=26.9230769230769, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=28.3185840707965, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790718, Length=308, Percent_Identity=26.2987012987013, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786825, Length=369, Percent_Identity=26.5582655826558, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786552, Length=378, Percent_Identity=26.4550264550265, Blast_Score=98, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=327, Percent_Identity=32.4159021406728, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=31.437125748503, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71988145, Length=279, Percent_Identity=28.673835125448, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=26.4880952380952, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=279, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=368, Percent_Identity=25.2717391304348, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=25, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=24.8520710059172, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=324, Percent_Identity=28.0864197530864, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322619, Length=317, Percent_Identity=27.7602523659306, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=317, Percent_Identity=27.4447949526814, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=373, Percent_Identity=25.7372654155496, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324486, Length=308, Percent_Identity=31.1688311688312, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=370, Percent_Identity=26.2162162162162, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=349, Percent_Identity=29.2263610315186, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=271, Percent_Identity=26.9372693726937, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=339, Percent_Identity=27.7286135693215, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=309, Percent_Identity=28.4789644012945, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323980, Length=282, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=306, Percent_Identity=27.1241830065359, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=28.6144578313253, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17137530, Length=330, Percent_Identity=26.6666666666667, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17737895, Length=376, Percent_Identity=25.7978723404255, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221457811, Length=183, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551930, Length=183, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550770, Length=183, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_CHRVO (Q7NXH5)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901321.1
- ProteinModelPortal:   Q7NXH5
- SMR:   Q7NXH5
- GeneID:   2550313
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1651
- NMPDR:   fig|243365.1.peg.1651
- HOGENOM:   HBG753318
- OMA:   EYVGVVA
- PhylomeDB:   Q7NXH5
- ProtClustDB:   PRK05396
- BioCyc:   CVIO243365:CV_1651-MONOMER
- BRENDA:   1.1.1.103
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR00692

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37262; Mature: 37262

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALAKLKAAPGLEMTDVPLPEVGHNDLLIKIVKTAICGTDIHIWNWDEWSQKTIPVPMH
CCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHH
VGHEYVGVVAGMGSEVQGFKIGQRVSGEGHITCGYCRNCRAGRRHLCRNTTGVGVNREGA
CCCHHHHHHHCCCCCCCCEECCCEECCCCCEEEHHHHCCHHHHHHHHCCCCCCCCCCCCC
FAEYLVIPAFNAFPIPDDISDDLASIFDPFGNAVHTALSFNLVGEDVLITGAGPIGIMAV
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCEEEEECCCHHHHHHH
AIAKHVGARHVVITDVNDYRLELAKKMGATRAVNVAREDLKAVMQELHMSEGFDVGLEMS
HHHHHCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GNPQAFRQMLETMNHGGKVALLGIPPSNTAIDWNQVIFKGLEIKGIYGREMFETWYKMVA
CCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
LIQSGLDISPIITHHFKVDEFEQGFAAMLSGQSGKVILDWR
HHHCCCCCCCHHHEEECCCHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MKALAKLKAAPGLEMTDVPLPEVGHNDLLIKIVKTAICGTDIHIWNWDEWSQKTIPVPMH
CCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHH
VGHEYVGVVAGMGSEVQGFKIGQRVSGEGHITCGYCRNCRAGRRHLCRNTTGVGVNREGA
CCCHHHHHHHCCCCCCCCEECCCEECCCCCEEEHHHHCCHHHHHHHHCCCCCCCCCCCCC
FAEYLVIPAFNAFPIPDDISDDLASIFDPFGNAVHTALSFNLVGEDVLITGAGPIGIMAV
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCEEEEECCCHHHHHHH
AIAKHVGARHVVITDVNDYRLELAKKMGATRAVNVAREDLKAVMQELHMSEGFDVGLEMS
HHHHHCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GNPQAFRQMLETMNHGGKVALLGIPPSNTAIDWNQVIFKGLEIKGIYGREMFETWYKMVA
CCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
LIQSGLDISPIITHHFKVDEFEQGFAAMLSGQSGKVILDWR
HHHCCCCCCCHHHEEECCCHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782